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Review

The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

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Pages 27-35 | Published online: 27 Jan 2006

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Alexandra E. Panaitiu, Tamar Basiashvili, Dale F. Mierke & Maria Pellegrini. (2022) An engineered construct of cFLIP provides insight into DED1 structure and interactions. Structure 30:2, pages 229-239.e5.
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Melanie Schwerdtfeger, Vincenzo Desiderio, Sebastian Kobold, Tarik Regad, Silvia Zappavigna & Michele Caraglia. (2021) Long non-coding RNAs in cancer stem cells. Translational Oncology 14:8, pages 101134.
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Sahdeo Prasad, Sharavan Ramachandran, Nehal Gupta, Itishree Kaushik & Sanjay K. Srivastava. (2020) Cancer cells stemness: A doorstep to targeted therapy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:4, pages 165424.
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Luisa Barbato, Marco Bocchetti, Anna Di Biase & Tarik Regad. (2019) Cancer Stem Cells and Targeting Strategies. Cells 8:8, pages 926.
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Hassan Dianat-Moghadam, Maryam Heidarifard, Rana Jahanban-Esfahlan, Yunes Panahi, Hamed Hamishehkar, Farhad Pouremamali, Reza Rahbarghazi & Mohammad Nouri. (2018) Cancer stem cells-emanated therapy resistance: Implications for liposomal drug delivery systems. Journal of Controlled Release 288, pages 62-83.
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Ah Ram Lee, Keo-Heun Lim, Eun-Sook Park, Doo Hyun Kim, Yong Kwang Park, Soree Park, Dong-Sik Kim, Gu-Choul Shin, Hong Seok Kang, Juhee Won, Heewoo Sim, Yea Na Ha, Byeongjune Jae, Seong Il Choi & Kyun-Hwan Kim. (2018) Multiple Functions of Cellular FLIP Are Essential for Replication of Hepatitis B Virus. Journal of Virology 92:16.
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Corina Cuceu, William Hempel, Laure Sabatier, Jacques Bosq, Patrice Carde & Radhia M’kacher. (2018) Chromosomal Instability in Hodgkin Lymphoma: An In-Depth Review and Perspectives. Cancers 10:4, pages 91.
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Ali Razaghi, Kirsten Heimann, Patrick M. Schaeffer & Spencer B. Gibson. (2018) Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies. Apoptosis 23:2, pages 93-112.
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Lijuan Bo, Bo Wei, Zhanfeng Wang, Chaohui Li, Zheng Gao & Zhuang Miao. (2017) Bioinformatic analysis of gene expression profiling of intracranial aneurysm. Molecular Medicine Reports.
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Christina Valbirk KonradReshma MuraliBinitha Anu VargheseRadhika Nair. (2017) The role of cancer stem cells in tumor heterogeneity and resistance to therapy. Canadian Journal of Physiology and Pharmacology 95:1, pages 1-15.
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Faustino Mollinedo & Consuelo Gajate. 2017. TRAIL, Fas Ligand, TNF and TLR3 in Cancer. TRAIL, Fas Ligand, TNF and TLR3 in Cancer 187 227 .
Ying‐Hua Wang & David T Scadden. (2015) Harnessing the apoptotic programs in cancer stem‐like cells. EMBO reports 16:9, pages 1084-1098.
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Jun-Kyum Kim, Hee-Young Jeon & Hyunggee Kim. (2014) The molecular mechanisms underlying the therapeutic resistance of cancer stem cells. Archives of Pharmacal Research 38:3, pages 389-401.
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Shaoqing Shi, Qiong Wang, Jennings Xu, Jun-Ho Jang, Mabel T. Padilla, Toru Nyunoya, Chengguo Xing, Lin Zhang & Yong Lin. (2015) Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget 6:3, pages 1640-1651.
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Michele Signore, Lucia Ricci-Vitiani & Ruggero De Maria. (2013) Targeting apoptosis pathways in cancer stem cells. Cancer Letters 332:2, pages 374-382.
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Hongqin Zhuang, Weiwei Jiang, Xiangyu Zhang, Fan Qiu, Ziyi Gan, Wei Cheng, Jing Zhang, Shengwen Guan, Bo Tang, Qilai Huang, Xinhua Wu, Xiaofeng Huang, Wenhui Jiang, Qingang Hu, Min Lu & Zi-Chun Hua. (2012) Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions. Journal of Molecular Medicine 91:2, pages 219-235.
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L. H. J. Looijenga, A. J. M. Gillis, H. Stoop, K. Biermann & J. W. Oosterhuis. (2011) Dissecting the molecular pathways of (testicular) germ cell tumour pathogenesis; from initiation to treatment-resistance. International Journal of Andrology 34:4pt2, pages e234-e251.
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Veronica Catalano, Miriam Gaggianesi, Valentina Spina, Flora Iovino, Francesco Dieli, Giorgio Stassi & Matilde Todaro. (2011) Colorectal Cancer Stem Cells and Cell Death. Cancers 3:2, pages 1929-1946.
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Wei Wang, Yong Fang, Ni Sima, Yan Li, Wei Li, Li Li, Linfei Han, Shujie Liao, Zhiqiang Han, Qinglei Gao, Kezhen Li, Dongrui Deng, Li Meng, Jianfeng Zhou, Shixuan Wang & Ding Ma. (2010) Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP. Apoptosis 16:1, pages 55-66.
