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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 6
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Review

HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth

Priyamvada AcharyaNational Institute of Allergy and Infectious Diseases/National Institutes of Health, Vaccine Research Center, Structural Biology Section, Room 4609B, 40 Convent Drive, Bethesda, MD 20892, USA
, PhD (Research Scientist) ,
Sabrina LusvarghiNational Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Bioorganic Chemistry, Building 8, Room 421, 8 Center Drive, Bethesda, MD 20892, USA
, PhD (Research Fellow) ,
Carole A BewleyNational Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Bioorganic Chemistry, Building 8, Room 421, 8 Center Drive, Bethesda, MD 20892, USA
, PhD (Senior Investigator) &
Peter D KwongNational Institute of Allergy and Infectious Diseases/National Institutes of Health, Vaccine Research Center, Structural Biology Section, Room 4609B, 40 Convent Drive, Bethesda, MD 20892, USA+1 301 594 8439; +1 301 480 2658; [email protected]
, PhD (Chief)
Pages 765-783 | Published online: 27 Feb 2015

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Alexander M. Andrianov, Grigory I. Nikolaev, Nikita A. Shuldov, Ivan P. Bosko, Arseny I. Anischenko & Alexander V. Tuzikov. (2022) Application of deep learning and molecular modeling to identify small drug-like compounds as potential HIV-1 entry inhibitors. Journal of Biomolecular Structure and Dynamics 40:16, pages 7555-7573.
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I. Chandra, S.V. Prabhu, C. Nayak & S.K. Singh. (2021) E-pharmacophore based screening to identify potential HIV-1 gp120 and CD4 interaction blockers for wild and mutant types. SAR and QSAR in Environmental Research 32:5, pages 353-377.
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Kateryna Kratzer, Landon J. Getz, Thibaut Peterlini, Jean-Yves Masson & Graham Dellaire. (2021) Addressing the dark matter of gene therapy: technical and ethical barriers to clinical application. Human Genetics 141:6, pages 1175-1193.
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Shibo Jiang, Alexander Tuzikov & Alexander Andrianov. (2022) Small-molecule HIV-1 entry inhibitors targeting the epitopes of broadly neutralizing antibodies. Cell Chemical Biology 29:5, pages 757-773.
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Charles Gotuaco Ang, Erik Carter, Ann Haftl, Shiyu Zhang, Adel A. Rashad, Michele Kutzler, Cameron F. Abrams & Irwin M. Chaiken. (2021) Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry. Microorganisms 9:6, pages 1286.
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Huan-Jun Lu, Yuan-Yuan Fu, Qian-Qi Wei & Zhi-Jun Zhang. (2021) Neuroinflammation in HIV-Related Neuropathic Pain. Frontiers in Pharmacology 12.
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Claudia A. Jette, Christopher O. Barnes, Sharon M. Kirk, Bruno Melillo, Amos B. SmithIIIIII & Pamela J. Bjorkman. (2021) Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nature Communications 12:1.
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Charles G. Ang, Md. Alamgir Hossain, Marg Rajpara, Harry Bach, Kriti Acharya, Alexej Dick, Adel A. Rashad, Michele Kutzler, Cameron F. Abrams & Irwin Chaiken. (2020) Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors. Biochemistry 59:6, pages 818-828.
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Alexander M. Andrianov, Grigory I. Nikolaev, Yuri V. Kornoushenko, Wei Xu, Shibo Jiang & Alexander V. Tuzikov. (2019) In Silico Identification of Novel Aromatic Compounds as Potential HIV-1 Entry Inhibitors Mimicking Cellular Receptor CD4. Viruses 11:8, pages 746.
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Ravi C. Dubey, Nawneet Mishra & Ritu Gaur. (2019) G protein-coupled and ATP-sensitive inwardly rectifying potassium ion channels are essential for HIV entry. Scientific Reports 9:1.
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Hannah L. Turner, Jesper Pallesen, Shanshan Lang, Sandhya Bangaru, Sarah Urata, Sheng Li, Christopher A. Cottrell, Charles A. Bowman, James E. Crowe, Ian A. Wilson & Andrew B. Ward. (2019) Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains. PLOS Biology 17:2, pages e3000139.
