2,430
Views
71
CrossRef citations to date
0
Altmetric
Drug Safety Evaluation

Reducing the harm of opioid overdose with the safe use of naloxone: a pharmacologic review

, MD MPH & , MD

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (14)

Ola Dale. (2022) Pharmacokinetic considerations for community-based dosing of nasal naloxone in opioid overdose in adults. Expert Opinion on Drug Metabolism & Toxicology 18:3, pages 203-217.
Read now
Soraya Mahmoudi, Amir Abbas Farshid, Esmaeal Tamaddonfard, Mehdi Imani & Farahnaz Noroozinia. (2022) Behavioral, histopathological, and biochemical evaluations on the effects of cinnamaldehyde, naloxone, and their combination in morphine-induced cerebellar toxicity. Drug and Chemical Toxicology 45:1, pages 250-261.
Read now
Tabitha E. Moses, May Chammaa, Rafael Ramos, Eva Waineo & Mark K. Greenwald. (2021) Incoming medical students’ knowledge of and attitudes toward people with substance use disorders: Implications for curricular training. Substance Abuse 42:4, pages 692-698.
Read now
Elizabeth Skoy, Amy Werremeyer, Jayme Steig, Heidi Eukel, Oliver Frenzel & Mark Strand. (2021) Patient acceptance of naloxone resulting from targeted intervention from community pharmacists to prevent opioid misuse and accidental overdose. Substance Abuse 42:4, pages 672-677.
Read now
Roy Purssell, Jesse Godwin, Jessica Moe, Jane Buxton, Alexis Crabtree, Andrew Kestler, Chris DeWitt, Frank Scheuermeyer, Shannon Erdelyi, Robert Balshaw, Adrianna Rowe, Christopher K. Cochrane, Benjamin Ng, Andy Jiang, Alessia Risi, Vi Ho & Jeffrey R. Brubacher. (2021) Comparison of rates of opioid withdrawal symptoms and reversal of opioid toxicity in patients treated with two naloxone dosing regimens: a retrospective cohort study. Clinical Toxicology 59:1, pages 38-46.
Read now
Sarah G. Mahonski, James B. Leonard, J. David Gatz, Hyunuk Seung, Erin E. Haas & Hong K. Kim. (2020) Prepacked naloxone administration for suspected opioid overdose in the era of illicitly manufactured fentanyl: a retrospective study of regional poison center data. Clinical Toxicology 58:2, pages 117-123.
Read now
Kenneth Williams, Eddy S. Lang, Ashish R. Panchal, James J. Gasper, Peter Taillac, John Gouda, John W. Lyng, Jeffrey M. Goodloe & Mary Hedges. (2019) Evidence-Based Guidelines for EMS Administration of Naloxone. Prehospital Emergency Care 23:6, pages 749-763.
Read now
Hong K. Kim, Nicholas J. Connors & Maryann E. Mazer-Amirshahi. (2019) The role of take-home naloxone in the epidemic of opioid overdose involving illicitly manufactured fentanyl and its analogs. Expert Opinion on Drug Safety 18:6, pages 465-475.
Read now
Felicia Wong, Christopher J. Edwards, Daniel H. Jarrell & Asad E. Patanwala. (2019) Comparison of lower-dose versus higher-dose intravenous naloxone on time to recurrence of opioid toxicity in the emergency department. Clinical Toxicology 57:1, pages 19-24.
Read now
Ludmila N. Bakhireva, Adriana Bautista, Sandra Cano, Shikhar Shrestha, Amy M. Bachyrycz & Theresa H. Cruz. (2018) Barriers and facilitators to dispensing of intranasal naloxone by pharmacists. Substance Abuse 39:3, pages 331-341.
Read now
Anita N. Jacobson$suffix/text()$suffix/text(), Jeffrey P. Bratberg$suffix/text()$suffix/text(), Miranda Monk & John Ferrentino. (2018) Retention of student pharmacists' knowledge and skills regarding overdose management with naloxone. Substance Abuse 39:2, pages 193-198.
Read now
George K. Avetian, Phillip Fiuty, Silvana Mazzella, Dave Koppa, Vivian Heye & Pratibha Hebbar. (2018) Use of naloxone nasal spray 4 mg in the community setting: a survey of use by community organizations. Current Medical Research and Opinion 34:4, pages 573-576.
