1,174
Views
67
CrossRef citations to date
0
Altmetric
Review

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease

, PhD (A.W. and Mary Margaret Clausen Distinguished Professor) , , PhD & , PhD

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Xian Zhou, Shijie Zhang, Fan Yu, Gan Zhao, Shuang Geng, Wencong Yu, Xuan-Yi Wang & Bin Wang. (2020) Tolerogenic vaccine composited with islet-derived multipeptides and cyclosporin A induces pTreg and prevents Type 1 diabetes in murine model. Human Vaccines & Immunotherapeutics 16:2, pages 240-250.
Read now
Amit Sharma & Dipayan Rudra. (2019) Regulatory T cells as therapeutic targets and mediators. International Reviews of Immunology 38:5, pages 183-203.
Read now
Joachim H. Maartens, Elena De-Juan-Pardo, Felix M. Wunner, Antonio Simula, Nicolas H. Voelcker, Simon C. Barry & Dietmar W. Hutmacher. (2017) Challenges and opportunities in the manufacture and expansion of cells for therapy. Expert Opinion on Biological Therapy 17:10, pages 1221-1233.
Read now

Articles from other publishers (64)

Nyerhovwo Obarorakpor, Deep Patel, Reni Boyarov, Nansalmaa Amarsaikhan, Joseph Ray Cepeda, Doreen Eastes, Sylvia Robertson, Travis Johnson, Kai Yang, Qizhi Tang & Li Zhang. (2023) Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes. Frontiers in Immunology 14.
Crossref
Farrah Kheradmand, Yun Zhang & David B. Corry. (2023) Contribution of adaptive immunity to human COPD and experimental models of emphysema. Physiological Reviews 103:2, pages 1059-1093.
Crossref
Fangfang Li, Wenxin Gao, Yanmei Li, Yiqing Wang, Lin Liu & Xuehong Zhang. (2023) Potential Biomarkers and Endometrial Immune Microenvironment in Recurrent Implantation Failure. Biomolecules 13:3, pages 406.
Crossref
Jacinta Jacob, Alessia Volpe, Qi Peng, Robert I. Lechler, Lesley A. Smyth, Giovanna Lombardi & Gilbert O. Fruhwirth. (2023) Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with 89Zr-oxine for Medium-Term In Vivo Cell Tracking. Molecules 28:3, pages 1482.
Crossref
Ru Ma, Hongling Su, Keping Jiao & Jian Liu. (2023) Role of Th17 cells, Treg cells, and Th17/Treg imbalance in immune homeostasis disorders in patients with chronic obstructive pulmonary disease. Immunity, Inflammation and Disease 11:2.
Crossref
Marcela Laukova & Arielle Glatman Zaretsky. (2023) Regulatory T cells as a therapeutic approach for inflammatory bowel disease. European Journal of Immunology 53:2.
Crossref
Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A. Schildberg, Paul A. Gleeson, Birgit M. Reipert, Johannes Oldenburg & Christian Kurts. (2022) Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs. Journal of Clinical Investigation 132:22.
Crossref
Lachlan M. Moldenhauer, M. Louise Hull, Kerrie L. Foyle, Catherine D. McCormack & Sarah A. Robertson. (2022) Immune–Metabolic Interactions and T Cell Tolerance in Pregnancy. The Journal of Immunology 209:8, pages 1426-1436.
Crossref
Mikhail V. Kiselevskiy, H. M. Treshalina, I. N. Mikhailova, D. V. Martirosyan, I. V. Manina, V. V. Reshetnikova & I. G. Kozlov. (2022) Opportunities for correction of immunosuppression in patients with COVID-19. Russian Journal of Infection and Immunity 12:4, pages 651-658.
Crossref
Minglu Hao, Lei Zhang & Pu Chen. (2022) Membrane Internalization Mechanisms and Design Strategies of Arginine-Rich Cell-Penetrating Peptides. International Journal of Molecular Sciences 23:16, pages 9038.
