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Expert Opinion on Biological Therapy Volume 4, 2004 - Issue 6
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Review

Hydrogels for oral delivery of therapeutic proteins

Nicholas A Peppas University of Texas at Austin, Laboratory for Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition, Departments of Chemical and Biomedical Engineering and Division of Pharmaceutics, Austin, TX 78712, USA
,
Kristy M Wood University of Texas at Austin, Laboratory for Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition, Departments of Chemical and Biomedical Engineering and Division of Pharmaceutics, Austin, TX 78712, USA
&
James O Blanchette University of Texas at Austin, Laboratory for Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition, Departments of Chemical and Biomedical Engineering and Division of Pharmaceutics, Austin, TX 78712, USA
Pages 881-887 | Published online: 23 Feb 2005

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Naveed Ahmad, Mohd Cairul Iqbal Mohd Amin, Ismanizan Ismail & Fhataheya Buang. (2016) Enhancement of oral insulin bioavailability: in vitro and in vivo assessment of nanoporous stimuli-responsive hydrogel microparticles. Expert Opinion on Drug Delivery 13:5, pages 621-632.
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Kai Dong, Yalin Dong, Cuiyu You, Wei Xu, Xiaoyan Huang, Yan Yan, Lu Zhang, Ke Wang & Jianfeng Xing. (2016) Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel. Drug Delivery 23:1, pages 174-184.
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Lindsey A Sharpe, Adam M Daily, Sarena D Horava & Nicholas A Peppas. (2014) Therapeutic applications of hydrogels in oral drug delivery. Expert Opinion on Drug Delivery 11:6, pages 901-915.
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Cody A. Schoener & Nicholas A. Peppas. (2013) pH-Responsive hydrogels containing PMMA nanoparticles: an analysis of controlled release of a chemotherapeutic conjugate and transport properties. Journal of Biomaterials Science, Polymer Edition 24:9, pages 1027-1040.
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Viraj Mane & Silvia Muro. (2012) Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice. International Journal of Nanomedicine 7, pages 4223-4237.
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Andrew Gregory & Martina H Stenzel. (2011) The use of reversible addition fragmentation chain transfer polymerization for drug delivery systems. Expert Opinion on Drug Delivery 8:2, pages 237-269.
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Wasfy M. Obeidat & Ihab M. Obaidat. (2007) Effect of the dispersion of Eudragit S100 powder on the properties of cellulose acetate butyrate microspheres containing theophylline made by the emulsion–solvent evaporation method. Journal of Microencapsulation 24:3, pages 263-273.
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Siddarth Venkatesh, Mark E Byrne, Nicholas A Peppas & J Zach Hilt. (2005) Applications of biomimetic systems in drug delivery. Expert Opinion on Drug Delivery 2:6, pages 1085-1096.
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Lev Bromberg. (2005) Intelligent hydrogels for the oral delivery of chemotherapeutics. Expert Opinion on Drug Delivery 2:6, pages 1003-1013.
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Cecilia Prego, Dolores Torres & Maria Jose Alonso. (2005) The potential of chitosan for the oral administration of peptides. Expert Opinion on Drug Delivery 2:5, pages 843-854.
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Melissa Kanzelberger Coolich, Olivia L. Lanier, Ethan Cisneros & Nicholas A. Peppas. (2023) PEGylated insulin loaded complexation hydrogels for protected oral delivery. Journal of Controlled Release 364, pages 216-226.
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Amani Elsayed, Mayyas Al-Remawi, Nisrein Jaber & Khalid M. Abu-Salah. (2023) Advances in buccal and oral delivery of insulin. International Journal of Pharmaceutics 633, pages 122623.
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Tyler D. Brown, Kathryn A. Whitehead & Samir Mitragotri. (2019) Materials for oral delivery of proteins and peptides. Nature Reviews Materials 5:2, pages 127-148.
