Expert Opinion on Biological Therapy, Volume 15, Issue sup1 (2015)

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Expert Opinion on Biological Therapy, Volume 15, Issue sup1 (2015)

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Proceedings of the Fourth International Symposium on Thymosins in Health and Disease

Foreword

Introduction for the Fourth International Symposium on Thymosins in Health and Disease
Enrico Garaci & Allan L Goldstein
Pages: 1-3
Published online: 14 Jul 2015
AbstractforIntroduction for the Fourth International Symposium on Thymosins in Health and Disease | Full Text | References | PDF (112.2 KB)
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Editorial

Editorial
Innovative medicines: new regulatory procedures for the third millennium
Guido Rasi & Sergio Bonini
Pages: 5-8
Published online: 16 Mar 2015
AbstractforInnovative medicines: new regulatory procedures for the third millennium | Full Text | References | PDF (128.6 KB)
  • 1476 Views
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Editorial
Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases
Michael Chopp & Zheng Gang Zhang
Pages: 9-12
Published online: 22 Jan 2015
AbstractforThymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases | Full Text | References | PDF (137.7 KB)
  • 3678 Views
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Review

Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine
Aurelio Cafaro, Antonella Tripiciano, Cecilia Sgadari, Stefania Bellino, Orietta Picconi, Olimpia Longo, Vittorio Francavilla, Stefano Buttò, Fausto Titti, Paolo Monini, Fabrizio Ensoli & Barbara Ensoli
Pages: 13-29
Published online: 22 Jun 2015
AbstractforDevelopment of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine | Full Text | References | PDF (828 KB)
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Historical review on thymosin α1 in oncology: preclinical and clinical experiences
Enrico Garaci, Francesca Pica, Claudia Matteucci, Roberta Gaziano, Cartesio D’Agostini, Martino Tony Miele, Roberto Camerini, Anna Teresa Palamara, Cartesio Favalli, Antonio Mastino, Annalucia Serafino & Paola Sinibaldi Vallebona
Pages: 31-39
Published online: 22 Jun 2015
AbstractforHistorical review on thymosin α1 in oncology: preclinical and clinical experiences | Full Text | References | PDF (496.5 KB)
  • 485 Views
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Original Research

Article
Evaluation of thymosin α 1 in nonclinical models of the immune-suppressing indications melanoma and sepsis
Robert S King PhD & Cynthia Tuthill PhD
Pages: 41-49
Published online: 02 Feb 2015
AbstractforEvaluation of thymosin α 1 in nonclinical models of the immune-suppressing indications melanoma and sepsis | Full Text | References | PDF (539.8 KB)
  • 333 Views
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Editorial

Editorial
Thymosin α1: burying secrets in the thymus
Silvia Moretti PhD, Vasileios Oikonomou PhD, Enrico Garaci MD PhD & Luigina Romani MD PhD
Pages: 51-58
Published online: 22 Jun 2015
AbstractforThymosin α1: burying secrets in the thymus | Full Text | References | PDF (564.8 KB)
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Original Research

Article
Dual effect of Thymosin α 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists
Elena Giacomini, Martina Severa, Melania Cruciani, Marilena Paola Etna, Fabiana Rizzo, Manuela Pardini, Carolina Scagnolari, Enrico Garaci & Eliana Marina Coccia
Pages: 59-70
Published online: 22 Jun 2015
AbstractforDual effect of Thymosin α 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists | Full Text | References | PDF (691.5 KB)
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Article
Thymosin α1 inserts N terminus into model membranes assuming a helical conformation
Ridvan Nepravishta, Walter Mandaliti, Tommaso Eliseo, Paola Sinibaldi Vallebona, Francesca Pica, Enrico Garaci & Maurizio Paci
Pages: 71-81
Published online: 02 Feb 2015
AbstractforThymosin α1 inserts N terminus into model membranes assuming a helical conformation | Full Text | References | PDF (1 MB)
  • 102 Views
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Article
Thymosin α 1 potentiates the release by CD8+ cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro
Claudia Matteucci PhD, Antonella Minutolo, Michela Pollicita, Emanuela Balestrieri, Sandro Grelli, Gabriella D’Ettorre, Vincenzo Vullo, Ilaria Bucci, Alessandra Luchini, Stefano Aquaro, Paola Sinibaldi-Vallebona, Beatrice Macchi, Carlo Federico Perno, Antonio Mastino & Enrico Garaci
Pages: 83-100
Published online: 22 Jun 2015
AbstractforThymosin α 1 potentiates the release by CD8+ cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro | Full Text | References | PDF (786.4 KB) | Supplemental
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Article
Thymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages
Annalucia Serafino, Federica Andreola, Eugenia Pittaluga, Ewa K Krasnowska, Giuseppe Nicotera, Gianluca Sferrazza, Paola Sinibaldi Vallebona, Pasquale Pierimarchi & Enrico Garaci (Professor)
Pages: 101-116
Published online: 22 Jun 2015
AbstractforThymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages | Full Text | References | PDF (1.3 MB) | Supplemental
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Review

Historical review of thymosin α 1 in infectious diseases
Roberto Camerini & Enrico Garaci
Pages: 117-127
Published online: 22 Jun 2015
AbstractforHistorical review of thymosin α 1 in infectious diseases | Full Text | References | PDF (408.1 KB)
  • 1090 Views
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Editorial