Crossref
Sarah A. Robertson, Lachlan M. Moldenhauer, Ella S. Green, Alison S. Care & M. Louise Hull. (2022) Immune determinants of endometrial receptivity: a biological perspective. Fertility and Sterility 117:6, pages 1107-1120.
Crossref
Christopher W.G. Redman, Sarah A. Robertson & Robert N. Taylor. 2022. Chesley's Hypertensive Disorders in Pregnancy. Chesley's Hypertensive Disorders in Pregnancy 131 153 .
Shun Takao, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Shinya Takahashi, Ayumu Nakashima & Noboru Hattori. (2021) Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis. Stem Cell Research & Therapy 12:1.
Crossref
Diego Vergani, Benedetta Terziroli Beretta-Piccoli & Giorgina Mieli-Vergani. (2021) A reasoned approach to the treatment of autoimmune hepatitis. Digestive and Liver Disease 53:11, pages 1381-1393.
Crossref
Jeong-su Do, Daniel Zwick, Jonathan D. Kenyon, Fei Zhong, David Askew, Alex Y. Huang, Wouter Van’t Hof, Marcie Finney & Mary J. Laughlin. (2021) Mesenchymal stromal cell mitochondrial transfer to human induced T-regulatory cells mediates FOXP3 stability. Scientific Reports 11:1.
Crossref
Ai-ris Y. Collier, Laura A. Smith & S. Ananth Karumanchi. (2021) Review of the immune mechanisms of preeclampsia and the potential of immune modulating therapy. Human Immunology 82:5, pages 362-370.
Crossref
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Onur Boyman, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Antonios Kolios, Francesca Levi‐Schaffer, Giuseppe Nocentini, Oscar Palomares, Frank Redegeld, Betty Van Esch & Cristiana Stellato. (2021) Immune modulation via T regulatory cell enhancement: Disease‐modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO). Allergy 76:1, pages 90-113.
Crossref
Sasan Mohammadi, Elham Abdollahi, Maria Nezamnia, Seyed-Alireza Esmaeili, Fataneh Tavasolian, Thozhukat Sathyapalan & Amirhossein Sahebkar. (2021) Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models. International Immunopharmacology 90, pages 107195.
Crossref
Naoya Shigeta, Keiichi Kumasawa & Kaori Koga. 2021. Reproductive Immunology. Reproductive Immunology 239 251 .
Dorota Iwaszkiewicz-Grzes, Mateusz Gliwinski, Anne Eugster, Magdalena Piotrowska, Andreas Dahl, Natalia Marek-Trzonkowska & Piotr Trzonkowski. (2020) Antigen-reactive regulatory T cells can be expanded in vitro with monocytes and anti-CD28 and anti-CD154 antibodies. Cytotherapy 22:11, pages 629-641.
Crossref
Howard W Davidson & Li Zhang. (2020) Immune therapies for autoimmune diabetes targeting pathogenic peptide–MHC complexes. Journal of Molecular Cell Biology 12:10, pages 759-763.
Crossref
Yu Liu, Guangying Qi, Joseph A. Bellanti, René Moser, Bernhard Ryffel & Song Guo Zheng. (2020) Regulatory T cells: A potential weapon to combat COVID‐19?. MedComm 1:2, pages 157-164.
Crossref
Neil Halliday, Jessica Katharine Dyson, Douglas Thorburn, Ansgar W. Lohse & Michael A. Heneghan. (2020) Review article: experimental therapies in autoimmune hepatitis. Alimentary Pharmacology & Therapeutics.
Crossref
Dan Liu, Xiaojuan Tu, Chuanmengyuan Huang, Yuncang Yuan, Ying Wang, Xiaona Liu & Wei He. (2020) Adoptive transfers of CD4 + CD25 + Tregs partially alleviate mouse premature ovarian insufficiency . Molecular Reproduction and Development 87:8, pages 887-898.
