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Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from Phase I to II

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Jay Meythaler, John Fath, Darren Fuerst, Hashem Zokary, Kristina Freese, Heidi Baird Martin, Joshua Reineke, Jean Peduzzi-Nelson & P. Tyler Roskos. (2019) Safety and feasibility of minocycline in treatment of acute traumatic brain injury. Brain Injury 33:5, pages 679-689.
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Mariajose Metcalfe, Brian T. David, Brett C. Langley & Caitlin E. Hill. (2023) Elevation of NAD+ by nicotinamide riboside spares spinal cord tissue from injury and promotes locomotor recovery. Experimental Neurology 368, pages 114479.
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James Hong, Noah Poulin & Michael G. Fehlings. 2022. Neural Repair and Regeneration After Spinal Cord Injury and Spine Trauma. Neural Repair and Regeneration After Spinal Cord Injury and Spine Trauma 523 535 .
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Palaniappan Ganesh Nagappan, Hong Chen & De-Yun Wang. (2020) Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury. Military Medical Research 7:1.
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Maryam Seif, Claudia AM Gandini Wheeler-Kingshott, Julien Cohen-Adad, Adam E Flanders & Patrick Freund. (2019) Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers. Spinal Cord 57:9, pages 717-728.
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Christine D. Yarberry, Aaron H. Puckett & Stephen M. Onifer. 2019. Animal Models of Acute Neurological Injury. Animal Models of Acute Neurological Injury 71 90 .
Dasa Cizkova, Adriana-Natalia Murgoci, Lenka Kresakova, Katarina Vdoviakova, Milan Cizek, Tomas Smolek, Veronika Cubinkova, Jusal Quanico, Isabelle Fournier & Michel Salzet. 2018. Essentials of Spinal Cord Injury Medicine. Essentials of Spinal Cord Injury Medicine.
Jessica C. PageJonghyuck ParkZhe ChenPeng CaoRiyi Shi. (2018) Parallel Evaluation of Two Potassium Channel Blockers in Restoring Conduction in Mechanical Spinal Cord Injury in Rat. Journal of Neurotrauma 35:9, pages 1057-1068.
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Dasa Cizkova, Veronika Cubinkova, Tomas Smolek, Adriana-Natalia Murgoci, Jan Danko, Katarina Vdoviakova, Filip Humenik, Milan Cizek, Jusal Quanico, Isabelle Fournier & Michel Salzet. (2018) Localized Intrathecal Delivery of Mesenchymal Stromal Cells Conditioned Medium Improves Functional Recovery in a Rat Model of Spinal Cord Injury. International Journal of Molecular Sciences 19:3, pages 870.
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Bernardo De Caro Martins, Bruno Benetti Junta Torres, Karen Maciel de Oliveira, Mario Sergio Lavor, Carla Maria Osório, Fabiola Bono Fukushima, Isabel Rodrigues Rosado & Eliane Gonçalves de Melo. (2018) Association of riluzole and dantrolene improves significant recovery after acute spinal cord injury in rats. The Spine Journal 18:3, pages 532-539.
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Eveline Huber, Patrice Lachappelle, Reto Sutter, Armin Curt & Patrick Freund. (2017) Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?. Annals of Neurology 81:5, pages 740-748.
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David Reigada, Rosa María Navarro-Ruiz, Marcos Javier Caballero-López, Ángela Del Águila, Teresa Muñoz-Galdeano, Rodrigo M. Maza & Manuel Nieto-Díaz. (2016) Diadenosine tetraphosphate (Ap4A) inhibits ATP-induced excitotoxicity: a neuroprotective strategy for traumatic spinal cord injury treatment. Purinergic Signalling 13:1, pages 75-87.
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Freda M. Warner, Jacquelyn J. Cragg, John D. Steeves & John L. K. Kramer. 2017. Neurological Aspects of Spinal Cord Injury. Neurological Aspects of Spinal Cord Injury 741 755 .
Samira Saadoun & Marios C. Papadopoulos. (2016) Spinal cord injury: is monitoring from the injury site the future?. Critical Care 20:1.
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Natália L. Vasconcelos, Eduardo D. Gomes, Eduarda P. Oliveira, Carlos J. Silva, Rui Lima, Nuno Sousa, António J. Salgado & Nuno A. Silva. (2016) Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury. The Spine Journal 16:8, pages 1015-1024.
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Sergiy V. KushchayevMorgan B. GiersDoris Hom Eng, Nikolay L. MartirosyanJennifer M. EschbacherMartin M. MortazaviNicholas TheodoreAlyssa Panitch & Mark C. Preul. (2016) Hyaluronic acid scaffold has a neuroprotective effect in hemisection spinal cord injury. Journal of Neurosurgery: Spine 25:1, pages 114-124.
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Irja Elliott DonaghueCharles H. TatorMolly S. Shoichet. (2016) Local Delivery of Neurotrophin-3 and Anti-NogoA Promotes Repair After Spinal Cord Injury. Tissue Engineering Part A 22:9-10, pages 733-741.
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Liliana R. Pires & Ana P. Pêgo. (2015) Bridging the lesion—engineering a permissive substrate for nerve regeneration. Regenerative Biomaterials 2:3, pages 203-214.
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Eveline Huber, Armin Curt & Patrick Freund. (2015) Tracking trauma-induced structural and functional changes above the level of spinal cord injury. Current Opinion in Neurology 28:4, pages 365-372.
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