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Review

Targeting chaperones in transformed systems – a focus on Hsp90 and cancer

Pages 37-50 | Published online: 27 Jan 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Thomas Ratajczak, Bryan Kenneth Ward, John Peter Walsh & Carmel Cluning. (2015) Hsp90 as a therapeutic target in endocrinology: current evidence. Research and Reports in Endocrine Disorders 5, pages 141-155.
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Ghassan Abu Sheikha, Mahmoud A. Al-Sha’er & Mutasem O. Taha. (2011) Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. Journal of Enzyme Inhibition and Medicinal Chemistry 26:5, pages 603-609.
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Samir Messaoudi, Jean-François Peyrat, Jean-Daniel Brion & Mouad Alami. (2011) Heat-shock protein 90 inhibitors as antitumor agents: a survey of the literature from 2005 to 2010. Expert Opinion on Therapeutic Patents 21:10, pages 1501-1542.
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Jon Amund Kyte. (2009) Cancer vaccination with telomerase peptide GV1001. Expert Opinion on Investigational Drugs 18:5, pages 687-694.
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Gabriela Chiosis, Yanlong Kang & Weilin Sun. (2008) Discovery and development of purine-scaffold Hsp90 inhibitors. Expert Opinion on Drug Discovery 3:1, pages 99-114.
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Articles from other publishers (60)

Gui-Sheng Xu, Yu-Ning Lin, Qingzhong Zeng, Zhi-Peng Li, Teng Xiao, Yong-Sheng Ye, Zhen-Yan Li & Xuejuan Gao. (2023) HSP90-regulated CHIP/TRIM21/p21 Axis Involves in the Senescence of Osteosarcoma Cells. Protein & Peptide Letters 30:6, pages 513-519.
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Simeng Chen, Jie Zhou, Chidimma Juliet Igbokwe, Yuqing Duan, Meihong Cai, Yuanqing He & Haihui Zhang. (2023) Oligopeptide of RDPEER from watermelon seeds prevents heat stress-induced liver injury by suppressing oxidative stress and inflammation responses. Journal of Functional Foods 105, pages 105563.
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Mingdong Li, Hasiqiqige, Yanqiang Huan, Xiaolei Wang, Mingkai Tao, Tianqi Jiang, Hongbin Xie, Wu Jisiguleng, Wei Xing, Zhibo Zhu, Aitao Wang & Yongxiong He. (2023) Calycosin ameliorates spinal cord injury by targeting Hsp90 to inhibit oxidative stress and apoptosis of nerve cells. Journal of Chemical Neuroanatomy 127, pages 102190.
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Kelly Schwarz, Swati Baindur-Hudson, Gregory Lloyd Blatch & Adrienne Lesley Edkins. 2023. The Networking of Chaperones by Co-Chaperones. The Networking of Chaperones by Co-Chaperones 81 125 .
Zi-Nan Li & Ying Luo. (2022) HSP90 inhibitors and cancer: Prospects for use in targeted therapies (Review). Oncology Reports 49:1.
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Giusy Tassone, Marco Mazzorana & Cecilia Pozzi. (2022) Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules. Pharmaceuticals 15:11, pages 1341.
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Francesco Paduano, Eugenio Gaudio & Francesco Trapasso. (2022) The Tumour Suppressor Fhit Protein Activates C-Raf Ubiquitination and Degradation in Human Melanoma Cells by Interacting with Hsp90. Biomedicines 10:10, pages 2551.
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Bereket Birbo, Elechi E. Madu, Chikezie O. Madu, Aayush Jain & Yi Lu. (2021) Role of HSP90 in Cancer. International Journal of Molecular Sciences 22:19, pages 10317.
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Tomoyuki Hioki, Haruhiko Tokuda, Daiki Nakashima, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Woo Kim, Junko Tachi, Kumiko Tanabe, Rie Matsushima‐Nishiwaki, Takanobu Otsuka, Hiroki Iida & Osamu Kozawa. (2020) HSP90 inhibitors strengthen extracellular ATP ‐stimulated synthesis of interleukin‐6 in osteoblasts: Amplification of p38 MAP kinase . Cell Biochemistry and Function 39:1, pages 88-97.
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Bixia Chen, Bo Yang, Jie Zhu, Jiaxin Wu, Junzhou Sha, Jiarui Sun, Endong Bao & Xiaohui Zhang. (2020) Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling. International Journal of Molecular Sciences 21:5, pages 1646.
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Zininga & Shonhai. (2019) Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites. International Journal of Molecular Sciences 20:23, pages 5930.
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Bjorn-Patrick Mohl & Polly Roy. (2019) Hsp90 Chaperones Bluetongue Virus Proteins and Prevents Proteasomal Degradation. Journal of Virology 93:20.
