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Review

Shp2 as a therapeutic target for leptin resistance and obesity

Pages 135-142 | Published online: 27 Jan 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Jingbo Yan, Fang C. Mei, Hongqiang Cheng, Dieu Hung Lao, Yaohua Hu, Jingna Wei, Igor Patrikeev, Dapeng Hao, Sonja J. Stutz, Kelly T. Dineley, Massoud Motamedi, Jonathan D. Hommel, Kathryn A. Cunningham, Ju Chen & Xiaodong Cheng. (2013) Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1. Molecular and Cellular Biology 33:5, pages 918-926.
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Articles from other publishers (28)

Peiyi Zhou, Liqun Ouyang, Ting Jiang, Yingpu Tian, Wenbo Deng, Haibin Wang, Shuangbo Kong & Zhongxian Lu. (2023) Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization. The FEBS Journal.
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Djedjiga Ait Eldjoudi, Alfonso Cordero Barreal, María Gonzalez-Rodríguez, Clara Ruiz-Fernández, Yousof Farrag, Mariam Farrag, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesús Pino & Oreste Gualillo. (2022) Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?. International Journal of Molecular Sciences 23:5, pages 2859.
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Xiaoyang Qi, Ziying Sun, Xugang Li, Yuwen Jiao, Shuai Chen, Peng Song, Zhifen Qian, Jun Qian, Xusheng Qiu & Liming Tang. (2022) Shp2 suppresses fat accumulation in white adipose tissue by activating Wnt/β‑catenin signaling following vertical sleeve gastrectomy in obese rats with type‑2 diabetes. Experimental and Therapeutic Medicine 23:4.
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Yang Liu, Xiaohe Yang, Yali Wang, Yueying Yang, Dejuan Sun, Hua Li & Lixia Chen. (2021) Targeting SHP2 as a therapeutic strategy for inflammatory diseases. European Journal of Medicinal Chemistry 214, pages 113264.
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Eleni Kyriakou, Stefanie Schmidt, Garron T. Dodd, Katrin Pfuhlmann, Stephanie E. Simonds, Dominik Lenhart, Arie Geerlof, Sonja C. Schriever, Meri De Angelis, Karl-Werner Schramm, Oliver Plettenburg, Michael A. Cowley, Tony Tiganis, Matthias H. Tschöp, Paul T. Pfluger, Michael Sattler & Ana C. Messias. (2018) Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus. Journal of Medicinal Chemistry 61:24, pages 11144-11157.
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Antonio La Cava. (2017) Leptin in inflammation and autoimmunity. Cytokine 98, pages 51-58.
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Y. H. Lee & S.‑C. Bae. (2016) Circulating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysisZirkulierender Leptinwert bei rheumatischer Arthritis und seine Korrelation mit der Erkrankungsaktivität: eine Metaanalyse. Zeitschrift für Rheumatologie 75:10, pages 1021-1027.
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J Tao, L Zheng, M Meng, Y Li & Z Lu. (2016) Shp2 suppresses the adipogenic differentiation of preadipocyte 3T3-L1 cells at an early stage. Cell Death Discovery 2:1.
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Kendra K. Bence. 2016. Protein Tyrosine Phosphatases in Cancer. Protein Tyrosine Phosphatases in Cancer 307 333 .
Éric Toussirot, Fabrice Michel, Delphine Binda & Gilles Dumoulin. (2015) The role of leptin in the pathophysiology of rheumatoid arthritis. Life Sciences 140, pages 29-36.
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Xiaopeng Hu, Zhenzhou Tang, Yang Li, Wensheng Liu, Shuang Zhang, Bingyan Wang, Yingpu Tian, Yinan Zhao, Hao Ran, Wenjie Liu, Gen-Sheng Feng, Jianwei Shuai, Haibin Wang & Zhongxian Lu. (2015) Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Scientific Reports 5:1.
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Hyun-Seuk Moon, Joo Young Huh, Fadime Dincer, Benjamin E. Schneider, Per-Olof Hasselgren & Christos S. Mantzoros. (2015) Identification and Saturable Nature of Signaling Pathways Induced by Metreleptin in Humans: Comparative Evaluation of In Vivo, Ex Vivo, and In Vitro Administration. Diabetes 64:3, pages 828-839.
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Beatriz de Carvalho Borges, Rodrigo C. Rorato, Ernane Torres Uchoa, Paula B. Marangon, Carol F. Elias, Jose Antunes-Rodrigues & Lucila L. K. Elias. (2015) Protein tyrosine phosphatase-1B contributes to LPS-induced leptin resistance in male rats. American Journal of Physiology-Endocrinology and Metabolism 308:1, pages E40-E50.
