1,121
Views
62
CrossRef citations to date
0
Altmetric
Reviews

Common pathogenic mechanisms and pathways in the development of COPD and lung cancer

, , , , , , , , & show all
Pages 439-456 | Published online: 02 Feb 2011

Bibliography

  • Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2009; Available from: www.goldcopd.com/ [Last accessed 22 January 2011]
  • Punturieri A, Szabo E, Croxton TL, Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. J Natl Cancer Inst 2009;101:554-9
  • Rodriguez-Roisin R, Soriano JB. Chronic obstructive pulmonary disease with lung cancer and/or cardiovascular disease. Proc Am Thorac Soc 2008;5:842-7
  • Young RP, Hopkins RJ, Christmas T, COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J 2009;34:380-6
  • Gullon JA, Suarez I, Medina A, Role of emphysema and airway obstruction in prognosis of lung cancer. Lung Cancer 2011;71:182-5
  • Wasswa-Kintu S, Gan WQ, Man SFP, Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis. Thorax 2005;60:570-5
  • Koshiol J, Rotunno M, Consonni D, Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study. PLoS ONE 2009;4:e7380
  • Mannino DM, Aguayo SM, Petty TL, Low lung function and incident lung cancer in the United States: data from the first national health and nutrition examination survey follow-up. Arch Intern Med 2003;163:1475-80
  • Mizuno S, Takiguchi Y, Fujikawa A, Chronic obstructive pulmonary disease and interstitial lung disease in patients with lung cancer. Respirology 2009;14:377-83
  • van Gestel YRBM, Hoeks SE, Sin DD, COPD and cancer mortality: the influence of statins. Thorax 2009;64:963-7
  • Wilson DO, Weissfeld JL, Balkan A, Association of radiographic emphysema and airflow obstruction with lung cancer. Am J Respir Crit Care Med 2008;178:738-44
  • de Torres JP, Bastarrika G, Wisnivesky JP, Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. Chest 2007;132:1932-8
  • Papi A, Casoni G, Caramori G, COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma. Thorax 2004;59:679-81
  • Kawabata Y, Hoshi E, Murai K, Smoking-related changes in the background lung of specimens resected for lung cancer: a semiquantitative study with correlation to postoperative course. Histopathology 2008;53:707-14
  • Katzenstein AL, Mukhopadhyay S, Zanardi C, Clinically occult interstitial fibrosis in smokers: classification and significance of a surprisingly common finding in lobectomy specimens. Hum Pathol 2010;41:316-25
  • Hogg JC, Chu F, Utokaparch S, The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-53
  • Hogg JC, McDonough JE, Gosselink JV, What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease? Proc Am Thorac Soc 2009;6:668-72
  • Cagle PT, Roggli VL. Pathology of small airways. In: Tomashefski JF, Cagle PT, Farver CF, Fraire AE, editors, Dail and hammar's pulmonary pathology. Springer, New York; 2008. p. 897-899
  • Tazelaar HD, Wright JL, Churg A. Desquamative interstitial pneumonia. Histopathology 2010: published online 21 September 2010, doi 10.1111/j.365-2559.010.03649.x
  • Roggli VL, Cagle PT. Emphysema and chronic bronchitis. In: Tomashefski JF, Cagle PT, Farver CF, Fraire AE, editors, Dail and hammar's pulmonary pathology. Springer, New York; 2008. p. 866-85
  • Wright JL, Tazelaar HD, Churg A. Fibrosis with emphysema. Histopathology 2010: published online 21 September 2010, doi 10.1111/j.365-2559.010.03648.x
  • Alberg AJ, Ford JG, Samet JM. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines. 2nd edition. Chest 2007;132(3 Suppl):29S-55S
  • Turner MC, Chen Y, Krewski D, Chronic obstructive pulmonary disease is associated with lung cancer mortality in a prospective study of never smokers. Am J Respir Crit Care Med 2007;176:285-90
  • Lin HH, Murray M, Cohen T, Effects of smoking and solid-fuel use on COPD, lung cancer, and tuberculosis in China: a time-based, multiple risk factor, modelling study. Lancet 2008;372:1473-83
  • Sørheim I-C, Bakke P, Gulsvik A, alpha1-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts. Chest 2010;138:1125-32
  • Yang P, Sun Z, Krowka MJ, Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk. Arch Intern Med 2008;168:1097-103
  • Brody JS, Spira A. State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thorac Soc 2006;3:535-7
  • Lee G, Walser TC, Dubinett SM. Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer. Curr Opin Pulm Med 2009;15:303-7
  • Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 2009;9:375-83
  • Caramori G, Casolari P, Cavallesco GN, Mechanisms involved in lung cancer development in COPD. Int J Biochem Cell Biol 2010: published online 14 October 2010, doi:10.1016/j.biocel.2010.08.022
