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Original Articles

Vesicular systems for delivering conventional small organic molecules and larger macromolecules to and through human skin

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Pages 149-163 | Published online: 24 Feb 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Sara Salatin, Farzaneh Lotfipour & Mitra Jelvehgari. (2019) A brief overview on nano-sized materials used in the topical treatment of skin and soft tissue bacterial infections. Expert Opinion on Drug Delivery 16:12, pages 1313-1331.
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Dana Kawar & Hamdy Abdelkader. (2019) Hyaluronic acid gel-core liposomes (hyaluosomes) enhance skin permeation of ketoprofen. Pharmaceutical Development and Technology 24:8, pages 947-953.
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Rania K. Eid, Ebtessam A. Essa & Gamal M. El Maghraby. (2019) Essential oils in niosomes for enhanced transdermal delivery of felodipine. Pharmaceutical Development and Technology 24:2, pages 157-165.
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Salma M. Mohyeldin, Mohammed M. Mehanna & Nazik A. Elgindy. (2016) Superiority of liquid crystalline cubic nanocarriers as hormonal transdermal vehicle: comparative human skin permeation-supported evidence. Expert Opinion on Drug Delivery 13:8, pages 1049-1064.
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Abdul Ahad, Mohd. Aqil, Kanchan Kohli, Yasmin Sultana & Mohd. Mujeeb. (2016) Nano vesicular lipid carriers of angiotensin II receptor blocker: Anti-hypertensive and skin toxicity study in focus. Artificial Cells, Nanomedicine, and Biotechnology 44:3, pages 1002-1007.
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Gamal M. El Maghraby, Mona F. Arafa & Mohamed A. Osman. (2014) Microemulsion for simultaneous transdermal delivery of benzocaine and indomethacin: in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy 40:12, pages 1637-1644.
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Nurul Fadhilah Kamalul Aripin, Rauzah Hashim, Thorsten Heidelberg, Dong-Keon Kweon & Hyun Jin Park. (2013) Effect of vesicle's membrane packing behaviour on skin penetration of model lipophilic drug. Journal of Microencapsulation 30:3, pages 265-273.
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Nina Dragicevic-Curic & Alfred Fahr. (2012) Liposomes in topical photodynamic therapy. Expert Opinion on Drug Delivery 9:8, pages 1015-1032.
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B Geusens, N Sanders, T Prow, M Van Gele & J Lambert. (2009) Cutaneous short-interfering RNA therapy. Expert Opinion on Drug Delivery 6:12, pages 1333-1349.
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Articles from other publishers (46)

Angela Bonaccorso, Anna Privitera, Margherita Grasso, Sonya Salamone, Claudia Carbone, Rosario Pignatello, Teresa Musumeci, Filippo Caraci & Giuseppe Caruso. (2023) The Therapeutic Potential of Novel Carnosine Formulations: Perspectives for Drug Development. Pharmaceuticals 16:6, pages 778.
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Reza Boshrouyeh, Samar Amari, Mohammad Boshrouyeh Ghandashtani, Seyed Ebrahim Alavi & Hasan Ebrahimi Shahmabadi. (2023) A topical gel nanoformulation of amphotericin B (AmB) for the treatment of cutaneous leishmaniasis (CL). Journal of Sol-Gel Science and Technology 105:3, pages 768-780.
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Sonia Pandey, Purnima Tripathi, Arti Gupta & Jitendra Singh Yadav. (2021) A comprehensive review on possibilities of treating psoriasis using dermal cyclosporine. Drug Delivery and Translational Research 12:7, pages 1541-1555.
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Despoina Despotopoulou, Nefeli Lagopati, Stergios Pispas, Maria Gazouli, Costas Demetzos & Natassa Pippa. (2022) The technology of transdermal delivery nanosystems: from design and development to preclinical studies. International Journal of Pharmaceutics 611, pages 121290.
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Sana Kalave, Bappaditya Chatterjee, Parth Shah & Ambikanandan Misra. (2021) Transdermal Delivery of Macromolecules Using Nano Lipid Carriers. Current Pharmaceutical Design 27:42, pages 4330-4340.
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Adrian Williams. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 507 534 .
Vijay Mishra, Manvendra Singh, Yachana Mishra, Nitin Charbe, Pallavi Nayak, Kalvatala Sudhakar, Alaa A. A. Aljabali, Seyed H. Shahcheraghi, Hamid Bakshi, Ángel Serrano-Aroca & Murtaza M. Tambuwala. (2021) Nanoarchitectures in Management of Fungal Diseases: An Overview. Applied Sciences 11:15, pages 7119.
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Syed Mahmood, Bappaditya Chatterjee & Uttam Kumar Mandal. (2021) Pharmacokinetic evaluation of the synergistic effect of raloxifene loaded transfersomes for transdermal delivery. Journal of Drug Delivery Science and Technology 63, pages 102545.