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O. Saoudi & N. Ghaouar. (2019) Biocatalytic characterization of free and immobilized laccase from Trametes versicolor in its activation zone. International Journal of Biological Macromolecules 128, pages 681-691.
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Nagarani Thotakura, Lokesh Kaushik, Vipin Kumar, Simran Preet & Penke Vijaya Babu. (2019) Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems. Current Pharmaceutical Design 24:43, pages 5147-5163.
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Yuanbo Zhong, Brian J. Zeberl, Xu Wang & Juntao Luo. (2018) Combinatorial approaches in post-polymerization modification for rational development of therapeutic delivery systems. Acta Biomaterialia 73, pages 21-37.
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Ananya Barui. 2018. Polymeric Gels. Polymeric Gels 143 178 .
Derya Aydin, Mohammad Alipour & Seda Kizilel. 2017. Functional Hydrogels in Drug Delivery. Functional Hydrogels in Drug Delivery 1 23 .
Lei Gao, Tingting Wang, Keke Jia, Xuan Wu, Chenhao Yao, Wei Shao, Dongmei Zhang, Xiao-Yu Hu & Leyong Wang. (2017) Glucose-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery. Chemistry - A European Journal 23:27, pages 6605-6614.
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Xu Wang, Changying Shi, Li Zhang, Alexa Bodman, Dandan Guo, Lili Wang, Walter A. Hall, Stephan Wilkens & Juntao Luo. (2016) Affinity-controlled protein encapsulation into sub-30 nm telodendrimer nanocarriers by multivalent and synergistic interactions. Biomaterials 101, pages 258-271.
Crossref
Hanif Ullah, Hélder A. Santos & Taous Khan. (2016) Applications of bacterial cellulose in food, cosmetics and drug delivery. Cellulose 23:4, pages 2291-2314.
Crossref
Vibhuti Agrahari, Vivek Agrahari & Ashim K Mitra. (2016) Nanocarrier fabrication and macromolecule drug delivery: challenges and opportunities. Therapeutic Delivery 7:4, pages 257-278.
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Sanita Pairatwachapun, Nophawan Paradee & Anuvat Sirivat. (2016) Controlled release of acetylsalicylic acid from polythiophene/carrageenan hydrogel via electrical stimulation. Carbohydrate Polymers 137, pages 214-221.
Crossref
J. A. Kaplan, P. Barthélémy & M. W. Grinstaff. (2016) Self-assembled nanofiber hydrogels for mechanoresponsive therapeutic anti-TNFα antibody delivery. Chemical Communications 52:34, pages 5860-5863.
Crossref
T. Werfel & C. Duvall. 2016. Polymers and Nanomaterials for Gene Therapy. Polymers and Nanomaterials for Gene Therapy 147 188 .
A Shetty & G Srinivasan. (2015) MICROFABRICATED ORAL DRUG DELIVERY SYSTEMS. INDIAN DRUGS 52:11, pages 5-13.
Crossref
Pablo Casuso, Ibon Odriozola, Adrián Pérez-San Vicente, Iraida Loinaz, Germán Cabañero, Hans-Jürgen Grande & Damien Dupin. (2015) Injectable and Self-Healing Dynamic Hydrogels Based on Metal(I)-Thiolate/Disulfide Exchange as Biomaterials with Tunable Mechanical Properties. Biomacromolecules 16:11, pages 3552-3561.
Crossref
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Marlene Lopes, Susana Simões, Francisco Veiga, Raquel Seiça & António Ribeiro. (2015) Why most oral insulin formulations do not reach clinical trials. Therapeutic Delivery 6:8, pages 973-987.
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Bijay Singh, Sushila Maharjan, Tao Jiang, Sang-Kee Kang, Yun-Jaie Choi & Chong-Su Cho. (2015) Attuning hydroxypropyl methylcellulose phthalate to oral delivery vehicle for effective and selective delivery of protein vaccine in ileum. Biomaterials 59, pages 144-159.