  • Bowman RV, Wright CM, Davidson MR, Epigenomic targets for the treatment of respiratory disease. Expert Opin Ther Target 2009;13:625-40
  • Bowman RV, Yang IA, Semmler AB, Epigenetics of lung cancer. Respirology 2006;11:355-65
  • Stampfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol 2009;9:377-84
  • Tauler J, Mulshine JL. Lung cancer and inflammation: interaction of chemokines and hnRNPs. Curr Opin Pharmacol 2009;9:384-8
  • Di Stefano A, Caramori G, Oates T, Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD. Eur Respir J 2002;20:556-63
  • Houghton AM, Rzymkiewicz DM, Ji H, Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med 2010;16:219-23
  • Moghaddam SJ, Li H, Cho S-N, Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am J Respir Cell Mol Biol 2009;40:443-53
  • Qu P, Roberts J, Li Y, Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease. Lung Cancer 2009;63:341-7
  • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009;119:1429-37
  • Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010;29:4741-51
  • Sohal SS, Reid D, Soltani A, Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. Respirology 2010;15:930-8
  • Hodge S, Hodge G, Jersmann H, Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;178:139-48
  • Anglim PP, Alonzo TA, Laird-Offringa IA. DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update. Mol Cancer 2008;7(1):81
  • Anglim PP, Galler JS, Koss MN, Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer 2008;7:62
  • Belinsky SA, Schiller JH, Stidley CA. DNA methylation biomarkers to assess therapy and chemoprevention for non-small cell lung cancer. Nutr Rev 2008;66(Suppl 1):S24-6
  • Brock MV, Hooker CM, Ota-Machida E, DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 2008;358:1118-28
  • Fukasawa M, Kimura M, Morita S, Microarray analysis of promoter methylation in lung cancers. J Hum Genet 2006;51:368-74
  • Shames DS, Girard L, Gao B, A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med 2006;3:e486
  • Luczak MW, Jagodzinski PP. The role of DNA methylation in cancer development. Folia Histochem Cytobiol 2006;44:143-54
  • Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005;74:481-514
  • Brena RM, Morrison C, Liyanarachchi S, Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. PLoS Med 2007;4(3):e108
  • Zochbauer-Muller S, Fong KM, Virmani AK, Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 2001;61:249-55
  • Fukui T, Kondo M, Ito G, Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer. Oncogene 2005;24:6323-7
  • Suzuki M, Shigematsu H, Nakajima T, Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer. Clin Cancer Res 2007;13:6087-92
  • Licchesi JD, Westra WH, Hooker CM, Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis 2008;29:895-904
  • Yang TM, Leu SW, Li JM, WIF-1 promoter region hypermethylation as an adjuvant diagnostic marker for non-small cell lung cancer-related malignant pleural effusions. J Cancer Res Clin Oncol 2009;135:919-24
  • Weber B, Stresemann C, Brueckner B, Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle 2007;6:1001-5
  • Lujambio A, Ropero S, Ballestar E, Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007;67:1424-9
  • Brueckner B, Stresemann C, Kuner R, The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res 2007;67:1419-23
  • Ito K, Ito M, Elliott WM, Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 2005;352:1967-76
  • Adcock IM, Ford P, Ito K, Epigenetics and airways disease. Respir Res 2006;7:21
  • Sood A, Petersen H, Blanchette CM, Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers. Am J Respir Crit Care Med 2010;182:1098-104
  • Schwartz AG, Prysak GM, Bock CH, The molecular epidemiology of lung cancer. Carcinogenesis 2007;28:507-18
  • Larsen JE, Colosimo ML, Yang IA, Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism. Cancer Causes Control 2005;16:579-85
  • Larsen JE, Colosimo ML, Yang IA, CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. Carcinogenesis 2006;27(3):525-32
  • Wright CM, Larsen JE, Colosimo ML, Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. Eur Respir J 2010;35:152-9
  • Yang IA, Seeney SL, Wolter JM, Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections. Genes Immun 2003;4:269-74
  • Young RP, Hopkins RJ, Hay BA, Lung cancer gene associated with COPD: triple whammy or possible confounding effect? Eur Respir J 2008;32:1158-64
  • Pillai SG, Ge D, Zhu G, A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009;5(3):e1000421
