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Targeting anti-HIV drugs to the CNS

, PhD, , PhD & , PhD
Pages 771-784 | Published online: 30 Jun 2009

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A. Borrajo, C. Spuch, M. A. Penedo, J. M. Olivares & R. C. Agís-Balboa. (2021) Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis. Annals of Medicine 53:1, pages 43-69.
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Chandrakant Kokare, Dhanashri Koli, Dnyandev Gadhave, Chandrashekhar Mote & Gajendra Khandekar. (2020) Efavirenz-loaded intranasal microemulsion for crossing blood-CNS interfaces in neuronal-AIDS: pharmacokinetic and in vivo safety evaluation. Pharmaceutical Development and Technology 25:1, pages 28-39.
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David Lembo, Manuela Donalisio, Andrea Civra, Monica Argenziano & Roberta Cavalli. (2018) Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections. Expert Opinion on Drug Delivery 15:1, pages 93-114.
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Maria João Gomes, José das Neves & Bruno Sarmento. (2014) Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system. International Journal of Nanomedicine 9, pages 1757-1769.
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Dina Tsukrov & Ekaterina Dadachova. (2014) The potential of radioimmunotherapy as a new hope for HIV patients. Expert Review of Clinical Immunology 10:5, pages 553-555.
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Abeer M Al-Ghananeem, Michael Smith, Maria L Coronel & Hieu Tran. (2013) Advances in brain targeting and drug delivery of anti-HIV therapeutic agents. Expert Opinion on Drug Delivery 10:7, pages 973-985.
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Najeh Maissar Khalil, Emerson Carraro, Luiz Fernando Cótica & Rubiana Mara Mainardes. (2011) Potential of polymeric nanoparticles in AIDS treatment and prevention. Expert Opinion on Drug Delivery 8:1, pages 95-112.
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Rama Mallipeddi & Lisa Cencia Rohan. (2010) Progress in antiretroviral drug delivery using nanotechnology. International Journal of Nanomedicine 5, pages 533-547.
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Caroline A Lee, Jack A Cook, Eric L Reyner & Dennis A Smith. (2010) P-glycoprotein related drug interactions: clinical importance and a consideration of disease states. Expert Opinion on Drug Metabolism & Toxicology 6:5, pages 603-619.
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Crossref
. 2016. Handbook of Clinical Nanomedicine. Handbook of Clinical Nanomedicine 1425 1452 .
Md Ataul Islam & Tahir S. Pillay. (2016) Structural requirements for potential HIV-integrase inhibitors identified using pharmacophore-based virtual screening and molecular dynamics studies. Molecular BioSystems 12:3, pages 982-993.
Crossref
Simeon K. Adesina & Emmanuel O. Akala. (2015) Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy. Molecular Pharmaceutics 12:12, pages 4175-4187.
Crossref
Paulo Emílio Corrêa Leite, Mariana Rodrigues Pereira & José Mauro Granjeiro. (2015) Hazard effects of nanoparticles in central nervous system: Searching for biocompatible nanomaterials for drug delivery. Toxicology in Vitro 29:7, pages 1653-1660.
Crossref
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Crossref
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Crossref
Pavan Puligujja, Shantanu S. Balkundi, Lindsey M. Kendrick, Hannah M. Baldridge, James R. Hilaire, Aditya N. Bade, Prasanta K. Dash, Gang Zhang, Larisa Y. Poluektova, Santhi Gorantla, Xin-Ming Liu, Tianlei Ying, Yang Feng, Yanping Wang, Dimiter S. Dimitrov, JoEllyn M. McMillan & Howard E. Gendelman. (2015) Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations. Biomaterials 41, pages 141-150.
Crossref
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Crossref
Supriya D. Mahajan, Ravikumar Aalinkeel, Jessica L. Reynolds, Bindukumar B. Nair, Manoj J. Mammen, Lili Dai, Paras N. Prasad & Stanley A. Schwartz. 2015. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases 251 268 .
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Crossref
A Singhal, V B Morris, V Labhasetwar & A Ghorpade. (2013) Nanoparticle-mediated catalase delivery protects human neurons from oxidative stress. Cell Death & Disease 4:11, pages e903-e903.
