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Expert Opinion on Biological Therapy Volume 15, 2015 - Issue sup1: Proceedings of the Fourth International Symposium on Thymosins in Health and Disease
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Original Research

Effects of thymosin β4 and its N-terminal fragment Ac-SDKP on TGF-β-treated human lung fibroblasts and in the mouse model of bleomycin-induced lung fibrosis

Enrico ConteUniversity of Catania, Department of Clinical and Experimental Medicine, Via Santa Sofia 78, 95123 Catania, Italy+39 095 378 1254; +39 095 378 1427; [email protected]
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Maria IemmoloUniversity of Catania, Department of Clinical and Experimental Medicine, Via Santa Sofia 78, 95123 Catania, Italy+39 095 378 1254; +39 095 378 1427; [email protected]
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Mary FrucianoUniversity of Catania, Department of Clinical and Experimental Medicine, Via Santa Sofia 78, 95123 Catania, Italy+39 095 378 1254; +39 095 378 1427; [email protected]
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Evelina FagoneUniversity of Catania, Department of Clinical and Experimental Medicine, Via Santa Sofia 78, 95123 Catania, Italy+39 095 378 1254; +39 095 378 1427; [email protected]
,
Elisa GiliUniversity of Catania, Department of Clinical and Experimental Medicine, Via Santa Sofia 78, 95123 Catania, Italy+39 095 378 1254; +39 095 378 1427; [email protected]
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Tiziana GenoveseUniversity of Messina, School of Medicine, Department of Clinical and Experimental Medicine and Pharmacology, Messina, Italy
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Emanuela EspositoUniversity of Messina, School of Medicine, Department of Clinical and Experimental Medicine and Pharmacology, Messina, Italy
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Salvatore CuzzocreaUniversity of Messina, School of Medicine, Department of Clinical and Experimental Medicine and Pharmacology, Messina, Italy
&
Carlo VancheriUniversity of Catania, Department of Clinical and Experimental Medicine, Via Santa Sofia 78, 95123 Catania, Italy+39 095 378 1254; +39 095 378 1427; [email protected]
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Pages 211-221 | Published online: 22 Jun 2015

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Je-Won Ko, Na-Rae Shin, Ji-Won Park, Sung-Hyeuk Park, In-Chul Lee, Joong-Sun Kim, Jong-Choon Kim, Kyung-Seop Ahn & In-Sik Shin. (2018) Copper oxide nanoparticles induce collagen deposition via TGF-β1/Smad3 signaling in human airway epithelial cells. Nanotoxicology 12:3, pages 239-250.
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Articles from other publishers (16)

