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Targeting interleukin-21 in inflammatory diseases

, PhD, , PhD, , MD & , PhD MD
Pages 695-702 | Published online: 11 Mar 2011

Bibliography

  • Parrish-Novak J, Dillon SR, Nelson A, Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57-63
  • Coquet JM, Kyparissoudis K, Pellicci DG, IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol 2007;178:2827-34
  • Chtanova T, Tangye SG, Newton R, T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004;173:68-78
  • Vogelzang A, McGuire HM, Yu D, A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008;29:127-37
  • Zhou L, Ivanov II, Spolski R, IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007;8:967-74
  • Monteleone G, Pallone F, Macdonald TT. Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease. Cytokine Growth Factor Rev 2009;20:185-91
  • Monteleone G, Pallone F, Macdonald TT. Interleukin-21 as a new therapeutic target for immune-mediated diseases. Trends Pharmacol Sci 2009;30:441-7
  • Monteleone G, Monteleone I, Fina D, Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 2005;128:687-94
  • Kim HP, Korn LL, Gamero AM, Leonard WJ. Calcium-dependent activation of interleukin-21 gene expression in T cells. J Biol Chem 2005;280:25291-7
  • Mehta DS, Wurster AL, Weinmann AS, Grusby MJ. NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci USA 2005;102:2016-21
  • Chen G, Hardy K, Bunting K, Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. J Immunol 2010;185:2350-9
  • Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009;27:485-517
  • Huber M, Brustle A, Reinhard K, IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci USA 2008;105:20846-51
  • Ho IC, Lo D, Glimcher LH. c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J Exp Med 1998;188:1859-66
  • Bauquet AT, Jin H, Paterson AM, The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2009;10:167-75
  • Asao H, Okuyama C, Kumaki S, Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 2001;167:1-5
  • Spolski R, Leonard WJ. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 2008;26:57-79
  • Jungel A, Distler JH, Kurowska-Stolarska M, Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum 2004;50:1468-76
  • Distler JH, Jungel A, Kowal-Bielecka O, Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum 2005;52:856-64
  • Monteleone G, Caruso R, Fina D, Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 2006;55:1774-80
  • Caruso R, Fina D, Peluso I, A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology 2007;132:166-75
  • Ozaki K, Kikly K, Michalovich D, Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci USA 2000;97:11439-44
  • Zeng R, Spolski R, Casas E, The molecular basis of IL-21-mediated proliferation. Blood 2007;109:4135-42
  • Fuqua CF, Akomeah R, Price JO, Adunyah SE. Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes. Cytokine 2008;44:101-7
  • Spolski R, Leonard WJ. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol 2008;20:295-301
  • Sarra M, Monteleone I, Stolfi C, Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases. Inflamm Bowel Dis 2010;16:1332-9
  • Wurster AL, Rodgers VL, Satoskar AR, Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 2002;196:969-77
  • Festen EA, Goyette P, Scott R, Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut 2009;58:799-804
  • Fina D, Sarra M, Fantini MC, Regulation of gut inflammation and Th17 cell response by interleukin-21. Gastroenterology 2008;134:1038-48
  • Caruso R, Fina D, Peluso I, IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol 2007;178:5957-65
  • Fina D, Sarra M, Caruso R, Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease. Gut 2008;57:887-92
  • Liu Y, Helms C, Liao W, A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008;4:e1000041
  • Caruso R, Botti E, Sarra M, Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med 2009;15:1013-105
  • Jin H, Oyoshi MK, Le Y, IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest 2009;119:47-60
  • Asano K, Ikegami H, Fujisawa T, Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes. Hum Immunol 2007;68:384-91
  • King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004;117:265-77
  • McGuire HM, Vogelzang A, Hill N, Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proc Natl Acad Sci USA 2009;106:19438-43
  • Spolski R, Kashyap M, Robinson C, IL-21 signaling is critical for the development of type 1 diabetes in the NOD mouse. Proc Natl Acad Sci USA 2008;105:14028-33
  • Datta S, Sarvetnick NE. IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms. PLoS One 2008;3:e3118
  • Ghoreschi K, Weigert C, Rocken M. Immunopathogenesis and role of T cells in psoriasis. Clin Dermatol 2007;25:574-80
  • Niu X, He D, Zhang X, IL-21 regulates Th17 cells in rheumatoid arthritis. Hum Immunol 2010;71:334-41
  • Andersson AK, Feldmann M, Brennan FM. Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis. Scand J Immunol 2008;68:103-11
  • Li J, Shen W, Kong K, Liu Z. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand J Immunol 2006;64:515-22
  • Young DA, Hegen M, Ma HL, Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum 2007;56:1152-63
  • Kouskoff V, Korganow AS, Duchatelle V, Organ-specific disease provoked by systemic autoimmunity. Cell 1996;87:811-22
  • Korganow AS, Ji H, Mangialaio S, From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451-61
  • Jang E, Kim HR, Cho SH, Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model. Arthritis Rheum 2006;54:492-8
  • Jang E, Cho SH, Park H, A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. J Immunol 2009;182:4649-56
  • Rahman A, Isenberg DA. Systemic lupus erythematosus. N Engl J Med 2008;358:929-39
  • Anolik J, Sanz I. B cells in human and murine systemic lupus erythematosus. Curr Opin Rheumatol 2004;16:505-12
  • Nagy G, Koncz A, Perl A. T- and B-cell abnormalities in systemic lupus erythematosus. Crit Rev Immunol 2005;25:123-40
  • Sawalha AH, Kaufman KM, Kelly JA, Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis 2008;67:458-61
  • Webb R, Merrill JT, Kelly JA, A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum 2009;60:2402-7
  • Mitoma H, Horiuchi T, Kimoto Y, Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. Int J Mol Med 2005;16:609-15
  • Bubier JA, Bennett SM, Sproule TJ, Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus. Ann NY Acad Sci 2007;1110:590-601
  • Ozaki K, Spolski R, Feng CG, A critical role for IL-21 in regulating immunoglobulin production. Science 2002;298:1630-4
  • Izui S, Ibnou-Zekri N, Fossati-Jimack L, Iwamoto M. Lessons from BXSB and related mouse models. Int Rev Immunol 2000;19:447-72
  • Bubier JA, Sproule TJ, Foreman O, A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 2009;106:1518-23
  • Herber D, Brown TP, Liang S, IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007;178:3822-30
  • Vollmer TL, Liu R, Price M, Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 2005;174:2696-701
  • Piao WH, Jee YH, Liu RL, IL-21 modulates CD4+ CD25+ regulatory T-cell homeostasis in experimental autoimmune encephalomyelitis. Scand J Immunol 2008;67:37-46
  • Monteleone G, Pallone F, Macdonald TT. Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol 2008;29:290-4
  • Elsaesser H, Sauer K, Brooks DG. IL-21 is required to control chronic viral infection. Science 2009;324:1569-72
  • Andorsky DJ, Timmerman JM. Interleukin-21: biology and application to cancer therapy. Expert Opin Biol Ther 2008;8:1295-307

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