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Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy

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Mei Yun Lin, Timothy A. Damron & Jason A. Horton. (2023) Cell cycle arrest and apoptosis are early events in radiosensitization of EWS::FLI1+ Ewing sarcoma cells by Mithramycin A. International Journal of Radiation Biology 99:10, pages 1570-1583.
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Victoria T Rizk, Christine M Walko & Andrew S Brohl. (2019) Precision medicine approaches for the management of Ewing sarcoma: current perspectives. Pharmacogenomics and Personalized Medicine 12, pages 9-14.
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Ngoc T Hoang, Luis A Acevedo, Michael J Mann & Bhairavi Tolani. (2018) A review of soft-tissue sarcomas: translation of biological advances into treatment measures. Cancer Management and Research 10, pages 1089-1114.
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David Schirmer, Thomas G. P. Grünewald, Richard Klar, Oxana Schmidt, Dirk Wohlleber, Rebeca Alba Rubío, Wolfgang Uckert, Uwe Thiel, Felix Bohne, Dirk H. Busch, Angela M. Krackhardt, Stefan Burdach & Günther H. S. Richter. (2016) Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity. OncoImmunology 5:6.
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Articles from other publishers (45)

Helong Gong, Busheng Xue, Jinlong Ru, Guoqing Pei & Yan Li. (2023) Targeted Therapy for EWS-FLI1 in Ewing Sarcoma. Cancers 15:16, pages 4035.
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Tali Rosenberg, Asaf Marco, Tatiana Kisliouk, Amit Haron, Dmitry Shinder, Shelly Druyan & Noam Meiri. (2022) Embryonic heat conditioning in chicks induces transgenerational heat/immunological resilience via methylation on regulatory elements. The FASEB Journal 36:7.
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Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Ryuto Tsuchiya, Takuya Ono, Taro Akiyama, Rumi Nakagawa, Satoshi Kamio, Kaoru Hirabayashi, Iwao Ozawa, Kazutaka Kikuta & Tadashi Kondo. (2022) Establishment and characterization of a novel patient-derived Ewing sarcoma cell line, NCC-ES2-C1. Human Cell 35:4, pages 1262-1269.
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Camilla Cristalli, Maria Cristina Manara, Sergio Valente, Evelin Pellegrini, Alberto Bavelloni, Alessandra De Feo, William Blalock, Elisabetta Di Bello, David Piñeyro, Angelika Merkel, Manel Esteller, Oscar M. Tirado, Antonello Mai & Katia Scotlandi. (2022) Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response. Frontiers in Endocrinology 13.
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Yuxue Wang, Yi Liu, Lei Xiang, Lintao Han, Xiaowei Yao, Yibing Hu & Fenghua Wu. (2021) Cyclin D1b induces changes in the macrophage phenotype resulting in promotion of tumor metastasis. Experimental Biology and Medicine 246:24, pages 2559-2569.
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Laura García-García, Enrique Fernández-Tabanera, Saint T. Cervera, Raquel M. Melero-Fernández de Mera, Santiago Josa, Laura González-González, Carlos Rodríguez-Martín, Thomas G. P. Grünewald & Javier Alonso. (2021) The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes. Cancers 13:22, pages 5668.
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Connor Barrett, Anuj Budhiraja, Vijay Parashar & Mona Batish. (2021) The Landscape of Regulatory Noncoding RNAs in Ewing’s Sarcoma. Biomedicines 9:8, pages 933.
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Saint T. Cervera, Carlos Rodríguez-Martín, Enrique Fernández-Tabanera, Raquel M. Melero-Fernández de Mera, Matias Morin, Sergio Fernández-Peñalver, Maria Iranzo-Martínez, Jorge Amhih-Cardenas, Laura García-García, Laura González-González, Miguel Angel Moreno-Pelayo & Javier Alonso. (2021) Therapeutic Potential of EWSR1–FLI1 Inactivation by CRISPR/Cas9 in Ewing Sarcoma. Cancers 13:15, pages 3783.
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Fatu Badiane Markey, Brigette Romero, Vijay Parashar & Mona Batish. (2021) Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing’s Sarcoma. Cells 10:6, pages 1300.
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Mei Yun Lin, Timothy A. Damron, Megan E. Oest & Jason A. Horton. (2021) Mithramycin A Radiosensitizes EWS:Fli1+ Ewing Sarcoma Cells by Inhibiting Double Strand Break Repair. International Journal of Radiation Oncology*Biology*Physics 109:5, pages 1454-1471.
