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Targeting interleukin-21 in inflammatory diseases

, PhD, , PhD, , MD & , PhD MD
Pages 695-702 | Published online: 11 Mar 2011

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Mark F. Maurer, Ursula Garrigues, Stephen R. Jaspers, Brent Meengs, Mark W. Rixon, Brenda L. Stevens, Kenneth B. Lewis, Susan H. Julien, Thomas R. Bukowski, Anitra C. Wolf, Nels B. Hamacher, Mark Snavely & Stacey R. Dillon. (2012) Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodies. mAbs 4:1, pages 69-83.
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Maria C Lebre, Pedro L Vieira, Man Wai Tang, Saïda Aarrass, Boy Helder, Thomas Newsom-Davis, Paul P Tak & Gavin R Screaton. (2017) Synovial IL-21/TNF-producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes. Journal of Leukocyte Biology 101:3, pages 775-783.
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Zhihua Zhao, Zhifeng Mao, Junjie Yin, Yaqing Shu, Wei Qiu, Zhengqi Lu & Xueqiang Hu. (2017) Immune characteristics study of AG490, a signal pathway inhibitor, in EAE model mice. Saudi Journal of Biological Sciences 24:2, pages 256-262.
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F Vallières & D Girard. (2017) Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages. Clinical and Experimental Immunology 187:2, pages 294-303.
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Li Xiao, Lei Jia, Yannan Zhang, Sifei Yu, Xingmei Wu, Binyan Yang, Huabin Li & Changyou Wu. (2015) Human IL-21+IFN-γ+CD4+ T cells in nasal polyps are regulated by IL-12. Scientific Reports 5:1.
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L. Xiao, Y. Wei, Y.-N. Zhang, X. Luo, B.-Y. Yang, S.-F. Yu, X.-M. Wu, C.-Y. Wu & H.-B. Li. (2015) Increased IL-21 expression in chronic rhinosinusitis with nasalpolyps. Clinical & Experimental Allergy 45:2, pages 404-413.
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Suhendan Ekmekcioglu, Razelle Kurzrock & Elizabeth A. Grimm. 2015. The Molecular Basis of Cancer. The Molecular Basis of Cancer 789 808.e4 .
Maohua Zhou, Ruqiong Zou, Huiquan Gan, Zhimei Liang, Fujun Li, Ting Lin, Yanfei Luo, Xiaoming Cai, Fang He & Erxia Shen. (2014) The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects. Immunity & Ageing 11:1.
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Alexandra Zanin-ZhorovJonathan M. WeissMelanie S. NyuydzefeWei ChenJose U. Scher, Rigen MoDavid DepoilNishta RaoBen LiuJianlu WeiSarah LucasMatthew KoslowMaria RocheOlivier Schueller, Sara WeissMasha V. PoyurovskyJames TonraKeli L. Hippen, Michael L. DustinBruce R. Blazar, Chuan-ju LiuSamuel D. Waksal. (2014) Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proceedings of the National Academy of Sciences 111:47, pages 16814-16819.
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Q. Pan, Y. Yu, Z. Tang, M. Xi, H. Jiang, Y. Xun, X. Liu, H. Liu, J. Hu & G. Zang. (2014) Increased levels of IL-21 responses are associated with the severity of liver injury in patients with chronic active hepatitis B. Journal of Viral Hepatitis 21:9, pages e78-e88.
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Elisabeth Salzer, Aydan Kansu, Heiko Sic, Peter Májek, Aydan Ikincioğullari, Figen E. Dogu, Nina Kathrin Prengemann, Elisangela Santos-Valente, Winfried F. Pickl, Ivan Bilic, Sol A Ban, Zarife Kuloğlu, Arzu Meltem Demir, Arzu Ensari, Jacques Colinge, Marta Rizzi, Hermann Eibel & Kaan Boztug. (2014) Early-onset inflammatory bowel disease and common variable immunodeficiency–like disease caused by IL-21 deficiency. Journal of Allergy and Clinical Immunology 133:6, pages 1651-1659.e12.
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Anshu Agrawal & Sudhir Gupta. 2014. Immunology of Aging. Immunology of Aging 65 73 .
Suresh Pallikkuth & Savita Pahwa. (2013) Interleukin-21 and T follicular helper cells in HIV infection: research focus and future perspectives. Immunologic Research 57:1-3, pages 279-291.
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Stasya Zarling, Dmitriy Berenzon, Sarat Dalai, Dmitry Liepinsh, Nick Steers & Urszula Krzych. (2013) The Survival of Memory CD8 T Cells That Is Mediated by IL-15 Correlates with Sustained Protection Against Malaria. The Journal of Immunology 190:10, pages 5128-5141.
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Carl K. EdwardsIIIIII, Michelle Pedler, Diana Fulan Yang, James E. Fitzpatrick, Mayumi Fujita, Karen Jonscher & David A. Norris. (2018) Recent Observations on the Heterogeneity of Human Effector Memory T Cells and Novel Cytokines Implicated in Cutaneous Inflammation and Psoriasis. Psoriasis Forum 18a:3, pages 126-141.
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Suresh Pallikkuth, Anita Parmigiani & Savita Pahwa. (2012) The role of interleukin-21 in HIV infection. Cytokine & Growth Factor Reviews 23:4-5, pages 173-180.
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Vanisha Mistry & David van Heel. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Krystyna Pawlak, Michal Mysliwiec & Dariusz Pawlak. (2011) Interleukin-21 in hemodialyzed patients: Association with the etiology of chronic kidney disease and the seropositivity against hepatitis C virus infection. Clinical Biochemistry 44:17-18, pages 1416-1420.
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