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Expert Opinion on Biological Therapy Volume 15, 2015 - Issue sup1: Proceedings of the Fourth International Symposium on Thymosins in Health and Disease
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Review

Advances in the basic and clinical applications of thymosin β4

Allan L GoldsteinThe George Washington University, School of Medicine and Health Sciences, Department of Biochemistry and Molecular Medicine, 2300 Eye Street NW, Ross Hall, Washington, DC, USA+1 240 899 2749; [email protected]
, PhD &
Hynda K KleinmanThe George Washington University, School of Medicine and Health Sciences, Department of Biochemistry and Molecular Medicine, 2300 Eye Street NW, Ross Hall, Washington, DC, USA+1 240 899 2749; [email protected]
, PhD
Pages 139-145 | Published online: 22 Jun 2015

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Heung-Mo Yang, Shin Wook Kang, Jihye Sung, Kyeongsoon Kim & Hynda Kleinman. (2020) Purinergic Signaling Involvement in Thymosin β4-mediated Corneal Epithelial Cell Migration. Current Eye Research 45:11, pages 1352-1358.
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Marie-Christine Pardon. (2018) Anti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases. Expert Opinion on Biological Therapy 18:sup1, pages 165-169.
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Peter J Hotez. (2018) Advancing biological therapies against a rising tide of American anti-science and other external threats. Expert Opinion on Biological Therapy 18:sup1, pages 5-7.
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Giorgia Renga, Vasilis Oikonomou, Claudia Stincardini, Marilena Pariano, Monica Borghi, Claudio Costantini, Andrea Bartoli, Enrico Garaci, Allan L. Goldstein & Luigina Romani. (2018) Thymosin β4 limits inflammation through autophagy. Expert Opinion on Biological Therapy 18:sup1, pages 171-175.
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Warren K. Y. Tan, Kristy Purnamawati, Leroy S. Pakkiri, Sock Hwee Tan, Xiaoxun Yang, Mark Y. Chan & Chester L. Drum. (2018) Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations. Expert Opinion on Biological Therapy 18:sup1, pages 141-147.
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Articles from other publishers (29)