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Carina Dinhof, Christine Pirker, Philipp Kroiss, Dominik Kirchhofer, Lisa Gabler, Johannes Gojo, Daniela Lötsch-Gojo, Mirjana Stojanovic, Gerald Timelthaler, Franziska Ferk, Siegfried Knasmüller, Johannes Reisecker, Sabine Spiegl-Kreinecker, Peter Birner, Matthias Preusser & Walter Berger. (2020) p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction. Cancers 12:11, pages 3205.
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Kirill I. Kirsanov, Ekaterina A. Lesovaya, Timur I. Fetisov, Beniamin Yu Bokhyan, Gennady A. Belitsky & Marianna G. Yakubovskaya. (2020) Current Approaches for Personalized Therapy of Soft Tissue Sarcomas. Sarcoma 2020, pages 1-15.
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Hadis Fathizadeh, Hamed Mirzaei & Zatollah Asemi. (2019) Melatonin: an anti-tumor agent for osteosarcoma. Cancer Cell International 19:1.
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Choh Yeung, Anna E. Gibson, Sameer H. Issaq, Nobu Oshima, Joshua T. Baumgart, Leah D. Edessa, Ganesha Rai, Daniel J. Urban, Michelle S. Johnson, Gloria A. Benavides, Giuseppe L. Squadrito, Marielle E. Yohe, Haiyan Lei, Sandy Eldridge, John HamreIIIIII, Tyrone Dowdy, Victor Ruiz-Rodado, Adrian Lita, Arnulfo Mendoza, Jack F. Shern, Mioara Larion, Lee J. Helman, Gordon M. Stott, Murali C. Krishna, Matthew D. Hall, Victor Darley-Usmar, Leonard M. Neckers & Christine M. Heske. (2019) Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma. Cancer Research 79:19, pages 5060-5073.
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Swati Srivastava, Nishanth Belugali Nataraj, Arunachalam Sekar, Soma Ghosh, Chamutal Bornstein, Diana Drago-Garcia, Lee Roth, Donatella Romaniello, Ilaria Marrocco, Eyal David, Yuval Gilad, Mattia Lauriola, Ron Rotkopf, Adi Kimchi, Yuya Haga, Yasuo Tsutsumi, Olivier Mirabeau, Didier Surdez, Andrei Zinovyev, Olivier Delattre, Heinrich Kovar, Ido Amit & Yosef Yarden. (2019) ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma. Cell Reports 29:1, pages 104-117.e4.
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Saravana P Selvanathan, Garrett T Graham, Alexander R Grego, Tabari M Baker, J Robert Hogg, Mark Simpson, Mona Batish, Brian Crompton, Kimberly Stegmaier, Eleni M Tomazou, Heinrich Kovar, Aykut Üren & Jeffrey A Toretsky. (2019) EWS–FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex. Nucleic Acids Research.
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Lehang Lin, Moli Huang, Xianping Shi, Anand Mayakonda, Kaishun Hu, Yan-Yi Jiang, Xiao Guo, Li Chen, Brendan Pang, Ngan Doan, Jonathan W Said, Jianjun Xie, Sigal Gery, Xu Cheng, Zhaoyu Lin, Jinsong Li, Benjamin P Berman, Dong Yin, De-Chen Lin & H Phillip Koeffler. (2019) Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic Acids Research 47:3, pages 1255-1267.
Crossref
Stacia L. Koppenhafer, Kelli L. Goss, William W. Terry & David J. Gordon. (2018) mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells. Molecular Cancer Therapeutics 17:12, pages 2676-2688.
Crossref
Michele Dowless, Caitlin D. Lowery, Terry Shackleford, Matthew Renschler, Jennifer Stephens, Robert Flack, Wayne Blosser, Simone Gupta, Julie Stewart, Yue Webster, Jack Dempsey, Alle B. VanWye, Philip Ebert, Philip Iversen, Jonathan B. Olsen, Xueqian Gong, Sean Buchanan, Peter Houghton & Louis Stancato. (2018) Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling. Clinical Cancer Research 24:23, pages 6028-6039.
