726
Views
34
CrossRef citations to date
0
Altmetric
Reviews

Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus

, , , &
Pages 209-223 | Published online: 27 Jan 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Marcella Nebbioso, Federica Pranno & Nicola Pescosolido. (2013) Lipoic acid in animal models and clinical use in diabetic retinopathy. Expert Opinion on Pharmacotherapy 14:13, pages 1829-1838.
Read now
M. Jaganjac, O. Tirosh, G. Cohen, S. Sasson & N. Zarkovic. (2013) Reactive aldehydes – second messengers of free radicals in diabetes mellitus. Free Radical Research 47:sup1, pages 39-48.
Read now

Articles from other publishers (32)

Triana Espinosa-Jiménez, Oriol Busquets, Amanda Cano, Elena Sánchez-López, Ester Verdaguer, Antoni Parcerisas, Jordi Olloquequi, Carme Auladell, Jaume Folch, Walter Wahli, Manuel Vázquez-Carrera, Antoni Camins & Miren Ettcheto. (2022) Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations. Frontiers in Pharmacology 13.
Crossref
Yulong ZhangChangzhong LiWenhui ZhangXiangqin ZhengXiujuan Chen. (2020) Decreased Insulin Resistance by Myo-Inositol Is Associated with Suppressed Interleukin 6/Phospho-STAT3 Signaling in a Rat Polycystic Ovary Syndrome Model. Journal of Medicinal Food 23:4, pages 375-387.
Crossref
Andres V Ardisson Korat, Vasanti S Malik, Jeremy D Furtado, Frank Sacks, Bernard Rosner, Kathryn M Rexrode, Walter C Willett, Dariush Mozaffarian, Frank B Hu & Qi Sun. (2020) Circulating Very-Long-Chain SFA Concentrations Are Inversely Associated with Incident Type 2 Diabetes in US Men and Women. The Journal of Nutrition 150:2, pages 340-349.
Crossref
Elin Strand, Vegard Lysne, Mari Lausund Grinna, Pavol Bohov, Asbjørn Svardal, Ottar Nygård, Rolf K. Berge & Bodil Bjørndal. (2019) Short-Term Activation of Peroxisome Proliferator-Activated Receptors and Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats . PPAR Research 2019, pages 1-12.
Crossref
Mohammad Zarei, Emma Barroso, Xavier Palomer, Joan Carles Escolà-Gil, Lidia Cedó, Walter Wahli & Manuel Vázquez-Carrera. (2019) Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes. Clínica e Investigación en Arteriosclerosis 31:3, pages 111-118.
Crossref
Mohammad Zarei, Emma Barroso, Xavier Palomer, Joan Carles Escolà-Gil, Lidia Cedó, Walter Wahli & Manuel Vázquez-Carrera. (2019) Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes. Clínica e Investigación en Arteriosclerosis (English Edition) 31:3, pages 111-118.
Crossref
Lucien NadeauCéline Aguer. (2019) Interleukin-15 as a myokine: mechanistic insight into its effect on skeletal muscle metabolism. Applied Physiology, Nutrition, and Metabolism 44:3, pages 229-238.
Crossref
Won Jun Kim, Woojung Lee, Yujung Jung, hyuk-Jai Jang, Yong Kee Kim & Su-Nam Kim. (2019) PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 510:4, pages 621-628.
Crossref
Mohammad Zarei, Emma Barroso, Xavier Palomer, Jianli Dai, Patricia Rada, Tania Quesada-López, Joan Carles Escolà-Gil, Lidia Cedó, Mohammad Reza Zali, Mahsa Molaei, Reza Dabiri, Santiago Vázquez, Eugènia Pujol, Ángela M. Valverde, Francesc Villarroya, Yong Liu, Walter Wahli & Manuel Vázquez-Carrera. (2018) Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease. Molecular Metabolism 8, pages 117-131.
Crossref
Laura Baselga-Escudero, Vanessa Souza-Mello, Aïda Pascual-Serrano, Tamiris Rachid, Adriana Voci, Ilaria Demori & Elena Grasselli. (2017) Beneficial effects of the Mediterranean spices and aromas on non-alcoholic fatty liver disease. Trends in Food Science & Technology 61, pages 141-159.
Crossref
Dorothea Portius, Cyril Sobolewski & Michelangelo Foti. (2017) MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. PPAR Research 2017, pages 1-19.
Crossref
Leonie Gellrich & Daniel Merk. (2017) Therapeutic Potential of Peroxisome Proliferator-Activated Receptor Modulation in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. Nuclear Receptor Research 4.
Crossref
Amar Bahadur Singh & Jingwen Liu. (2017) Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ. Journal of Biological Chemistry 292:3, pages 884-897.
Crossref
Julia Naidenow, Igor Hrgovic, Monika Doll, Tsige Hailemariam-Jahn, Victoria Lang, Johannes Kleemann, Stefan Kippenberger, Roland Kaufmann, Nadja Zöller & Markus Meissner. (2016) Peroxisome proliferator-activated receptor (PPAR) α and δ activators induce ICAM-1 expression in quiescent non stimulated endothelial cells. Journal of Inflammation 13:1.
