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Drug Safety Evaluation

Safety and tolerability of 5-grass pollen tablet sublingual immunotherapy: pooled analysis and clinical review

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L. Klimek, R. Brehler, R. Mösges, P. Demoly, J. Mullol, D. Y. Wang, R. E. O’Hehir, A. Didier, M. Kopp, C. Bos & E. Karagiannis. (2022) Update about Oralair® as a treatment for grass pollen allergic rhinitis. Human Vaccines & Immunotherapeutics 18:5.
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Giorgio Walter Canonica, Philippe Devillier, Thomas Casale, Pascal Demoly, Catherine Bos, Efstrathios Karagiannis, Giovanni Passalacqua, Ulrich Wahn & Laurent Mascarell. (2019) Clinical efficacy of sublingual immunotherapy tablets for allergic rhinitis is unlikely to be derived from in vitro allergen-release data. Expert Review of Clinical Immunology 15:9, pages 921-928.
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David I. Bernstein, Jose A. Bardelas$suffix/text()$suffix/text(), Bodil Svanholm Fogh, Amarjot Kaur, Ziliang Li & Hendrik Nolte. (2017) A practical guide to the sublingual immunotherapy tablet adverse event profile: implications for clinical practice. Postgraduate Medicine 129:6, pages 590-597.
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Giovanni Passalacqua, Joaquín Sastre, Oliver Pfaar, Ulrich Wahn & Pascal Demoly. (2016) Comparison of allergenic extracts from different origins: the value of the FDA’s bioequivalent allergy unit (BAU). Expert Review of Clinical Immunology 12:7, pages 733-739.
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Giorgio Ciprandi, Gian Luigi Marseglia, Riccardo Castagnoli, Chiara Valsecchi, Carlotta Tagliacarne, Silvia Caimmi & Amelia Licari. (2015) From IgE to clinical trials of allergic rhinitis. Expert Review of Clinical Immunology 11:12, pages 1321-1333.
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Articles from other publishers (31)

Marie‐Lee Simard, Natalija Novak, Jean‐Philippe Drolet, Marie‐Claude Joly, Hendrik Nolte, Eike Wuestenberg & Rémi Gagnon. (2023) Tolerability of sublingual versus vestibular allergy immunotherapy tablet administration: A randomized pilot study. Clinical & Experimental Allergy.
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Mistrello Gianni. (2023) Evolution of Immunotherapy Against Pollen Allergy. Current Protein & Peptide Science 24:6, pages 488-502.
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Andreas Horn, David I. Bernstein, Kimihiro Okubo, Terrie Dalgaard, Ole Hels, Helle Frobøse Sørensen, Marianne Henriksen, Ryuji Azuma, Jan Mikler & Hendrik Nolte. (2023) House dust mite sublingual immunotherapy tablet safety in adolescents with allergic rhinoconjunctivitis. Annals of Allergy, Asthma & Immunology 130:6, pages 797-804.e2.
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Lawrence DuBuske. (2022) Efficacy and safety of sublingual allergen immunotherapy. Allergy and Asthma Proceedings 43:4, pages 272-280.
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Désirée Larenas-Linnemann. (2022) Long-term adherence strategies for allergen immunotherapy. Allergy and Asthma Proceedings 43:4, pages 299-304.
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K. Lam, J.M. Pinto, S.E. Lee, K. Rance & H. Nolte. (2022) Delivery options for sublingual immunotherapy for allergic rhinoconjunctivitis: clinical considerations for North America. Rhinology Online 5:5, pages 70-86.
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Anne K. Ellis, Lori Connors, Marie-Josee Francoeur & Douglas P. Mack. (2021) Rupatadine to prevent local allergic reactions to sublingual allergy immunotherapy: a case series. Allergy, Asthma & Clinical Immunology 17:1.
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Susan Waserman, Anita Shah & Ernie Avilla. (2021) Recent development on the use of sublingual immunotherapy tablets for allergic rhinitis. Annals of Allergy, Asthma & Immunology 127:2, pages 165-175.e1.