Read now
Nazey Gulec, Joseph Lahey, James C. Suozzi, Matthew Sholl, Charles D. MacLean & Daniel L. Wolfson. (2018) Basic and Advanced EMS Providers Are Equally Effective in Naloxone Administration for Opioid Overdose in Northern New England. Prehospital Emergency Care 22:2, pages 163-169.
Read now
Mark J. Elzey, Jeffrey Fudin & Eric S. Edwards. (2017) Take-home naloxone treatment for opioid emergencies: a comparison of routes of administration and associated delivery systems. Expert Opinion on Drug Delivery 14:9, pages 1045-1058.
Read now

Articles from other publishers (57)

Susan M. Cibulsky, Timo Wille, Renée Funk, Danny Sokolowski, Christine Gagnon, Marc Lafontaine, Carol Brevett, Rabih Jabbour, Jessica Cox, David R. Russell, David A. Jett, Jerry D. Thomas & Lewis S. Nelson. (2023) Public health and medical preparedness for mass casualties from the deliberate release of synthetic opioids. Frontiers in Public Health 11.
Crossref
Rajendra Raman. (2023) High-potency benzodiazepine misuse in opioid-dependent patients: use naloxone with care. Emergency Medicine Journal 40:3, pages 224-227.
Crossref
Zahra Zeineb Iqbal, Thanh Mai Thi Nguyen, Mette Brekke & Odd Martin Vallersnes. (2022) Unspecified opioids among opioid overdoses in Oslo, Norway. BMC Research Notes 15:1.
Crossref
Victor Lei, Max Ferguson, Rachael Geiger, Sierra Williams, Lisa Liu & Jane A. Buxton. (2022) Factors associated with take-home naloxone kit usage in British Columbia: an analysis of administrative data. Substance Abuse Treatment, Prevention, and Policy 17:1.
Crossref
Max Ferguson, Andrea Medley, Katherine Rittenbach, Thomas D. Brothers, Carol Strike, Justin Ng, Pamela Leece, Tara Elton-Marshall, Farihah Ali, Diane L. Lorenzetti & Jane A. Buxton. (2022) Priority setting for Canadian Take-Home Naloxone best practice guideline development: an adapted online Delphi method. Harm Reduction Journal 19:1.
Crossref
Raymond Cho, Roy Purssell, Ronald Joe, Yueqiao Elle Wang, Fiona O’Sullivan, Kathleen Lin, Adrianna Rowe & Jessica Moe. (2022) Opioid Overdose and Naloxone Dosing at Insite Supervised Injection Facility in British Columbia: A Retrospective Cohort Study. Canadian Journal of Addiction 13:4, pages 22-31.
Crossref
Marta Tikhomirov, Paweł Jajor, Tomasz Śniegocki & Błażej Poźniak. (2022) Predicting the efficacy of opioid sequestration by intravenous lipid emulsion using biologically relevant in vitro models of drug distribution. Scientific Reports 12:1.
Crossref
Enrico Polati, Marta Nizzero, Jacopo Rama, Alvise Martini, Leonardo Gottin, Katia Donadello, Giovanna Del Balzo, Giustino Varrassi, Franco Marinangeli, Alessandro Vittori, Erica Secchettin & Vittorio Schweiger. (2022) Oxycodone-Naloxone Combination Hinders Opioid Consumption in Osteoarthritic Chronic Low Back Pain: A Retrospective Study with Two Years of Follow-Up. International Journal of Environmental Research and Public Health 19:20, pages 13354.
Crossref
Katherine Z. Isoardi, Lachlan Parker, Keith Harris, Stephen Rashford & Geoffrey K. Isbister. (2022) Acute Opioid Withdrawal Following Intramuscular Administration of Naloxone 1.6 mg: A Prospective Out-Of-Hospital Series. Annals of Emergency Medicine 80:2, pages 120-126.
Crossref
Arne Kristian Skulberg, Ida Tylleskär, Morten Valberg, Anne‐Cathrine Braarud, Jostein Dale, Fridtjof Heyerdahl, Tore Skålhegg, Jan Barstein, Sindre Mellesmo & Ola Dale. (2022) Comparison of intranasal and intramuscular naloxone in opioid overdoses managed by ambulance staff: a double‐dummy, randomised, controlled trial. Addiction 117:6, pages 1658-1667.
Crossref
Ana K. Ruiz‐Quiñonez, Zyanya P. Espinosa‐Riquer, César J. Carranza‐Aguilar, Thom BrowneJr.Jr. & Silvia L. Cruz. (2022) Co‐administration of morphine and levamisole increases death risk, produces neutropenia and modifies antinociception in mice. Addiction Biology 27:3.
