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Expert Opinion on Drug Delivery Volume 8, 2011 - Issue 4
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Challenges and advances in the development of inhalable drug formulations for cystic fibrosis lung disease

Basma M Ibrahim Purdue University, College of Pharmacy, Department of Industrial and Physical Pharmacy, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA +1 765 496 9608; +1 765 494 6545; [email protected]
,
Michael D Tsifansky Advocate Lutheran General Children's Hospital, Divisions of Pediatric Critical Care Medicine and Pediatric Pulmonology, Department of Pediatrics, 1775 Dempster St, Park Ridge, IL 60068, USA
, MD,
Yan Yang Jilin University, College of Life Science, Research Center for Drug Metabolism, Changchun 130021, PR China
, PhD &
Yoon Yeo Purdue University, College of Pharmacy, Department of Industrial and Physical Pharmacy, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA +1 765 496 9608; +1 765 494 6545; [email protected]; Purdue University, Weldon School of Biomedical Engineering, West Lafayette, IN 47907, USA
, PhD
Pages 451-466 | Published online: 05 Mar 2011

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Zara Sheikh, Hui Xin Ong, Michele Pozzoli, Paul M Young & Daniela Traini. (2018) Is there a role for inhaled anti-inflammatory drugs in cystic fibrosis treatment?. Expert Opinion on Orphan Drugs 6:1, pages 69-84.
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Ivana d'Angelo, Claudia Conte, Agnese Miro, Fabiana Quaglia & Francesca Ungaro. (2014) Core–shell nanocarriers for cancer therapy. Part I: biologically oriented design rules. Expert Opinion on Drug Delivery 11:2, pages 283-297.
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Articles from other publishers (21)

Gemma Conte, Gabriella Costabile, Domizia Baldassi, Valeria Rondelli, Rosaria Bassi, Diego Colombo, Giulia Linardos, Ersilia V. Fiscarelli, Raffaella Sorrentino, Agnese Miro, Fabiana Quaglia, Paola Brocca, Ivana d’Angelo, Olivia M. Merkel & Francesca Ungaro. (2022) Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference?. ACS Applied Materials & Interfaces 14:6, pages 7565-7578.
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Nasser Alhajj, Niall J. O'Reilly & Helen Cathcart. (2022) Developing ciprofloxacin dry powder for inhalation: A story of challenges and rational design in the treatment of cystic fibrosis lung infection. International Journal of Pharmaceutics 613, pages 121388.
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Maliha Zahid, Timothy N. Feinstein, Anthony Oro, Molly Schwartz, Alex D. Lee & Cecilia W. Lo. (2020) Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia. Biomolecules 10:8, pages 1182.
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Cecilia Velino, Francesca Carella, Alessio Adamiano, Maurizio Sanguinetti, Alberto Vitali, Daniele Catalucci, Francesca Bugli & Michele Iafisco. (2019) Nanomedicine Approaches for the Pulmonary Treatment of Cystic Fibrosis. Frontiers in Bioengineering and Biotechnology 7.
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Joscelyn C. Mejías, Osric A. Forrest, Camilla Margaroli, David A. Frey Rubio, Liliana Viera, Jindong Li, Xin Xu, Amit Gaggar, Rabindra Tirouvanziam & Krishnendu Roy. (2019) Neutrophil-targeted, protease-activated pulmonary drug delivery blocks airway and systemic inflammation. JCI Insight 4:23.
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Caterina Cristallini, Niccoletta Barbani, Letizia Ventrelli, Chiara Summa, Sara Filippi, Tania Capelôa, Emanuela Vitale, Carlo Albera, Barbara Messore & Claudia Giachino. (2019) Biodegradable microparticles designed to efficiently reach and act on cystic fibrosis mucus barrier. Materials Science and Engineering: C 95, pages 19-28.
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Jun-Jie Koh, Shuimu Lin, Yang Bai, Wendy Wan Ling Sin, Thet Tun Aung, Jianguo Li, Verma Chandra, Konstantin Pervushin, Roger W. Beuerman & Shouping Liu. (2018) Antimicrobial activity profiles of Amphiphilic Xanthone derivatives are a function of their molecular Oligomerization. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860:11, pages 2281-2298.
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Sara I. Ruiz, Larry E. Bowen, Mark M. Bailey & Cory Berkland. (2018) Pulmonary Delivery of Ceftazidime for the Treatment of Melioidosis in a Murine Model. Molecular Pharmaceutics 15:3, pages 1371-1376.
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Elena Fernández Fernández, Nadine Bangel-Ruland, Katja Tomczak & Wolf-Michael Weber. (2016) Optimization of CFTR-mRNA transfection in human nasal epithelial cells. Translational Medicine Communications 1:1.
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Zimeng Wang & Samantha A. Meenach. (2016) Synthesis and Characterization of Nanocomposite Microparticles (nCmP) for the Treatment of Cystic Fibrosis-Related Infections. Pharmaceutical Research 33:8, pages 1862-1872.
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Xiao-Fei Yang, Ying Xu, Da-Sheng Qu & Hao-Ying Li. (2015) The influence of amino acids on aztreonam spray-dried powders for inhalation. Asian Journal of Pharmaceutical Sciences 10:6, pages 541-548.
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Abhijeet Pandey & Darshana S. Jain. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 151 172 .
Xiao-Fei Yang, Ying Xu, Da-Sheng Qu, Jian Zhu & Hao-Ying Li. (2015) Excipient-free, spray-dried powders for pulmonary aztreonam delivery. Journal of Drug Delivery Science and Technology 28, pages 7-10.
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Romain Merlos, Karim Amighi & Nathalie Wauthoz. (2014) Recent Developments in Inhaled Triazoles Against Invasive Pulmonary Aspergillosis. Current Fungal Infection Reports 8:4, pages 331-342.
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Nathalie Wauthoz & Karim Amighi. (2014) Phospholipids in pulmonary drug delivery. European Journal of Lipid Science and Technology 116:9, pages 1114-1128.
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Ivana d'Angelo, Claudia Conte, Maria Immacolata La Rotonda, Agnese Miro, Fabiana Quaglia & Francesca Ungaro. (2014) Improving the efficacy of inhaled drugs in cystic fibrosis: Challenges and emerging drug delivery strategies. Advanced Drug Delivery Reviews 75, pages 92-111.
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M. C. Gaspar, W. Couet, J.-C. Olivier, A. A. C. C. Pais & J. J. S. Sousa. (2013) Pseudomonas aeruginosa infection in cystic fibrosis lung disease and new perspectives of treatment: a review. European Journal of Clinical Microbiology & Infectious Diseases 32:10, pages 1231-1252.
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Hui Xin Ong, Daniela Traini, Rania Salama, Sandra D. Anderson, Evangelia Daviskas & Paul M. Young. (2013) The Effects of Mannitol on the Transport of Ciprofloxacin across Respiratory Epithelia. Molecular Pharmaceutics 10:8, pages 2915-2924.
Crossref
Francesca Ungaro, Ivana d' Angelo, Agnese Miro, Maria I La Rotonda & Fabiana Quaglia. (2012) Engineered PLGA nano- and micro-carriers for pulmonary delivery: challenges and promises. Journal of Pharmacy and Pharmacology 64:9, pages 1217-1235.
Crossref
Joy Conway. (2012) Lung imaging — Two dimensional gamma scintigraphy, SPECT, CT and PET. Advanced Drug Delivery Reviews 64:4, pages 357-368.
Crossref
Daniel J Smith, David W Reid & Scott C Bell. (2011) Treatment of pulmonary exacerbations in cystic fibrosis. Therapy 8:6, pages 623-643.
Crossref

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