Crossref
Tarek Y. El Ahmadieh, Jack M. Raisanen, James Botros, Jean-Luc Kabangu, Edward Pan & Wayne Gluf. (2018) Successful Novel Treatment of a Paraspinal Primitive Neuroectodermal Tumor with Predominantly Glial Differentiation: A 3-Year Follow-Up After Surgery, Intensity-Modulated Radiation Therapy and Oral Temozolomide. World Neurosurgery 119, pages 340-344.
Crossref
Janet K. Parrish, Tyler S. McCann, Marybeth Sechler, Lays M. Sobral, Wenhua Ren, Kenneth L. Jones, Aik Choon Tan & Paul Jedlicka. (2018) The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth. Oncotarget 9:69, pages 33110-33123.
Crossref
Nathaniel D. Anderson, Richard de Borja, Matthew D. Young, Fabio FuligniAndrej Rosic, Nicola D. Roberts, Simon HajjarMehdi Layeghifard, Ana NovokmetPaul E. KowalskiMatthew AnakaScott Davidson, Mehdi ZarreiBadr Id Said, L. Christine Schreiner, Remi Marchand, Joseph Sitter, Nalan Gokgoz, Ledia Brunga, Garrett T. Graham, Anthony Fullam, Nischalan Pillay, Jeffrey A. Toretsky, Akihiko YoshidaTatsuhiro ShibataMarkus Metzler, Gino R. SomersStephen W. Scherer, Adrienne M. FlanaganPeter J. CampbellJoshua D. Schiffman, Mary Shago, Ludmil B. Alexandrov, Jay S. Wunder, Irene L. Andrulis, David Malkin, Sam Behjati & Adam Shlien. (2018) Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. Science 361:6405.
Crossref
Kelli L. Goss, Stacia L. Koppenhafer, Kathryn M. Harmoney, William W. Terry & David J. Gordon. (2017) Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine. Oncotarget 8:50, pages 87016-87032.
Crossref
Tsion Zewdu Minas, Didier Surdez, Tahereh Javaheri, Miwa Tanaka, Michelle Howarth, Hong-Jun Kang, Jenny Han, Zhi-Yan Han, Barbara Sax, Barbara E. Kream, Sung-Hyeok Hong, Haydar Çelik, Franck Tirode, Jan Tuckermann, Jeffrey A. Toretsky, Lukas Kenner, Heinrich Kovar, Sean Lee, E. Alejandro Sweet-Cordero, Takuro Nakamura, Richard Moriggl, Olivier Delattre & Aykut Üren. (2016) Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model. Oncotarget 8:21, pages 34141-34163.
Crossref
Cornelia N. Mutz, Raphaela Schwentner, Dave N.T. Aryee, Eric D.J. Bouchard, Edgard M. Mejia, Grant M. Hatch, Maximilian O. Kauer, Anna M. Katschnig, Jozef Ban, Antje Garten, Javier Alonso, Versha Banerji & Heinrich Kovar. (2017) EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells. Oncotarget 8:15, pages 24679-24693.
Crossref
F Cidre-Aranaz, T G P Grünewald, D Surdez, L García-García, J Carlos Lázaro, T Kirchner, L González-González, A Sastre, P García-Miguel, S E López-Pérez, S Monzón, O Delattre & J Alonso. (2016) EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma. Oncogene 36:6, pages 766-776.
Crossref
James V. Tricoli, Archie Bleyer, Jakob Anninga & Ronald Barr. 2017. Cancer in Adolescents and Young Adults. Cancer in Adolescents and Young Adults 43 67 .
Maria Cristina Manara, Mario Terracciano, Caterina Mancarella, Marika Sciandra, Clara Guerzoni, Michela Pasello, Andrea Grilli, Nicoletta Zini, Piero Picci, Mario P. Colombo, Andrea Morrione & Katia Scotlandi. (2016) CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Oncotarget 7:48, pages 79925-79942.
Crossref
Sudan N. Loganathan, Nan Tang, Jonathan T. Fleming, Yufang Ma, Yan Guo, Scott C. Borinstein, Chin Chiang & Jialiang Wang. (2016) BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma. Oncotarget 7:28, pages 43504-43517.
Crossref
Cornelia N. Mutz, Raphaela Schwentner, Maximilian O. Kauer, Anna M. Katschnig, Florian Kromp, Dave N. T. Aryee, Sophie Erhardt, Michel Goiny, Javier Alonso, Dietmar Fuchs & Heinrich Kovar. (2016) EWS‐FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway. FEBS Letters 590:14, pages 2063-2075.