Crossref
Nasim Nikoubakht, Poupak Rahimzadeh, Mahzad Alimian, Amineh Shafeinia & Saber Moghaddam. (2022) The effect of different doses of naloxone on postoperative hyperalgesia in patients who received high-dose remifentanil during hysterectomy procedures; a double-blind randomized clinical trial. Perioperative Care and Operating Room Management 26, pages 100237.
Crossref
Scott A. Borden, Armin Saatchi, Gregory W. Vandergrift, Jan Palaty, Mark Lysyshyn & Chris G. Gill. (2021) A new quantitative drug checking technology for harm reduction: Pilot study in Vancouver, Canada using paper spray mass spectrometry. Drug and Alcohol Review 41:2, pages 410-418.
Crossref
Jayashree C. Patel & Suphiya Parveen. (2021) In Vitro and In Vivo Analysis of Fentanyl and Fentalog Metabolites using Hyphenated Chromatographic Techniques: A Review. Chemical Research in Toxicology 35:1, pages 30-42.
Crossref
Carolyn A. Chan, Bethany Canver, Ryan McNeil & Kimberly L. Sue. (2022) Harm Reduction in Health Care Settings. Medical Clinics of North America 106:1, pages 201-217.
Crossref
Lakeisha A. Lewter, Marisa C. Johnson, Anny C. Treat, Andrew J. Kassick, Saadyah Averick & Benedict J. Kolber. (2020) Slow‐sustained delivery of naloxone reduces typical naloxone‐induced precipitated opioid withdrawal effects in male morphine‐dependent mice. Journal of Neuroscience Research 100:1, pages 339-352.
Crossref
Amina Moustaqim-Barrette, Damon Dhillon, Justin Ng, Kristen Sundvick, Farihah Ali, Tara Elton-Marshall, Pamela Leece, Katherine Rittenbach, Max Ferguson & Jane A. Buxton. (2021) Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review. BMC Public Health 21:1.
Crossref
Matthew Thomas, Laura Brady, Monika Wozniak, Elizabeth Terranova, Cheryll Moore & Linda S Kahn. (2021) Training to improve responder attitudes and knowledge of opioid overdose. Journal of Paramedic Practice 13:8, pages 1-18.
Crossref
Nicholas J Connors, Maryann Mazer-Amirshahi, Sergey Motov & Hong K Kim. (2021) Relative addictive potential of opioid analgesic agents. Pain Management 11:2, pages 201-215.
Crossref
Miriam Boeri & Aukje K. Lamonica. (2021) Naloxone perspectives from people who use opioids: Findings from an ethnographic study in three states. Journal of the American Association of Nurse Practitioners 33:4, pages 294-303.
Crossref
Susana Barbosa Méndez, Maura Matus-Ortega, Ricardo Hernández Miramontes & Alberto Salazar-Juárez. (2021) Effect of the morphine/heroin vaccine on opioid and non-opioid drug-induced antinociception in mice. European Journal of Pharmacology 891, pages 173718.
Crossref
Nasim Zamani, Nicholas A. Buckley & Hossein Hassanian-Moghaddam. (2020) Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial. Critical Care 24:1.
Crossref
Mario I. OrtizRaquel Cariño-CortésGilberto Castañeda-Hernández. (2020) Participation of the opioid receptor – nitric oxide – cGMP – K + channel pathway in the peripheral antinociceptive effect of nalbuphine and buprenorphine in rats . Canadian Journal of Physiology and Pharmacology 98:11, pages 753-762.
Crossref
Andrea Piccioni, Sara Cicchinelli, Luisa Saviano, Emanuele Gilardi, Christian Zanza, Mattia Brigida, Gianluca Tullo, Gianpietro Volonnino, Marcello Covino, Francesco Franceschi & Raffaele La Russa. (2020) Risk Management in First Aid for Acute Drug Intoxication. International Journal of Environmental Research and Public Health 17:21, pages 8021.
Crossref
Amina Moustaqim-Barrette, Kristi Papamihali, Zahra Mamdani, Sierra Williams & Jane A. Buxton. (2020) Accessing Take-Home Naloxone in British Columbia and the role of community pharmacies: Results from the analysis of administrative data. PLOS ONE 15:9, pages e0238618.
Crossref
Dino Luethi & Matthias E. Liechti. (2020) Designer drugs: mechanism of action and adverse effects. Archives of Toxicology 94:4, pages 1085-1133.
