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Expert Opinion on Biological Therapy Volume 11, 2011 - Issue 5
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Genotoxicity of retroviral hematopoietic stem cell gene therapy

Grant D Trobridge Washington State University, Department of Pharmaceutical Sciences and School of Molecular Biosciences, P.O. Box 646534, Pullman, WA 99164-6534, USA +1 509 335 3573; +1 509 335 4875; +1 509 335 5902; [email protected]
, PhD
Pages 581-593 | Published online: 07 Mar 2011

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Maximilian Georg Wolfgang Witzel, Christian Joerg Braun, Kaan Boztug & Christoph Klein. (2013) Gene therapy for Wiskott–Aldrich syndrome. Expert Opinion on Orphan Drugs 1:9, pages 705-715.
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Articles from other publishers (31)

Elizabeth M. Everson, Jonah D. Hocum & Grant D. Trobridge. (2018) Efficacy and safety of a clinically relevant foamy vector design in human hematopoietic repopulating cells. The Journal of Gene Medicine 20:7-8, pages e3028.
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Atul Kamboj, Claus V. Hallwirth, Ian E. Alexander, Geoffrey B. McCowage & Belinda Kramer. (2017) Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data. BMC Bioinformatics 18:1.
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Sara El Ashkar, Dominique Van Looveren, Franziska Schenk, Lenard S. Vranckx, Jonas Demeulemeester, Jan De Rijck, Zeger Debyser, Ute Modlich & Rik Gijsbers. (2017) Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy. Molecular Therapy - Nucleic Acids 7, pages 231-245.
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D L Browning, E M Everson, D J Leap, J D Hocum, H Wang, G Stamatoyannopoulos & G D Trobridge. (2016) Evidence for the in vivo safety of insulated foamy viral vectors. Gene Therapy 24:3, pages 187-198.
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Rhiannon M. David & Ann T. Doherty. (2017) Viral Vectors: The Road to Reducing Genotoxicity. Toxicological Sciences 155:2, pages 315-325.
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Nicolas A. Gillet, Anat Melamed & Charles R. M. Bangham. 2017. Human T-Lymphotropic Viruses. Human T-Lymphotropic Viruses 127 141 .
Cathy X. WangPaula M. Cannon. (2016) Clinical Applications of Genome Editing to HIV Cure. AIDS Patient Care and STDs 30:12, pages 539-544.
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Jonah D. Hocum, Ian Linde, Dustin T. Rae, Casey P. Collins, Lindsay K. Matern & Grant D. Trobridge. (2016) Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes. Scientific Reports 6:1.
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Victor Bii & Grant Trobridge. (2016) Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral Vectors. Cancers 8:11, pages 99.
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Cathy X. Wang & Paula M. Cannon. (2016) The clinical applications of genome editing in HIV. Blood 127:21, pages 2546-2552.
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Diana L. Browning, Casey P. CollinsJonah D. HocumDavid J. LeapDustin T. RaeGrant D. Trobridge. (2016) Insulated Foamy Viral Vectors. Human Gene Therapy 27:3, pages 255-266.
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Sandeep Satapathy. (2016) Provirus Silencing in Stem Cells: The Forbidden Regulators of Cell Fate. Signal Transduction Insights 5, pages STI.S12311.
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Jonah D. Hocum, Logan R. Battrell, Ryan Maynard, Jennifer E. Adair, Brian C. Beard, David J. Rawlings, Hans-Peter Kiem, Daniel G. Miller & Grant D. Trobridge. (2015) VISA - Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing. BMC Bioinformatics 16:1.
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Victor M. Bii, Dustin T. Rae & Grant D. Trobridge. (2015) A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker . Oncotarget 6:37, pages 39507-39520.
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Sheng ZhouMelissa A. BonnerYong-Dong WangSamuel RappSuk See De RavinHarry L. MalechBrian P. Sorrentino. (2015) Quantitative Shearing Linear Amplification Polymerase Chain Reaction: An Improved Method for Quantifying Lentiviral Vector Insertion Sites in Transplanted Hematopoietic Cell Systems. Human Gene Therapy Methods 26:1, pages 4-12.
