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Volume 19, Issue 6

Expert Opinion on Therapeutic Targets

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Expert Opinion on Therapeutic Targets, Volume 19, Issue 6 (2015)

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Expert Opinion on Therapeutic Targets, Volume 19, Issue 6 (2015)

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Editorial

Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity

Jean-Sébastien Joyal MD PhD, Vikrant K Bhosle & Sylvain Chemtob MD PhD

Pages: 717-721

Published online: 14 May 2015

AbstractforSubcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity | Full Text | References | PDF (271.1 KB)

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Original Research

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Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia

Yu Hu, Xiuwen Wang, Shuang Yu, Yu Hou, Daoxin Ma & Ming Hou

Pages: 723-732

Published online: 14 May 2015

AbstractforNeutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia | Full Text | References | PDF (788.1 KB) | Supplemental

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Article

Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy

Helena Pópulo, Regina Caldas, José Manuel Lopes, Joana Pardal, Valdemar Máximo & Paula Soares

Pages: 733-745

Published online: 14 May 2015

AbstractforOverexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy | Full Text | References | PDF (861.2 KB)

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Review

Sleep- and circadian rhythm–associated pathways as therapeutic targets in bipolar disorder

Frank Bellivier MD PhD, Pierre-Alexis Geoffroy MD, Bruno Etain MD PhD & Jan Scott MBBS PhD

Pages: 747-763

Published online: 02 Mar 2015

AbstractforSleep- and circadian rhythm–associated pathways as therapeutic targets in bipolar disorder | Full Text | References | PDF (428.7 KB)

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HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth

Priyamvada Acharya (Research Scientist) PhD, Sabrina Lusvarghi (Research Fellow) PhD, Carole A Bewley (Senior Investigator) PhD & Peter D Kwong (Chief) PhD

Pages: 765-783

Published online: 27 Feb 2015

AbstractforHIV-1 gp120 as a therapeutic target: navigating a moving labyrinth | Full Text | References | PDF (880.8 KB)

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The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders

Jian Guan, Paul Harris, Margaret Brimble, Yang Lei, Jun Lu, Yang Yang & Alistair J Gunn

Pages: 785-793

Published online: 05 Feb 2015

AbstractforThe role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders | Full Text | References | PDF (354.3 KB)

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Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

Dominik Horn, Jochen Hess, Kolja Freier, Jürgen Hoffmann & Christian Freudlsperger

Pages: 795-805

Published online: 05 Feb 2015

AbstractforTargeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma | Full Text | References | PDF (511.4 KB)

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Angiogenesis in salivary gland tumors: from clinical significance to treatment

Stamatios Theocharis, George Gribilas, Constantinos Giaginis (Assistant Professor of Human Physiology) , Efstratios Patsouris & Jerzy Klijanienko

Pages: 807-819

Published online: 08 May 2015

AbstractforAngiogenesis in salivary gland tumors: from clinical significance to treatment | Full Text | References | PDF (280.1 KB)

154 Views
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Breast cancer treatment and sulfotransferase

Xi-Wei Ji, Tian-Yan Zhou, Yuan Lu, Min-Ji Wei, Wei Lu & William C Cho

Pages: 821-834

Published online: 12 Feb 2015

AbstractforBreast cancer treatment and sulfotransferase | Full Text | References | PDF (637.5 KB)

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Targeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodies

Terry F Davies & Rauf Latif

Pages: 835-847

Published online: 13 Mar 2015

AbstractforTargeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodies | Full Text | References | PDF (635.4 KB)

438 Views
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The influence of the telomere-telomerase system on diabetes mellitus and its vascular complications

Wu Qi Nan, Zhang Ling & Chen Bing

Pages: 849-864

Published online: 13 Feb 2015

AbstractforThe influence of the telomere-telomerase system on diabetes mellitus and its vascular complications | Full Text | References | PDF (610.8 KB)

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