  • Lambrechts D, Buysschaert I, Zanen P, The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. Am J Respir Crit Care Med 2010;181:486-93
  • Cho MH, Boutaoui N, Klanderman BJ, Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet 2010;42:200-2
  • Minna JD. Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. J Clin Invest 2003;111:31-3
  • Zia S, Ndoye A, Nguyen VT, Nicotine enhances expression of the alpha3, alpha4, alpha5, and alpha7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res Commun Mol Pathol Pharmacol 1997;97:243-62
  • Maus ADJ, Pereira EFR, Karachunski PI, Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol 1998;54:779-88
  • Wang Y, Pereira EFR, Maus ADJ, Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors. Mol Pharmacol 2001;60(6):1201-9
  • West KA, Brognard J, Clark AS, Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003;111:81-90
  • Plummer HK III, Dhar M, Schuller HM. Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells. Respir Res 2005;6:29
  • Carlisle DL, Liu X, Hopkins TM, Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulm Pharmacol Ther 2007;20:629-41
  • Lam DC-l, Girard L, Ramirez R, Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res 2007;67:4638-47
  • Falvella FS, Galvan A, Frullanti E, Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Clin Cancer Res 2009;15:1837-42
  • Bierut LJ, Stitzel JA, Wang JC, Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 2008;165:1163-71
  • Fu XW, Lindstrom J, Spindel ER. Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Am J Respir Cell Mol Biol 2009;41:93-9
  • Zhang Q, Tang X, Zhang Z-F, Nicotine induces hypoxia-inducible factor-alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. Clin Cancer Res 2007;13:4686-94
  • Martinez-Garcia E, Irigoyen M, Anso E, Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation. Toxicol Appl Pharmacol 2008;228:334-42
  • Tournier J-M, Maouche K, Coraux C, alpha3alpha5beta2-Nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells. Am J Pathol 2006;168:55-68
  • Tan DSP, Lambros MBK, Natrajan R, Getting it right: designing microarray (and not ‘microawry’) comparative genomic hybridization studies for cancer research. Lab Invest 2007;87:737-54
  • Michels E, Preter KD, Roy NV, Detection of DNA copy number alterations in cancer by array comparative genomic hybridization. Genet Med 2007;9:574-84
  • Pinkel D, Albertson DG. Comparative genomic hybridization. Annu Rev Genomics Hum Genet 2005;6:331-54
  • Balsara BR, Testa JR. Chromosomal imbalances in human lung cancer. Oncogene 2002;21:6877-83
  • Goeze A, Schluns K, Wolf G, Chromosomal imbalances of primary and metastatic lung adenocarcinomas. J Pathol 2002;196:8-16
  • Petersen S, Aninat-Meyer M, Schluns K, Chromosomal alterations in the clonal evolution to the metastatic stage of squamous cell carcinomas of the lung. Br J Cancer 2000;82:65-73
  • Boelens MC, Kok K, van der Vlies P, Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. Lung Cancer 2009;66:372-8
  • Broet P, Camilleri-Broet S, Zhang S, Prediction of clinical outcome in multiple lung cancer cohorts by integrative genomics: implications for chemotherapy selection. Cancer Res 2009;69:1055-62
  • Gallegos Ruiz MlI, Floor K, Roepman P, Integration of gene dosage and gene expression in non-small cell lung cancer, identification of hsp90 as potential target. PLoS ONE 2008;3(3):e0001722
  • Janssens W, Nuytten H, Dupont LJ, Genomic copy number determines functional expression of beta-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182:163-9
  • Yang IA, Francis SM. Deconstructing COPD using genomic tools. Respirology 2009;14:313-7
  • Spira A, Beane JE, Shah V, Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med 2007;13:361-6
  • Spira A, Beane J, Shah V, Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci USA 2004;101:10143-8
  • Golpon HA, Coldren CD, Zamora MR, Emphysema lung tissue gene expression profiling. AJRCMB 2004;31:595-600
  • Spira A, Beane J, Pinto-Plata V, Gene expression profiling of human lung tissue from smokers with severe emphysema. AJRCMB 2004;31:601-10
  • Pierrou S, Broberg P, O'Donnell RA, Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. AJRCCM 2007;175:577-86
  • Savarimuthu Francis SM, Larsen JE, Pavey SJ, Expression profiling identifies genes involved in emphysema severity. Respir Res 2009;10(1):81
  • Larsen JE, Pavey SJ, Passmore LH, Expression profiling defines a recurrence signature in lung squamous cell carcinoma. Carcinogenesis 2007;28:760-6
