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Expert Opinion on Therapeutic Targets Volume 10, 2006 - Issue 1
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Review

The small-molecule immune response modifier imiquimod – its mode of action and clinical use in the treatment of skin cancer

Michael P Schön Professor of Dermatology and Experimental Biomedicine, Julius-Maximilians-University of Würzburg, Rudolf-Virchow-Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology and Venereology, Versbacher Str. 9, 97078 Würzburg, Germany. [email protected]
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Margarete Schön Associate Professor of Molecular Biology, Julius-Maximilians-University of Würzburg, Rudolf-Virchow-Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology and Venereology, Versbacher Str. 9, 97078 Würzburg, Germany
Pages 69-76 | Published online: 27 Jan 2006

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Flavia Lozzi, Caterina Lanna, Mauro Mazzeo, Virginia Garofalo, Vincenzo Palumbo, Sara Mazzilli, Laura Diluvio, Alessandro Terrinoni, Luca Bianchi & Elena Campione. (2019) Investigational drugs currently in phase II clinical trials for actinic keratosis. Expert Opinion on Investigational Drugs 28:7, pages 629-642.
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Evangelia Papadavid, Alexandros J Stratigos & Matthew E Falagas. (2007) Imiquimod: an immune response modifier in the treatment of precancerous skin lesions and skin cancer. Expert Opinion on Pharmacotherapy 8:11, pages 1743-1755.
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Articles from other publishers (22)