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Ritika Gupta & Amrish Kumar. (2021) Transfersomes: The Ultra-Deformable Carrier System for Non-Invasive Delivery of Drug. Current Drug Delivery 18:4, pages 408-420.
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Mi So Lee, Ju Won Lee, Su Ji Kim, Oanh‐Vu Pham‐Nguyen, Jongmin Park, Ju Hyun Park, Young Mee Jung, Jun Bae Lee & Hyuk Sang Yoo. (2021) Comparison Study of the Effects of Cationic Liposomes on Delivery across 3D Skin Tissue and Whitening Effects in Pigmented 3D Skin. Macromolecular Bioscience 21:5, pages 2000413.
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Drashti Patel & Bappaditya Chatterjee. (2021) Identifying Underlying Issues Related to the Inactive Excipients of Transfersomes based Drug Delivery System. Current Pharmaceutical Design 27:7, pages 971-980.
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Nimmathota Madhavi, Beeravelli Sudhakar & K. V. N. Suresh Reddy. 2021. Smart Nanomaterials in Biomedical Applications. Smart Nanomaterials in Biomedical Applications 487 506 .
Ahmed Alaa Kassem & Sameh Hosam Abd El-Alim. 2021. Nanopharmaceuticals: Principles and Applications Vol. 2. Nanopharmaceuticals: Principles and Applications Vol. 2 155 209 .
Suresh Kumar Sahu, Rakesh Raj, Pooja Mongia Raj & Ram Alpana. (2020) Topical Lipid Based Drug Delivery Systems for Skin Diseases: A Review. Current Drug Therapy 15:4, pages 283-298.
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Ying-Chen Cheng, Tzong Shiun Li, Hong Lin Su, Po Chun Lee & Hui-Min David Wang. (2020) Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care. Molecules 25:21, pages 5051.
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Antonella Barone, Maria Chiara Cristiano, Felisa Cilurzo, Marcello Locatelli, Dalila Iannotta, Luisa Di Marzio, Christian Celia & Donatella Paolino. (2020) Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery. Colloids and Surfaces B: Biointerfaces 193, pages 111152.
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Mengyang Liu, Jingyuan Wen & Manisha Sharma. (2020) Solid Lipid Nanoparticles for Topical Drug Delivery: Mechanisms, Dosage Form Perspectives, and Translational Status. Current Pharmaceutical Design 26:27, pages 3203-3217.
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Maria Chiara Cristiano, Francesca Froiio, Antonia Mancuso, Michelangelo Iannone, Massimo Fresta, Serena Fiorito, Christian Celia & Donatella Paolino. (2020) In vitro and in vivo trans-epidermal water loss evaluation following topical drug delivery systems application for pharmaceutical analysis. Journal of Pharmaceutical and Biomedical Analysis 186, pages 113295.
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Sameh Hosam Abd El-Alim, Abeer Salama & Asmaa Badawy Darwish. (2020) Provesicular elastic carriers of Simvastatin for enhanced wound healing activity: An in-vitro/in-vivo study. International Journal of Pharmaceutics 585, pages 119470.
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Roland Böttger, Griffin Pauli, Po-Han Chao, Nojoud AL Fayez, Lukas Hohenwarter & Shyh-Dar Li. (2020) Lipid-based nanoparticle technologies for liver targeting. Advanced Drug Delivery Reviews 154-155, pages 79-101.
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Bibhash C. Mohanta, Narahari N. Palei, Vijayaraj Surendran, Subas C. Dinda, Jayaraman Rajangam, Jyotirmoy Deb & Biswa M. Sahoo. (2019) Lipid Based Nanoparticles: Current Strategies for Brain Tumor Targeting. Current Nanomaterials 4:2, pages 84-100.
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Monica Sharma. 2019. Applications of Targeted Nano Drugs and Delivery Systems. Applications of Targeted Nano Drugs and Delivery Systems 499 550 .
Zhen Zhang, Jun Chen, Jun Huang, Yan Wo, Yixin Zhang & Xiangdong Chen. (2018) Experimental Study of 5-fluorouracil Encapsulated Ethosomes Combined with CO2 Fractional Laser to Treat Hypertrophic Scar. Nanoscale Research Letters 13:1.
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Noha W. El Khayat, Ahmed A. Donia, Omer Y. Mady & Gamal M. El Maghraby. (2018) Optimization of eugenol microemulsion for transdermal delivery of indomethacin. Journal of Drug Delivery Science and Technology 48, pages 311-318.
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Zora Rukavina, Maja Šegvić Klarić, Jelena Filipović-Grčić, Jasmina Lovrić & Željka Vanić. (2018) Azithromycin-loaded liposomes for enhanced topical treatment of methicillin-resistant Staphyloccocus aureus (MRSA) infections. International Journal of Pharmaceutics 553:1-2, pages 109-119.