Crossref
Reuben J. Strayer, Kathryn Hawk, Bryan D. Hayes, Andrew A. Herring, Eric Ketcham, Alexis M. LaPietra, Joshua J. Lynch, Sergey Motov, Zachary Repanshek, Scott G. Weiner & Lewis S. Nelson. (2020) Management of Opioid Use Disorder in the Emergency Department: A White Paper Prepared for the American Academy of Emergency Medicine. The Journal of Emergency Medicine 58:3, pages 522-546.
Crossref
Olivia Magwood, Ginetta Salvalaggio, Michaela Beder, Claire Kendall, Victoire Kpade, Wahab Daghmach, Gilbert Habonimana, Zack Marshall, Ellen Snyder, Tim O’Shea, Robin Lennox, Helen Hsu, Peter Tugwell & Kevin Pottie. (2020) The effectiveness of substance use interventions for homeless and vulnerably housed persons:  A systematic review of systematic reviews on supervised consumption facilities, managed alcohol programs, and pharmacological agents for opioid use disorder. PLOS ONE 15:1, pages e0227298.
Crossref
Hyo-Sun You, Jane Ha, Cyra-Y. Kang, Leeseul Kim, Jinah Kim, Jay J. Shen, Seong-Min Park, Sung-Youn Chun, Jinwook Hwang, Takashi Yamashita, Se Won Lee, Georgia Dounis, Yong-Jae Lee, Dong-Hun Han, David Byun, Ji Won Yoo & Hee-Taik Kang. (2020) Regional variation in states’ naloxone accessibility laws in association with opioid overdose death rates-Observational study (STROBE compliant). Medicine 99:22, pages e20033.
Crossref
Lindsay Victoria Shaw, Jessica Moe, Roy Purssell, Jane A. Buxton, Jesse Godwin, Mary M. Doyle-Waters, Penelope M. A. Brasher, Jeffrey P. Hau, Jason Curran & Corinne M. Hohl. (2019) Naloxone interventions in opioid overdoses: a systematic review protocol. Systematic Reviews 8:1.
Crossref
Ronald B. Moss & Dennis J. Carlo. (2019) Higher doses of naloxone are needed in the synthetic opioid era. Substance Abuse Treatment, Prevention, and Policy 14:1.
Crossref
Sophie Salle, Sandra Bodeau, Alice Dhersin, Mathilde Ferdonnet, Ruben Goncalves, Marie Lenski, Benjamin Lima, Marie Martin, Jonathan Outreville, Jules Vaucel & Nicolas Fabresse. (2019) Novel synthetic opioids: A review of the literature. Toxicologie Analytique et Clinique 31:4, pages 298-316.
Crossref
Chloe J. Jordan, Jianjing Cao, Amy Hauck Newman & Zheng-Xiong Xi. (2019) Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine. Neuropharmacology 158, pages 107609.
Crossref
John Strang, Rebecca McDonald, Gabrielle Campbell, Louisa Degenhardt, Suzanne Nielsen, Alison Ritter & Ola Dale. (2019) Take-Home Naloxone for the Emergency Interim Management of Opioid Overdose: The Public Health Application of an Emergency Medicine. Drugs 79:13, pages 1395-1418.
Crossref
Joseph V. Pergolizzi, Jo A. Lequang, Steven Passik & Flaminia Coluzzi. (2019) Using opioid therapy for pain in clinically challenging situations: questions for clinicians. Minerva Anestesiologica 85:8.
Crossref
Bahar Dhowan, Jongcheon Lim, Michael D. MacLean, Alycia G. Berman, Min Ku Kim, Qi Yang, Jacqueline Linnes, Chi Hwan Lee, Craig J. Goergen & Hyowon Lee. (2019) Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose. Journal of Controlled Release 306, pages 130-137.
Crossref
Jacob A. Lebin, Betty C. Chen & Matthew J. Valento. (2019) Reversal of Pediatric Opioid Toxicity with Take-Home Naloxone: a Case Report. Journal of Medical Toxicology 15:2, pages 134-135.
Crossref
Senad Handanagic, Ivana Bozicevic, Mario Sekerija, George W. Rutherford & Josip Begovac. (2019) Overdose mortality rates in Croatia and factors associated with self-reported drug overdose among persons who inject drugs in three Croatian cities. International Journal of Drug Policy 64, pages 95-102.
Crossref
Amy Bachyrycz, Mikiko Y. Takeda, Kristina Wittstrom & Barry Bleske. (2019) Opioid overdose response training in pharmacy education: An analysis of students’ perception of naloxone use for opioid overdose prevention. Currents in Pharmacy Teaching and Learning 11:2, pages 166-171.
