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Original Research

Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study

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Pages 1787-1804 | Published online: 25 Jun 2010

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R. Freynhagen, C. Elling, T. Radic, M. Sohns, H. Liedgens, D. James, R. McCool & M. Edwards. (2021) Safety of tapentadol compared with other opioids in chronic pain treatment: network meta-analysis of randomized controlled and withdrawal trials. Current Medical Research and Opinion 37:1, pages 89-100.
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Jeffrey Gudin, Andrew G Kaufman & Samyadev Datta. (2020) Are Opioids Needed to Treat Chronic Low Back Pain? A Review of Treatment Options and Analgesics in Development. Journal of Pain Research 13, pages 1007-1022.
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Filippo Caraci, Flaminia Coluzzi, Franco Marinangeli, Sebastiano Mercadante, Giuseppe Rinonapoli, Patrizia Romualdi, Mariaflavia Nicora & Anthony H. Dickenson. (2020) Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?. Current Medical Research and Opinion 36:6, pages 1015-1024.
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Donald M. Bushnell, Mona L. Martin, Mariёlle Eerdekens, Annette Christoph, Georg Kralidis & Hiltrud Liedgens. (2020) Pain assessment for chronic lower back pain: performance of the PAL-S and PAL-I patient-reported measures for symptoms and impacts. Current Medical Research and Opinion 36:5, pages 853-863.
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Laura E. Gressler, Drayton A. Hammond & Jacob T. Painter. (2017) Serotonin Syndrome in Tapentadol Literature: Systematic Review of Original Research. Journal of Pain & Palliative Care Pharmacotherapy 31:3-4, pages 228-236.
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Nalini Vadivelu, Alice Kai, Benjamin Maslin, Gopal Kodumudi, Aron Legler & Jack M Berger. (2015) Tapentadol extended release in the management of peripheral diabetic neuropathic pain. Therapeutics and Clinical Risk Management 11, pages 95-105.
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Flaminia Coluzzi, Robert B Raffa, Joseph Pergolizzi, Alessandra Rocco, Pamela Locarini, Natalia Cenfra, Giuseppe Cimino & Consalvo Mattia. (2015) Tapentadol prolonged release for patients with multiple myeloma suffering from moderate-to-severe cancer pain due to bone disease. Journal of Pain Research 8, pages 229-238.
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Nebojsa Nick Knezevic, Tatiana Tverdohleb, Ivana Knezevic & Kenneth D Candido. (2015) Unique pharmacology of tapentadol for treating acute and chronic pain. Expert Opinion on Drug Metabolism & Toxicology 11:9, pages 1475-1492.
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Carmelo Scarpignato & Luigi Gatta. (2015) Comparing tapentadol to oxycodone/naloxone combination: building castles in the air. Current Medical Research and Opinion 31:2, pages 335-338.
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Ece Esin & Suayib Yalcin. (2014) Neuropathic cancer pain: What we are dealing with? How to manage it?. OncoTargets and Therapy 7, pages 599-618.
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Volker Strick. (2014) Management of severe chronic pain with tapentadol prolonged release – long-term data from pain specialists. Current Medical Research and Opinion 30:10, pages 2085-2092.
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Sebastiano Mercadante, Giampiero Porzio, Claudio Adile, Federica Aielli, Andrea Cortegiani, Anthony Dickenson & Alessandra Casuccio. (2014) Tapentadol at medium to high doses in patients previously receiving strong opioids for the management of cancer pain. Current Medical Research and Opinion 30:10, pages 2063-2068.
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Howard S. Smith, Robert B. Raffa, Joseph V. Pergolizzi, Robert Taylor & Ronald J. Tallarida. (2014) Combining Opioid and Adrenergic Mechanisms for Chronic Pain. Postgraduate Medicine 126:4, pages 98-114.
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Bansri Desai, Erin Freeman, Ellen Huang, Anna Hung, Edward Knapp, Ian M Breunig, Mary L McPherson & Fadia T Shaya. (2014) Clinical value of tapentadol extended-release in painful diabetic peripheral neuropathy. Expert Review of Clinical Pharmacology 7:2, pages 203-209.
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Nalini Vadivelu, Yili Huang, Brian Mirante, Michael Jacoby, Ferne R Braveman, Roberta L Hines & Raymond Sinatra. (2013) Patient considerations in the use of tapentadol for moderate to severe pain. Drug, Healthcare and Patient Safety 5, pages 151-159.