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Astrid Glaser, Bradley McColl & Jim Vadolas. (2015) The therapeutic potential of genome editing for β-thalassemia. F1000Research 4, pages 1431.
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Bradley McColl, Sara Howden & Jim Vadolas. 2015. Bacterial Artificial Chromosomes. Bacterial Artificial Chromosomes 309 321 .
Ellyn N Schinke, Victor Bii, Arun Nalla, Dustin T Rae, Laura Tedrick, Gary G Meadows & Grant D Trobridge. (2014) A novel approach to identify driver genes involved in androgen-independent prostate cancer. Molecular Cancer 13:1.
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Mamuka Kvaratskhelia, Amit Sharma, Ross C. Larue, Erik Serrao & Alan Engelman. (2014) Molecular mechanisms of retroviral integration site selection. Nucleic Acids Research 42:16, pages 10209-10225.
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Laura Rose & Hasan Uludağ. (2013) Realizing the potential of gene-based molecular therapies in bone repair. Journal of Bone and Mineral Research 28:11, pages 2245-2262.
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Y Yang, F Xiao, Z Lu, Z Li, H Zuo, Q Zhang, Q Li, H Wang & L-S Wang. (2013) Development of a novel adenovirus–alphavirus hybrid vector with RNA replicon features for malignant hematopoietic cell transduction. Cancer Gene Therapy 20:8, pages 429-436.
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Guilherme Baldo, David F. Wozniak, Kevin K. Ohlemiller, Yanming Zhang, Roberto Giugliani & Katherine P. Ponder. (2012) Retroviral-vector-mediated gene therapy to mucopolysaccharidosis I mice improves sensorimotor impairments and other behavioral deficits. Journal of Inherited Metabolic Disease 36:3, pages 499-512.
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Perry B. Hackett, David A. Largaespada, Kirsten C. Switzer & Laurence J.N. Cooper. (2013) Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy. Translational Research 161:4, pages 265-283.
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Chuanfeng WuAlexander JaresThomas WinklerJianjun XieJean-Yves MetaisCynthia E. Dunbar. (2013) High Efficiency Restriction Enzyme–Free Linear Amplification-Mediated Polymerase Chain Reaction Approach for Tracking Lentiviral Integration Sites Does Not Abrogate Retrieval Bias. Human Gene Therapy 24:1, pages 38-47.
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Grant Trobridge, Peter Horn, Brian Beard & Hans-Peter Kiem. (2012) Large Animal Models for Foamy Virus Vector Gene Therapy. Viruses 4:12, pages 3572-3588.
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Cecilia N Barese, Allen E Krouse, Mark E Metzger, Connor A King, Catia Traversari, Frank C Marini, Robert E Donahue & Cynthia E Dunbar. (2012) Thymidine Kinase Suicide Gene-mediated Ganciclovir Ablation of Autologous Gene-modified Rhesus Hematopoiesis. Molecular Therapy 20:10, pages 1932-1943.
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Mauro Giacca & Serena Zacchigna. (2012) Virus-mediated gene delivery for human gene therapy. Journal of Controlled Release 161:2, pages 377-388.
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Katherine P Ponder, Thomas M O'Malley, Ping Wang, Patricia A O'Donnell, Anne M Traas, Van W Knox, Gustavo A Aguirre, N Matthew Ellinwood, Jason A Metcalf, Bin Wang, Emma J Parkinson-Lawrence, Meg M Sleeper, Doug A Brooks, John J Hopwood & Mark E Haskins. (2012) Neonatal Gene Therapy With a Gamma Retroviral Vector in Mucopolysaccharidosis VI Cats. Molecular Therapy 20:5, pages 898-907.
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Luca Biasco, Cristina Baricordi & Alessandro Aiuti. (2012) Retroviral Integrations in Gene Therapy Trials. Molecular Therapy 20:4, pages 709-716.
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Laura C. Rose, Cezary Kucharski & Hasan Uludağ. (2012) Protein expression following non-viral delivery of plasmid DNA coding for basic FGF and BMP-2 in a rat ectopic model. Biomaterials 33:11, pages 3363-3374.
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Chuanfeng Wu & Cynthia E. Dunbar. (2011) Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity. Frontiers of Medicine 5:4, pages 356-371.
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