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The argument of antidepressant drugs in the treatment of bipolar depression: mixed evidence or mixed states?

, MD PhD, , MD, , MD & , MD
Pages 2037-2051 | Published online: 04 Sep 2012

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Hotaka Shinzato, Munenaga Koda, Akifumi Nakamura & Tsuyoshi Kondo. (2019) Development of the 12-item questionnaire for quantitative assessment of depressive mixed state (DMX-12). Neuropsychiatric Disease and Treatment 15, pages 1983-1991.
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Michele Fornaro, Andrea Fusco, Annalisa Anastasia, Carlo Ignazio Cattaneo & Domenico De Berardis. (2019) Brexpiprazole for treatment-resistant major depressive disorder. Expert Opinion on Pharmacotherapy 20:16, pages 1925-1933.
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Elie Cheniaux & Antonio E. Nardi. (2019) Evaluating the efficacy and safety of antidepressants in patients with bipolar disorder. Expert Opinion on Drug Safety 18:10, pages 893-913.
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Michele Fornaro, Lubna Kardash, Stefano Novello, Andrea Fusco, Annalisa Anastasia, Domenico De Berardis, Giampaolo Perna & Mauro Giovanni Carta. (2018) Progress in bipolar disorder drug design toward the development of novel therapeutic targets: a clinician’s perspective. Expert Opinion on Drug Discovery 13:3, pages 221-228.
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Yigit Kivilcim, Merih Altintas, Fusun Mayda Domac, Erkal Erzincan & Huseyin Gülec. (2017) Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics. Neuropsychiatric Disease and Treatment 13, pages 631-641.
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Michele Fornaro, Domenico De Berardis, Ann Sarah Koshy, Giampaolo Perna, Alessandro Valchera, Davy Vancampfort & Brendon Stubbs. (2016) Prevalence and clinical features associated with bipolar disorder polypharmacy: a systematic review. Neuropsychiatric Disease and Treatment 12, pages 719-735.
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Michele Fornaro, Michael J McCarthy, Domenico De Berardis, Concetta De Pasquale, Massimo Tabaton, Matteo Martino, Salvatore Colicchio, Carlo Ignazio Cattaneo, Emanuela D’Angelo & Pantaleo Fornaro. (2013) Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study. Neuropsychiatric Disease and Treatment 9, pages 243-251.
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Articles from other publishers (21)

