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Expert Opinion on Pharmacotherapy Volume 8, 2007 - Issue 5
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Drug Evaluation

Review of azelastine nasal spray in the treatment of allergic and non-allergic rhinitis

Christina Lee Research Physician, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Section of Clinical Immunology and Allergy, University of California, Los Angeles and Allergy Research Foundation, Los Angeles, CA, USA
&
Jonathan Corren Medical Director and Associate Clinical Professor of Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Section of Clinical Immunology and Allergy, University of California, Los Angeles and Allergy Research Foundation, 11620 Wilshire Blvd., Suite 200, Los Angeles, CA 90025, USA. [email protected]
Pages 701-709 | Published online: 22 Mar 2007

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Swapnil Sharadkumar Chudiwal & Mohamed Hassan G. Dehghan. (2018) Quality by design (QbD) approach for design and development of drug-device combination products: a case study on flunisolide nasal spray. Pharmaceutical Development and Technology 23:10, pages 1077-1087.
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Friedrich Horak & Ursula Petra Zieglmayer. (2009) Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis. Expert Review of Clinical Immunology 5:6, pages 659-669.
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Friedrich Horak. (2008) Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis. Therapeutics and Clinical Risk Management 4:5, pages 1009-1022.
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Articles from other publishers (25)

Ewa Trybus, Wojciech Trybus & Teodora Król. (2023) Cytological Study of Topical Effect of Azelastine Hydrochloride on the Nasal Mucous Membrane Cells in Various Nasal Rhinitis Types. Cells 12:23, pages 2697.
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Yasir Mehmood, Hira Shahid, Muhammad Abbas, Umar Farooq, Sultan Alshehri, Prawez Alam, Faiyaz Shakeel & Mohammed M. Ghoneim. (2023) Developing Nanosuspension Loaded with Azelastine for Potential Nasal Drug Delivery: Determination of Proinflammatory Interleukin IL-4 mRNA Expression and Industrial Scale-Up Strategy. ACS Omega 8:26, pages 23812-23824.
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Jens Peter Klussmann, Maria Grosheva, Peter Meiser, Clara Lehmann, Eszter Nagy, Valéria Szijártó, Gábor Nagy, Robert Konrat, Michael Flegel, Frank Holzer, Dorothea Groß, Charlotte Steinmetz, Barbara Scherer, Henning Gruell, Maike Schlotz, Florian Klein, Paula Aguiar de Aragão, Henning Morr, Helal Al Saleh, Andreas Bilstein, Belisa Russo, Susanne Müller-Scholtz, Cengizhan Acikel, Hacer Sahin, Nina Werkhäuser, Silke Allekotte & Ralph Mösges. (2023) Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients. Scientific Reports 13:1.
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Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Mösges, Jens Peter Klussmann & Thorsten Lehr. (2022) Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients. Pharmaceutics 14:10, pages 2059.
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Ewa Trybus, Teodora Król & Wojciech Trybus. (2022) The Multidirectional Effect of Azelastine Hydrochloride on Cervical Cancer Cells. International Journal of Molecular Sciences 23:11, pages 5890.
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S. Shekhar & A. Bali. (2021) Spectrofluorimetric Method for the Determination of Azelastine Hydrochloride in Bulk and Nasal Formulations. Journal of Applied Spectroscopy 88:3, pages 674-680.
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Emel Tahir, Cemal Cingi & Sarah K. Wise. 2020. All Around the Nose. All Around the Nose 311 317 .
A V Sobolev, Ya I Kozlova, A V Pyatakova, O V Aak & N N Klimko. (2017) Allergic rhinitis: the choice of rational treatment. Russian Journal of Allergy 14:2, pages 71-75.
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Panayiotis A. Procopiou, Alison J. Ford, Paul M. Gore, Ashley P. Hancock, Simon T. Hodgson, Duncan S. Holmes, Brian E. Looker, Sadie Vile, Kenneth L. Clark, Ken A. Saunders, Robert J. Slack & Clarissa J. Watts. (2017) Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis. Bioorganic & Medicinal Chemistry Letters 27:21, pages 4914-4919.
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Panayiotis A. Procopiou, Alison J. Ford, Paul M. Gore, Brian E. Looker, Simon T. Hodgson, Duncan S. Holmes, Sadie Vile, Kenneth L. Clark, Ken A. Saunders, Robert J. Slack, James E. Rowedder & Clarissa J. Watts. (2017) Design of Phthalazinone Amide Histamine H 1 Receptor Antagonists for Use in Rhinitis . ACS Medicinal Chemistry Letters 8:5, pages 577-581.