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Woo Kim, Haruhiko Tokuda, Tetsu Kawabata, Kazuhiko Fujita, Go Sakai, Daiki Nakashima, Junko Tachi, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Takanobu Otsuka, Hiroki Iida & Osamu Kozawa. (2019) Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase. Prostaglandins & Other Lipid Mediators 143, pages 106327.
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Asmaa Aboelnour, Ahmed E. Noreldin & Islam M. Saadeldin. 2019. Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Protein 90 in Human Diseases and Disorders 183 200 .
Sang-Hoon Song, Won-Jun Jang, Jihye Hwang, Byoungduck Park, Jung-Hee Jang, Young-Ho Seo, Chae Ha Yang, Sooyeun Lee & Chul-Ho Jeong. (2018) Transcriptome profiling of whisker follicles in methamphetamine self-administered rats. Scientific Reports 8:1.
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Kazuhiko Fujita, Takanobu Otsuka, Tetsu Kawabata, Shingo Kainuma, Go Sakai, Rie Matsushima‑Nishiwaki, Osamu Kozawa & Haruhiko Tokuda. (2018) HSP90 limits thrombin‑stimulated IL‑6 synthesis in osteoblast‑like MC3T3‑E1 cells: Regulation of p38 MAPK. International Journal of Molecular Medicine.
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Tetsu Kawabata, Takanobu Otsuka, Kazuhiko Fujita, Shingo Kainuma, Naohiro Yamamoto, Gen Kuroyanagi, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa & Haruhiko Tokuda. (2017) Suppression by HSP90 inhibitors of BMP-4-stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase. Molecular Medicine Reports 16:6, pages 8507-8512.
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Kazuhiko Fujita, Haruhiko Tokuda, Gen Kuroyanagi, Naohiro Yamamoto, Shingo Kainuma, Tetsu Kawabata, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa & Takanobu Otsuka. (2017) HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts. PLOS ONE 12:5, pages e0177878.
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Rosa Pennisi, Paolo Ascenzi & Alessandra di Masi. (2015) Hsp90: A New Player in DNA Repair?. Biomolecules 5:4, pages 2589-2618.
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Roberto Gomez-Casal, Chitralekha Bhattacharya, Michael Epperly, Per Basse, Hong Wang, Xinhui Wang, David Proia, Joel Greenberger, Mark Socinski & Vera Levina. (2015) The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells. Cancers 7:2, pages 876-907.
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Swati Baindur-Hudson, Adrienne L. Edkins & Gregory L. Blatch. 2015. The Networking of Chaperones by Co-chaperones. The Networking of Chaperones by Co-chaperones 69 90 .
Won‐Jun Jang, Sung‐Keun Jung, Jong‐Soon Kang, Joo‐Won Jeong, Moon‐Kyoung Bae, Sang Hoon Joo, Gyu Hwan Park, Joydeb K. Kundu, Young‐Soo Hong & Chul‐Ho Jeong. (2014) Anti‐tumor activity of WK 88‐1, a novel geldanamycin derivative, in gefitinib‐resistant non‐small cell lung cancers with Met amplification . Cancer Science 105:10, pages 1245-1253.
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Rafiqa Eachkoti, M.V. Ramana Reddy, Yen K. Lieu, Stephen C. Cosenza & E. PremKumar Reddy. (2014) Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140. European Journal of Cancer 50:11, pages 1982-1992.
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Dea Shahinas, Asongna Folefoc, Tony Taldone, Gabriela Chiosis, Ian Crandall & Dylan R. Pillai. (2013) A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90). PLoS ONE 8:9, pages e75446.
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Alexandra Silva, Belém Sampaio-Marques, Ângela Fernandes, Laura Carreto, Fernando Rodrigues, Martin Holcik, Manuel A. S. Santos & Paula Ludovico. (2013) Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid. PLoS ONE 8:8, pages e71294.
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Jo-Anne de la Mare, Jessica C. Lawson, Maynard T. Chiwakata, Denzil R. Beukes, Adrienne L. Edkins & Gregory L. Blatch. (2012) Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro. Investigational New Drugs 30:6, pages 2187-2200.
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Jack-Michel Renoir. (2012) Estradiol receptors in breast cancer cells: Associated co-factors as targets for new therapeutic approaches. Steroids 77:12, pages 1249-1261.
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Carmel T. ChanRobert E. ReevesRon Geller, Shahriar S. YaghoubiAileen HoehneDavid E. Solow-CorderoGabriela ChiosisTarik F. Massoud, Ramasamy PaulmuruganSanjiv S. Gambhir. (2012) Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. Proceedings of the National Academy of Sciences 109:37.
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David G. I. Kingston & David J. Newman. 2012. Natural Products in Chemical Biology. Natural Products in Chemical Biology 325 349 .
Frank Wuest, Vincent Bouvet, BaoChan Mai & Paul LaPointe. (2012) Fluorine- and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90. Organic & Biomolecular Chemistry 10:33, pages 6724.