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Crossref
Lu-Bo Meng, Wenyi Zhang, Dongqi Li, Yan Li, Xiao-Yu Hu, Leyong Wang & Guigen Li. (2015) pH-Responsive supramolecular vesicles assembled by water-soluble pillar[5]arene and a BODIPY photosensitizer for chemo-photodynamic dual therapy. Chemical Communications 51:76, pages 14381-14384.
Crossref
Settimio Pacelli, Patrizia Paolicelli, Inge Dreesen, Shuichiro Kobayashi, Annabella Vitalone & Maria Antonietta Casadei. (2015) Injectable and photocross-linkable gels based on gellan gum methacrylate: A new tool for biomedical application. International Journal of Biological Macromolecules 72, pages 1335-1342.
Crossref
Naveed Ahmad, Mohd Cairul Iqbal Mohd Amin, Shalela Mohd Mahali, Ismanizan Ismail & Victor Tuan Giam Chuang. (2014) Biocompatible and Mucoadhesive Bacterial Cellulose -g- Poly(acrylic acid) Hydrogels for Oral Protein Delivery . Molecular Pharmaceutics 11:11, pages 4130-4142.
Crossref
Ana Carmona-Ribeiro & Letícia de Melo Carrasco. (2014) Novel Formulations for Antimicrobial Peptides. International Journal of Molecular Sciences 15:10, pages 18040-18083.
Crossref
Ankur Singh & Nicholas A. Peppas. (2014) Hydrogels and Scaffolds for Immunomodulation. Advanced Materials 26:38, pages 6530-6541.
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Jun Wu, Nazila Kamaly, Jinjun Shi, Lili Zhao, Zeyu Xiao, Geoffrey Hollett, Rohit John, Shaunak Ray, Xiaoyang Xu, Xueqing Zhang, Philip W. Kantoff & Omid C. Farokhzad. (2014) Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers. Angewandte Chemie International Edition 53:34, pages 8975-8979.
Crossref
Jun Wu, Nazila Kamaly, Jinjun Shi, Lili Zhao, Zeyu Xiao, Geoffrey Hollett, Rohit John, Shaunak Ray, Xiaoyang Xu, Xueqing Zhang, Philip W. Kantoff & Omid C. Farokhzad. (2014) Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers. Angewandte Chemie 126:34, pages 9121-9125.
Crossref
Vivek Gupta, Byeong Hee Hwang, JooHee Lee, Aaron C. Anselmo, Nishit Doshi & Samir Mitragotri. (2013) Mucoadhesive intestinal devices for oral delivery of salmon calcitonin. Journal of Controlled Release 172:3, pages 753-762.
Crossref
Benjamin J Bruno, Geoffrey D Miller & Carol S Lim. (2013) Basics and recent advances in peptide and protein drug delivery. Therapeutic Delivery 4:11, pages 1443-1467.
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Cody A. Schoener, Heather N. Hutson & Nicholas A. Peppas. (2013) pH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics. Journal of Biomedical Materials Research Part A 101A:8, pages 2229-2236.
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Qunpeng Duan, Yu Cao, Yan Li, Xiaoyu Hu, Tangxin Xiao, Chen Lin, Yi Pan & Leyong Wang. (2013) pH-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[6]arene and Ferrocene Derivative for Drug Delivery. Journal of the American Chemical Society 135:28, pages 10542-10549.
Crossref
Shivaan Cooppan, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Valence M.K. Ndesendo & Viness Pillay. (2012) A novel gastric release PEG‐enclatherated polymethacrylate‐based memblet system. Journal of Applied Polymer Science 128:6, pages 4327-4338.
Crossref
Thomas Lane, Julianne L. Holloway, Amir H. Milani, Jennifer M. Saunders, Anthony J. Freemont & Brian R. Saunders. (2013) Double network hydrogels prepared from pH-responsive doubly crosslinked microgels. Soft Matter 9:33, pages 7934.