Joelle Obeid, Abdullah Shaito, Hiba El Hajj, Carine Deleuze‑masquefa, Pierre-Antoine Bonnet, Marwan El‑Sabban & Jessica Saliba. (2023) Biological applications of imiquimod analogues: An update (Review). World Academy of Sciences Journal 5:3.
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Emilio Garcia-Mouronte, Emilio Berna-Rico, Belen de Nicolas-Ruanes, Carlos Azcarraga-Llobet, Luis Alonso-Martinez de Salinas & Sonia Bea-Ardebol. (2023) Imiquimod as Local Immunotherapy in the Management of Premalignant Cutaneous Conditions and Skin Cancer. International Journal of Molecular Sciences 24:13, pages 10835.
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Jiehan Li, Guang Luo, Chuchu Zhang, Shuaiyu Long, Leiming Guo, Ge Yang, Feng Wang, Lingling Zhang, Liyang Shi, Yang Fu & Yingjie Zhang. (2022) In situ injectable hydrogel-loaded drugs induce anti-tumor immune responses in melanoma immunochemotherapy. Materials Today Bio 14, pages 100238.
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Franco Maximiliano Salinas, Antonela Díaz Nebreda, Luciana Vázquez, María Virginia Gentilini, Victoria Marini, Martina Benedetti, Mercedes Soledad Nabaes Jodar, Mariana Viegas, Carina Shayo & Carlos Alberto Bueno. (2020) Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs. Antiviral Research 179, pages 104817.
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Cristian Navarrete-Dechent, Kelly C. Nelson, Anthony M. Rossi, Erica H. Lee, Christopher A. Barker, Kishwer S. Nehal & Susan M. Swetter. 2020. Cutaneous Melanoma. Cutaneous Melanoma 925 951 .
Julia Hartmann, Alexander H. Enk & Ferdinand Toberer. (2019) Hautinfiltrate einer chronisch lymphatischen Leukämie getriggert durch topische Imiquimodtherapie. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 17:S2, pages 9-11.
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Cristian Navarrete-Dechent, Kelly C. Nelson, Anthony M. Rossi, Erica H. Lee, Christopher A. Barker, Kishwer S. Nehal & Susan M. Swetter. 2020. Cutaneous Melanoma. Cutaneous Melanoma 1 27 .
Elise Ng & Vicki Levine. 2017. Lentigo Maligna Melanoma. Lentigo Maligna Melanoma 139 151 .
Alain H. RookJoel M. GelfandMaria WysockaAndrea B. TroxelBernice BenoitChristian SurberRosalie ElenitsasMarie A. BuchananDeborah S. LeahyRei WatanabeIlan R. Kirsch, Ellen J. KimRachael A. Clark. (2015) Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma. Blood 126:12, pages 1452-1461.
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Mihael Skerlev, Ivana Čulav-Košćak, Suzana Ljubojević Hadžavdić & Maja Sirotković-Skerlev. 2015. European Handbook of Dermatological Treatments. European Handbook of Dermatological Treatments 1465 1471 .
Yuji Kan, Tamaki Okabayashi, Shin-ichi Yokota, Soh Yamamoto, Nobuhiro Fujii & Toshiharu Yamashita. (2012) Imiquimod Suppresses Propagation of Herpes Simplex Virus 1 by Upregulation of Cystatin A via the Adenosine Receptor A 1 Pathway . Journal of Virology 86:19, pages 10338-10346.
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N. J. Horscroft, D. C. Pryde & H. Bright. (2012) Antiviral applications of Toll-like receptor agonists. Journal of Antimicrobial Chemotherapy 67:4, pages 789-801.
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Pierre L TriozziRalph J Tuthill & Ernest Borden. (2011) Re-inventing intratumoral immunotherapy for melanoma. Immunotherapy 3:5, pages 653-671.
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Jörg Vollmer. (2009) Autophagy Links Pattern Recognition Receptors to Tumor Cell Apoptosis. Molecular Therapy 17:11, pages 1839-1841.
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Vincenzo De Giorgi, Camilla Salvini, Alessandra Chiarugi, Milena Paglierani, Vincenza Maio, Paola Nicoletti, Marco Santucci, Paolo Carli & Daniela Massi. (2009) In vivo characterization of the inflammatory infiltrate and apoptotic status in imiquimod-treated basal cell carcinoma . International Journal of Dermatology 48:3, pages 312-321.
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Nicole M Haynes, Robbert G van der Most, Richard A Lake & Mark J Smyth. (2008) Immunogenic anti-cancer chemotherapy as an emerging concept. Current Opinion in Immunology 20:5, pages 545-557.
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Alexander Kreuter, Anja Potthoff, Norbert H. Brockmeyer, Thilo Gambichler, Markus Stücker, Peter Altmeyer, Jochen Swoboda, Herbert Pfister & Ulrike Wieland. (2008) Imiquimod Leads to a Decrease of Human Papillomavirus DNA and to a Sustained Clearance of Anal Intraepithelial Neoplasia in HIV-Infected Men. Journal of Investigative Dermatology 128:8, pages 2078-2083.
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Kiriaki Aroni, Aikaterini Mastoraki, George Agrogiannis, Eleftherios Ioannidis & Efstratios Patsouris. (2007) Successful treatment of keratoacanthoma centrifugum marginatum with local application of imiquimod cream. International Journal of Dermatology 46:12, pages 1321-1322.
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Kiriaki Aroni, Aikaterini Mastoraki, Evridiki Kyriazi, Anna Liossi & Eleftherios Ioannidis. (2007) Silver-stained nucleolar organizer regions and immunoglobulins in cutaneous squamocellular tumors. Pathology - Research and Practice 203:12, pages 857-862.
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Kiriaki Aroni, Aikaterini Mastoraki, Evridiki Kyriazi, Eleftherios Ioannidis & Efstratios Patsouris. (2007) Silver-stained organizer regions and immunoglobulins in cutaneous keratoacanthomas and squamous cell carcinomas. Pathology - Research and Practice 203:9, pages 659-665.
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Konstanze Spieth, Adorjan Kovács, Manfred Wolter, Reinhold Bug, Roland Kaufmann & Jens Gille. (2006) Topical imiquimod: effectiveness in intraepithelial melanoma of oral mucosa. The Lancet Oncology 7:12, pages 1036-1037.
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Gerda Trutnovsky, Olaf Reich, Elmar A. Joura, Magdalena Holter, Alexandra Ciresa-König, Andreas Widschwendter, Christian Schauer, Gerhard Bogner, Ziga Jan, Angelika Boandl, Martin Simon Kalteis, Sigrid Regauer & Karl Tamussino. (2021) Topical Imiquimod Versus Surgery for Vulvar Intraepithelial Neoplasia:A Multicentre, Randomised, Phase 3, Non-Inferiority Trial. SSRN Electronic Journal.
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