Shujiao Li, Yuying Li, Ying Liu, Yifan Wu, Qiuyu Wang, Lili Jin & Dianbao Zhang. (2023) Therapeutic Peptides for Treatment of Lung Diseases: Infection, Fibrosis, and Cancer. International Journal of Molecular Sciences 24:10, pages 8642.
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Lystra P. Hayden, Brian D. Hobbs, Robert Busch, Michael H. Cho, Ming Liu, Camila M. Lopes-Ramos, David A. Lomas, Per Bakke, Amund Gulsvik, Edwin K. Silverman, James D. Crapo, Terri H. Beaty, Nan M. Laird, Christoph Lange & Dawn L. DeMeo. (2023) X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study. Respiratory Research 24:1.
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Hynda K. Kleinman, Veronika Kulik & Allan L. Goldstein. (2023) Thymosin β4 and the anti-fibrotic switch. International Immunopharmacology 115, pages 109628.
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Gabriel Sosne, Hynda K. Kleinman, Clark Springs, Robert Hollis Gross, Jihye Sung & Shinwook Kang. (2022) 0.1% RGN-259 (Thymosin ß4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial. International Journal of Molecular Sciences 24:1, pages 554.
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Wei Wang, Wenning Jia & Chunping Zhang. (2022) The Role of Tβ4-POP-Ac-SDKP Axis in Organ Fibrosis. International Journal of Molecular Sciences 23:21, pages 13282.
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Shumin Li, Yaqian Li, Yi Zhang, Shifeng Li, Min Zhang, Fuyu Jin, Zhongqiu Wei, Yi Yang, Xuemin Gao, Na Mao, Xingchen Ge, Hong Xu & Fang Yang. (2020) N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial–mesenchymal transition in silicotic mice. Toxicology and Applied Pharmacology 408, pages 115255.
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Cai Chen, Xiankui Li & Lei Wang. (2020) Thymosinβ4 alleviates cholestatic liver fibrosis in mice through downregulating PDGF/PDGFR and TGFβ/Smad pathways. Digestive and Liver Disease 52:3, pages 324-330.
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Gui-hong Zhang, Krishna Dilip Murthy, Rahmawati Binti Pare & Yi-hua Qian. (2020) Protective effect of Tβ4 on central nervous system tissues and its developmental prospects. European Journal of Inflammation 18, pages 205873922093455.
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Hanchao Li, Qian Li, Xueting Zhang, Xiaoyan Zheng, Qiannan Zhang & Zhiming Hao. (2018) Thymosin β4 suppresses CCl 4 -induced murine hepatic fibrosis by down-regulating transforming growth factor β receptor-II . The Journal of Gene Medicine 20:9, pages e3043.
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Philip J. O’Reilly, Qiang Ding, Samia Akthar, Guoqiang Cai, Kristopher R. Genschmer, Dhiren F. Patel, Patricia L. Jackson, Liliana Viera, Mojtaba Roda, Morgan L. Locy, Ellen A. Bernstein, Clare M. Lloyd, Kenneth E. Bernstein, Robert J. Snelgrove & J. Edwin Blalock. (2017) Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis. JCI Insight 2:22.
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Je-Won Ko, Na-Rae Shin, Sung-Hyeuk Park, In-Chul Lee, Jung-Min Ryu, Ha-Jung Kim, Young-Kwon Cho, Jong-Choon Kim & In-Sik Shin. (2017) Silibinin inhibits the fibrotic responses induced by cigarette smoke via suppression of TGF-β1/Smad 2/3 signaling. Food and Chemical Toxicology 106, pages 424-429.
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Xiankui Li, Lei Wang & Cai Chen. (2017) Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis. Scientific Reports 7:1.
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Enrico Conte, Evelina Fagone, Elisa Gili, Mary Fruciano, Maria Iemmolo, Maria Provvidenza Pistorio, Daniela Impellizzeri, Marika Cordaro, Salvatore Cuzzocrea & Carlo Vancheri. (2016) Preventive and therapeutic effects of thymosin β4 N-terminal fragment Ac-SDKP in the bleomycin model of pulmonary fibrosis. Oncotarget 7:23, pages 33841-33854.
Crossref
Rylosona Janarthini, Xiaolei Wang, Lulu Chen, Lei Gao & Lingxia Zhao. (2016) A Tobacco-Derived Thymosin β 4 Concatemer Promotes Cell Proliferation and Wound Healing in Mice . BioMed Research International 2016, pages 1-8.
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Zhu-Xia Tan, Yuan-Hua Chen, Shen Xu, Hou-Ying Qin, Cheng Zhang, Hui Zhao & De-Xiang Xu. (2016) Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response and epithelial–mesenchymal transition in mice. Toxicology Letters 240:1, pages 161-171.
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Rosanna Abbate, Nasser M. Al-Daghri, Paolo Andreozzi, Niels Borregaard, Günay Can, Gianluca Caridi, Maren Carstensen-Kirberg, Gabriele Cioni, Enrico Conte, Rosario Cuomo, Marie A. Denis, Gohar Fakhfouri, G. Fakhfouri, Renné Fiasse, Andreas Glenthøj, Georg Goliasch, Thomas Gremmel, Christian Herder, Maria Iemmolo, Zhi-Cheng Jing, Robert Krause, Oreste Marrone, Bartosz Miazgowski, Tomasz Miazgowski, Lorenzo Minchiotti, Kazem Mousavizadeh, Gjin Ndrepepa, Alexander Niessner, Cristina Ogayar Luque, Altan Onat, Ioannis Papassotiriou, Martín Ruiz Ortiz, Shaun Sabico, C. Mary Schooling, Sophia D. Sakka, P. Sołtysiak, Frank L. J. Visseren, Jasmin Wagner, Xiao-Jian Wang & Jan Westerink. (2015) Research update for articles published in EJCI in 2013. European Journal of Clinical Investigation 45:10, pages 1005-1016.
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