Gabriel Sosne & Elizabeth A. Berger. (2023) Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis. International Immunopharmacology 118, pages 109953.
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Wandi Li, Yan Yang, Xiaoyu Zhang, Yan Lin, Haoran Li, Yu Yao & Dali Mu. (2022) The preliminary study of exosomes derived from thymosin beta 4-treated adipose-derived stem cells in fat grafting. Genes & Genomics 45:4, pages 413-427.
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Hynda K. Kleinman, Veronika Kulik & Allan L. Goldstein. (2023) Thymosin β4 and the anti-fibrotic switch. International Immunopharmacology 115, pages 109628.
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Gabriel Sosne, Hynda K. Kleinman, Clark Springs, Robert Hollis Gross, Jihye Sung & Shinwook Kang. (2022) 0.1% RGN-259 (Thymosin ß4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial. International Journal of Molecular Sciences 24:1, pages 554.
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Shahram Parvin, Masoud Arabfard, Ali Ghazvini, Mostafa Ghanei & Ali Najafi. (2022) Comparative proteomic analysis of mustard lung as a complicated disease using systems biology approach. BMC Pulmonary Medicine 22:1.
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Evanthia Asimakopoulou, Aspasia Andreou, Athina Patelarou, Evridiki Patelarou, Idriz Sopjani & Alexandros Argyriadis. (2022) Epidermolysis Bullosa: A case study in Cyprus and the nursing care plan. International Journal of Nursing Knowledge 33:4, pages 312-320.
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Lanzhou Li, Chenfei Zhao, Fange Kong, Yi-Cong Li, Chunxia Wang, Shanshan Chen, Hor-Yue Tan, Yang Liu & Di Wang. (2022) Calf Thymus Polypeptide Restrains the Growth of Colorectal Tumor via Regulating the Intestinal Microbiota-Mediated Immune Function. Frontiers in Pharmacology 13.
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Yanfang Zhai, Xiaoxiang Zheng, Yunyun Mao, Kai Li, Yanhong Liu, Yuemei Gao, Mengsu Zhao, Rui Yang, Rui Yu & Wei Chen. (2022) Recombinant Human Thymosin β4 (rhTβ4) Modulates the Anti-Inflammatory Responses to Alleviate Benzalkonium Chloride (BAC)-Induced Dry Eye Disease. International Journal of Molecular Sciences 23:10, pages 5458.
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Yuan Xing, Yumeng Ye, Hongyan Zuo & Yang Li. (2021) Progress on the Function and Application of Thymosin β4. Frontiers in Endocrinology 12.
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Ping-Chen Hou, Han-Tang Wang, Stasha Abhee, Wei-Ting Tu, John A. McGrath & Chao-Kai Hsu. (2021) Investigational Treatments for Epidermolysis Bullosa. American Journal of Clinical Dermatology 22:6, pages 801-817.
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Anna A. Druzina, Akim V. Shmalko, Igor B. Sivaev & Vladimir I. Bregadze. (2021) Cyclic oxonium derivatives of cobalt and iron bis(dicarbollides) and their use in organic synthesis. Russian Chemical Reviews 90:7, pages 785-830.
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Voddu Suresh, Varshasnata Mohanty, Kiran Avula, Arup Ghosh, Bharati Singh, Rajendra Kumar Reddy, Deepti Parida, Amol Ratnakar Suryawanshi, Sunil Kumar Raghav, Soma Chattopadhyay, Punit Prasad, Rajeeb Kumar Swain, Rupesh Dash, Ajay Parida, Gulam Hussain Syed & Shantibhusan Senapati. (2021) Quantitative proteomics of hamster lung tissues infected with SARS‐CoV‐2 reveal host factors having implication in the disease pathogenesis and severity. The FASEB Journal 35:7.
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Klaudia Maar, Roland Hetenyi, Szabolcs Maar, Gabor Faskerti, Daniel Hanna, Balint Lippai, Aniko Takatsy & Ildiko Bock-Marquette. (2021) Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies. Cells 10:6, pages 1343.
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Bonggoo Park, Min Hwa Shin, Jiyoung Kim, Gayoung Park, Yun-Kyoung Ryu, Jae-Wook Lee, Tae Jin Kim, Eun-Yi Moon & Kyung-Mi Lee. (2021) Ectopic Expression of Human Thymosin β4 Confers Resistance to Legionella pneumophila during Pulmonary and Systemic Infection in Mice. Infection and Immunity 89:4.
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Krishnanand Padmanabhan, Hanna Grobe, Jonathan Cohen, Arad Soffer, Adnan Mahly, Orit Adir, Ronen Zaidel-Bar & Chen Luxenburg. (2020) Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity. Development 147:23.
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Gui-hong Zhang, Krishna Dilip Murthy, Rahmawati Binti Pare & Yi-hua Qian. (2020) Protective effect of Tβ4 on central nervous system tissues and its developmental prospects. European Journal of Inflammation 18, pages 205873922093455.
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Krzysztof Fink, Janusz Boratyński, Maria Paprocka & Tomasz M. Goszczyński. (2019) Metallacarboranes as a tool for enhancing the activity of therapeutic peptides. Annals of the New York Academy of Sciences 1457:1, pages 128-141.
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Joanna Izabela Lachowicz, Mariusz Jaremko, Lukasz Jaremko, Giuseppina Pichiri, Pierpaolo Coni & Marco Piludu. (2019) Metal coordination of thymosin β4: Chemistry and possible implications. Coordination Chemistry Reviews 396, pages 117-123.
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Martina Severa, Jing Zhang, Elena Giacomini, Fabiana Rizzo, Marilena Paola Etna, Melania Cruciani, Enrico Garaci, Michael Chopp & Eliana Marina Coccia. (2019) Thymosins in multiple sclerosis and its experimental models: moving from basic to clinical application. Multiple Sclerosis and Related Disorders 27, pages 52-60.
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Hynda K. Kleinman, Kyeongsoon Kim & Hunhee Kang. (2018) Matrigel uses in cell biology and for the identification of thymosin β4, a mediator of tissue regeneration. Applied Biological Chemistry 61:6, pages 703-708.
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Krzysztof Fink, Kamil Kobak, Monika Kasztura, Janusz Boratyński & Tomasz M. Goszczyński. (2018) Synthesis and Biological Activity of Thymosin β4-Anionic Boron Cluster Conjugates. Bioconjugate Chemistry 29:11, pages 3509-3515.
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Joo-Heon Yoon, Junsun RyuSeung Joon Baek. (2018) Moonlighting Activity of Secreted Inflammation-Regulatory Proteins. Yonsei Medical Journal 59:4, pages 463.
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Yuheng Hong, Qingbin Yao & Lina Zheng. (2017) Thymosin β4 attenuates liver fibrosis via suppressing Notch signaling. Biochemical and Biophysical Research Communications 493:4, pages 1396-1401.
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Weili Zhang, Liya Nie, Lina Du, Wenyang Chen, Zhihong Wu & Yiguang Jin. (2017) Topical treatment of corneal alkali burns with Gly-thymosin β 4 solutions and in situ hydrogels via inhibiting corneal neovascularization and improving corneal epidermal recovery in experimental rabbits. Burns.
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Jing Liang, Wenjuan Cai, Tao Han, Li Jing, Zhe Ma & Yingtang Gao. (2016) The expression of thymosin β4 in chronic hepatitis B combined nonalcoholic fatty liver disease. Medicine 95:52, pages e5763.
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Heather I. Cohn & Joyce M.C. Teng. (2016) Advancement in management of epidermolysis bullosa. Current Opinion in Pediatrics 28:4, pages 507-516.
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Rylosona Janarthini, Xiaolei Wang, Lulu Chen, Lei Gao & Lingxia Zhao. (2016) A Tobacco-Derived Thymosin β 4 Concatemer Promotes Cell Proliferation and Wound Healing in Mice . BioMed Research International 2016, pages 1-8.
Crossref
L. Renault. 2016. Thymosins. Thymosins 25 54 .
H.K. Kleinman & G. Sosne. 2016. Thymosins. Thymosins 251 275 .

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