Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 6
Submit an article Journal homepage
676
Views
29
CrossRef citations to date
0
Altmetric
Review

The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders

Jian GuanUniversity of Auckland, Liggins Institute, Private Bag 92019, Auckland, New Zealand+64 93 737 599 ext. 86134; +64 93 082 385; [email protected];University of Auckland, Centre for Brain Research, Faculty of Medicine and Health Sciences, Auckland, New Zealand
,
Paul HarrisUniversity of Auckland, School of Chemistry, Department of Medicinal Chemistry, Auckland, New Zealand
,
Margaret BrimbleUniversity of Auckland, Centre for Brain Research, Faculty of Medicine and Health Sciences, Auckland, New Zealand;University of Auckland, School of Chemistry, Department of Medicinal Chemistry, Auckland, New Zealand
,
Yang LeiNortheast Normal University, Institute of Genetics and Cytology, Changchuen, China;Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
,
Jun LuNortheast Normal University, Institute of Genetics and Cytology, Changchuen, China
,
Yang YangInstitute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;Wuhan University of Technology, Affiliated Tian-you Hospital, Department of Endocrine and Metabolism, Wuhan, China
&
Alistair J GunnUniversity of Auckland, Centre for Brain Research, Faculty of Medicine and Health Sciences, Auckland, New Zealand;University of Auckland, School of Medical Sciences, Department of Physiology, Auckland, New Zealand
 show all
Pages 785-793 | Published online: 05 Feb 2015

Citations (29)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Gagandeep Singh-Mallah, Maryam Ardalan, Dali Kang, Kuljeet Singh, Christopher D. McMahon, Carina Mallard & Jian Guan. (2022) Administration of cyclic glycine-proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats. Nutritional Neuroscience 25:12, pages 2517-2527.
Read now

Articles from other publishers (28)

