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Common pathogenic mechanisms and pathways in the development of COPD and lung cancer

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Pages 439-456 | Published online: 02 Feb 2011

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Robert P Young & Raewyn J Hopkins. (2013) Update on the potential role of statins in chronic obstructive pulmonary disease and its co-morbidities. Expert Review of Respiratory Medicine 7:5, pages 533-544.
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Brian Tiep, Rick Carter, Finly Zachariah, Anna C Williams, David Horak, Mary Barnett & Rachel Dunham. (2013) Oxygen for end-of-life lung cancer care: managing dyspnea and hypoxemia. Expert Review of Respiratory Medicine 7:5, pages 479-490.
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Crossref
Frazer Lowe. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 65 87 .
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Crossref
Desmond Mascarenhas, Sheri Routt & Baljit K. Singh. (2012) Mammalian target of rapamycin complex 2 regulates inflammatory response to stress. Inflammation Research 61:12, pages 1395-1404.
Crossref
George K. Acquaah-Mensah, Deepti Malhotra, Madhulika Vulimiri, Jason E. McDermott & Shyam Biswal. (2012) Suppressed Expression of T-Box Transcription Factors Is Involved in Senescence in Chronic Obstructive Pulmonary Disease. PLoS Computational Biology 8:7, pages e1002597.
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JOHN W. HOLLOWAY, SANTIYAGU SAVARIMUTHU FRANCIS, KWUN M. FONG & IAN A. YANG. (2012) Genomics and the respiratory effects of air pollution exposure. Respirology 17:4, pages 590-600.
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Mariza de Andrade, Yan Li, Randolph S. Marks, Claude Deschamps, Paul D. Scanlon, Curtis L. Olswold, Ruoxiang Jiang, Stephen J. Swensen, Zhifu Sun, Julie M. Cunningham, Jason A. Wampfler, Andrew H. Limper, David E. Midthun & Ping Yang. (2012) Genetic Variants Associated with the Risk of Chronic Obstructive Pulmonary Disease with and without Lung Cancer. Cancer Prevention Research 5:3, pages 365-373.
Crossref
. (2012) Guía de Práctica Clínica para el Diagnóstico y Tratamiento de Pacientes con Enfermedad Pulmonar Obstructiva Crónica (EPOC) - Guía Española de la EPOC (GesEPOC). Archivos de Bronconeumología 48, pages 2-58.
Crossref
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Crossref
Ákos VégváriBalázs Döme. (2011) State-of-the-art MS technology applications in lung disease. Bioanalysis 3:23, pages 2665-2677.
Crossref
Michael Roth. (2011) Is There a Regulatory Role of Immunoglobulins on Tissue Forming Cells Relevant in Chronic Inflammatory Lung Diseases?. Journal of Allergy 2011, pages 1-9.
Crossref
ROBERT P. YOUNG & RAEWYN J. HOPKINS. (2011) How the genetics of lung cancer may overlap with COPD. Respirology 16:7, pages 1047-1055.
Crossref

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