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Jun Li, Yujia Kang, Longgang Wei, Wenjie Liu, Yingpu Tian, Baozhen Chen, Xiandong Lin, Yang Li, Gen-Sheng Feng & Zhongxian Lu. (2014) Tyrosine Phosphatase Shp2 Mediates the Estrogen Biological Action in Breast Cancer via Interaction with the Estrogen Extranuclear Receptor. PLoS ONE 9:7, pages e102847.
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Mete Civelek, Raffi Hagopian, Calvin Pan, Nam Che, Wen-pin Yang, Paul S. Kayne, Niyas K. Saleem, Henna Cederberg, Johanna Kuusisto, Peter S. Gargalovic, Todd G. Kirchgessner, Markku Laakso & Aldons J. Lusis. (2013) Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Human Molecular Genetics 22:15, pages 3023-3037.
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Hyun-Seuk MoonMaria DalamagaSang-Yong KimStergios A. PolyzosOle-Petter HamnvikFaidon MagkosJason ParuthiChristos S. Mantzoros. (2013) Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals. Endocrine Reviews 34:3, pages 377-412.
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A. Zeki Al Hazzouri, K. L. Stone, M. N. Haan & K. Yaffe. (2012) Leptin, Mild Cognitive Impairment, and Dementia Among Elderly Women. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68:2, pages 175-180.
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Murielle M. Véniant, Clarence Hale, Joan Helmering, Michelle M. Chen, Shanaka Stanislaus, Jim Busby, Steven Vonderfecht, Jing Xu & David J. Lloyd. (2012) FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice. PLoS ONE 7:7, pages e40164.
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Naoto Nagata, Kosuke Matsuo, Ahmed Bettaieb, Jesse Bakke, Izumi Matsuo, James Graham, Yannan Xi, Siming Liu, Alexey Tomilov, Natalia Tomilova, Susan Gray, Dae Young Jung, Jon J. Ramsey, Jason K. Kim, Gino Cortopassi, Peter J. Havel & Fawaz G. Haj. (2012) Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice. Endocrinology 153:7, pages 3158-3169.
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Julie St-Pierre & Michel L. Tremblay. (2012) Modulation of Leptin Resistance by Protein Tyrosine Phosphatases. Cell Metabolism 15:3, pages 292-297.
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Dongping Liu, Guiping Kong, Quan Cheng Chen, Guanghui Wang, Jie Li, Yang Xu, Ting lin, Yingpu Tian, Xiaokun Zhang, Xinsheng Yao, Gensheng Feng, Zhongxian Lu & Haifeng Chen. (2011) Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. Bioorganic & Medicinal Chemistry Letters 21:22, pages 6833-6837.
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Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Naoto Nagata, Samah Chahed, Siming Liu & Fawaz G. Haj. (2011) Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis. Metabolism 60:8, pages 1193-1201.
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Beatriz C. Borges, Rodrigo Rorato, Yosefa Avraham, Lilian E. C. M. da Silva, Margaret Castro, Lia Vorobiav, Elliot Berry, Jose Antunes-Rodrigues & Lucila L. K. Elias. (2011) Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. American Journal of Physiology-Endocrinology and Metabolism 300:5, pages E858-E869.
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Yanyan Bu, Tao Shi, Minghui Meng, Guiping Kong, Yingpu Tian, Quancheng Chen, Xinsheng Yao, Gensheng Feng, Haifeng Cheng & Zhongxian Lu. (2011) A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2. Bioorganic & Medicinal Chemistry Letters 21:2, pages 874-878.
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Ryoichi Banno, Derek Zimmer, Bart C. De Jonghe, Marybless Atienza, Kimberly Rak, Wentian Yang & Kendra K. Bence. (2010) PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. Journal of Clinical Investigation 120:3, pages 720-734.
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Karen F. Holden, Karla Lindquist, Frances A. Tylavsky, Caterina Rosano, Tamara B. Harris & Kristine Yaffe. (2009) Serum leptin level and cognition in the elderly: Findings from the Health ABC Study. Neurobiology of Aging 30:9, pages 1483-1489.
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Weimin Zhang, Xixiong Zhang, Dingren Bi, Xiliang Wang, Yinghong Cai, Hanchuan Dai & Shunyou Chen. (2008) Feeding with supplemental squalene enhances the productive performance in boars. Animal Reproduction Science 104:2-4, pages 445-449.
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M. Otero, R. Lago, R. Gomez, C. Dieguez, F. Lago, J. Gómez-Reino & O. Gualillo. (2006) Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology 45:8, pages 944-950.
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