Crossref
Elena Beletkaia, Susanne F. Fenz, Wim Pomp, B. Ewa Snaar-Jagalska, Pancras W.C. Hogendoorn & Thomas Schmidt. (2016) CXCR4 signaling is controlled by immobilization at the plasma membrane. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:4, pages 607-616.
Crossref
Samantha G. PattendenJeremy M. SimonAminah WaliChatura N. JayakodyJacob TroutmanAndrew W. McFaddenJoshua WootenCameron C. WoodStephen V. FryeWilliam P. JanzenIan J. Davis. (2016) High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility. Proceedings of the National Academy of Sciences 113:11, pages 3018-3023.
Crossref
Tim Hensel, Chiara Giorgi, Oxana Schmidt, Julia Calzada-Wack, Frauke Neff, Thorsten Buch, Felix K. Niggli, Beat W. Schäfer, Stefan Burdach & Günther H.S. Richter. (2015) Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma. Oncotarget 7:2, pages 1451-1463.
Crossref
Patrick J. Grohar, Suntae Kim, Guillermo O. Rangel Rivera, Nirmalya Sen, Sara Haddock, Matt L. Harlow, Nichole K. Maloney, Jack Zhu, Maura O’Neill, Tamara L. Jones, Konrad Huppi, Magdalena Grandin, Kristen Gehlhaus, Carleen A. Klumpp-Thomas, Eugen Buehler, Lee J. Helman, Scott E. Martin & Natasha J. Caplen. (2016) Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma. Cell Reports 14:3, pages 598-610.
Crossref
. 2016. Diagnostic Pathology: Head and Neck. Diagnostic Pathology: Head and Neck 140 145 .
Konstantin Agelopoulos, Günther H.S. Richter, Eva Schmidt, Uta Dirksen, Kristina von Heyking, Benjamin Moser, Hans-Ulrich Klein, Udo Kontny, Martin Dugas, Kathrin Poos, Eberhard Korsching, Thorsten Buch, Matthias Weckesser, Isabell Schulze, Regina Besoke, Anika Witten, Monika Stoll, Gabriele Köhler, Wolfgang Hartmann, Eva Wardelmann, Claudia Rossig, Daniel Baumhoer, Heribert Jürgens, Stefan Burdach, Wolfgang E. Berdel & Carsten Müller-Tidow. (2015) Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma. Clinical Cancer Research 21:21, pages 4935-4946.
Crossref
Alyssa L. Kennedy, Mounica Vallurupalli, Liying Chen, Brian Crompton, Glenn Cowley, Francisca Vazquez, Barbara A. Weir, Aviad Tsherniak, Sudha Parasuraman, Sunkyu Kim, Gabriela Alexe & Kimberly Stegmaier. (2015) Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma. Oncotarget 6:30, pages 30178-30193.
Crossref
Heinrich Kovar. (2015) SLFN11: Achilles' Heel or Troublemaker. Clinical Cancer Research 21:18, pages 4033-4034.
Crossref
Ana M. Sanchez-Sanchez, Isaac Antolin, Noelia Puente-Moncada, Santos Suarez, Marina Gomez-Lobo, Carmen Rodriguez & Vanesa Martin. (2015) Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells. PLOS ONE 10:8, pages e0135420.
Crossref
Florencia Cidre-Aranaz & Javier Alonso. (2015) EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma. Frontiers in Oncology 5.
Crossref
R. Tancredi, A. Zambelli, G. A. DaPrada, V. Fregoni, L. Pavesi, A. Riccardi, S. Burdach, P. J. Grohar & M. D’Incalci. (2015) Targeting the EWS–FLI1 transcription factor in Ewing sarcoma. Cancer Chemotherapy and Pharmacology 75:6, pages 1317-1320.
Crossref
José L Ordóñez, Ana T Amaral & Enrique de Álava. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 11 .
Heinrich Kovar. 2017. Encyclopedia of Cancer. Encyclopedia of Cancer 1655 1658 .
Heinrich Kovar. 2016. Encyclopedia of Cancer. Encyclopedia of Cancer 1 4 .
Brian D. Stewart, John D. Reith, Jacquelyn A. Knapik & Angela C. Chi. (2014) Bone- and Cartilage-Forming Tumors and Ewing Sarcoma: An Update with a Gnathic Emphasis. Head and Neck Pathology 8:4, pages 454-462.
Crossref

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