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Drug Evaluation

Ezatiostat hydrochloride for the treatment of myelodysplastic syndromes

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Shu-Chen Dong, Huan-Huan Sha, Xiao-Yue Xu, Tian-Mu Hu, Rui Lou, Huizi Li, Jian-Zhong Wu, Chen Dan & Jifeng Feng. (2018) Glutathione S-transferase π: a potential role in antitumor therapy. Drug Design, Development and Therapy 12, pages 3535-3547.
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Lingjuan Chen, Gaoli Chen, Lixuan Guo, Yaping Wang & Chengjin Ai. (2023) Hypoxia-Induced GST1 Exerts Protective Effects on Trophoblasts via Inhibiting Reactive Oxygen Species (ROS) Accumulation. Analytical Cellular Pathology 2023, pages 1-12.
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Yoshiro NIITSU, Yasushi SATO & Tetsuji TAKAYAMA. (2022) Implications of glutathione-S transferase P1 in MAPK signaling as a CRAF chaperone: In memory of Dr. Irving Listowsky. Proceedings of the Japan Academy, Series B 98:2, pages 72-86.
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Kecheng Lei, Xiaoxia Gu, Alvaro G. Alvarado, Yuhong Du, Shilin Luo, Eun Hee Ahn, Seong Su Kang, Bing Ji, Xia Liu, Hui Mao, Haian Fu, Harley I. Kornblum, Lingjing Jin, Hua Li & Keqiang Ye. (2020) Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma. Journal of Hematology & Oncology 13:1.
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Yoshiro NiitsuYasushi Sato, Kunihiro TakanashiTsuyoshi HayashiNaoko Kubo-BirukawaFumiko ShimizuNaoki FujitaniRai Shimoyama, Takehiro KukitsuWataru KurataYasuyuki TashiroIrving Listowsky. (2020) A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations . Proceedings of the National Academy of Sciences 117:32, pages 19435-19445.
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Kecheng Lei, Yiyuan Xia, Xiao-Chuan Wang, Eun Hee Ahn, Lingjing Jin & Keqiang Ye. (2020) C/EBPβ mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation. Redox Biology 34, pages 101578.
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Rahul R. Singh, Jiyan Mohammad, Megan Orr & Katie M. Reindl. (2020) Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways. Cancers 12:6, pages 1501.
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Sophie Möltgen, Eleonora Piumatti, Giuseppe Massafra, Sabine Metzger, Ulrich Jaehde & Ganna Kalayda. (2020) Cisplatin Protein Binding Partners and Their Relevance for Platinum Drug Sensitivity. Cells 9:6, pages 1322.
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Jie Zhang, Zhi-Wei Ye, Yvonne Janssen-Heininger, Danyelle M. Townsend & Kenneth D. Tew. 2021. Reactive Oxygen Species. Reactive Oxygen Species 71 91 .
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Martín Cancela, Jéssica A. Paes, Hercules Moura, John R. Barr, Arnaldo Zaha & Henrique B. Ferreira. (2019) Unraveling oxidative stress response in the cestode parasite Echinococcus granulosus. Scientific Reports 9:1.
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Naoki Fujitani, Akihiro Yoneda, Motoko Takahashi, Akira Takasawa, Tomoyuki Aoyama & Tadaaki Miyazaki. (2019) RETRACTED ARTICLE: Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction. Scientific Reports 9:1.
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Maria C Fernandez & Cristian O’Flaherty. (2018) Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa. Human Reproduction 33:8, pages 1394-1407.
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Claudia Rita Corso & Alexandra Acco. (2018) Glutathione system in animal model of solid tumors: From regulation to therapeutic target. Critical Reviews in Oncology/Hematology 128, pages 43-57.
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Jie Zhang, Zhi-wei Ye, Shweta Singh, Danyelle M. Townsend & Kenneth D. Tew. (2018) An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation. Free Radical Biology and Medicine 120, pages 204-216.
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Nerino Allocati, Michele Masulli, Carmine Di Ilio & Luca Federici. (2018) Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases. Oncogenesis 7:1.
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R.N. Armstrong, R. Morgenstern & P.G. Board. 2018. Comprehensive Toxicology. Comprehensive Toxicology 326 362 .
Elie HatemNadine El BannaMeng-Er Huang. (2017) Multifaceted Roles of Glutathione and Glutathione-Based Systems in Carcinogenesis and Anticancer Drug Resistance. Antioxidants & Redox Signaling 27:15, pages 1217-1234.
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Sharon M. Louie, Elizabeth A. Grossman, Lisa A. Crawford, Lucky Ding, Roman Camarda, Tucker R. Huffman, David K. Miyamoto, Andrei Goga, Eranthie Weerapana & Daniel K. Nomura. (2016) GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity. Cell Chemical Biology 23:5, pages 567-578.
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