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N M Nenasheva, N I Ilina & T G Fedoskova. (2016) The effectiveness of intranasal corticosteroids and antihistamines combination - mometasone furoate and azelastine hydrochloride nasal spray in adults with seasonal allergic rhinitis (The results of clinical trial). Russian Journal of Allergy 13:2, pages 54-64.
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T G Fedoskova, V M Svistushkin & E A Shevchik. (2016) Allergic rhinitis is a seasonal trouble and off-seasonal problem. Russian Journal of Allergy 13:2, pages 36-43.
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Fulvio Braido, Federica Arcadipane, Fiorenza Marugo, Mituki Hayashi & Ruby Pawankar. (2014) Allergic rhinitis. Current Opinion in Allergy & Clinical Immunology 14:2, pages 168-176.
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Paul A. JohnstonMalabika SenYun HuaDaniel CamarcoTong Ying ShunJohn S. LazoJennifer R. Grandis. (2014) High-Content pSTAT3/1 Imaging Assays to Screen for Selective Inhibitors of STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. ASSAY and Drug Development Technologies 12:1, pages 55-79.
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Silviu Albu & Sorin Baschir. (2013) Intranasal phototherapy versus azelastine in the treatment of seasonal allergic rhinitis. Auris Nasus Larynx 40:5, pages 447-451.
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João Ferreira de Mello Júnior, Olavo de Godoy Mion, Nilvano Alves de Andrade, Wilma Terezinha Anselmo-Lima, Aldo Eden Cassol Stamm, Washingthon Luiz de Cerqueira Almeida, Pedro Oliveira Cavalcante Filho, Jair de Carvalho e Castro, Francini Grecco de Melo Padua, Fabrizio Ricci Romano, Rodrigo de Paulo Santos, Renato Roitmann, Richard Louis Voegels, Roberto Campos Meirelles, Leonardo Conrado Barbosa Sá, Moacyr Tabasnik Moacyr, Marco Cesar Jorge dos Santos & Roberto Eustáquio Santos Guimarães. (2013) Brazilian Academy of Rhinology position paper on topical intranasal therapy. Brazilian Journal of Otorhinolaryngology 79:3, pages 391-400.
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Bengü Çobanoğlu, Elina Toskala, Ahmet Ural & Cemal Cingi. (2013) Role of Leukotriene Antagonists and Antihistamines in the Treatment of Allergic Rhinitis. Current Allergy and Asthma Reports 13:2, pages 203-208.
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Panayiotis A. Procopiou, Christopher Browning, Paul M. Gore, Sean M. Lynn, Stephen A. Richards, Robert J. Slack & Steven L. Sollis. (2012) Synthesis and pharmacological investigation of azaphthalazinone human histamine H1 receptor antagonists. Bioorganic & Medicinal Chemistry 20:20, pages 6097-6108.
Crossref
Panayiotis A. Procopiou, Christopher Browning, Jennifer M. Buckley, Kenneth L. Clark, Lise Fechner, Paul M. Gore, Ashley P. Hancock, Simon T. Hodgson, Duncan S. Holmes, Michael Kranz, Brian E. Looker, Karen M. L. Morriss, Daniel L. Parton, Linda J. Russell, Robert J. Slack, Steven L. Sollis, Sadie Vile & Clarissa J. Watts. (2011) The Discovery of Phthalazinone-Based Human H 1 and H 3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis . Journal of Medicinal Chemistry 54:7, pages 2183-2195.
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Ayse Fusun Kalpaklioglu & Ayse Baccioglu Kavut. (2010) Comparison of Azelastine versus Triamcinolone Nasal Spray in Allergic and Nonallergic Rhinitis. American Journal of Rhinology & Allergy 24:1, pages 29-33.
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Shailen R. Shah, Anjuli Nayak, Paul Ratner, Peter Roland & G. Michael Wall. (2009) Effects of olopatadine hydrochloride nasal spray 0.6% in the treatment of seasonal allergie rhinitis: A phase III, multicenter, randomized, double-blind, active- and placebo-controlled study in adolescents and adults. Clinical Therapeutics 31:1, pages 99-107.
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Glenis K. Scadding. 2009. Allergy Frontiers: Clinical Manifestations. Allergy Frontiers: Clinical Manifestations 49 65 .
Robert A. Nathan. (2008) The pathophysiology, clinical impact, and management of nasal congestion in allergic rhinitis. Clinical Therapeutics 30:4, pages 573-586.
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Michael A. Kaliner. (2007) A novel and effective approach to treating rhinitis with nasal antihistamines. Annals of Allergy, Asthma & Immunology 99:5, pages 383-391.
Crossref
Jerzy Kruszewski. (2007) Leki przeciwhistaminowe w alergicznych nieżytach nosa. Otolaryngologia Polska 61:4, pages 522-526.
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