Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 14, 2010 - Issue 5
Submit an article Journal homepage
311
Views
38
CrossRef citations to date
0
Altmetric
Reviews

Targeting TRPC6 channels in oesophageal carcinoma growth

Xia Ding Institute of Neuroscience, Institute for Biological Sciences, Laboratory of Neural Signal Transduction, Shanghai 320 Yueyang Road, Shanghai, 200031, China +86 21 54921793; +86 21 54921735; [email protected]; The Graduate School, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China
,
Zhuohao He Institute of Neuroscience, Institute for Biological Sciences, Laboratory of Neural Signal Transduction, Shanghai 320 Yueyang Road, Shanghai, 200031, China +86 21 54921793; +86 21 54921735; [email protected]; The Graduate School, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China
,
Yu Shi Department of Thoracic Surgery, ZhongShan Hospital and Shanghai Medical School, Fudan University, Shanghai, China
,
Qun Wang Department of Thoracic Surgery, ZhongShan Hospital and Shanghai Medical School, Fudan University, Shanghai, China
&
Yizheng Wang Institute of Neuroscience, Institute for Biological Sciences, Laboratory of Neural Signal Transduction, Shanghai 320 Yueyang Road, Shanghai, 200031, China +86 21 54921793; +86 21 54921735; [email protected]
Pages 513-527 | Published online: 17 Mar 2010

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Natalia Prevarskaya, Roman Skryma & Yaroslav Shuba. (2013) Targeting Ca2+ transport in cancer: close reality or long perspective?. Expert Opinion on Therapeutic Targets 17:3, pages 225-241.
Read now
Qi Wan, Ai Zheng, Xiaojing Liu, Yali Chen & Ling Han. (2012) Expression of transient receptor potential channel 6 in cervical cancer. OncoTargets and Therapy 5, pages 171-176.
Read now

Articles from other publishers (36)

