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Expert Opinion on Biological Therapy Volume 13, 2013 - Issue 7
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Original Research

Influence of lipoplex surface charge on siRNA delivery: application to the in vitro downregulation of CXCR4 HIV-1 co-receptor

Carole LavigneNational HIV & Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, 200 Tunney's Pasture Driveway, Ottawa, Ontario K1A 0K9, Canada+1 613 941 8857; +1 613 948 4026; [email protected]
, PhD,
Kathryn SlaterNational HIV & Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, 200 Tunney's Pasture Driveway, Ottawa, Ontario K1A 0K9, Canada+1 613 941 8857; +1 613 948 4026; [email protected]
,
Niranjala GajanayakaNational HIV & Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, 200 Tunney's Pasture Driveway, Ottawa, Ontario K1A 0K9, Canada+1 613 941 8857; +1 613 948 4026; [email protected]
,
Christian DuguayNational HIV & Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, 200 Tunney's Pasture Driveway, Ottawa, Ontario K1A 0K9, Canada+1 613 941 8857; +1 613 948 4026; [email protected]
,
Erika Arnau PeyrotteNational HIV & Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, 200 Tunney's Pasture Driveway, Ottawa, Ontario K1A 0K9, Canada+1 613 941 8857; +1 613 948 4026; [email protected]
,
Germaine FortierNational HIV & Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, 200 Tunney's Pasture Driveway, Ottawa, Ontario K1A 0K9, Canada+1 613 941 8857; +1 613 948 4026; [email protected]
,
Martin SimardNational HIV & Retrovirology Laboratories, National Microbiology Laboratory, Public Health Agency of Canada, 200 Tunney's Pasture Driveway, Ottawa, Ontario K1A 0K9, Canada+1 613 941 8857; +1 613 948 4026; [email protected]
,
Arnold J KellNational Research Council, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
,
Michael L BarnesNational Research Council, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
&
Alain R ThierryInstitut de Recherche en Cancérologie de Montpellier (U896), CRLC Val d'Aurelle – Paul Lamarque, 208 rue des Apothicaires, 34298 Montpellier, France
 show all
Pages 973-985 | Published online: 07 Jan 2013

Citations (13)

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Anne-Sophie Guedj, Arnold J Kell, Michael Barnes, Sandra Stals, David Gonçalves, Denis Girard & Carole Lavigne. (2015) Preparation, characterization, and safety evaluation of poly(lactide-co-glycolide) nanoparticles for protein delivery into macrophages. International Journal of Nanomedicine 10, pages 5965-5979.
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Hojat Borna, Saber Imani, Maryam Iman & Sadegh Azimzadeh Jamalkandi. (2015) Therapeutic face of RNAi: in vivo challenges. Expert Opinion on Biological Therapy 15:2, pages 269-285.
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Articles from other publishers (11)

Nina Královič - Kanjaková, Lukáš Hubčík, Alexander Búcsi, Mária Klacsová, Sophie Combet, José Teixeira, Juan Carlos Martínez & Daniela Uhríková. (2021) Calcium mediated DNA binding in non-lamellar structures formed by DOPG/glycerol monooleate. Chemistry and Physics of Lipids 239, pages 105118.
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Azam Bolhassani & Alireza Milani. (2020) Small Interfering RNAs and their Delivery Systems: A Novel Powerful Tool for the Potential Treatment of HIV Infections. Current Molecular Pharmacology 13:3, pages 173-181.
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Weiqi Zhang, Bo Han, Xinning Lai, Chen Xiao, Shilin Xu, Xianghui Meng, Zifu Li, Jie Meng, Tao Wen, Xiangliang Yang, Jian Liu & Haiyan Xu. (2020) Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells. Chemical Communications 56:8, pages 1255-1258.
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Eric Berger, Dalibor Breznan, Sandra Stals, Viraj J Jasinghe, David Gonçalves, Denis Girard, Sylvie Faucher, Renaud Vincent, Alain R Thierry & Carole Lavigne. (2017) Cytotoxicity assessment, inflammatory properties, and cellular uptake of Neutraplex lipid-based nanoparticles in THP-1 monocyte-derived macrophages. Nanobiomedicine 4, pages 184954351774625.
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Monika Rak, Anna Ochałek, Ewa Bielecka, Joanna Latasiewicz, Katarzyna Gawarecka, Jolanta Sroka, Jarosław Czyż, Katarzyna Piwowarczyk, Marek Masnyk, Marek Chmielewski, Tadeusz Chojnacki, Ewa Swiezewska & Zbigniew Madeja. (2016) Efficient and non-toxic gene delivery by anionic lipoplexes based on polyprenyl ammonium salts and their effects on cell physiology. The Journal of Gene Medicine 18:11-12, pages 331-342.
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A. Frère, B. Evrard, D. Mottet & G. Piel. 2016. Nanoarchitectonics for Smart Delivery and Drug Targeting. Nanoarchitectonics for Smart Delivery and Drug Targeting 503 540 .
Simeon K. Adesina & Emmanuel O. Akala. (2015) Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy. Molecular Pharmaceutics 12:12, pages 4175-4187.
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Xianghui Zeng, Anne Marit de Groot, Alice J. A. M. Sijts, Femke Broere, Erik Oude Blenke, Stefano Colombo, Willem van Eden, Henrik Franzyk, Hanne Mørck Nielsen & Camilla Foged. (2015) Surface coating of siRNA–peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro. Nanoscale 7:46, pages 19687-19698.
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Vijay Mishra, Prashant Kesharwani & Narendra K. Jain. (2014) siRNA nanotherapeutics: a Trojan horse approach against HIV. Drug Discovery Today 19:12, pages 1913-1920.
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Aristides D. Tagalakis, Do Hyang D. Lee, Alison S. Bienemann, Haiyan Zhou, Mustafa M. Munye, Luisa Saraiva, David McCarthy, Zixiu Du, Conrad A. Vink, Ruhina Maeshima, Edward A. White, Kenth Gustafsson & Stephen L. Hart. (2014) Multifunctional, self-assembling anionic peptide-lipid nanocomplexes for targeted siRNA delivery. Biomaterials 35:29, pages 8406-8415.
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Aristides D. Tagalakis, Gavin D. Kenny, Alison S. Bienemann, David McCarthy, Mustafa M. Munye, Hannah Taylor, Marcella J. Wyatt, Mark F. Lythgoe, Edward A. White & Stephen L. Hart. (2014) PEGylation improves the receptor-mediated transfection efficiency of peptide-targeted, self-assembling, anionic nanocomplexes. Journal of Controlled Release 174, pages 177-187.
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