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Review

Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML

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Pages 51-68 | Published online: 27 Jan 2006

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Galina Tsykunova, Håkon Reikvam, Aymen Bushra Ahmed, Ina Nepstad, Bjørn Tore Gjertsen & Øystein Bruserud. (2012) Targeting of polo-like kinases and their cross talk with Aurora kinases – possible therapeutic strategies in human acute myeloid leukemia?. Expert Opinion on Investigational Drugs 21:5, pages 587-603.
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Kimberley Joanne Hatfield, Philippe Lassalle, Rafael Alexander Leiva, Roald Lindås, Øystein Wendelboe & Øystein Bruserud. (2011) Serum levels of endothelium-derived endocan are increased in patients with untreated acute myeloid leukemia. Hematology 16:6, pages 351-356.
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Camilla Stapnes, Bjørn Tore Gjertsen, Håkon Reikvam & Øystein Bruserud. (2009) Targeted therapy in acute myeloid leukaemia: current status and future directions. Expert Opinion on Investigational Drugs 18:4, pages 433-455.
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Anita Ryningen, Camilla Stapnes, Kristin Paulsen, Philippe Lassalle, Bjørn Tore Gjertsen & Øystein Bruserud. (2008) In vivo biological effects of ATRA in the treatment of AML. Expert Opinion on Investigational Drugs 17:11, pages 1623-1633.
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Hanne Hagland, Julie Nikolaisen, Linn I Hodneland, Bjøorn T Gjertsen, Øystein Bruserud & Karl J Tronstad. (2007) Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. Expert Opinion on Therapeutic Targets 11:8, pages 1055-1069.
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Guanya Li, Dunhui Li, Tao Wang & Shanping He. (2021) Pyrimidine Biosynthetic Enzyme CAD: Its Function, Regulation, and Diagnostic Potential. International Journal of Molecular Sciences 22:19, pages 10253.
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Yu Bai, Daid Ahmad, Ting Wang, Guihua Cui & Wenliang Li. (2019) Research Advances in the Use of Histone Deacetylase Inhibitors for Epigenetic Targeting of Cancer. Current Topics in Medicinal Chemistry 19:12, pages 995-1004.
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Joanna Zabkiewicz, Marie Gilmour, Robert Hills, Pares Vyas, Elizabeth Bone, Alan Davidson, Alan Burnett & Steven Knapper. (2016) The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias . Oncotarget 7:13, pages 16650-16662.
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Nicola A. Philbrook & Louise M. Winn. (2015) Investigating the effects of in utero benzene exposure on epigenetic modifications in maternal and fetal CD-1 mice. Toxicology and Applied Pharmacology 289:1, pages 12-19.
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Giedre Valiuliene, Ieva Stirblyte, Dovile Cicenaite, Algirdas Kaupinis, Mindaugas Valius & Ruta Navakauskiene. (2015) Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling . Journal of Cellular and Molecular Medicine 19:7, pages 1742-1755.
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Kristy R. StengelScott W. Hiebert. (2015) Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy. Antioxidants & Redox Signaling 23:1, pages 51-65.
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Xiao-Jian Sun, Na Man, Yurong Tan, Stephen D. Nimer & Lan Wang. (2015) The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Frontiers in Oncology 5.
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Ingvild Haaland, Jill A Opsahl, Frode S Berven, Håkon Reikvam, Hanne K Fredly, Ragnhild Haugse, Bernd Thiede, Emmet McCormack, Sonia Lain, Øystein Bruserud & Bjørn Tore Gjertsen. (2014) Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia. Molecular Cancer 13:1.
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Jurate Savickiene, Grazina Treigyte, Giedre Valiuliene, Ieva Stirblyte & Ruta Navakauskiene. (2014) Epigenetic and molecular mechanisms underlying the antileukemic activity of the histone deacetylase inhibitor belinostat in human acute promyelocytic leukemia cells. Anti-Cancer Drugs 25:8, pages 938-949.
