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Volume 11, Issue 12

Expert Opinion on Therapeutic Targets

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Expert Opinion on Therapeutic Targets, Volume 11, Issue 12 (2007)

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Expert Opinion on Therapeutic Targets, Volume 11, Issue 12 (2007)

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Review

Article

Targeting platelets for prevention and treatment of cardiovascular disease

Todd A Duhamel PhD, Yan-Jun Xu MD PhD, Amarjit S Arneja MD & Naranjan S Dhalla PhD MD DSc

Pages: 1523-1533

Published online: 18 Nov 2007

AbstractforTargeting platelets for prevention and treatment of cardiovascular disease | Full Text | References | PDF (193.3 KB)

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Article

Targeting insulin-like growth factor-1 to treat Alzheimer's disease

Ignacio Torres-Aleman

Pages: 1535-1542

Published online: 18 Nov 2007

AbstractforTargeting insulin-like growth factor-1 to treat Alzheimer's disease | Full Text | References | PDF (276.6 KB)

203 Views
31 CrossRef citations
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Article

The parkin protein as a therapeutic target in Parkinson's disease

Konstanze F Winklhofer MD PhD

Pages: 1543-1552

Published online: 18 Nov 2007

AbstractforThe parkin protein as a therapeutic target in Parkinson's disease | Full Text | References | PDF (193 KB)

227 Views
24 CrossRef citations
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Article

Molecular prognostic factors in patients with pancreatic cancer

Giuseppe Tonini MD PhD, Francesco Pantano, Bruno Vincenzi, Armando Gabbrielli, Roberto Coppola & Daniele Santini

Pages: 1553-1569

Published online: 18 Nov 2007

AbstractforMolecular prognostic factors in patients with pancreatic cancer | Full Text | References | PDF (179 KB)

133 Views
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Article

Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence

Antonio Russo, Maria E Fratto, Viviana Bazan, Valentina Schiró, Valentina Agnese, Giuseppe Cicero, Bruno Vincenzi, Giuseppe Tonini & Daniele Santini MD PhD

Pages: 1571-1586

Published online: 18 Nov 2007

AbstractforTargeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence | Full Text | References | PDF (272.4 KB)

149 Views
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Article

Selective Raf inhibition in cancer therapy

Vladimir Khazak, Igor Astsaturov, Ilya G Serebriiskii & Erica A Golemis

Pages: 1587-1609

Published online: 18 Nov 2007

AbstractforSelective Raf inhibition in cancer therapy | Full Text | References | PDF (755 KB)

436 Views
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Article

Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway

Zhijie Li MD PhD & Carol J Thiele PhD

Pages: 1611-1621

Published online: 18 Nov 2007

AbstractforTargeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway | Full Text | References | PDF (220.7 KB)

293 Views
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Article

Molecular mechanisms of cellular senescence and immortalization of human cells

Tohru Kiyono

Pages: 1623-1637

Published online: 18 Nov 2007

AbstractforMolecular mechanisms of cellular senescence and immortalization of human cells | Full Text | References | PDF (1.2 MB)

224 Views
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Article

The role of estrogen receptor in melanoma

Atsushi Tanemura MD PhD, Anneke Q van Hoesel MD, Takuji Mori MD PhD, Terrance Yu & Dave SB Hoon PhD

Pages: 1639-1648

Published online: 18 Nov 2007

AbstractforThe role of estrogen receptor in melanoma | Full Text | References | PDF (1.8 MB)

142 Views
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Article

Is DARPP-32 a potential therapeutic target?

Helton J Reis, Daniela VF Rosa, Melissa M Guimarães, Bruno R Souza, Alexandre GA Barros, Flávio J Pimenta, Renan P Souza, Karen CL Torres & Marco A Romano-Silva MD PhD

Pages: 1649-1661

Published online: 18 Nov 2007

AbstractforIs DARPP-32 a potential therapeutic target? | Full Text | References | PDF (343.4 KB)

199 Views
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