Crossref
Kiran Chaturvedi, Kuntal Ganguly, Mallikarjuna N. Nadagouda & Tejraj M. Aminabhavi. (2013) Polymeric hydrogels for oral insulin delivery. Journal of Controlled Release 165:2, pages 129-138.
Crossref
Nicholas A. Peppas & Allan S. Hoffman. 2013. Biomaterials Science. Biomaterials Science 166 179 .
Praveen B. Kajjari, Lata S. Manjeshwar & Tejraj M. Aminabhavi. (2012) Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid. AAPS PharmSciTech 13:4, pages 1147-1157.
Crossref
Dimitris Tsiourvas, Zili Sideratou, Nikoletta Sterioti, Athanasios Papadopoulos, George Nounesis & Constantinos M. Paleos. (2012) Insulin complexes with PEGylated basic oligopeptides. Journal of Colloid and Interface Science 384:1, pages 61-72.
Crossref
Amir H. Milani, Anthony J. Freemont, Judith A. Hoyland, Daman J. Adlam & Brian R. Saunders. (2012) Injectable Doubly Cross-Linked Microgels for Improving the Mechanical Properties of Degenerated Intervertebral Discs. Biomacromolecules 13:9, pages 2793-2801.
Crossref
Cody A Schoener, Heather N Hutson & Nicholas A Peppas. (2012) pH-responsive hydrogels with dispersed hydrophobic nanoparticles for the delivery of hydrophobic therapeutic agents. Polymer International 61:6, pages 874-879.
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Shilpa Sant, Sarah L. Tao, Omar Z. Fisher, Qiaobing Xu, Nicholas A. Peppas & Ali Khademhosseini. (2012) Microfabrication technologies for oral drug delivery. Advanced Drug Delivery Reviews 64:6, pages 496-507.
Crossref
Ning Han, Jed Johnson, John J. Lannutti & Jessica O. Winter. (2012) Hydrogel–electrospun fiber composite materials for hydrophilic protein release. Journal of Controlled Release 158:1, pages 165-170.
Crossref
Chaoliang He, Xiuli Zhuang, Zhaohui Tang, Huayu Tian & Xuesi Chen. (2012) Stimuli-Sensitive Synthetic Polypeptide-Based Materials for Drug and Gene Delivery. Advanced Healthcare Materials 1:1, pages 48-78.
Crossref
C.A. Schoener & N.A. Peppas. (2012) Oral delivery of chemotherapeutic agents: background and potential of drug delivery systems for colon delivery. Journal of Drug Delivery Science and Technology 22:6, pages 459-468.
Crossref
Somaieh Salehpour, Christopher J. Zuliani & Marc A. Dubé. (2011) Synthesis of novel stimuli‐responsive polyglycerol‐based hydrogels. European Journal of Lipid Science and Technology 114:1, pages 92-99.
Crossref
Cody A. Schoener, Heather N. Hutson, Grace K. Fletcher & Nicholas A. Peppas. (2011) Amphiphilic Interpenetrating Networks for the Delivery of Hydrophobic, Low Molecular Weight Therapeutic Agents. Industrial & Engineering Chemistry Research 50:22, pages 12556-12561.
Crossref
William B. Liechty, Mary Caldorera-Moore, Margaret A. Phillips, Cody Schoener & Nicholas A. Peppas. (2011) Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics. Journal of Controlled Release 155:2, pages 119-127.
Crossref
Chuanping Wei, Huiqing Zhou & Jie Zhou. (2011) Ultrasensitively sensing acephate using molecular imprinting techniques on a surface plasmon resonance sensor. Talanta 83:5, pages 1422-1427.
Crossref
Jianxun Ding, Xiuli Zhuang, Chunsheng Xiao, Yilong Cheng, Li Zhao, Chaoliang He, Zhaohui Tang & Xuesi Chen. (2011) Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery. Journal of Materials Chemistry 21:30, pages 11383.