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Hilde Kvestad, Lasse Evensen, James B. Lorens, Øystein Bruserud & Kimberley J. Hatfield. (2014) In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells . Leukemia Research and Treatment 2014, pages 1-12.
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A Mims, A R Walker, X Huang, J Sun, H Wang, R Santhanam, A M Dorrance, C Walker, P Hoellerbauer, S S Tarighat, K K Chan, R B Klisovic, D Perrotti, M A Caligiuri, J C Byrd, C-S Chen, L James Lee, S Jacob, K Mrózek, C D Bloomfield, W Blum, R Garzon, S Schwind & G Marcucci. (2012) Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia. Leukemia 27:4, pages 871-878.
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Hanne Fredly, Håkon Reikvam, Bjørn Tore Gjertsen & Øystein Bruserud. (2012) Disease‐stabilizing treatment with all‐trans retinoic acid and valproic acid in acute myeloid leukemia: Serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti‐leukemic treatment. American Journal of Hematology 87:4, pages 368-376.
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Wenjuan Yu, Jianxiang Wang, Jie Jin, Wenbin Qian, Jiejing Qian, Yizhi Cheng & Lei Wang. (2011) Heat shock protein 90 inhibition results in altered downstream signaling of mutant KIT and exerts synergistic effects on Kasumi-1 cells when combining with histone deacetylase inhibitor. Leukemia Research 35:9, pages 1212-1218.
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Jianjun XieAndre LarochelleIrina MaricMarion FaulhaberRobert E. DonahueCynthia E. Dunbar. (2010) Repetitive Busulfan Administration After Hematopoietic Stem Cell Gene Therapy Associated with a Dominant HDAC7 Clone in a Nonhuman Primate. Human Gene Therapy 21:6, pages 695-703.
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Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Håkon Reikvam & Øystein Bruserud. 2010. The Chemokine System in Experimental and Clinical Hematology. The Chemokine System in Experimental and Clinical Hematology 149 172 .
Suzanne E. Wardell, Olga R. Ilkayeva, Heather L. Wieman, Daniel E. Frigo, Jeffrey C. Rathmell, Christopher B. Newgard & Donald P. McDonnell. (2009) Glucose Metabolism as a Target of Histone Deacetylase Inhibitors. Molecular Endocrinology 23:3, pages 388-401.
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Anne M. Distler, Janos Kerner, Kwangwon Lee & Charles L. Hoppel. 2009. Mitochondrial Function, Part B: Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases. Mitochondrial Function, Part B: Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases 97 115 .
Akua K. Oduro, Michael K. Fritsch & Fern E. Murdoch. (2008) Chromatin context dominates estrogen regulation of pS2 gene expression. Experimental Cell Research 314:15, pages 2796-2810.
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Matthias Körner & Ulrich Tibes. 2008. Progress in Medicinal Chemistry Volume 46. Progress in Medicinal Chemistry Volume 46 205 280 .
Bjørn Tore Gjertsen & Gry Sjøholt. 2008. Cancer Proteomics. Cancer Proteomics 161 187 .
K L Rice, I Hormaeche & J D Licht. (2007) Epigenetic regulation of normal and malignant hematopoiesis. Oncogene 26:47, pages 6697-6714.
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Anita Ryningen, Camilla Stapnes & Øystein Bruserud. (2007) Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting. Leukemia Research 31:9, pages 1303-1313.
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Anne M. Distler, Janos Kerner & Charles L. Hoppel. (2007) Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1774:5, pages 628-636.
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Camilla Stapnes, Anne P. Døskeland, Kimberley Hatfield, Elisabeth Ersvær, Anita Ryningen, James B. Lorens, Bjørn Tore Gjertsen & Øystein Bruserud. (2007) The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. British Journal of Haematology 136:6, pages 814-828.
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T C Karagiannis & A El-Osta. (2006) Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?. Leukemia 21:1, pages 61-65.
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N Ånensen, J Skavland, C Stapnes, A Ryningen, A-L Børresen-Dale, B T Gjertsen & Ø Bruserud. (2006) Acute myelogenous leukemia in a patient with Li–Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report. Leukemia 20:4, pages 734-736.
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