  • Boelens MC, Gustafson AM, Postma DS, A chronic obstructive pulmonary disease related signature in squamous cell lung cancer. Lung Cancer 2010: published online, 15 September 2010 doi:10.1016/j.lungcan.2010.08.014
  • Brody JS, Spira A. State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thoracic Soc 2006;3:535-7
  • Bhattacharya S, Srisuma S, Demeo DL, Molecular biomarkers for quantitative and discrete COPD phenotypes. Am J Respir Cell Mol Biol 2009;40:359-67
  • Wang IM, Stepaniants S, Boie Y, Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer. Am J Respir Crit Care Med 2008;177:402-11
  • Yanaihara N, Caplen N, Bowman E, Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006;9:189-98
  • Davidson MR, Larsen JE, Yang IA, MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS ONE 2010;5:e12560
  • Schembri F, Sridhar S, Perdomo C, MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA 2009;106:2319-24
  • Parimon T, Chien JW, Bryson CL, Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:712-9
  • Kiri VA, Fabbri LM, Davis KJ, Inhaled corticosteroids and risk of lung cancer among COPD patients who quit smoking. Respir Med 2009;103:85-90
  • Calverley PM, Anderson JA, Celli B, Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007;356:775-89
  • Lam S, leRiche JC, McWilliams A, A randomized Phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium. Clin Cancer Res 2004;10:6502-11
  • van den Berg RM, van Tinteren H, van Zandwijk N, The influence of fluticasone inhalation on markers of carcinogenesis in bronchial epithelium. Am J Respir Crit Care Med 2007;175:1061-5
  • Spinola M, Leoni VP, Galvan A, Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. Cancer Lett 2007;251:311-6
  • Amos CI, Wu X, Broderick P, Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 2008;40:616-22
  • Hung RJ, McKay JD, Gaborieau V, A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008;452:633-7
  • Thorgeirsson TE, Geller F, Sulem P, A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008;452:638-42
  • McKay JD, Hung RJ, Gaborieau V, Lung cancer susceptibility locus at 5p15.33. Nat Genet 2008;40:1404-6
  • Wang Y, Broderick P, Webb E, Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet 2008;40:1407-9
  • Broderick P, Wang Y, Vijayakrishnan J, Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Res 2009;69:6633-41
  • Landi MT, Chatterjee N, Yu K, A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet 2009;85:679-91
  • Liu JZ, Tozzi F, Waterworth DM, Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010;42:436-40
  • The Tobacco and Genetics Consortium. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010;42:441-7
  • Thorgeirsson TE, Gudbjartsson DF, Surakka I, Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 2010;42:448-53
  • Massion PP, Kuo W-L, Stokoe D, Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway. Cancer Res 2002;62:3636-40
  • Jiang F, Yin Z, Caraway NP, Genomic profiles in stage I primary non small cell lung cancer using comparative genomic hybridization analysis of cDNA microarrays. Neoplasia 2004;6:623-35
  • Tonon G, Wong K-K, Maulik G, High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci USA 2005;102:9625-30
  • Shibata T, Uryu S, Kokubu A, Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res 2005;11:6177-85
  • Kim T-M, Yim S-H, Lee J-S, Genome-wide screening of genomic alterations and their clinicopathologic implications in non-small cell lung cancers. Clin Cancer Res 2005;11:8235-42
  • Garnis C, Lockwood WW, Vucic E, High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH. Int J Cancer 2006;118:1556-64
  • Li R, Wang H, Bekele BN, Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene 2005;25:2628-35
  • Choi Y-W, Choi JS, Zheng LT, Comparative genomic hybridization array analysis and real time PCR reveals genomic alterations in squamous cell carcinomas of the lung. Lung Cancer 2007;55:43-51
  • Choi JS, Zheng LT, Ha E, Comparative genomic hybridization array analysis and real-time PCR reveals genomic copy number alteration for lung adenocarcinomas. Lung 2006;184:355-62
  • Dehan E, Ben-Dor A, Liao W, Chromosomal aberrations and gene expression profiles in non-small cell lung cancer. Lung Cancer 2007;56:175-84
  • Lo KC, Stein LC, Panzarella JA, Identification of genes involved in squamous cell carcinoma of the lung using synchronized data from DNA copy number and transcript expression profiling analysis. Lung Cancer 2008;59:315-31
  • Choi JS, Lee WJ, Baik SH, Array CGH reveals genomic aberrations in human emphysema. Lung 2009;187:165-72

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.