293
Views
31
CrossRef citations to date
0
Altmetric
Review

Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway

, MD PhD & , PhD
Pages 1611-1621 | Published online: 18 Nov 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Weili Sun & Shakeel Modak. (2012) Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine. OncoTargets and Therapy 5, pages 21-29.
Read now
Sanjeev Ranjan, Rohit Sood, Jozsef Dudas, Rudolf Glueckert, Anneliese Schrott-Fischer, Soumen Roy, Ilmari Pyykkö & Paavo KJ Kinnunen. (2012) Peptide-mediated targeting of liposomes to TrkB receptor-expressing cells. International Journal of Nanomedicine 7, pages 3475-3485.
Read now
Raymond L Stallings, Niamh H Foley, Kenneth Bryan, Patrick G Buckley & Isabella Bray. (2010) Therapeutic targeting of miRNAs in neuroblastoma. Expert Opinion on Therapeutic Targets 14:9, pages 951-962.
Read now
Michelle KY Siu, Oscar GW Wong & Annie NY Cheung. (2009) TrkB as a therapeutic target for ovarian cancer. Expert Opinion on Therapeutic Targets 13:10, pages 1169-1178.
Read now
Hervé Sartelet, Luc-Laurier Oligny & Gilles Vassal. (2008) AKT pathway in neuroblastoma and its therapeutic implication. Expert Review of Anticancer Therapy 8:5, pages 757-769.
Read now

Articles from other publishers (26)