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Maira Gaspar Tosato, Julie V. Maya Girón, Airton A. Martin, Vamshi Krishna Tippavajhala, Mónica Fernández Lorenzo de Mele & Lelia Dicelio. (2018) Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes. Materials Science and Engineering: C 90, pages 356-364.
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Kyounghee Shin, Hayoung Choi, Sun Kwang Song, Ji Won Yu, Jin Yong Lee, Eun Ji Choi, Dong Hee Lee, Sun Hee Do & Jin Woong Kim. (2018) Nanoemulsion Vehicles as Carriers for Follicular Delivery of Luteolin. ACS Biomaterials Science & Engineering.
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Thumuganti Gayathri, A. Vijayalakshmi, Sreejith Mangalath, Joshy Joseph, N. Madhusudhana Rao & Surya Prakash Singh. (2018) Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy. ACS Medicinal Chemistry Letters 9:4, pages 323-327.
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A. Behtash Oskuie, S.A. Nasrollahi & S. Nafisi. (2018) Design, synthesis of novel vesicular systems using turpentine as a skin permeation enhancer. Journal of Drug Delivery Science and Technology 43, pages 327-332.
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Gamal M. El Maghraby, Mona F. Arafa & Ebtessam A. Essa. 2018. Applications of Nanocomposite Materials in Drug Delivery. Applications of Nanocomposite Materials in Drug Delivery 469 490 .
Yibang Zhang, Weibeng Ng, Xue Feng, Fangying Cao & Huaxi Xu. (2017) Lipid vesicular nanocarrier: Quick encapsulation efficiency determination and transcutaneous application. International Journal of Pharmaceutics 516:1-2, pages 225-230.
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Elisabetta Esposito, Markus Drechsler, Nicolas Huang, Gabriella Pavoni, Rita Cortesi, Debora Santonocito & Carmelo Puglia. (2016) Ethosomes and organogels for cutaneous administration of crocin. Biomedical Microdevices 18:6.
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Gamal M. El Maghraby. 2016. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 137 145 .
Gamal M. El Maghraby. 2016. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 111 119 .
Nina Dragicevic, Daya Dass Verma & Alfred Fahr. 2016. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 77 92 .
Susan Hua. (2015) Lipid-based nano-delivery systems for skin delivery of drugs and bioactives. Frontiers in Pharmacology 6.
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Gamal M. El Maghraby, Amal A. Ahmed & Mohamed A. Osman. (2015) Penetration enhancers in proniosomes as a new strategy for enhanced transdermal drug delivery. Saudi Pharmaceutical Journal 23:1, pages 67-74.
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Jelena Predic Atkinson, Howard I. Maibach & Nina Dragicevic. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 93 108 .
Zhen Zhang, Yan Wo, Yixin Zhang, Danru Wang, Rong He, Huijin Chen & Daxiang Cui. (2012) In vitro study of ethosome penetration in human skin and hypertrophic scar tissue. Nanomedicine: Nanotechnology, Biology and Medicine 8:6, pages 1026-1033.
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Nina Østergaard Knudsen, Stine Rønholt, Ragnhild Djønne Salte, Lene Jorgensen, Thorsten Thormann, Line Hollesen Basse, Jens Hansen, Sven Frokjaer & Camilla Foged. (2012) Calcipotriol delivery into the skin with PEGylated liposomes. European Journal of Pharmaceutics and Biopharmaceutics 81:3, pages 532-539.
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Nathalie Schleich & Véronique Préat. 2012. Nanostructured Biomaterials for Overcoming Biological Barriers. Nanostructured Biomaterials for Overcoming Biological Barriers 316 325 .
Maria Bernadete Riemma Pierre & Irina dos Santos Miranda Costa. (2011) Liposomal systems as drug delivery vehicles for dermal and transdermal applications. Archives of Dermatological Research 303:9.
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Barbara Geusens, Tine Strobbe, Stefanie Bracke, Peter Dynoodt, Niek Sanders, Mireille Van Gele & Jo Lambert. (2011) Lipid-mediated gene delivery to the skin. European Journal of Pharmaceutical Sciences 43:4, pages 199-211.
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A. Gillet, P. Compère, F. Lecomte, P. Hubert, E. Ducat, B. Evrard & G. Piel. (2011) Liposome surface charge influence on skin penetration behaviour. International Journal of Pharmaceutics 411:1-2, pages 223-231.
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A. Gillet, B. Evrard & G. Piel. (2011) Liposomes and parameters affecting their skin penetration behaviour. Journal of Drug Delivery Science and Technology 21:1, pages 35-42.
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V. Rai, I. Ghosh, S. Bose, S.M.C. Silva, P. Chandra & B. Michniak-Kohn. (2010) A transdermal review on permeation of drug formulations, modifier compounds and delivery methods. Journal of Drug Delivery Science and Technology 20:2, pages 75-88.
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