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Expert Opinion on Biological Therapy Volume 14, 2014 - Issue 3
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Kinase-inhibitor–insensitive cancer stem cells in chronic myeloid leukemia

Alessandro MorottiUniversity Turin, San Luigi Hospital, Division of Hematology and Internal Medicine, Department of Oncology, Orbassano – Turin, [email protected]
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Cristina PanuzzoUniversity Turin, San Luigi Hospital, Division of Hematology and Internal Medicine, Department of Oncology, Orbassano – Turin, [email protected]
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Carmen FavaUniversity Turin, San Luigi Hospital, Division of Hematology and Internal Medicine, Department of Oncology, Orbassano – Turin, [email protected]
&
Giuseppe SaglioUniversity Turin, San Luigi Hospital, Division of Hematology and Internal Medicine, Department of Oncology, Orbassano – Turin, [email protected]
Pages 287-299 | Published online: 03 Jan 2014

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Salma Younes, Mohamed A. Ismail, Rana Al-Jurf, Ayah Ziyada, Gheyath K. Nasrallah, Palli Valapila Abdulrouf, Mohamed Nagy, Hatem Zayed, Thomas Farrell, Claudio Sorio, Hisham Morsi, M. Walid Qoronfleh & Nader I. Al-Dewik. (2023) Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies. Hematology 28:1.
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Giovanna Carrà, Antonio Cartellà, Beatrice Maffeo & Alessandro Morotti. (2019) Strategies For Targeting Chronic Myeloid Leukaemia Stem Cells. Blood and Lymphatic Cancer: Targets and Therapy 9, pages 45-52.
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Elham Yektaei-Karin, Ana Zovko, Anders Nilsson, Barbro Näsman-Glaser, Lena Kanter, Olof Rådmark, Jonas Wallvik, Marja Ekblom, Monika Dolinska, Hong Qian & Leif Stenke. (2017) Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia. Leukemia & Lymphoma 58:8, pages 1903-1913.
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Carmen Fava, Alessandro Morotti, Irene Dogliotti, Giuseppe Saglio & Giovanna Rege-Cambrin. (2015) Update on emerging treatments for chronic myeloid leukemia. Expert Opinion on Emerging Drugs 20:2, pages 183-196.
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Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Carmen Fava, Angelo Guerrasio, Pier Paolo Pandolfi & Giuseppe Saglio. (2015) BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation . Cell Cycle 14:7, pages 973-979.
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Giovanna Carrà, Isabella Russo, Angelo Guerrasio & Alessandro Morotti. (2019) Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy. Cells 8:10, pages 1248.
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Simona Soverini, Manuela Mancini, Luana Bavaro, Michele Cavo & Giovanni Martinelli. (2018) Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy. Molecular Cancer 17:1.
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Riad El Fakih, Elias Jabbour, Farhad Ravandi, Mona Hassanein, Farhan Anjum, Syed Ahmed & Hagop Kantarjian. (2018) Current paradigms in the management of Philadelphia chromosome positive acute lymphoblastic leukemia in adults. American Journal of Hematology 93:2, pages 286-295.
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Junli Zhang, Aiqi Zhao, Li Sun, Weiqun Chen, Haiming Zhang, Zhichao Chen & Fang Liu. (2017) Selective surface marker and miRNA profiles of CD34+ blast-derived microvesicles in chronic myelogenous leukemia. Oncology Letters 14:2, pages 1866-1874.
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Alessandro Morotti, Sabrina Crivellaro, Cristina Panuzzo, Giovanna Carrà, Angelo Guerrasio & Giuseppe Saglio. (2017) IκB-α: At the crossroad between oncogenic and tumor-suppressive signals. Oncology Letters 13:2, pages 531-534.
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Wiltrud Prinzhorn, Michael Stehle, Helga Kleiner, Sabrina Ruppenthal, Martin C. Müller, Wolf-Karsten Hofmann, Alice Fabarius & Wolfgang Seifarth. (2016) c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia. Biomarker Research 4:1.
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Sabrina Crivellaro, Giovanna Carrà, Cristina Panuzzo, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio & Alessandro Morotti. (2016) The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase. BMC Cancer 16:1.
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Giovanna Carrà, Davide Torti, Sabrina Crivellaro, Cristina Panuzzo, Riccardo Taulli, Daniela Cilloni, Angelo Guerrasio, Giuseppe Saglio & Alessandro Morotti. (2016) The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias. Oncotarget 7:40, pages 66287-66298.
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Giuseppe Saglio & Carmen Fava. (2016) BCR-ABL1 mutation ≠ ponatinib resistance. Blood 127:6, pages 666-667.
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Mara Brancaccio, Stefania Rocca, Laura Seclì, Elena Busso & Federica Fusella. (2015) The double face of Morgana in tumorigenesis. Oncotarget 6:40, pages 42603-42612.
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Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Davide Torti, Angelo Guerrasio & Giuseppe Saglio. (2015) The Role of PTEN in Myeloid Malignancies. Hematology Reports 7:4, pages 6027.
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Augusta Di Savino, Cristina PanuzzoStefania Rocca, Ubaldo FamiliariRocco PiazzaSabrina CrivellaroGiovanna CarràRoberta Ferretti, Federica Fusella, Emilia GiuglianoAnnalisa Camporeale, Irene Franco, Barbara Miniscalco, Juan Carlos Cutrin, Emilia Turco, Lorenzo Silengo, Emilio Hirsch, Giovanna Rege-CambrinCarlo Gambacorti-PasseriniPier Paolo Pandolfi, Mauro PapottiGiuseppe SaglioGuido Tarone, Alessandro MorottiMara Brancaccio. (2015) Morgana acts as an oncosuppressor in chronic myeloid leukemia. Blood 125:14, pages 2245-2253.
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Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Angelo Guerrasio & Giuseppe Saglio. (2015) HAUSP compartmentalization in chronic myeloid leukemia. European Journal of Haematology 94:4, pages 318-321.
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Alessandro Morotti, Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio & Giuseppe Saglio. (2015) Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias. Advances in Hematology 2015, pages 1-6.
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Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carr?Angelo Guerrasio, Giuseppe Saglio & Alessandro Morotti. (2014) BCR-ABL Promotes PTEN Downregulation in Chronic Myeloid Leukemia. PLoS ONE 9:10, pages e110682.
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Juhua Zhou. (2014) Advances and Prospects in Cancer Immunotherapy. New Journal of Science 2014, pages 1-13.
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