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Albert Roger Reig, Clara Padró Casas, Diego Gutiérrez Fernández, José Carlos Orta Cuevas, Germán Sánchez López & José Luis Corzo Higueras. (2021) A Retrospective Nationwide Non-Interventional Study of an Aqueous Sublingual Immunotherapy Formulation Administered with a 200-µL Dosing Pump. Drugs - Real World Outcomes 8:2, pages 241-251.
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D. Caimmi & P. Demoly. (2021) Recommandations pour la prescription de l’immunothérapie allergénique et le suivi du patient — Questions développées et revue de la littérature. Revue Française d'Allergologie 61:1, pages 35-56.
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Moisés A. Calderon, Susan Waserman, David I. Bernstein, Pascal Demoly, Jo Douglass, Remi Gagnon, Constance H. Katelaris, Harold Kim, Harold S. Nelson, Yoshitaka Okamoto, Kimihiro Okubo, J. Christian Virchow, Lawrence DuBuske, Thomas B. Casale, G. Walter Canonica & Hendrik Nolte. (2020) Clinical Practice of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Asthma: An Expert Panel Report. The Journal of Allergy and Clinical Immunology: In Practice 8:9, pages 2920-2936.e1.
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Hendrik Nolte, David I. Bernstein, Harold S. Nelson, Anne K. Ellis, Jörg Kleine-Tebbe & Susan Lu. (2020) Efficacy and Safety of Ragweed SLIT-Tablet in Children with Allergic Rhinoconjunctivitis in a Randomized, Placebo-Controlled Trial. The Journal of Allergy and Clinical Immunology: In Practice 8:7, pages 2322-2331.e5.
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Mike Tankersley, Joseph K. Han & Hendrik Nolte. (2020) Clinical aspects of sublingual immunotherapy tablets and drops. Annals of Allergy, Asthma & Immunology 124:6, pages 573-582.
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Montserrat Alvaro‐Lozano, Cezmi A. Akdis, Mubeccel Akdis, Cherry Alviani, Elisabeth Angier, Stefania Arasi, Lisa Arzt‐Gradwohl, Domingo Barber, Raphaëlle Bazire, Ozlem Cavkaytar, Pasquale Comberiati, Stephanie Dramburg, Stephen R. Durham, Aarif O. Eifan, Leandra Forchert, Susanne Halken, Max Kirtland, Umut C. Kucuksezer, Janice A. Layhadi, Paolo Maria Matricardi, Antonella Muraro, Cevdet Ozdemir, Giovanni Battista Pajno, Oliver Pfaar, Ekaterina Potapova, Carmen Riggioni, Graham Roberts, Pablo Rodríguez del Río, Mohamed H. Shamji, Gunter J. Sturm & Marta Vazquez‐Ortiz. (2020) Allergen Immunotherapy in Children User’s Guide. Pediatric Allergy and Immunology 31:S25, pages 1-101.
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Susanne Halken, Graham Roberts, Erkka Valovirta, Hendrik Nolte, Veronica Hulstrøm & Michael S. Blaiss. (2020) Safety of Timothy Grass Sublingual Immunotherapy Tablet in Children: Pooled Analyses of Clinical Trials. The Journal of Allergy and Clinical Immunology: In Practice 8:4, pages 1387-1393.e2.
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Enrico Compalati, Cristoforo Incorvaia, Sara Urbano, Paola Strada & Franco Frati. (2020) The safety of carbamylated monomeric allergoids for sublingual immunotherapy. Data from a pharmacovigilance study. Immunotherapy 12:3, pages 195-202.
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Gunter Johannes Sturm, Christian Vogelberg, Miriam Marchon, Andreas Horn, Hans-Georg Vitzthum, Marco-Parwis Memar-Baschi & Jörg Kleine-Tebbe. (2019) Coadministration of Sublingual Immunotherapy Tablets and Management of Potential Adverse Effects: Austrian, German, and Swiss Expert Recommendations. Clinical Therapeutics 41:9, pages 1880-1888.