Yesim Kaya, Seren Kucukvardar & Aysegul Yildiz. (2020) Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells. Molecular and Cellular Biochemistry 473:1-2, pages 133-141.
Crossref
Hidemi Toyoda, Dong-Qing Xu, Lei Qi & Masahiro Hirayama. 2020. Biophysical Chemistry - Advance Applications. Biophysical Chemistry - Advance Applications.
Zhongyan Hua, Yue Zhan, Simeng Zhang, Yudi Dong, Min Jiang, Fei Tan, Zhihui Liu, Carol J. Thiele & Zhijie Li. (2018) P53/PUMA are potential targets that mediate the protection of brain-derived neurotrophic factor (BDNF)/TrkB from etoposide-induced cell death in neuroblastoma (NB). Apoptosis 23:7-8, pages 408-419.
Crossref
Akira Nakagawara, Yuanyuan Li, Hideki Izumi, Katsumi Muramori, Hiroko Inada & Masanori Nishi. (2018) Neuroblastoma. Japanese Journal of Clinical Oncology 48:3, pages 214-241.
Crossref
Amir Tajbakhsh, Amin Mokhtari-Zaer, Mehdi Rezaee, Fahimeh Afzaljavan, Mehdi Rivandi, Seyed Mahdi Hassanian, Gordon A Ferns, Alireza Pasdar & Amir Avan. (2017) Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and Perspectives. Journal of Cellular Biochemistry 118:9, pages 2502-2515.
Crossref
Magdalena Bartnik, Adrianna Sławińska-Brych, Aleksandra Żurek, Martyna Kandefer-Szerszeń & Barbara Zdzisińska. (2017) 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. Journal of Ethnopharmacology 207, pages 19-29.
Crossref
Brian H. Kushner, Nai-Kong V. Cheung, Shakeel Modak, Oren J. Becher, Ellen M. Basu, Stephen S. Roberts, Kim Kramer & Ira J. Dunkel. (2017) A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma. International Journal of Cancer 140:2, pages 480-484.
Crossref
Zhihui Liu & Carol J. Thiele. 2017. Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors. Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors 83 125 .
Ying Jiang, Longling Li, Jingxi Ma, Lina Zhang, Fei Niu, Tao Feng & Changqing Li. (2016) Auricular vagus nerve stimulation promotes functional recovery and enhances the post-ischemic angiogenic response in an ischemia/reperfusion rat model. Neurochemistry International 97, pages 73-82.
Crossref
Aislinn J. Williams & Hisashi Umemori. (2014) The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease. Frontiers in Synaptic Neuroscience 6.
Crossref
Mike-Andrew Westhoff, Najmeh Faham, Daniela Marx, Lisa Nonnenmacher, Claudia Jennewein, Stefanie Enzenmüller, Patrick Gonzalez, Simone Fulda & Klaus-Michael Debatin. (2013) Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma. PLoS ONE 8:12, pages e83128.
Crossref
XIAOMEI YANG, TRACEY A. MARTIN & WEN GUO JIANG. (2013) Biological influence of brain-derived neurotrophic factor (BDNF) on colon cancer cells. Experimental and Therapeutic Medicine 6:6, pages 1475-1481.
Crossref
Wan-Ling Ho, Mei-Ieng Che, Chih-Hsing Chou, Hsiu-Hao Chang, Yung-Ming Jeng, Wen-Ming Hsu, Kai-Hsin Lin & Min-Chuan Huang. (2013) B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastoma. Cancer Science 104:12, pages 1600-1608.
Crossref
Andrei Leitão, Alexander Schramm & Angelika Eggert. (2013) Discovery of a New Bioactive Molecule for Neuroblastoma. Chemical Biology & Drug Design 82:2, pages 233-241.
Crossref
XIAOMEI YANG, TRACEY A. MARTIN & WEN G. JIANG. (2012) Biological influence of brain-derived neurotrophic factor on breast cancer cells. International Journal of Oncology 41:4, pages 1541-1546.
Crossref
Junegoo Lee, Tilahun Jiffar & Michael E. Kupferman. (2012) A Novel Role for BDNF-TrkB in the Regulation of Chemotherapy Resistance in Head and Neck Squamous Cell Carcinoma. PLoS ONE 7:1, pages e30246.
Crossref
Jian Li, Yangde Zhang, Jingfeng Zhao, Fangren Kong & Yuxiang Chen. (2011) Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. Molecular and Cellular Biochemistry 357:1-2, pages 31-38.
Crossref
Linda A. Dokas, Amy M. Malone, Frederick E. Williams, Surya M. Nauli & William S. MesserJr.Jr.. (2011) Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. Neuropharmacology 61:1-2, pages 12-24.
Crossref
Yoshinori Takei & Ronald Laskey. 2011. Advances in TNF Family Research. Advances in TNF Family Research 559 565 .
Siyang Zhang, Dawei Guo, Wenting Luo, Qingfu Zhang, Ying Zhang, Chunyan Li, Yao Lu, Zeshi Cui & Xueshan Qiu. (2010) TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells. BMC Cancer 10:1.
Crossref
Matylda Macias, Dorota Nowicka, Artur Czupryn, Dorota Sulejczak, Małgorzata Skup, Jolanta Skangiel-Kramska & Julita Czarkowska-Bauch. (2009) Exercise-induced motor improvement after complete spinal cord transection and its relation to expression of brain-derived neurotrophic factor and presynaptic markers. BMC Neuroscience 10:1.
Crossref
W Li, Y Xie, R W-Y Sun, Q Liu, J Young, W-Y Yu, C-M Che, P K Tam & Y Ren. (2009) Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition. British Journal of Cancer 101:2, pages 342-349.
Crossref
John Inge Johnsen, Per Kogner, Ami Albihn & Marie Arsenian Henriksson. (2009) Embryonal neural tumours and cell death. Apoptosis 14:4, pages 424-438.
Crossref
W T Arscott, A E LaBauve, V May & U V Wesley. (2008) Suppression of neuroblastoma growth by dipeptidyl peptidase IV: relevance of chemokine regulation and caspase activation. Oncogene 28:4, pages 479-491.
Crossref
Tiziana Servidei, Anna Riccardi, Simona Mozzetti, Cristiano Ferlini & Riccardo Riccardi. (2008) Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib. International Journal of Cancer 123:12, pages 2939-2949.
Crossref
Graham M. Strub, Amy Depcrynski, Lynne W. Elmore & Shawn E. Holt. (2008) Recovery from stress is a function of age and telomere length. Cell Stress and Chaperones 13:4, pages 475-482.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.