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Expert Opinion on Therapeutic Targets Volume 17, 2013 - Issue 8
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Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses

Vito FerroThe University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane QLD 4072, Australia+61 7 3346 9598; +61 3365 4299; [email protected]
, PhD
Pages 965-975 | Published online: 24 Jun 2013

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Daniele Pala, Laura Scalvini, Gian Marco Elisi, Alessio Lodola, Marco Mor, Gilberto Spadoni, Fabiana F. Ferrara, Emiliano Pavoni, Giuseppe Roscilli, Ferdinando M. Milazzo, Gianfranco Battistuzzi, Silvia Rivara & Giuseppe Giannini. (2020) New classes of potent heparanase inhibitors from ligand-based virtual screening. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1685-1696.
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Articles from other publishers (26)

Etrusca Brogi, Federico Coccolini & Francesco Forfori. 2022. Postinjury Multiple Organ Failure. Postinjury Multiple Organ Failure 9 31 .
Rio S. Boothello & Umesh Desai. 2022. Glycosaminoglycans. Glycosaminoglycans 259 278 .
Mohit Chhabra, Gareth G. Doherty, Nicholas W. See, Neha S. Gandhi & Vito Ferro. (2021) From Cancer to COVID‐19: A Perspective on Targeting Heparan Sulfate‐Protein Interactions. The Chemical Record 21:11, pages 3087-3101.
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Antony Cheudjeu. (2021) Antiviral strategies should focus on stimulating the biosynthesis of heparan sulfates, not their inhibition. Life Sciences 277, pages 119508.
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Mohit Chhabra & Vito Ferro. 2020. Heparanase. Heparanase 473 491 .
Giancarlo Ghiselli. (2019) Heparin Binding Proteins as Therapeutic Target: An Historical Account and Current Trends. Medicines 6:3, pages 80.
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Jonathan H. LeeXiaoman LuoXiafei RenTuan Chun TanRaymond A.A. SmithKunchithapadam SwaminathanSakthivel SekarKishore BhakooVictor NurcombeJames H. HuiSimon M. Cool. (2019) A Heparan Sulfate Device for the Regeneration of Osteochondral Defects. Tissue Engineering Part A 25:5-6, pages 352-363.
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Bartlomiej Kalaska, Joanna Miklosz, Kamil Kamiński, Bogdan Musielak, Shin-Ichi Yusa, Dariusz Pawlak, Maria Nowakowska, Krzysztof Szczubiałka & Andrzej Mogielnicki. (2019) The neutralization of heparan sulfate by heparin-binding copolymer as a potential therapeutic target. RSC Advances 9:6, pages 3020-3029.
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Aroon Supramaniam, Xiang Liu, Vito Ferro & Lara J. Herrero. (2018) Prophylactic Antiheparanase Activity by PG545 Is Antiviral In Vitro and Protects against Ross River Virus Disease in Mice . Antimicrobial Agents and Chemotherapy 62:4.
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Junko Yano, Brian M. Peters, Mairi C. Noverr & Paul L. FidelJr.Jr.. (2018) Novel Mechanism behind the Immunopathogenesis of Vulvovaginal Candidiasis: “Neutrophil Anergy”. Infection and Immunity 86:3.
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Junko Yano, Mairi C. Noverr & Paul L. FidelJr.Jr.. (2017) Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis. mBio 8:2.
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Ditmer T. Talsma, Mohamed R. Daha & Jacob van den Born. (2016) The bittersweet taste of tubulo-interstitial glycans. Nephrology Dialysis Transplantation, pages gfw371.
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Lorrie A. Burnham, Dinesh Jaishankar, Jeffrey M. Thompson, Kevin S. Jones, Deepak Shukla & Vaibhav Tiwari. (2016) Liposome-Mediated Herpes Simplex Virus Uptake Is Glycoprotein-D Receptor-Independent but Requires Heparan Sulfate. Frontiers in Microbiology 7.
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Daniele Pala, Silvia Rivara, Marco Mor, Ferdinando Maria Milazzo, Giuseppe Roscilli, Emiliano Pavoni & Giuseppe Giannini. (2016) Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase. Glycobiology 26:6, pages 640-654.
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Tobias Pasqualon, Hongqi Lue, Sabine Groening, Jessica Pruessmeyer, Holger Jahr, Bernd Denecke, Jürgen Bernhagen & Andreas Ludwig. (2016) Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:4, pages 717-726.
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Marina WeissmannGil ArvatzNetanel HorowitzSari FeldInna NaroditskyYi ZhangMary NgEdward HammondEviatar Nevo, Israel VlodavskyNeta Ilan. (2016) Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis. Proceedings of the National Academy of Sciences 113:3, pages 704-709.
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Laura Ferreras, Neil S. Sheerin, John A. Kirby & Simi Ali. (2015) Mechanisms of Renal Graft Chronic Injury and Progression to Interstitial Fibrosis. Current Transplantation Reports 2:3, pages 259-268.
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John Baldwin, Erika Maus, Brian Zanotti, Michael V. Volin, Ritesh Tandon, Deepak Shukla & Vaibhav Tiwari. (2015) A Role for 3- O -Sulfated Heparan Sulfate in Promoting Human Cytomegalovirus Infection in Human Iris Cells . Journal of Virology 89:9, pages 5185-5192.
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Vitor H. Pomin. (2015) Sulfated glycans in inflammation. European Journal of Medicinal Chemistry 92, pages 353-369.
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Vaibhav Tiwari, Morgan Tarbutton & Deepak Shukla. (2015) Diversity of Heparan Sulfate and HSV Entry: Basic Understanding and Treatment Strategies. Molecules 20:2, pages 2707-2727.
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Shifaza Mohamed & Vito Ferro. 2015. 21 61 .
Abraam M. Yakoub, Nistha Rawal, Erika Maus, John Baldwin, Deepak Shukla & Vaibhav Tiwari. (2014) Comprehensive Analysis of Herpes Simplex Virus 1 (HSV-1) Entry Mediated by Zebrafish 3- O -Sulfotransferase Isoforms: Implications for the Development of a Zebrafish Model of HSV-1 Infection . Journal of Virology 88:21, pages 12915-12922.
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Jenny K. Sabol, Wei Wei, Marcos López-Hoyos, Youjin Seo, Armann Andaya & Julie A. Leary. (2014) Heparan sulfate differences in rheumatoid arthritis versus healthy sera. Matrix Biology 40, pages 54-61.
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Claudio Pisano, Israel Vlodavsky, Neta Ilan & Franco Zunino. (2014) The potential of heparanase as a therapeutic target in cancer. Biochemical Pharmacology 89:1, pages 12-19.
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Thessicar Evadney AntoineKevin S. JonesRodney M. DaleDeepak ShuklaVaibhav Tiwari. (2014) Zebrafish: Modeling for Herpes Simplex Virus Infections. Zebrafish 11:1, pages 17-25.
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Jennifer C. Wilson, Andrew Elohim Laloo, Sanjesh Singh & Vito Ferro. (2014) 1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase. Biochemical and Biophysical Research Communications 443:1, pages 185-188.
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