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Expert Opinion on Biological Therapy Volume 12, 2012 - Issue 8
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Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials

Giuseppe Derosaa University of Pavia, Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, P.le C. Golgi, 2 - 27100 Pavia, Italy+39 0382 526217; +39 0382 526259; [email protected]
, MD PhD,
Pamela Maffiolia University of Pavia, Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, P.le C. Golgi, 2 - 27100 Pavia, Italy+39 0382 526217; +39 0382 526259; [email protected]
, MD &
Arrigo FG Cicerob University of Bologna, “G. Descovich” Atherosclerosis Study Center, “D. Campanacci” Clinical Medicine and Applied Biotechnology Department, Bologna, Italy
, MD PhD
Pages 1113-1124 | Published online: 11 Jul 2012

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Faezeh Izadparast, Bamdad Riahi-Zajani, Fatemeh Yarmohammadi, A. Wallace Hayes & Gholamreza Karimi. (2022) Protective effect of berberine against LPS-induced injury in the intestine: a review. Cell Cycle 21:22, pages 2365-2378.
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Giuseppe Derosa, Angela D’Angelo, Arianna Vanelli & Pamela Maffioli. (2020) An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia. Diabetes, Metabolic Syndrome and Obesity 13, pages 653-661.
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Safieh Firouzi, Mahsa Malekahmadi, Majid Ghayour-Mobarhan, Gordon Ferns & Hamid Reza Rahimi. (2018) Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action. Diabetes, Metabolic Syndrome and Obesity 11, pages 699-705.
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Arrigo F. G. Cicero & Alessandro Colletti. (2018) An update on the safety of nutraceuticals and effects on lipid parameters. Expert Opinion on Drug Safety 17:3, pages 303-313.
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Francesco Di Pierro, Pietro Putignano, Tarcisio Ferrara, Carmela Raiola, Giuliana Rapacioli & Nicola Villanova. (2017) Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in patients with dyslipidemia. Clinical Pharmacology: Advances and Applications 9, pages 1-7.
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Hongmei Qiu, Yang Wu, Quanhua Wang, Changqing Liu, Lai Xue, Hong Wang, Qin Wu & Qingsong Jiang. (2017) Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV. Pharmaceutical Biology 55:1, pages 227-232.
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Arrigo F G Cicero, Martino Morbini, Angelo Parini, Riccardo Urso, Martina Rosticci, Elisa Grandi & Claudio Borghi. (2016) Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects. Therapeutics and Clinical Risk Management 12, pages 281-286.
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Arrigo F.G. Cicero, Martino Morbini, Marilisa Bove, Sergio D’Addato, Federica Fogacci, Martina Rosticci & Claudio Borghi. (2016) Additional therapy for cholesterol lowering in ezetimibe-treated, statin-intolerant patients in clinical practice: results from an internal audit of a university lipid clinic. Current Medical Research and Opinion 32:10, pages 1633-1638.
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Giuseppe Derosa & Pamela Maffioli. (2015) Nutraceuticals for the treatment of metabolic diseases: evidence from clinical practice. Expert Review of Endocrinology & Metabolism 10:3, pages 297-304.
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Francesco Di Pierro, Pietro Putignano, Nicola Villanova, Luca Montesi, Simona Moscatiello & Giulio Marchesini. (2013) Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes. Clinical Pharmacology: Advances and Applications 5, pages 167-174.
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Giuseppe Derosa, Aldo Bonaventura, Lucio Bianchi, Davide Romano, Angela D'Angelo, Elena Fogari & Pamela Maffioli. (2013) Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients. Expert Opinion on Biological Therapy 13:11, pages 1495-1506.
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Paramjit S Tappia, Yan–Jun Xu & Naranjan S Dhalla. (2013) Reduction of cholesterol and other cardiovascular disease risk factors by alternative therapies. Clinical Lipidology 8:3, pages 345-359.
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Giuseppe Derosa, Angela D'Angelo, Aldo Bonaventura, Lucio Bianchi, Davide Romano & Pamela Maffioli. (2013) Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert Opinion on Biological Therapy 13:4, pages 475-482.
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Jie V. Zhao, Xin Huang, Junmeng Zhang, Yap-Hang Chan, Hung-Fat Tse & Joseph E. Blais. (2023) Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. The Journal of Nutrition 153:10, pages 2939-2950.
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Di Zhang, Li Ke, Zhen Ni, Yu Chen, Lin-Hui Zhang, Shao-Hua Zhu, Chan-Juan Li, Lei Shang, Jie Liang & Yong-Quan Shi. (2017) Berberine containing quadruple therapy for initial Helicobacter pylori eradication. Medicine 96:32, pages e7697.
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Chae-Min Yi, Jihyun Yu, Hyunbin Kim, Na-Rae Lee, Sang Won Kim, Noh-Jin Lee, Jun Lee, Jihye Seong, Nam-Jung Kim & Kyung-Soo Inn. (2017) Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly. Chemical Communications 53:52, pages 7045-7047.
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