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Jason N. Sterrenberg, Gregory L. Blatch & Adrienne L. Edkins. (2011) Human DNAJ in cancer and stem cells. Cancer Letters 312:2, pages 129-142.
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James H. AhnWenjie LuoJoungnam KimAnna RodinaCristina C. ClementJulia AguirreWeilin SunYanlong KangRonnie MaharajKamalika MoulickDanuta ZatorskaMalgorzata KokoszkaJeffrey L. BrodskyGabriela Chiosis. (2011) Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators. ASSAY and Drug Development Technologies 9:3, pages 236-246.
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Wenjie Luo, Weilin Sun, Tony Taldone, Anna Rodina & Gabriela Chiosis. (2010) Heat shock protein 90 in neurodegenerative diseases. Molecular Neurodegeneration 5:1.
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Leandro C. Cerchietti, Katerina Hatzi, Eloisi Caldas-Lopes, Shao Ning Yang, Maria E. Figueroa, Ryan D. Morin, Martin Hirst, Lourdes Mendez, Rita Shaknovich, Philip A. Cole, Kapil Bhalla, Randy D. Gascoyne, Marco Marra, Gabriela Chiosis & Ari Melnick. (2010) BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. Journal of Clinical Investigation 120:12, pages 4569-4582.
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Martin Rowlands, Craig McAndrew, Chris Prodromou, Laurence Pearl, Andrew Kalusa, Keith Jones, Paul Workman & Wynne Aherne. (2010) Detection of the ATPase Activity of the Molecular Chaperones Hsp90 and Hsp72 Using the Transcreener™ ADP Assay Kit. SLAS Discovery 15:3, pages 279-286.
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Yanke Yu, Adel Hamza, Tao Zhang, Mancang Gu, Peng Zou, Bryan Newman, Yanyan Li, A.A. Leslie Gunatilaka, Chang-Guo Zhan & Duxin Sun. (2010) Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochemical Pharmacology 79:4, pages 542-551.
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Véronique Marsaud & Jack-Michel Renoir. 2010. Macromolecular Anticancer Therapeutics. Macromolecular Anticancer Therapeutics 571 611 .
Tony Taldone, Weilin Sun & Gabriela Chiosis. (2009) Discovery and development of heat shock protein 90 inhibitors. Bioorganic & Medicinal Chemistry 17:6, pages 2225-2235.
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Hui Tao, Yanlong Kang, Tony Taldone & Gabriela Chiosis. (2009) Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines. Bioorganic & Medicinal Chemistry Letters 19:2, pages 415-417.
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Wenjie Luo, Anna Rodina & Gabriela Chiosis. (2008) Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?. BMC Neuroscience 9:S2.
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Yanlong Kang, Tony Taldone, Cristina C. Clement, Sheara W. Fewell, Julia Aguirre, Jeffrey L. Brodsky & Gabriela Chiosis. (2008) Design of a fluorescence polarization assay platform for the study of human Hsp70. Bioorganic & Medicinal Chemistry Letters 18:13, pages 3749-3751.
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Tadhg P. BegleyDavid G. I. Kingston & David J. Newman. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology 1 12 .
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Leah E. Cowen. (2008) The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nature Reviews Microbiology 6:3, pages 187-198.
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Joanna L. Holmes, Swee Y. Sharp, Steve Hobbs & Paul Workman. (2008) Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin. Cancer Research 68:4, pages 1188-1197.
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SWEE Y SHARP, KEITH JONES & PAUL WORKMAN. 2008. Cancer Drug Design and Discovery. Cancer Drug Design and Discovery 305 335 .
Yuhong Du, Kamalika Moulick, Anna Rodina, Julia Aguirre, Sara Felts, Raymond Dingledine, Haian Fu & Gabriela Chiosis. (2007) High-Throughput Screening Fluorescence Polarization Assay for Tumor-Specific Hsp90. SLAS Discovery 12:7, pages 915-924.
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D. Eric Dollins, Joshua J. Warren, Robert M. Immormino & Daniel T. Gewirth. (2007) Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Molecular Cell 28:1, pages 41-56.
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Anna Rodina, Maria Vilenchik, Kamalika Moulick, Julia Aguirre, Joungnam Kim, Anne Chiang, Julie Litz, Cristina C Clement, Yanlong Kang, Yuhong She, Nian Wu, Sara Felts, Peter Wipf, Joan Massague, Xuejun Jiang, Jeffrey L Brodsky, Geoffrey W Krystal & Gabriela Chiosis. (2007) Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature Chemical Biology 3:8, pages 498-507.
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Wenjie Luo, Fei Dou, Anna Rodina, Sophorn Chip, Joungnam Kim, Qi Zhao, Kamalika Moulick, Julia Aguirre, Nian Wu, Paul Greengard & Gabriela Chiosis. (2007) Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences 104:22, pages 9511-9516.
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