Crossref
Mohammad Zarei, Emma Barroso, Rosana Leiva, Marta Barniol-Xicota, Eugènia Pujol, Carmen Escolano, Santiago Vázquez, Xavier Palomer, Virginia Pardo, Águeda González-Rodríguez, Ángela M. Valverde, Tania Quesada-López, Francesc Villarroya, Walter Wahli & Manuel Vázquez-Carrera. (2016) Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency. Diabetes 65:10, pages 3185-3199.
Crossref
Tanja Taivassalo & Sabah N.A. Hussain. (2016) Contribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients With COPD. Chest 149:5, pages 1302-1312.
Crossref
D. K. Coletta, M. Fernandez, E. Cersosimo, A. Gastaldelli, N. Musi & R. A. DeFronzo. (2015) The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo . Diabetic Medicine 32:5, pages 657-664.
Crossref
Chin Fung Kelvin Kan, Amar Bahadur Singh, Bin Dong, Vikram Ravindra Shende & Jingwen Liu. (2015) PPARδ activation induces hepatic long-chain acyl-CoA synthetase 4 expression in vivo and in vitro. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1851:5, pages 577-587.
Crossref
Emma Barroso, Rosalía Rodríguez-Rodríguez, Matilde R. Chacón, Elsa Maymó-Masip, Laura Ferrer, Laia Salvadó, Emilio Salmerón, Martin Wabistch, Xavier Palomer, Joan Vendrell, Walter Wahli & Manuel Vázquez-Carrera. (2015) PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:5, pages 1049-1058.
Crossref
Khouloud Chehaibi, Lídia Cedó, Jari Metso, Xavier Palomer, David Santos, Helena Quesada, Mohamed Naceur Slimane, Walter Wahli, Josep Julve, Manuel Vázquez-Carrera, Matti Jauhiainen, Francisco Blanco-Vaca & Joan Carles Escolà-Gil. (2015) PPAR-β/δ activation promotes phospholipid transfer protein expression. Biochemical Pharmacology 94:2, pages 101-108.
Crossref
Jihan Youssef & Mostafa Badr. (2015) Peroxisome Proliferator-Activated Receptors Features, Functions, and Future. Nuclear Receptor Research 2.
Crossref
Wenshuang Li, Changyuan Wang, Jinyong Peng, Jing Liang, Yue Jin, Qi Liu, Qiang Meng, Kexin Liu & Huijun Sun. (2015) α-Lipoic acid protects HAECs from high glucose-induced apoptosis via decreased oxidative stress, ER stress and mitochondrial injury. RSC Advances 5:87, pages 70726-70736.
Crossref
Zhong Wang, Guo-qiang Chen, Gui-ping Yu & Chang-jian Liu. (2014) Pyrroloquinoline quinone protects mouse brain endothelial cells from high glucose-induced damage in vitro. Acta Pharmacologica Sinica 35:11, pages 1402-1410.
Crossref
Joaquín Pérez-Schindler, Kristoffer Svensson, Elyzabeth Vargas-Fernández, Gesa Santos, Walter Wahli & Christoph Handschin. (2014) The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia 57:11, pages 2405-2412.
Crossref
Jose Cordoba-ChaconManuel D. GaheteNaveen K. PokalaDavid GeldermannMaria Alba, Roberto Salvatori, Raul M. LuqueRhonda D. Kineman. (2014) Long- But Not Short-Term Adult-Onset, Isolated GH Deficiency in Male Mice Leads to Deterioration of β-Cell Function, Which Cannot Be Accounted for by Changes in β-Cell Mass. Endocrinology 155:3, pages 726-735.
Crossref
Xavier Palomer, Laia Salvadó, Emma Barroso & Manuel Vázquez-Carrera. (2013) An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy. International Journal of Cardiology 168:4, pages 3160-3172.
Crossref
Laureane N. Masi, Alice C. Rodrigues & Rui Curi. (2013) Fatty acids regulation of inflammatory and metabolic genes. Current Opinion in Clinical Nutrition and Metabolic Care, pages 1.
Crossref
K. Alexa Orr Gandy & Lina M. Obeid. 2013. Sphingolipids in Disease. Sphingolipids in Disease 275 303 .
Jihan A. Youssef & Mostafa Z. BadrJihan A. Youssef & Mostafa Z. Badr. 2013. Peroxisome Proliferator-Activated Receptors. Peroxisome Proliferator-Activated Receptors 87 90 .
Jihan A. Youssef & Mostafa Z. BadrJihan A. Youssef & Mostafa Z. Badr. 2013. Peroxisome Proliferator-Activated Receptors. Peroxisome Proliferator-Activated Receptors 33 69 .
Walter Wahli & Liliane Michalik. (2012) PPARs at the crossroads of lipid signaling and inflammation. Trends in Endocrinology & Metabolism 23:7, pages 351-363.
Crossref
Joseph Vamecq, Jean-Marie Colet, Jean Jacques Vanden Eynde, Gilbert Briand, Nicole Porchet & Stéphane Rocchi. (2012) PPARs: Interference with Warburg’ Effect and Clinical Anticancer Trials. PPAR Research 2012, pages 1-23.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.