Qiaonan GuoPengjun QiuKelun PanJianpeng ChenBaiwei WangJianqing Lin. (2023) Construction and validation of a transient receptor potential-related long noncoding RNA signature for prognosis prediction in breast cancer patients. Medicine 102:46, pages e35978.
Crossref
Yadong Zhang, Di Wen, Jiwei Shen, Lu Tian, Yan Zhu, Jifang Zhang, Leyan Zhao, Shi Ding, Ju Liu & Ye Chen. (2023) Application and SARs of Pyrazolo[1,5-a]pyrimidine as Antitumor Agents Scaffold. Current Topics in Medicinal Chemistry 23:12, pages 1043-1064.
Crossref
Li-ping Bai, Ya-li Chen & Ai Zheng. (2022) Pharmacological targeting transient receptor potential canonical channel 6 modulates biological behaviors for cervical cancer HeLa and SiHA cell. Cancer Cell International 22:1.
Crossref
Lincheng Li, Zhaohui Xiao, Pengyi He, Wenbo Zou, Zhaoda Deng, Gong Zhang & Rong Liu. (2022) Molecular subtyping based on TRP family and prognostic assessment for TRP-associated lncRNAs in pancreatic adenocarcinoma. BMC Gastroenterology 22:1.
Crossref
Mengxi Xiu, Li Li, Yandong Li & Yong Gao. (2022) An update regarding the role of WNK kinases in cancer. Cell Death & Disease 13:9.
Crossref
Yan Chang, Souvik Roy & Zui Pan. (2021) Store-Operated Calcium Channels as Drug Target in Gastroesophageal Cancers. Frontiers in Pharmacology 12.
Crossref
Yingjie Wei, Mengxian Zhang, Zhenbin Lyu, Guolin Yang, Tian Tian, Mingmin Ding, Xiaodong Zeng, Fuchun Xu, Pengyu Wang, Fangfang Li, Yixuan Liu, Zhengyu Cao, Jing Lu, Xuechuan Hong & Hongbo Wang. (2021) Benzothiazole Amides as TRPC3/6 Inhibitors for Gastric Cancer Treatment. ACS Omega 6:13, pages 9196-9203.
Crossref
George Shapovalov, Dmitri Gordienko & Natalia Prevarskaya. 2021. Inter-Organellar Ca2+ Signaling in Health and Disease - Part B. Inter-Organellar Ca2+ Signaling in Health and Disease - Part B 123 168 .
Francesco De Logu, Filippo Ugolini, Chiara Caporalini, Annarita Palomba, Sara Simi, Francesca Portelli, Domenico Andrea Campanacci, Giovanni Beltrami, Daniela Massi & Romina Nassini. (2020) TRPA1 Expression in Synovial Sarcoma May Support Neural Origin. Biomolecules 10:10, pages 1446.
Crossref
Eszter Becskeházi, Marietta Margaréta Korsós, Bálint Erőss, Péter Hegyi & Viktória Venglovecz. (2020) OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions. Frontiers in Physiology 11.
Crossref
JianHong Ding, Zhe Jin, Xiaoxu Yang, Jun Lou, Weixi Shan, Yanxia Hu, Qian Du, Qiushi Liao, Jingyu Xu & Rui Xie. (2020) Plasma membrane Ca2+-permeable channels and sodium/calcium exchangers in tumorigenesis and tumor development of the upper gastrointestinal tract. Cancer Letters 475, pages 14-21.
Crossref
Christian Stock. 2021. Transportome Malfunction in the Cancer Spectrum. Transportome Malfunction in the Cancer Spectrum 129 222 .
Jun Yu, Ming Zhu, Min Lv, Xiaoliu Wu, Xiaomei Zhang, Yuanying Zhang, Jintian Li & Qin Zhang. (2019) Characterization of a five-microRNA signature as a prognostic biomarker for esophageal squamous cell carcinoma. Scientific Reports 9:1.
Crossref
Mingmin Ding, Hongbo Wang, Chunrong Qu, Fuchun Xu, Yingmin Zhu, Guangyao Lv, Yungang Lu, Qingjun Zhou, Hui Zhou, Xiaodong Zeng, Jingwen Zhang, Chunhong Yan, Jiacheng Lin, Huai-Rong Luo, Zixing Deng, Yuling Xiao, Jinbin Tian, Michael X. Zhu & Xuechuan Hong. (2018) Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer. Cancer Letters 432, pages 47-55.
Crossref
Guochao Zhang, Xuefei Wang & Qi Xue. (2018) Combined targeted ion channel therapy: Can it be an alternative choice for esophageal cancer patients?. Medical Hypotheses 117, pages 59-62.
Crossref
Ekaterina Pchelintseva & Mustafa B. A. Djamgoz. (2017) Mesenchymal stem cell differentiation: Control by calcium‐activated potassium channels. Journal of Cellular Physiology 233:5, pages 3755-3768.
Crossref
Natalia Prevarskaya, Roman Skryma & Yaroslav Shuba. (2018) Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?. Physiological Reviews 98:2, pages 559-621.
Crossref
Zhen Chen, Yaodan Zhu, Yongfei Dong, Peng Zhang, Xiping Han, Jian Jin & Xin Ma. (2017) Overexpression of TrpC5 promotes tumor metastasis via the HIF-1α–Twist signaling pathway in colon cancer. Clinical Science 131:19, pages 2439-2450.
Crossref
Tullio Genova, Guillaume P. Grolez, Chiara Camillo, Michela Bernardini, Alexandre Bokhobza, Elodie Richard, Marco Scianna, Loic Lemonnier, Donatella Valdembri, Luca Munaron, Mark R. Philips, Virginie Mattot, Guido Serini, Natalia Prevarskaya, Dimitra Gkika & Alessandra Fiorio Pla. (2017) TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1. Journal of Cell Biology 216:7, pages 2107-2130.