Crossref
Stephanie M. Ryan, Ramon M. Eichenberger, Roland Ruscher, Paul R. Giacomin & Alex Loukas. (2020) Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities. PLOS Pathogens 16:5, pages e1008508.
Crossref
S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I. Joosten & H. J. P. M. Koenen. (2020) Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation. Journal of Immunology Research 2020, pages 1-11.
Crossref
CM Hope, J Welch, A Mohandas, S Pederson, D Hill, B Gundsambuu, N Eastaff‐Leung, R Grosse, S Bresatz, G Ang, M Papadimetrios, H Zola, T Duhen, D Campbell, CY Brown, D Krumbiegel, T Sadlon, JJ Couper & SC Barry. (2019) Peptidase Inhibitor 16 identifies a human regulatory T cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes. European Journal of Immunology.
Crossref
Sarah A. Robertson, Ella S. Green, Alison S. Care, Lachlan M. Moldenhauer, Jelmer R. Prins, M. Louise Hull, Simon C. Barry & Gustaaf Dekker. (2019) Therapeutic Potential of Regulatory T Cells in Preeclampsia—Opportunities and Challenges. Frontiers in Immunology 10.
Crossref
Fabio Caliendo, Marina Dukhinova & Velia Siciliano. (2019) Engineered Cell-Based Therapeutics: Synthetic Biology Meets Immunology. Frontiers in Bioengineering and Biotechnology 7.
Crossref
Mei Ding, Johan Brengdahl, Madelene Lindqvist, Ulf Gehrmann, Elke Ericson, Stefan von Berg, Lena Ripa & Rajneesh Malhotra. (2019) A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression. ACS Chemical Biology 14:3, pages 543-553.
Crossref
Stefanie Klinge, Karsten Yan, Daniel Reimers, Karen-Maria Brede, Joanna Schmid, Hans-Joachim Paust, Christian F. Krebs, Ulf Panzer, Helmut Hopfer & Hans-Willi Mittrücker. (2019) Role of regulatory T cells in experimental autoimmune glomerulonephritis. American Journal of Physiology-Renal Physiology 316:3, pages F572-F581.
Crossref
Willem van Eden, Manon A. A. Jansen, Irene S. Ludwig, Paul Leufkens, Marlies C. van der Goes, Jacob M. van Laar & Femke Broere. (2019) Heat Shock Proteins Can Be Surrogate Autoantigens for Induction of Antigen Specific Therapeutic Tolerance in Rheumatoid Arthritis. Frontiers in Immunology 10.
Crossref
Andrew D. Vonberg, Maria Acevedo-Calado, Aaron R. Cox, Susan L. Pietropaolo, Roberto Gianani, Steven K. Lundy & Massimo Pietropaolo. (2018) CD19+IgM+ cells demonstrate enhanced therapeutic efficacy in type 1 diabetes mellitus. JCI Insight 3:23.
Crossref
Nicholas A. Zwang, Balaji B. Ganesh, Kim T. Cardenas, Anita S. Chong, Patricia W. Finn & David L. Perkins. (2018) An optimized protocol to quantify signaling in human transitional B cells by phospho flow cytometry. Journal of Immunological Methods 463, pages 112-121.
Crossref
Jastaranpreet Singh & Juan Carlos Zúñiga-Pflücker. (2018) Producing proT cells to promote immunotherapies. International Immunology 30:12, pages 541-550.
Crossref
Sayantani Ghosh, Sinchita Roy-Chowdhuri, Keunsoo Kang, Sin-Hyeog Im & Dipayan Rudra. (2018) The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells. Nature Communications 9:1.
Crossref
Tzu-Sheng Hsu & Ming-Zong Lai. (2018) Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions. Journal of Leukocyte Biology 104:5, pages 911-918.
Crossref
Sarah A. Robertson, Alison S. Care & Lachlan M. Moldenhauer. (2018) Regulatory T cells in embryo implantation and the immune response to pregnancy. Journal of Clinical Investigation 128:10, pages 4224-4235.