Yu Zamami, Hotaka Shinzato, Kazuhiro Kurihara, Munenaga Koda, Akifumi Nakamura & Tsuyoshi Kondo. (2021) Prevalence and profile of depressive mixed state in patients with autism spectrum disorder. Psychiatry Research 300, pages 113932.
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M. Fornaro, S. Novello, A. Fusco, A. Anastasia, M. De Prisco, A.M. Mondin, P. Mosca, F. Iasevoli & A. de Bartolomeis. (2021) Clinical features associated with early drop-out among outpatients with unipolar and bipolar depression. Journal of Psychiatric Research 136, pages 522-528.
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Hotaka Shinzato, Yu Zamami & Tsuyoshi Kondo. (2020) The 12-Item Self-Rating Questionnaire for Depressive Mixed State (DMX-12) for Screening of Mixed Depression and Mixed Features. Brain Sciences 10:10, pages 678.
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Terence A. Ketter. 2020. New Directions in Psychiatry. New Directions in Psychiatry 83 99 .
Hotaka Shinzato & Tsuyoshi Kondo. (2019) The 12-item self-rating questionnaire for depressive mixed state (DMX-12) in relation to categorical diagnoses of mixed depression and mixed features. Clinical Neuropsychopharmacology and Therapeutics 10:0, pages 18-25.
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Giulio E. Brancati, Eduard Vieta, Jean-Michel Azorin, Jules Angst, Charles L. Bowden, Sergey Mosolov, Allan H. Young & Giulio Perugi. (2019) The role of overlapping excitatory symptoms in major depression: are they relevant for the diagnosis of mixed state?. Journal of Psychiatric Research 115, pages 151-157.
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Michele Fornaro, Annalisa Anastasia, Alessandro Valchera, Alessandro Carano, Laura Orsolini, Federica Vellante, Gabriella Rapini, Luigi Olivieri, Serena Di Natale, Giampaolo Perna, Giovanni Martinotti, Massimo Di Giannantonio & Domenico De Berardis. (2019) The FDA “Black Box” Warning on Antidepressant Suicide Risk in Young Adults: More Harm Than Benefits?. Frontiers in Psychiatry 10.
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Michele Fornaro. (2019) Reply to Dr. Gentili’ “Analysis of tolerance to antidepressant drugs in FDA Adverse Event Reporting System”. Pharmacological Research 141, pages 618.
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Michele Fornaro, Annalisa Anastasia, Francesco Monaco, Stefano Novello, Andrea Fusco, Felice Iasevoli, Domenico De Berardis, Nicola Veronese, Marco Solmi & Andrea de Bartolomeis. (2018) Clinical and psychopathological features associated with treatment-emergent mania in bipolar-II depressed outpatients exposed to antidepressants. Journal of Affective Disorders 234, pages 131-138.
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Gianni L. Faedda & Ciro Marangoni. (2016) What is the role of conventional antidepressants in the treatment of major depressive episodes with Mixed Features Specifier?. CNS Spectrums 22:2, pages 120-125.
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Michele Fornaro, Domenico De Berardis, Giampaolo Perna, Marco Solmi, Nicola Veronese, Laura Orsolini, Elisabetta Filomena Buonaguro, Felice Iasevoli, Cristiano André Köhler, André Ferrer Carvalho & Andrea de Bartolomeis. (2017) Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews. BioMed Research International 2017, pages 1-17.
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M. Fornaro, L. Orsolini, S. Marini, D. De Berardis, G. Perna, A. Valchera, L. Ganança, M. Solmi, N. Veronese & B. Stubbs. (2016) The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis. Journal of Affective Disorders 195, pages 105-118.
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Michele Fornaro, Brendon Stubbs, Domenico De Berardis, Giampaolo Perna, Alessandro Valchera, Nicola Veronese, Marco Solmi & Licínia Ganança. (2016) Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placebo-Controlled Clinical Trials. International Journal of Molecular Sciences 17:2, pages 241.
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Tsuyoshi Kondo, Hotaka Shinzato & Munenaga Koda. (2016) Diagnostic and Therapeutic Considerations in Depressive Mixed State. Clinical Neuropsychopharmacology and Therapeutics 7:0, pages 41-47.
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Jay A. Salpekar, Paramjit T. Joshi, David A. Axelson, Shauna P. Reinblatt, Gayane Yenokyan, Abanti Sanyal, John T. Walkup, Benedetto Vitiello, Joan L. Luby, Karen Dineen Wagner, Nasima Nusrat & Mark A. Riddle. (2015) Depression and Suicidality Outcomes in the Treatment of Early Age Mania Study. Journal of the American Academy of Child & Adolescent Psychiatry 54:12, pages 999-1007.e4.
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Michele Fornaro, Domenico De Berardis, Monica Mazza, Mariachiara Pino, Ettore Favaretto, Fulvio Bedani, Christian Wieser, Luisa Indelicato, Vito Fabio Paternò, Francesca Lo Monaco, Febronia Dugo, Antonio Ventriglio, Sergio Mungo, Valerio Selle, Alessandro Valchera, Mai Elassy, Giovanni Martinotti, Andrea De Bartolomeis, Felice Iasevoli, Carmine Tomasetti, Livia Avvisati, Sergio Tartaglione, Giampaolo Perna, Carlo Ignazio Cattaneo, Giorgio Consoli, Anna Romano, Alessandro Del Debbio, Matteo Martino, Emanuela D׳Angelo, Concetta De Pasquale, Ann Sarah Koshy & Jules Angst. (2015) Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2). Journal of Affective Disorders 178, pages 112-120.
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Michele Fornaro, Mai Elassy, Mina Mounir, Noran Abd-Elmoneim, Hala Ashour, Rania Hamed, Abdullah Al-Shehri, Samir Bedir, Ibrahem Rashed, Noha Amer, Talal A. Mohammed, Domenico De Berardis, Monica Mazza, Mariachiara Pino, Ann Sarah Koshy, Concetta De Pasquale, Tarek Okasha & Jules Angst. (2015) Factor structure and reliability of the Arabic adaptation of the Hypomania Check List-32, second revision (HCL-32-R2). Comprehensive Psychiatry 59, pages 141-150.
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Michele Fornaro, Domenico De Berardis, Concetta De Pasquale, Luisa Indelicato, Rocco Pollice, Alessandro Valchera, Giampaolo Perna, Felice Iasevoli, Carmine Tomasetti, Giovanni Martinotti, Ann Sarah Koshy, Ole Bernt Fasmer & Ketil Joachim Oedegaard. (2015) Prevalence and clinical features associated to bipolar disorder–migraine comorbidity: a systematic review. Comprehensive Psychiatry 56, pages 1-16.
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Michele Fornaro, Domenico De Berardis, Felice Iasevoli, Maria Luisa Pistorio, Emanuela D'Angelo, Sergio Mungo, Matteo Martino, Antonio Ventriglio, Carlo Ignazio Cattaneo, Ettore Favaretto, Alessandro Del Debbio, Anna Romano, Giovanni Ciampa, Mai Elassy, Giulio Perugi & Concetta De Pasquale. (2013) Treatment adherence towards prescribed medications in bipolar-II acute depressed patients: Relationship with cyclothymic temperament and “therapeutic sensation seeking” in response towards subjective intolerance to pain. Journal of Affective Disorders 151:2, pages 596-604.
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Michele Fornaro, Antonio Ventriglio, Concetta De Pasquale, Maria Luisa Pistorio, Domenico De Berardis, Carlo Ignazio Cattaneo, Ettore Favaretto, Giovanni Martinotti, Carmine Tomasetti, Mai Elassy, Emanuela D'Angelo, Sergio Mungo, Alessandro Del Debbio, Anna Romano, Giovanni Ciampa & Salvatore Colicchio. (2013) Sensation seeking in major depressive patients: Relationship to sub-threshold bipolarity and cyclothymic temperament. Journal of Affective Disorders 148:2-3, pages 375-383.
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Eduard Vieta & Marc Valentí. (2013) Mixed states in DSM-5: Implications for clinical care, education, and research. Journal of Affective Disorders 148:1, pages 28-36.
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