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Bao-wen GUO, Qi-jia LI, Lin YANG, Qing-an XIA, Bao-liang ZHANG & Rui-hai WANG. (2010) Expression of apoptosis associated protein FLIP,FADD in colorectal cancer and its correlation with cell apoptosis and proliferation. Academic Journal of Second Military Medical University 30:8, pages 912-913.
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Frank K. Braun, Burkhard Hirsch, Nadya Al-Yacoub, Horst Dürkop, Chalid Assaf, Marshall E. Kadin, Wolfram Sterry & Jürgen Eberle. (2010) Resistance of Cutaneous Anaplastic Large-Cell Lymphoma Cells to Apoptosis by Death Ligands Is Enhanced by CD30-Mediated Overexpression of c-FLIP. Journal of Investigative Dermatology 130:3, pages 826-840.
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Simone Fulda & Shazib Pervaiz. (2010) Apoptosis signaling in cancer stem cells. The International Journal of Biochemistry & Cell Biology 42:1, pages 31-38.
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Haresh Mani & Elaine S. Jaffe. (2009) Hodgkin Lymphoma: An Update on Its Biology With New Insights Into Classification. Clinical Cancer Reviews 3:1, pages 54-64.
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Yu-Yi Hou, Mu-Ling Wu, Yu-Chun Hwang, Fang-Rong Chang, Yang-Chang Wu & Chin-Chung Wu. (2009) The natural diterpenoid ovatodiolide induces cell cycle arrest and apoptosis in human oral squamous cell carcinoma Ca9-22 cells. Life Sciences 85:1-2, pages 26-32.
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Haresh Mani & Elaine S. Jaffe. (2009) Hodgkin Lymphoma: An Update on its Biology with New Insights into Classification. Clinical Lymphoma and Myeloma 9:3, pages 206-216.
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Liang Qiao & Benjamin C.Y. Wong. (2009) Targeting apoptosis as an approach for gastrointestinal cancer therapy. Drug Resistance Updates 12:3, pages 55-64.
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Zhi-Min Liu & George G. Chen. 2009. Apoptosis in Carcinogenesis and Chemotherapy. Apoptosis in Carcinogenesis and Chemotherapy 347 374 .
M Sun, L Song, Y Li, T Zhou & R S Jope. (2008) Identification of an antiapoptotic protein complex at death receptors. Cell Death & Differentiation 15:12, pages 1887-1900.
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Lihui Han, Yishu Zhao & Xiaoqing Jia. (2008) Mathematical modeling identified c-FLIP as an apoptotic switch in death receptor induced apoptosis. Apoptosis 13:10, pages 1198-1204.
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Margaret A. Park, Guo Zhang, Clint Mitchell, Mohamed Rahmani, Hossein Hamed, Michael P. Hagan, Adly Yacoub, David T. Curiel, Paul B. Fisher, Steven Grant & Paul Dent. (2008) Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95 . Molecular Cancer Therapeutics 7:9, pages 2633-2648.
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Catherine Wilson, Timothy Wilson, Patrick G. Johnston, Daniel B. Longley & David J.J. Waugh. (2008) Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Molecular Cancer Therapeutics 7:9, pages 2649-2661.
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Susan R. Mallery, Jared C. Zwick, Ping Pei, Meng Tong, Peter E. Larsen, Brian S. Shumway, Bo Lu, Henry W. Fields, Russell J. Mumper & Gary D. Stoner. (2008) Topical Application of a Bioadhesive Black Raspberry Gel Modulates Gene Expression and Reduces Cyclooxygenase 2 Protein in Human Premalignant Oral Lesions. Cancer Research 68:12, pages 4945-4957.
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Xia Wang, Wenshu Chen, Weihua Zeng, Lang Bai, Yohannes Tesfaigzi, Steven A. Belinsky & Yong Lin. (2008) Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Molecular Cancer Therapeutics 7:5, pages 1156-1163.
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Gioacchin Iannolo, Concetta Conticello, Lorenzo Memeo & Ruggero De Maria. (2008) Apoptosis in normal and cancer stem cells. Critical Reviews in Oncology/Hematology 66:1, pages 42-51.
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Lia Elena Perez, Nancy Parquet, Kenneth Shain, Ramadevi Nimmanapalli, Melissa Alsina, Claudio Anasetti & William Dalton. (2008) Bone Marrow Stroma Confers Resistance to Apo2 Ligand/TRAIL in Multiple Myeloma in Part by Regulating c-FLIP. The Journal of Immunology 180:3, pages 1545-1555.
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Frank K. Braun, Lothar F. Fecker, Constanze Schwarz, Peter Walden, Chalid Assaf, Horst Dürkop, Wolfram Sterry & Jürgen Eberle. (2007) Blockade of Death Receptor-Mediated Pathways Early in the Signaling Cascade Coincides with Distinct Apoptosis Resistance in Cutaneous T-Cell Lymphoma Cells. Journal of Investigative Dermatology 127:10, pages 2425-2437.
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Robin Mathew & Eileen White. (2006) FLIPping the Balance between Apoptosis and Proliferation in Thyroid Cancer. Clinical Cancer Research 12:12, pages 3648-3651.
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