Crossref
Lisa A. Ferrara. 2011. The Comprehensive Treatment of the Aging Spine. The Comprehensive Treatment of the Aging Spine 447 451 .
F. Topuz, D. Buenger, D. Tanaka & J. Groll. 2011. Comprehensive Biomaterials. Comprehensive Biomaterials 491 517 .
Baljit Singh & Nirmala Chauhan. (2010) Dietary fiber psyllium based hydrogels for use in insulin delivery. International Journal of Diabetes Mellitus 2:1, pages 32-37.
Crossref
Wasfy M. Obeidat, Alaa H. Abuznait & Al-Sayed A. Sallam. (2010) Sustained Release Tablets Containing Soluble Polymethacrylates: Comparison with Tableted Polymethacrylate IPEC Polymers. AAPS PharmSciTech 11:1, pages 54-63.
Crossref
Eric Simone, Thomas Dziubla, Vladimir Shuvaev & Vladimir R. Muzykantov. 2010. Free Radicals and Antioxidant Protocols. Free Radicals and Antioxidant Protocols 145 164 .
Irma Y. Sanchez & Nicholas A. Peppas. 2010. Biomedical Applications of Hydrogels Handbook. Biomedical Applications of Hydrogels Handbook 45 64 .
Chien-Chi Lin & Kristi S. Anseth. (2009) Glucagon-Like Peptide-1 Functionalized PEG Hydrogels Promote Survival and Function of Encapsulated Pancreatic β-Cells. Biomacromolecules 10:9, pages 2460-2467.
Crossref
Wasfy M. Obeidat, Safwan M. Obeidat & Nizar M. Alzoubi. (2009) Investigations on the Physical Structure and the Mechanism of Drug Release from an Enteric Matrix Microspheres with a Near-Zero-Order Release Kinetics Using SEM and Quantitative FTIR. AAPS PharmSciTech 10:2, pages 615-623.
Crossref
Daniel A. Carr & Nicholas A. Peppas. (2009) Molecular Structure of Physiologically-Responsive Hydrogels Controls Diffusive Behavior. Macromolecular Bioscience 9:5, pages 497-505.
Crossref
Laura Serra, Josep Doménech & Nicholas A. Peppas. (2009) Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents. European Journal of Pharmaceutics and Biopharmaceutics 71:3, pages 519-528.
Crossref
Antonio Fern?ndez-Barbero, Iv?n J. Su?rez, B. Sierra-Mart?n, A. Fern?ndez-Nieves, F. Javier de las Nieves, Manuel Marquez, J. Rubio-Retama & Enrique L?pez-Cabarcos. (2009) Gels and microgels for nanotechnological applications. Advances in Colloid and Interface Science 147-148, pages 88-108.
Crossref
P. Colombo, F. Sonvico, G. Colombo & R. Bettini. (2009) Novel Platforms for Oral Drug Delivery. Pharmaceutical Research 26:3, pages 601-611.
Crossref
Sanem Argin-Soysal, Peter Kofinas & Y. Martin Lo. (2009) Effect of complexation conditions on xanthan–chitosan polyelectrolyte complex gels. Food Hydrocolloids 23:1, pages 202-209.
Crossref
Deenu Kanjickal, Stephanie Lopina, M. Michelle Evancho-Chapman, Steven Schmidt & Duane Donovan. (2008) Effects of sterilization on poly(ethylene glycol) hydrogels. Journal of Biomedical Materials Research Part A 87A:3, pages 608-617.
Crossref
Suma Somasekharan, Robert Brandt, Takeo Iwamoto, John M. Tomich & Bruce D. Schultz. (2008) Epithelial Barrier Modulation by a Channel Forming Peptide. Journal of Membrane Biology 222:1, pages 17-30.
Crossref
Kristy M. Ainslie, Casey M. Kraning & Tejal A. Desai. (2008) Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics. Lab on a Chip 8:7, pages 1042.