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Patrick Blin, Pascal Demoly, Martine Drouet, Bruno Falissard, Séverine Lignot-Maleyran, Hélène Maizi, Simon Lorrain, Régis Lassalle, Cécile Droz-Perroteau, Nicholas Moore & Mathieu Molimard. (2018) An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France. Allergy, Asthma & Clinical Immunology 14:1.
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Thomas B. Casale, Linda S. Cox, Ulrich Wahn, David B.K. Golden, Brigitte Bons & Alain Didier. (2017) Safety Review of 5-Grass Pollen Tablet from Pooled Data of Clinical Trials. The Journal of Allergy and Clinical Immunology: In Practice 5:6, pages 1717-1727.e1.
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Margot Berings, Cagatay Karaaslan, Can Altunbulakli, Philippe Gevaert, Mübeccel Akdis, Claus Bachert & Cezmi A. Akdis. (2017) Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance. Journal of Allergy and Clinical Immunology 140:5, pages 1250-1267.
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Philippe Moingeon & Laurent Mascarell. (2017) Differences and similarities between sublingual immunotherapy of allergy and oral tolerance. Seminars in Immunology 30, pages 52-60.
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M. A. Calderón, C. Vidal, P. Rodríguez del Río, J. Just, O. Pfaar, A. I. Tabar, I. Sánchez-Machín, P. Bubel, J. Borja, P. Eberle, R. Reiber, M. Bouvier, A. Lepelliez, L. Klimek & P. Demoly. (2017) European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): a real-life clinical assessment. Allergy 72:3, pages 462-472.
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Tolly G. Epstein, Christopher Calabria, Linda S. Cox & Sten Dreborg. (2017) Current Evidence on Safety and Practical Considerations for Administration of Sublingual Allergen Immunotherapy (SLIT) in the United States. The Journal of Allergy and Clinical Immunology: In Practice 5:1, pages 34-40.e2.
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Jocelyne Just, Antoine Deschildre & Etienne Beaudouin. 2017. Allergies Alimentaires. Allergies Alimentaires 229 258 .
Claus Bachert & Elien Gevaert. (2016) Advances in rhinitis and rhinosinusitis in 2015. Journal of Allergy and Clinical Immunology 138:5, pages 1277-1283.
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Linda S. Cox, Alain Didier, Pascal Demoly, Ulrich Wahn, André Pradalier, Anthony J. Frew & Philippe Devillier. (2016) Methodological aspects of a meta-analysis of grass pollen allergen sublingual immunotherapy tablets. Journal of Allergy and Clinical Immunology 138:1, pages 314-315.e4.
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Désirée Larenas-Linnemann. (2016) Direct comparison of efficacy of sublingual immunotherapy tablets for rhinoconjunctivitis. Annals of Allergy, Asthma & Immunology 116:4, pages 274-286.
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Liesbeth Ras, Hans de Groot, Cornelis H.M. Stengs & Ranny van Weissenbruch. (2016) Persistence of treatment with 5-grass pollen tablets in patients with allergic rhinitis: a real-life study. Annals of Allergy, Asthma & Immunology 116:1, pages 52-58.e2.
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Cristoforo Incorvaia, Marina Mauro & Erminia Ridolo. (2015) Sublingual immunotherapy for allergic rhinitis: where are we now?. Immunotherapy 7:10, pages 1105-1110.
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Pascal Demoly, Gianni Passalacqua, Moises A. Calderon & Tarik Yalaoui. (2015) Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose. Clinical and Translational Allergy 5:1.
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Oliver Pfaar, Heinz-Gerd Richter, Ludger Klimek, Jochen Sieber, Meike Hadler & Efstrathios Karagiannis. (2015) Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study. BioMed Research International 2015, pages 1-11.
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