Editorial
Thymosin alpha-1 treatment in chronic hepatitis B
Xiaoning Wu, Jidong Jia & Hong You
Pages: 129-132
Published online: 01 Feb 2015
AbstractforThymosin alpha-1 treatment in chronic hepatitis B | Full Text | References | PDF (153.7 KB)
  • 3099 Views
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Editorial
A multicenter, randomized, observation-controlled clinical trial to evaluate the efficacy and safety of thymalfasin adjuvant therapy in patients with HBV-related HCC after curative resection – first announcement of the protocol
Shuang-Jian Qiu, Zhong-Guo Zhou, Feng Shen, Ai-Jun Li, Min-Shan Chen, Min-Gang Ying, Zhong Chen, Yi-Xin Zhang, Hui-Chuan Sun & Jia Fan
Pages: 133-137
Published online: 22 Jun 2015
AbstractforA multicenter, randomized, observation-controlled clinical trial to evaluate the efficacy and safety of thymalfasin adjuvant therapy in patients with HBV-related HCC after curative resection – first announcement of the protocol | Full Text | References | PDF (210.6 KB)
  • 2618 Views
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Review

Advances in the basic and clinical applications of thymosin β4
Allan L Goldstein PhD & Hynda K Kleinman PhD
Pages: 139-145
Published online: 22 Jun 2015
AbstractforAdvances in the basic and clinical applications of thymosin β4 | Full Text | References | PDF (377.4 KB)
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Original Research

Article
Identification of PDGF-BB binding to thymosin β4 by chemical cross-linking
Jana Knop, Christine App, Thomas Huff, Federica Iavarone, Massimo Castagnola & Ewald Hannappel
Pages: 147-154
Published online: 22 Jun 2015
AbstractforIdentification of PDGF-BB binding to thymosin β4 by chemical cross-linking | Full Text | References | PDF (655.9 KB)
  • 150 Views
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Article
Thymosin β4 significantly reduces the signs of dryness in a murine controlled adverse environment model of experimental dry eye
Gabriel Sosne, Chaesik Kim & Hynda K Kleinman
Pages: 155-161
Published online: 22 Jun 2015
AbstractforThymosin β4 significantly reduces the signs of dryness in a murine controlled adverse environment model of experimental dry eye | Full Text | References | PDF (351.7 KB)
  • 268 Views
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Review

Thymosin β4: multiple functions in protection, repair and regeneration of the mammalian heart
Sveva Bollini PhD, Paul R Riley PhD & Nicola Smart PhD
Pages: 163-174
Published online: 22 Jun 2015
AbstractforThymosin β4: multiple functions in protection, repair and regeneration of the mammalian heart | Full Text | References | PDF (349.4 KB)
  • 572 Views
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Original Research

Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway
Teresa Trenkwalder MD, Elisabeth Deindl PhD, Dario Bongiovanni MD, Seungmin Lee, Heribert Schunkert MD, Christian Kupatt MD & Rabea Hinkel DVM
Pages: 175-185
Published online: 04 Feb 2015
AbstractforThymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway | Full Text | References | PDF (1,004.1 KB)
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Editorial

Editorial
The role of thymosin-β4 in kidney disease
Elisavet Vasilopoulou, Paul JD Winyard, Paul R Riley & David A Long
Pages: 187-190
Published online: 22 Jun 2015
AbstractforThe role of thymosin-β4 in kidney disease | Full Text | References | PDF (160.5 KB)
  • 2360 Views
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Original Research

Article
High-resolution mass spectrometry for thymosins detection and characterization
Tiziana Cabras PhD, Federica Iavarone PhD, Claudia Martelli, Daniela Delfino, Diana Valeria Rossetti, Ilaria Inserra, Barbara Manconi PhD, Claudia Desiderio PhD, Irene Messana, Ewald Hannappel, Gavino Faa & Massimo Castagnola (Professor)
Pages: 191-201
Published online: 22 Jun 2015
AbstractforHigh-resolution mass spectrometry for thymosins detection and characterization | Full Text | References | PDF (539.1 KB)
  • 145 Views
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Article
Thymosin β4 attenuates microcirculatory and hemodynamic destabilization in sepsis
Dario Bongiovanni, Tilman Ziegler, Sascha D’Almeida, Tianqiong Zhang, Judy KM Ng, Steffen Dietzel, Rabea Hinkel & Christian Kupatt
Pages: 203-210
Published online: 21 Jan 2015
AbstractforThymosin β4 attenuates microcirculatory and hemodynamic destabilization in sepsis | Full Text | References | PDF (629.2 KB)
  • 221 Views
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Article
Effects of thymosin β4 and its N-terminal fragment Ac-SDKP on TGF-β-treated human lung fibroblasts and in the mouse model of bleomycin-induced lung fibrosis
Enrico Conte, Maria Iemmolo, Mary Fruciano, Evelina Fagone, Elisa Gili, Tiziana Genovese, Emanuela Esposito, Salvatore Cuzzocrea & Carlo Vancheri
Pages: 211-221
Published online: 22 Jun 2015
AbstractforEffects of thymosin β4 and its N-terminal fragment Ac-SDKP on TGF-β-treated human lung fibroblasts and in the mouse model of bleomycin-induced lung fibrosis | Full Text | References | PDF (910.2 KB)
  • 263 Views
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Article
Evidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies
Olaposi Omotuyi, Hayato Matsunaga & Hiroshi Ueda
Pages: 223-229
Published online: 21 Jan 2015
AbstractforEvidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies | Full Text | References | PDF (425.1 KB)
  • 173 Views
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