Crossref
Jordan S. Miller & Jennifer L. West. 2008. Bio-Materials and Prototyping Applications in Medicine. Bio-Materials and Prototyping Applications in Medicine 49 65 .
J. Zach Hilt. 2007. Nanotechnologies for the Life Sciences. Nanotechnologies for the Life Sciences.
G. Gallego Ferrer, M. Salmer?n S?nchez, J.L. G?mez Ribelles, F.J. Romero Colomer & M. Monle?n Pradas. (2007) Nanodomains in a hydrophilic?hydrophobic IPN based on poly(2-hydroxyethyl acrylate) and poly(ethyl acrylate). European Polymer Journal 43:8, pages 3136-3145.
Crossref
Itziar Silva, Mariló Gurruchaga & Isabel Goñi. (2007) The Influence of Crosslinking Amylose-Methacrylic Acid Graft Copolymers on the Release of BSA. Macromolecular Symposia 253:1, pages 82-87.
Crossref
Mariliz Achilleos, Theodora Krasia-Christoforou & Costas S. Patrickios. (2007) Amphiphilic Model Conetworks Based on Combinations of Methacrylate, Acrylate, and Styrenic Units:  Synthesis by RAFT Radical Polymerization and Characterization of the Swelling Behavior. Macromolecules 40:15, pages 5575-5581.
Crossref
Yalong Zhang, Qingjia Yao, Chengfeng Xia, Xi Jiang & Peng George Wang. (2006) Trapping Norovirus by Glycosylated Hydrogels: a Potential Oral Antiviral Drug. ChemMedChem 1:12, pages 1361-1366.
Crossref
Laura Serra, Joseph Doménech & Nicholas A. Peppas. (2006) Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels. Biomaterials 27:31, pages 5440-5451.
Crossref
Michel Wathier, M. Starck Johnson, Michael A. Carnahan, Claxton Baer, Brooks W. McCuen, Terry Kim & Mark W. Grinstaff. (2006) In Situ Polymerized Hydrogels for Repairing Scleral Incisions Used in Pars Plana Vitrectomy Procedures. ChemMedChem 1:8, pages 821-825.
Crossref
Le Zhang, Eric M. Furst & Kristi L. Kiick. (2006) Manipulation of hydrogel assembly and growth factor delivery via the use of peptide–polysaccharide interactions. Journal of Controlled Release 114:2, pages 130-142.
Crossref
Liliana Verestiuc, Oana Nastasescu, Eugen Barbu, Indrajeetsinh Sarvaiya, Keith L. Green & John Tsibouklis. (2006) Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: Synthesis, in vitro assessment, and in vivo evaluation . Journal of Biomedical Materials Research Part A 77A:4, pages 726-735.
Crossref
N. A. Peppas, J. Z. Hilt, A. Khademhosseini & R. Langer. (2006) Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology. Advanced Materials 18:11, pages 1345-1360.
Crossref
Serguei V. Vinogradov, Ekta Kohli & Arin D. Zeman. (2006) Comparison of Nanogel Drug Carriers and their Formulations with Nucleoside 5′-Triphosphates. Pharmaceutical Research 23:5, pages 920-930.
Crossref
J Brock Thomas, Nicholas Peppas, Michiko Sato & Thomas Webster. 2006. Nanomaterials Handbook. Nanomaterials Handbook.
Carmen Rodriguez-Tenreiro, Carmen Alvarez-Lorenzo, Ana Rodriguez-Perez, Angel Concheiro & Juan J. Torres-Labandeira. (2006) New Cyclodextrin Hydrogels Cross-Linked with Diglycidylethers with a High Drug Loading and Controlled Release Ability. Pharmaceutical Research 23:1, pages 121-130.
Crossref
J. Zachary Hilt & Nicholas A. Peppas. (2005) Microfabricated drug delivery devices. International Journal of Pharmaceutics 306:1-2, pages 15-23.
Crossref

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