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А.М. Андрианов & A.M. Andrianov. (2018) Development of Potential HIV-1 Inhibitors by In Silico Click Chemistry And Molecular Modeling Methods. Математическая биология и биоинформатика Mathematical Biology and Bioinformatics 13:2, pages 507-525.
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Jorge Carrillo, Bonaventura Clotet & Julià Blanco. (2018) Antibodies and Antibody Derivatives: New Partners in HIV Eradication Strategies. Frontiers in Immunology 9.
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Sabrina Lusvarghi, Rodolfo Ghirlando, Jack R. Davison & Carole A. Bewley. 2018. Chemical Glycobiology Part B. Monitoring Glycans and their Interactions. Chemical Glycobiology Part B. Monitoring Glycans and their Interactions 3 35 .
Liyan Yue, Wei Wan, Pan Xu, Linjuan Li, Chen Wang, Yuanyuan Zhang, Heng Xu, Rukang Zhang, Junchi Hu, Wenchao Lu, Hao Jiang & Cheng Luo. 2018. Targeting Protein-Protein Interactions by Small Molecules. Targeting Protein-Protein Interactions by Small Molecules 179 211 .
MingRui Jia, Timothy Shaw, Xing Zhang, Dong Liu, Ye Shen, Amara E. Ezeamama, Chunfu Yang & Ming Zhang. (2017) Decoding noises in HIV computational genotyping. Virology 511, pages 249-255.
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Priyamvada Acharya, Qingbo Liu, Xiaochu Ma, Maolin Lu, Venkat Dandey, Edward T Eng, William J Rice, Christoph Wigge, Tatsiana Bylund, Gwo-Yu Chuang, Aliaksandr Druz, Hui Geng, Jason Gorman, Tongqing Zhou, Walther Mothes, Paolo Lusso, Bridget Carragher, Clinton S Potter & Peter D Kwong. (2017) Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM. Microscopy and Microanalysis 23:S1, pages 1190-1191.
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Francesca Curreli, Young Do Kwon, Dmitry S. Belov, Ranjith R. Ramesh, Alexander V. Kurkin, Andrea Altieri, Peter D. Kwong & Asim K. Debnath. (2017) Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120. Journal of Medicinal Chemistry 60:7, pages 3124-3153.
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Adel A. Rashad, Kriti Acharya, Ann Haftl, Rachna Aneja, Alexej Dick, Andrew P. Holmes & Irwin Chaiken. (2017) Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring. Organic & Biomolecular Chemistry 15:37, pages 7770-7782.
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Alexander M. Andrianov, Ivan A. Kashyn & Alexander V. Tuzikov. (2017) Computational identification of novel entry inhibitor scaffolds mimicking primary receptor CD4 of HIV-1 gp120. Journal of Molecular Modeling 23:1.
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A. M. Andrianov, I. A. Kashyn & A. V. Tuzikov. 2017. Pattern Recognition and Information Processing. Pattern Recognition and Information Processing 14 23 .
Sabrina Lusvarghi, Katheryn Lohith, Jeanne Morin-Leisk, Rodolfo Ghirlando, Jenny E. Hinshaw & Carole A. Bewley. (2016) Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV-1 Viral Particles. ACS Infectious Diseases 2:11, pages 882-891.
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Sabrina Lusvarghi & Carole Bewley. (2016) Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential. Viruses 8:10, pages 296.
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Gianni Marone, Gilda Varricchi, Stefania Loffredo, Maria Rosaria Galdiero, Felice Rivellese & Amato de Paulis. (2016) Are Basophils and Mast Cells Masters in HIV Infection?. International Archives of Allergy and Immunology 171:3-4, pages 158-165.
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Athina Geronikaki, Phaedra Eleftheriou & Vladimir Poroikov. 2018. Communicable Diseases of the Developing World. Communicable Diseases of the Developing World 37 95 .
Irwin Chaiken & Adel A Rashad. (2015) Peptide triazole inactivators of HIV-1: how do they work and what is their potential?. Future Medicinal Chemistry 7:17, pages 2305-2310.
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Adel A. Rashad, Ramalingam Venkat Kalyana Sundaram, Rachna Aneja, Caitlin Duffy & Irwin Chaiken. (2015) Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter . Journal of Medicinal Chemistry 58:18, pages 7603-7608.
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