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Nalini Sehgal, James Colson & Howard S Smith. (2013) Chronic pain treatment with opioid analgesics: benefits versus harms of long-term therapy. Expert Review of Neurotherapeutics 13:11, pages 1201-1220.
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Keiichiro Imanaka, Yushin Tominaga, Mila Etropolski, Ilse van Hove, Masaki Ohsaka, Mikio Wanibe, Keiichiro Hirose & Taka Matsumura. (2013) Efficacy and safety of oral tapentadol extended release in Japanese and Korean patients with moderate to severe, chronic malignant tumor-related pain. Current Medical Research and Opinion 29:10, pages 1399-1409.
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A. Schwittay, C. Schumann, B. C. Litzenburger & K. Schwenke. (2013) Tapentadol Prolonged Release for Severe Chronic Pain: Results of a Noninterventional Study Involving General Practitioners and Internists. Journal of Pain & Palliative Care Pharmacotherapy 27:3, pages 225-234.
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Sebastiano Mercadante, Giampiero Porzio, Federica Aielli, Claudio Adile, Lucilla Verna, Corrado Ficorella, Antonello Giarratano & Alessandra Casuccio. (2013) Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids. Current Medical Research and Opinion 29:6, pages 661-666.
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Sebastiano Mercadante, Giampiero Porzio, Patrizia Ferrera, Federica Aielli, Claudio Adile, Corrado Ficorella, Antonello Giarratano & Alessandra Casuccio. (2012) Tapentadol in cancer pain management: a prospective open-label study. Current Medical Research and Opinion 28:11, pages 1775-1779.
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Robert Ikenberg, Nadine Hertel, R. Andrew Moore, Marko Obradovic, Garth Baxter, Pete Conway & Hiltrud Liedgens. (2012) Cost-effectiveness of tapentadol prolonged release compared with oxycodone controlled release in the UK in patients with severe non-malignant chronic pain who failed 1st line treatment with morphine. Journal of Medical Economics 15:4, pages 724-736.
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Ilona Steigerwald, Matthias Müller, Anthony Davies, Daniel Samper, Rainer Sabatowski, Ralf Baron, Sylvie Rozenberg, Anna Szczepanska-Szerej, Antonio Gatti & Hans G. Kress. (2012) Effectiveness and safety of tapentadol prolonged release for severe, chronic low back pain with or without a neuropathic pain component: results of an open-label, phase 3b study. Current Medical Research and Opinion 28:6, pages 911-936.
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Craig T Hartrick & Jose Rafael Rodríguez Hernandez. (2012) Tapentadol for pain: a treatment evaluation. Expert Opinion on Pharmacotherapy 13:2, pages 283-286.
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Joseph Pergolizzi, Eli Alon, Ralf Baron, Cesare Bonezzi, Jan Dobrogowski, Rafael Gálvez, Troels Jensen, Hans-Georg Kress, Marco AE Marcus, Bart Morlion, Serge Perrot & Rolf-Detlef Treede. (2011) Tapentadol in the management of chronic low back pain: a novel approach to a complex condition?. Journal of Pain Research 4, pages 203-210.
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Nalini Vadivelu, Alexander Timchenko, Yili Huang & Raymond Sinatra. (2011) Tapentadol extended-release for treatment of chronic pain: a review. Journal of Pain Research 4, pages 211-218.
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Rob Riemsma, Carol Forbes, Julie Harker, Gill Worthy, Kate Misso, Michael Schäfer, Jos Kleijnen & Steffen Stürzebecher. (2011) Systematic review of tapentadol in chronic severe pain. Current Medical Research and Opinion 27:10, pages 1907-1930.
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G.E. Bekkering, K. Soares-Weiser, K. Reid, A.G. Kessels, A. Dahan, R.D. Treede & J. Kleijnen. (2011) Can morphine still be considered to be the standard for treating chronic pain? A systematic review including pair-wise and network meta-analyses. Current Medical Research and Opinion 27:7, pages 1477-1491.
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Sherwyn Schwartz, Mila Etropolski, Douglas Y. Shapiro, Akiko Okamoto, Robert Lange, Juergen Haeussler & Christine Rauschkolb. (2011) Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results of a randomized-withdrawal, placebo-controlled trial. Current Medical Research and Opinion 27:1, pages 151-162.
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