Crossref
Charles J. Kroger, Matthew Clark, Qi Ke & Roland M. Tisch. (2018) Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes. Frontiers in Immunology 9.
Crossref
Sija Landman, Vivian L. de Oliveira, Piet E. J. van Erp, Esther Fasse, Stijn C. G. Bauland, Irma Joosten & Hans J. P. M. Koenen. (2018) Intradermal injection of low dose human regulatory T cells inhibits skin inflammation in a humanized mouse model. Scientific Reports 8:1.
Crossref
Tingting Fan, Xiaowen Huang, Cuilian Liu, Ruiling Liu, Ting Wang & Qingguo Ruan. (2018) Egress of murine regulatory T cells from the thymus requires TIPE2. Biochemical and Biophysical Research Communications 500:2, pages 376-383.
Crossref
Charlotte de Wolf, Marja van de Bovenkamp & Marcel Hoefnagel. (2018) Regulatory perspective on in vitro potency assays for human T cells used in anti-tumor immunotherapy. Cytotherapy 20:5, pages 601-622.
Crossref
Margot Zöller. (2018) Janus-Faced Myeloid-Derived Suppressor Cell Exosomes for the Good and the Bad in Cancer and Autoimmune Disease. Frontiers in Immunology 9.
Crossref
Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang & Ming-Zong Lai. (2018) IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nature Communications 9:1.
Crossref
Willem van Eden. (2017) Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes. Philosophical Transactions of the Royal Society B: Biological Sciences 373:1738, pages 20160531.
Crossref
Manon A. A. Jansen, Rachel Spiering, Femke Broere, Jacob M. van Laar, John D. Isaacs, Willem van Eden & Catharien M. U. Hilkens. (2018) Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?. Immunology 153:1, pages 51-59.
Crossref
Walter Gottlieb LandWalter Gottlieb Land. 2018. Damage-Associated Molecular Patterns in Human Diseases. Damage-Associated Molecular Patterns in Human Diseases 791 827 .
Bahman Delalat, Frances Harding, Batjargal Gundsambuu, Elena M. De-Juan-Pardo, Felix M. Wunner, Marie-Luise Wille, Marek Jasieniak, Kristen A.L. Malatesta, Hans J. Griesser, Antonio Simula, Dietmar W. Hutmacher, Nicolas H. Voelcker & Simon C. Barry. (2017) 3D printed lattices as an activation and expansion platform for T cell therapy. Biomaterials 140, pages 58-68.
Crossref
Ziyuan Lu, Na Xu, Xuan Zhou, Guanlun Gao, Lin Li, Jixian Huang, Yuling Li, Qisi Lu, Bolin He, Chengyun Pan & Xiaoli Liu. (2017) Therapeutic immune monitoring of CD4+CD25+ T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Oncology Letters 14:2, pages 1363-1372.
Crossref
Carolina Purroy, Robert L. Fairchild, Toshiaki Tanaka, William M. Baldwin, Joaquin Manrique, Joren C. Madsen, Robert B. Colvin, Alessandro Alessandrini, Bruce R. Blazar, Miguel Fribourg, Chiara Donadei, Umberto Maggiore, Peter S. Heeger & Paolo Cravedi. (2017) Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. Journal of the American Society of Nephrology 28:8, pages 2377-2392.
Crossref
Jorg van Loosdregt, Femke van Wijk, Berent Prakken & Bas Vastert. (2017) Update on research and clinical translation on specific clinical areas from biology to bedside: Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis. Best Practice & Research Clinical Rheumatology 31:4, pages 460-475.
Crossref
Ning Kang, Wendy M. Toyofuku, Xining Yang & Mark D. Scott. (2017) Inhibition of allogeneic cytotoxic T cell (CD8+) proliferation via polymer-induced Treg (CD4+) cells. Acta Biomaterialia 57, pages 146-155.