Crossref
Pavan Puligujja, JoEllyn McMillan, Lindsey Kendrick, Tianyuzi Li, Shantanu Balkundi, Nathan Smith, Ram S. Veerubhotla, Benson J. Edagwa, Alexander V. Kabanov, Tatiana Bronich, Howard E. Gendelman & Xin-Ming Liu. (2013) Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections. Nanomedicine: Nanotechnology, Biology and Medicine 9:8, pages 1263-1273.
Crossref
Lesego Tshweu, Lebogang Katata, Lonji Kalombo & Hulda Swai. (2013) Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment. Journal of Nanoparticle Research 15:11.
Crossref
Nagsen Gautam, Upal Roy, Shantanu Balkundi, Pavan Puligujja, Dongwei Guo, Nathan Smith, Xin-Ming Liu, Benjamin Lamberty, Brenda Morsey, Howard S. Fox, JoEllyn McMillan, Howard E. Gendelman & Yazen Alnouti. (2013) Preclinical Pharmacokinetics and Tissue Distribution of Long-Acting Nanoformulated Antiretroviral Therapy. Antimicrobial Agents and Chemotherapy 57:7, pages 3110-3120.
Crossref
Iris R. Bell, Gary E. Schwartz, Nancy N. Boyer, Mary Koithan & Audrey J. Brooks. (2013) Advances in integrative nanomedicine for improving infectious disease treatment in public health. European Journal of Integrative Medicine 5:2, pages 126-140.
Crossref
Rafik Naccache, Emma Martín Rodríguez, Nicoleta Bogdan, Francisco Sanz-Rodríguez, Maria del Carmen Iglesias de la Cruz, Ángeles Juarranz de la Fuente, Fiorenzo Vetrone, Daniel Jaque, José García Solé & John A. Capobianco. (2012) High Resolution Fluorescence Imaging of Cancers Using Lanthanide Ion-Doped Upconverting Nanocrystals. Cancers 4:4, pages 1067-1105.
Crossref
Hilda A. Namanja, Dana Emmert, David A. Davis, Christopher Campos, David S. Miller, Christine A. Hrycyna & Jean Chmielewski. (2011) Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-Glycoprotein at the Blood–Brain Barrier with Prodrug Abacavir Dimers. Journal of the American Chemical Society 134:6, pages 2976-2980.
Crossref
Lindsay M Ferguson & Lisa Cencia Rohan. (2011) The importance of the vaginal delivery route for antiretrovirals in HIV prevention. Therapeutic Delivery 2:12, pages 1535-1550.
Crossref
Ranjita Shegokar & Kamalinder K. Singh. (2011) Surface modified nevirapine nanosuspensions for viral reservoir targeting: In vitro and in vivo evaluation. International Journal of Pharmaceutics 421:2, pages 341-352.
Crossref
Irena Kadiu, Ari Nowacek, JoEllyn McMillan & Howard E Gendelman. (2011) Macrophage endocytic trafficking of antiretroviral nanoparticles. Nanomedicine 6:6, pages 975-994.
Crossref
Kathleen BorgmannKavitha S. RaoVinod LabhasetwarAnuja Ghorpade. (2011) Efficacy of Tat-Conjugated Ritonavir-Loaded Nanoparticles in Reducing HIV-1 Replication in Monocyte-Derived Macrophages and Cytocompatibility with Macrophages and Human Neurons. AIDS Research and Human Retroviruses 27:8, pages 853-862.
Crossref
Ari S. Nowacek, Shantanu Balkundi, JoEllyn McMillan, Upal Roy, Andrea Martinez-Skinner, R. Lee Mosley, Georgette Kanmogne, Alexander V. Kabanov, Tatiana Bronich & Howard E. Gendelman. (2011) Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages. Journal of Controlled Release 150:2, pages 204-211.
Crossref
Jiehua Zhou & John J. Rossi. 2011. Intracellular Delivery. Intracellular Delivery 97 123 .
Serguei V Vinogradov, Larisa Y Poluektova, Edward Makarov, Trevor Gerson & Madapathage T Senanayake. (2010) Nano-NRTIs: Efficient Inhibitors of HIV Type-1 in Macrophages with a Reduced Mitochondrial Toxicity. Antiviral Chemistry and Chemotherapy 21:1, pages 1-14.
Crossref
Ranjita Misra, Sarbari Acharya & Sanjeeb K. Sahoo. (2010) Cancer nanotechnology: application of nanotechnology in cancer therapy. Drug Discovery Today 15:19-20, pages 842-850.
Crossref
Asli Ovat, Zhao Zhao Li, Christina Y. Hampton, Seneshaw A. Asress, Facundo M. Fernández, Jonathan D. Glass & James C. Powers. (2010) Peptidyl α-Ketoamides with Nucleobases, Methylpiperazine, and Dimethylaminoalkyl Substituents as Calpain Inhibitors. Journal of Medicinal Chemistry 53:17, pages 6326-6336.
Crossref
Luis Rivas, Juan Román Luque-Ortega, María Fernández-Reyes & David Andreu. (2010) Membrane-active peptides as anti-infectious agents. Journal of Applied Biomedicine 8:3, pages 159-167.
Crossref

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