Tushar Arora & Shiv K. Sharma. (2023) Cyclic Glycine-Proline Improves Memory and Reduces Amyloid Plaque Load in APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease. International Journal of Alzheimer's Disease 2023, pages 1-9.
Crossref
Huiping Wang, Jin Wang, Chunsong Geng, Cong Wang, Rongrong Gu & Zhansheng Zhu. (2022) A variant rs6214 within IGF-1 confers risk for ulcerative colitis in Chinese Han populations. Functional & Integrative Genomics 23:1.
Crossref
Sara C. Silva-Reis, Ivo E. Sampaio-Dias, Vera M. Costa, Xavier Cruz Correia, Hugo F. Costa-Almeida, Xerardo García-Mera & José E. Rodríguez-Borges. (2023) Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences. ACS Chemical Neuroscience 14:4, pages 554-572.
Crossref
Jian Guan, Fengxia Li, Dali Kang, Tim Anderson, Toni Pitcher, John Dalrymple-Alford, Paul Shorten & Gagandeep Singh-Mallah. (2023) Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions. Molecules 28:3, pages 1021.
Crossref
Biswajit Gorai & Harish Vashisth. (2022) Structural models of viral insulin‐like peptides and their analogs. Proteins: Structure, Function, and Bioinformatics 91:1, pages 62-73.
Crossref
Linhong Zhong, Xiaofan Ma, Yixuan Niu, Lei Zhang, Zhenyu Xue, Jia Yan & Hong Jiang. (2022) Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway. Frontiers in Neuroscience 16.
Crossref
Hui Lin, Shuo Tian, Yizhong Peng, Ling Wu, Yan Xiao, Xiangcheng Qing & Zengwu Shao. (2022) IGF Signaling in Intervertebral Disc Health and Disease. Frontiers in Cell and Developmental Biology 9.
Crossref
Elizabeth L. Berg, Stela P. Petkova, Heather A. Born, Anna Adhikari, Anne E. Anderson & Jill L. Silverman. (2021) Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome. Molecular Autism 12:1.
Crossref
Lindsay M. Milich, James S. Choi, Christine Ryan, Susana R. Cerqueira, Sofia Benavides, Stephanie L. Yahn, Pantelis Tsoulfas & Jae K. Lee. (2021) Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord. Journal of Experimental Medicine 218:8.
Crossref
A. A. Abdullina, E. V. Vasil’eva, E. A. Kondrakhin, K. N. Kolyasnikova, T. A. Gudasheva & G. I. Kovalev. (2021) Psychotropic and Neuroreceptor Effects of Cyclopropylglycine Upon Intranasal Administration. Pharmaceutical Chemistry Journal 55:5, pages 483-489.
Crossref
Nycole A. Copping, Stephanie M. McTighe, Kyle D. Fink & Jill L. Silverman. (2021) Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome. Neurotherapeutics 18:3, pages 1535-1547.
Crossref
Sara C. Silva-Reis, A. Catarina V. D. dos Santos, Xerardo García-Mera, José E. Rodríguez-Borges & Ivo E. Sampaio-Dias. (2020) Bioinspired design for the assembly of Glypromate® neuropeptide conjugates with active pharmaceutical ingredients. New Journal of Chemistry 44:48, pages 21049-21063.
Crossref
L. F. Zainullina, T. V. Ivanova, T. A. Gudasheva, Yu. V. Vakhitova & S. B. Seredenin. (2020) Effect of Neuropeptide Cyclo-L-Prolylglycine on Cell Proliferative Activity. Bulletin of Experimental Biology and Medicine 169:3, pages 347-350.
Crossref
Tushar Arora, Pablo Caviedes & Shiv Kumar Sharma. (2019) Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Foetal Hippocampus of a Trisomy 16 Mouse: an Animal Model of Down Syndrome. Neurotoxicity Research 37:3, pages 714-723.
Crossref
Gary Steinman & David Mankuta. (2020) The role of oligopeptides in preventing autism. Medical Hypotheses, pages 109604.
Crossref
Dawei Fan, Toni Pitcher, John Dalrymple‐Alford, Michael MacAskill, Tim Anderson & Jian Guan. (2020) Changes of plasma cGP/IGF‐1 molar ratio with age is associated with cognitive status of Parkinson disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 12:1.
Crossref
Milan Obradovic, Sonja Zafirovic, Sanja Soskic, Julijana Stanimirovic, Andreja Trpkovic, Danimir Jevremovic & Esma R. Isenovic. (2019) Effects of IGF-1 on the Cardiovascular System. Current Pharmaceutical Design 25:35, pages 3715-3725.
Crossref
Magdalena Misiura & Wojciech Miltyk. (2019) Proline‐containing peptides—New insight and implications: A Review. BioFactors 45:6, pages 857-866.
Crossref
Jinlin Zhang, Jingjing Wu, Fengguo Liu, Lijuan Tong, Zhuo Chen, Jinliang Chen, Haiyan He, Rong Xu, Yaoying Ma & Chao Huang. (2019) Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review. European Journal of Pharmacology 858, pages 172500.
Crossref
David Aguado-Llera, Sandra Canelles, Cristina Fernández-Mendívil, Laura M. Frago, Jesús Argente, Eduardo Arilla-Ferreiro, Manuela G. López & Vicente Barrios. (2019) Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system. Neuropharmacology 151, pages 112-126.
Crossref
I. N. Sharonova, Yu. V. Bukanova, T. A. Gudasheva & V. G. Skrebitsky. (2019) Effect of Endogenous Neuropeptide Cycloprolylglycine on GABAA Receptors in Cerebellar Purkinje Cells. Bulletin of Experimental Biology and Medicine 167:1, pages 39-42.
Crossref
Dawei Fan, Yassar Alamri, Karen Liu, Michael MacAskill, Paul Harris, Margaret Brimble, John Dalrymple-Alford, Tim Prickett, Oliver Menzies, Andrew Laurenson, Tim Anderson & Jian Guan. (2018) Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function. Nutrients 10:6, pages 714.
Crossref
Gagandeep Singh-Mallah, Christopher D. McMahon, Jian Guan & Kuljeet Singh. (2017) Cyclic-glycine-proline accelerates mammary involution by promoting apoptosis and inhibiting IGF-1 function. Journal of Cellular Physiology 232:12, pages 3369-3383.
Crossref
Cristina Almengló, Pablo Devesa, Jesús Devesa & Víctor Arce. (2017) GPE Promotes the Proliferation and Migration of Mouse Embryonic Neural Stem Cells and Their Progeny In Vitro. International Journal of Molecular Sciences 18:6, pages 1280.
Crossref
Songhua Xiao, Daoyou Zhou, Ping Luan, Beibei Gu, Longbao Feng, Shengnuo Fan, Wang Liao, Wenli Fang, Lianhong Yang, Enxiang Tao, Rui Guo & Jun Liu. (2016) Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability. Biomaterials 106, pages 98-110.
Crossref
Gagandeep Singh-Mallah, Kuljeet Singh, Christopher D. McMahon, Paul HarrisMargaret A. BrimbleEric ThorstensenJian Guan. (2016) Maternally Administered Cyclic Glycine-Proline Increases Insulin-Like Growth Factor-1 Bioavailability and Novelty Recognition in Developing Offspring. Endocrinology 157:8, pages 3130-3139.
Crossref
Julien Simon, Julien Pytkowicz, Nathalie Lensen, Grégory Chaume & Thierry Brigaud. (2016) Incorporation of Trifluoromethylated Proline and Surrogates into Peptides: Application to the Synthesis of Fluorinated Analogues of the Neuroprotective Glycine-Proline-Glutamate (GPE) Tripeptide. The Journal of Organic Chemistry 81:13, pages 5381-5392.
Crossref
Eva Baquedano, Emma Burgos-Ramos, Sandra Canelles, Agueda González-Rodríguez, Julie A. Chowen, Jesús Argente, Vicente Barrios, Angela M. Valverde & Laura M. Frago. (2016) Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model. Disease Models & Mechanisms 9:5, pages 573-583.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.