Crossref
Yasaman Aghazadeh & Maria Cristina Nostro. (2017) Cell Therapy for Type 1 Diabetes: Current and Future Strategies. Current Diabetes Reports 17:6.
Crossref
Hong Xu, Xin Xiao Zheng, Wensheng Zhang, Yiming Huang & Suzanne T. Ildstad. (2017) A Critical Role for TGF-β/Fc and Nonlytic IL-2/Fc Fusion Proteins in Promoting Chimerism and Donor-Specific Tolerance. Transplantation 101:2, pages 294-301.
Crossref
Hyun-Joo Kim, Gil Sun Cha, Ji-Young Joo, Juyoun Lee, Sung-Jo Kim, Jeongae Lee, So Youn Park & Jeomil Choi. (2017) Targeting the epitope spreader Pep19 by naïve human CD45RA + regulatory T cells dictates a distinct suppressive T cell fate in a novel form of immunotherapy . Journal of Periodontal & Implant Science 47:5, pages 292.
Crossref
Jie Yang, Lidong Liu, Yiming Yang, Ning Kong, Xueyu Jiang, Juan Sun & Rufeng Xie. (2017) Adoptive Cell Therapy of Induced Regulatory T Cells Expanded by Tolerogenic Dendritic Cells on Murine Autoimmune Arthritis. Journal of Immunology Research 2017, pages 1-13.
Crossref
Shahram Kordasti, Benedetta CostantiniThomas SeidlPilar Perez AbellanMarc Martinez LlordellaDonal McLornanKirsten E. DigginsAustin KulasekararajCinzia BenfattoXingmin Feng, Alexander SmithSyed A. MianRossella Melchiotti, Emanuele de Rinaldis, Richard Ellis, Nedyalko Petrov, Giovanni A. M. PovoleriSun Sook ChungN. Shaun B. ThomasFarzin FarzanehJonathan M. IrishSusanne Heck, Neal S. Young, Judith C. W. MarshGhulam J. Mufti. (2016) Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment. Blood 128:9, pages 1193-1205.
Crossref
Uma Chandrasekaran, Woelsung Yi, Sanjay Gupta, Chien-Huan Weng, Eugenia Giannopoulou, Yurii Chinenov, Rolf Jessberger, Casey T. Weaver, Govind Bhagat & Alessandra B. Pernis. (2016) Regulation of Effector Treg Cells in Murine Lupus. Arthritis & Rheumatology 68:6, pages 1454-1466.
Crossref
Xin Chen, Yong Du, XiuQing Lin, Yan Qian, Ting Zhou & ZhiMing Huang. (2016) CD4 + CD25 + regulatory T cells in tumor immunity. International Immunopharmacology 34, pages 244-249.
Crossref
James B. Wing, Atsushi Tanaka & Shimon Sakaguchi. 2016. Chronic Inflammation. Chronic Inflammation 475 488 .
Silvia Gregori, Laura Passerini & Maria-Grazia Roncarolo. (2015) Clinical Outlook for Type-1 and FOXP3+ T Regulatory Cell-Based Therapy. Frontiers in Immunology 6.
Crossref
Jeffrey A. BluestoneJane H. BucknerMark FitchStephen E. GitelmanShipra GuptaMarc K. HellersteinKevan C. HeroldAngela LaresMichael R. LeeKelvin LiWeihong LiuS. Alice LongLisa M. MasielloVinh NguyenAmy L. PutnamMary RieckPeter H. SayreQizhi Tang. (2015) Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Science Translational Medicine 7:315.
Crossref
Doaa Salah Hegab & Mohamed Attia Saad Attia. (2015) Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity. Dermatology Research and Practice 2015, pages 1-7.
Crossref
Vitalijs Ovcinnikovs & Lucy S.K. Walker. 2015. Regulatory T Cells in Health and Disease. Regulatory T Cells in Health and Disease 245 277 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.