Crossref
Chunrong Qu, Mingmin Ding, Yingmin Zhu, Yungang Lu, Juan Du, Melissa Miller, Jinbin Tian, Jinmei Zhu, Jian Xu, Meng Wen, AGA Er-Bu, Jule Wang, Yuling Xiao, Meng Wu, Owen B. McManus, Min Li, Jilin Wu, Huai-Rong Luo, Zhengyu Cao, Bing Shen, Hongbo Wang, Michael X. Zhu & Xuechuan Hong. (2017) Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. Journal of Medicinal Chemistry 60:11, pages 4680-4692.
Crossref
Chaochu Cui, Robert Merritt, Liwu Fu & Zui Pan. (2017) Targeting calcium signaling in cancer therapy. Acta Pharmaceutica Sinica B 7:1, pages 3-17.
Crossref
Hua Zhang, Suya Sun, Lili Wu, Ekaterina Pchitskaya, Olga Zakharova, Klementina Fon Tacer & Ilya Bezprozvanny. (2016) Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment. The Journal of Neuroscience 36:47, pages 11837-11850.
Crossref
Gajalakshmi Ramanathan & Christine Mannhalter. (2016) Increased expression of transient receptor potential canonical 6 (TRPC6) in differentiating human megakaryocytes. Cell Biology International 40:2, pages 223-231.
Crossref
Anne-Sophie Borowiec, Gabriel Bidaux, Natascha Pigat, Vincent Goffin, Sophie Bernichtein & Thierry Capiod. (2014) Calcium channels, external calcium concentration and cell proliferation. European Journal of Pharmacology 739, pages 19-25.
Crossref
Gentzon HallJanelle RowellFederica FarinelliRasheed A. Gbadegesin, Peter Lavin, Guanghong WuAlison HomstadAndrew MaloneThomas LindseyRuiji JiangRobert SpurneyGordon F. TomaselliDavid A. KassMichelle P. Winn. (2014) Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. American Journal of Physiology-Renal Physiology 306:12, pages F1442-F1450.
Crossref
M Gautier, I Dhennin-Duthille, A S Ay, P Rybarczyk, I Korichneva & H Ouadid-Ahidouch. (2014) New insights into pharmacological tools to TR(i)P cancer up. British Journal of Pharmacology 171:10, pages 2582-2592.
Crossref
Natalia Prevarskaya, Halima Ouadid-Ahidouch, Roman Skryma & Yaroslav Shuba. (2014) Remodelling of Ca 2+ transport in cancer: how it contributes to cancer hallmarks? . Philosophical Transactions of the Royal Society B: Biological Sciences 369:1638, pages 20130097.
Crossref
Shui-Shen Zhang, Jing Wen, Fu Yang, Xiao-Li Cai, Hong Yang, Kong-Jia Luo, Qian Wen Liu, Rong-Gui Hu, Xuan Xie, Qing-Yuan Huang, Jun Ying Chen, Jian Hua Fu & Yi Hu. (2013) High expression of Transient potential receptor C6 correlated with poor prognosis in patients with esophageal squamous cell carcinoma. Medical Oncology 30:3.
Crossref
Halima Ouadid-Ahidouch, Isabelle Dhennin-Duthille, Mathieu Gautier, Henri Sevestre & Ahmed Ahidouch. (2013) TRP channels: diagnostic markers and therapeutic targets for breast cancer?. Trends in Molecular Medicine 19:2, pages 117-124.
Crossref
Anne-Sophie Borowiec, Gabriel Bidaux & Thierry Capiod. 2013. Trends in Stem Cell Proliferation and Cancer Research. Trends in Stem Cell Proliferation and Cancer Research 65 92 .
L. Alexandre, T. Broughton, Y. Loke & I. L. P. Beales. (2012) Meta-analysis: risk of esophageal adenocarcinoma with medications which relax the lower esophageal sphincter. Diseases of the Esophagus 25:6, pages 535-544.
Crossref
Halima Ouadid-Ahidouch, Isabelle Dhennin-Duthille, Mathieu Gautier, Henri Sevestre & Ahmed Ahidouch. (2012) Canaux cationiques TRP dans le cancer du sein : expression, rôle et corrélation avec des paramètres cliniques. Bulletin du Cancer 99:6, pages 655-664.
Crossref
Mehdi Moghanibashi, Ferdous Rastgar Jazii, Zahra-Soheila Soheili, Maryam Zare, Aliasghar Karkhane, Kazem Parivar & Parisa Mohamadynejad. (2012) Proteomics of a new esophageal cancer cell line established from Persian patient. Gene 500:1, pages 124-133.
Crossref
Maike Glitsch. (2011) Protons and Ca 2+ : Ionic Allies in Tumor Progression? . Physiology 26:4, pages 252-265.
Crossref
Bing Shen, Hiu-Yee Kwan, Xin Ma, Ching-On Wong, Juan Du, Yu Huang & Xiaoqiang Yao. (2011) cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway. Journal of Biological Chemistry 286:22, pages 19439-19445.
Crossref
Isabelle Dhennin-Duthille, Mathieu Gautier, Malika Faouzi, Arnaud Guilbert, Marie Brevet, David Vaudry, Ahmed Ahidouch, Henri Sevestre & Halima Ouadid-Ahidouch. (2011) High Expression of Transient Receptor Potential Channels in Human Breast Cancer Epithelial Cells and Tissues: Correlation with Pathological Parameters. Cellular Physiology and Biochemistry 28:5, pages 813-822.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.