Crossref
Florence Noble & Nicolas Marie. (2019) Management of Opioid Addiction With Opioid Substitution Treatments: Beyond Methadone and Buprenorphine. Frontiers in Psychiatry 9.
Crossref
Esther Blessing, Sanya Virani & John Rotrosen. 2020. Substance Use Disorders. Substance Use Disorders 167 202 .
Paolo Frisoni, Erica Bacchio, Sabrine Bilel, Anna Talarico, Rosa Gaudio, Mario Barbieri, Margherita Neri & Matteo Marti. (2018) Novel Synthetic Opioids: The Pathologist’s Point of View. Brain Sciences 8:9, pages 170.
Crossref
Robert B Dunne. (2018) Prescribing naloxone for opioid overdose intervention. Pain Management 8:3, pages 197-208.
Crossref
Patil Armenian, Kathy T. Vo, Jill Barr-Walker & Kara L. Lynch. (2018) Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review. Neuropharmacology 134, pages 121-132.
Crossref
Joanna G. Katzman, Mikiko Y. Takeda, Snehal R. Bhatt, Monica Moya Balasch, Nina Greenberg & Howard Yonas. (2018) An Innovative Model for Naloxone Use Within an OTP Setting: A Prospective Cohort Study. Journal of Addiction Medicine 12:2, pages 113-118.
Crossref
Alex Wang & Aaron S. Kesselheim. (2021) Government Patent Use to Address the Rising Cost of Naloxone: 28 U.S.C. § 1498 and Evzio. Journal of Law, Medicine & Ethics 46:2, pages 472-484.
Crossref
Michael Evans-Brown & Roumen Sedefov. 2018. New Psychoactive Substances. New Psychoactive Substances 3 49 .
Matthew P. Prekupec, Peter A. Mansky & Michael H. Baumann. (2017) Misuse of Novel Synthetic Opioids: A Deadly New Trend. Journal of Addiction Medicine 11:4, pages 256-265.
Crossref
Amanda Roxburgh, Shane Darke, Allison M. Salmon, Timothy Dobbins & Marianne Jauncey. (2017) Frequency and severity of non-fatal opioid overdoses among clients attending the Sydney Medically Supervised Injecting Centre. Drug and Alcohol Dependence 176, pages 126-132.
Crossref
Joshua L. Akers, Ryan N. Hansen & Ryan D. Oftebro. (2017) Implementing take-home naloxone in an urban community pharmacy. Journal of the American Pharmacists Association 57:2, pages S161-S167.
Crossref
Wayne Hall & John Strang. (2017) Value for money in reducing opioid-related deaths. The Lancet Public Health 2:3, pages e124-e125.
Crossref
Anthony J. Tomassoni, Kathryn F. Hawk, Karen Jubanyik, Daniel P. Nogee, Thomas Durant, Kara L. Lynch, Rushaben Patel, David Dinh, Andrew Ulrich & Gail D’Onofrio. (2017) Multiple Fentanyl Overdoses — New Haven, Connecticut, June 23, 2016. MMWR. Morbidity and Mortality Weekly Report 66:4, pages 107-111.
Crossref
Robert B. Raffa, Robert TaylorJr.Jr., Joseph V. PergolizziJr.Jr., Srinivas Nalamachu, Eric S. Edwards & Evan T. Edwards. (2016) Application of human factors engineering (HFE) to the design of a naloxone auto-injector for the treatment of opioid emergencies. Drug Delivery and Translational Research 7:1, pages 1-10.
Crossref
Richard Gentry Wilkerson, Hong K. Kim, Thomas Andrew Windsor & Darren P. Mareiniss. (2016) The Opioid Epidemic in the United States. Emergency Medicine Clinics of North America 34:2, pages e1-e23.
Crossref
Marco L.A. Sivilotti. (2016) Flumazenil, naloxone and the ‘coma cocktail’. British Journal of Clinical Pharmacology 81:3, pages 428-436.
Crossref
Euan A. Sandilands & D Nicholas Bateman. (2016) Opioids. Medicine 44:3, pages 187-189.
Crossref
Hong K. Kim & Lewis S. Nelson. (2015) Reversal of Opioid-Induced Ventilatory Depression Using Low-Dose Naloxone (0.04?mg): a Case Series. Journal of Medical Toxicology 12:1, pages 107-110.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.