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The development of rectal microbicides for HIV prevention

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Chang Liu, Yongqiang Kou, Xin Zhang, Hongbo Cheng, Xianzhi Chen & Shirui Mao. (2018) Strategies and industrial perspectives to improve oral absorption of biological macromolecules. Expert Opinion on Drug Delivery 15:3, pages 223-233.
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Tanushree Malik, Gaurav Chauhan, Goutam Rath, R. S. R. Murthy & Amit K. Goyal. (2017) “Fusion and binding inhibition” key target for HIV-1 treatment and pre-exposure prophylaxis: targets, drug delivery and nanotechnology approaches. Drug Delivery 24:1, pages 608-621.
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Heather A. Pines, Pamina M. Gorbach, Cathy J. Reback, Raphael J. Landovitz, Matt G. Mutchler & Ronald Mitsuyasu. (2014) Commercial lubricant use among HIV-negative men who have sex with men in Los Angeles: implications for the development of rectal microbicides for HIV prevention. AIDS Care 26:12, pages 1609-1618.
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Articles from other publishers (36)

Seul Ki Choi, José Bauermeister, Ryan C. Tingler, Sherri Johnson, Nicole Macagna, Ken Ho, Craig Hoesley, Albert Liu, Noel Kayange, Thesla Palanee-Phillips, Suwat Chariyalertsak, Pedro Gonzales, Jeanna M. Piper, Abigail Mnemba, Alinafe Kamanga, Annie Munthali, Daniel Gondwe, Linly Seyama, Yamikani Mbilizi, Mary Chadza, Josiah Mayani, Helen Rees, Kerushini Moodley, Krishnaveni Reddy, Andile Twala, Ashleigh Jacques, Tsitsi Nyamuzihwa, Nazneen Cassim, Ana Miranda, Diana Morales, Helen Chapa, Javier Valencia, Milagros Sabaduche, Karina Pareja, Katherine Milagros, Charri Macassi, Pongpun Saokhieo, Veruree Manoyos, Nataporn Kosachunhanan, Piyathida Sroysuwan, Allison Matthews, Amy Player, Andrea Thurman, Carol Mitchell, Christine O’Neill, Christy Pappalardo, Christopher Quan, Cindy Jacobson, Clifford Yip, Craig Hoesley, Danielle Camp, Deon Powell, Devika Singh, Diana Ng, Edward Livant, Elizabeth Brown, Emily Helms, Emily Schaeffer, Faye Heard, Gina Brown, Gustavo Doncel, Holly Gundacker, Hyman Scott, Jackie Fitzpatrick, James Gavel, Jenna Weber, Jennifer Schille, Jessica Webster, Jessica Maitz, Jillian Zemanek, Jim Pickett, Jonathan Lucas, Julie Nowak, Kathleen Dietz, Krissa Welch, Kristine Heath, Lisa Rohan, Lizardo Lacanlale, Lynn Mitterer, Lorna Richards, Marcus Bolton, Mei Song, Naana Cleland, Nicholas Ng, Nnennaya Okey-Igwe, Onkar Singh, Patricia Peters, Rebecca Giguere, Renee Weinman, Roberta Black, Scott Fields, Sharon Riddler, Sharon Hillier, Sherri Karas, Stacey Edick, Sufia Dadabhai, Susan Buchbinder, Taha Taha, Tarana Billups, Teri Senn, Theresa Wagner, Tim McCormick & Yuqing Jiao. (2023) A latent trajectory analysis of young sexual and gender minorities’ adherence to three rectal microbicide placebo formulations (MTN-035; a randomized crossover trial). BMC Public Health 23:1.
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Natalia Makarova, Tyana Singletary, M. Melissa Peet, James Mitchell, Angela Holder, Chuong Dinh, Vivek Agrahari, Maria Mendoza, Yi Pan, Walid Heneine, Meredith R. Clark, J. Gerardo García-Lerma, James M. Smith & Gustavo F. Doncel. (2022) Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaques. eBioMedicine 86, pages 104338.
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José A. BauermeisterRyan C. TinglerKen HoRachel ScheckterTara McClureJontraye DavisJeanna PiperBarbara A. FriedlandStacey EdickMei SongYuqing JiaoCraig W. HendrixCraig Hoesley. (2022) Acceptability of PC-1005 Gel Administered Rectally to HIV-1 Seronegative Adults at Three Different Volume Levels (MTN-037). AIDS Education and Prevention 34:4, pages 257-271.
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José A. Bauermeister, Ryan C. Tingler, Clara Dominguez, Eileen F. Dunne, Craig Hoesley, Ken Ho, Sherri Johnson, Jonathan Lucas, Nicole Macagna, Elizabeth Brown, Holly Gundacker, Melissa Peda, Cindy E. Jacobson, Lindsay Kramzer, Devika Singh, Charlene S. Dezzutti, Ratiya Pamela Kunjara Na Ayudhya, Mark A. Marzinke, Jeanna Piper, Bríd Devlin, Jeremy Nuttall, Ian McGowan, Craig W. Hendrix & Ross D. Cranston. (2021) Acceptability of a Dapivirine/Placebo Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-026). AIDS and Behavior 26:5, pages 1333-1346.
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José Neves & Bruno Sarmento. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 471 506 .
José A. BauermeisterRyan C. TinglerSherri JohnsonNicole MacagnaJonathan LucasClara Dominguez-IslasDaniel SzydloJulie NgoCindy E. JacobsonLindsay KramzerDevika SinghCharlene S. DezzuttiRatiya Pamela Kunjara Na AyudhyaJeanna PiperBríd DevlinCraig W. HendrixKen Ho. (2021) Acceptability of a Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-033 Study). AIDS Education and Prevention 33:5, pages 361-376.
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Branwen N. Owen, Mathieu M-Giroux, Sindy Matse, Zandile Mnisi, Stefan Baral, Sosthenes C. Ketende, Rebecca F. Baggaley & Marie-Claude Boily. (2020) Prevalence and correlates of anal intercourse among female sex workers in eSwatini. PLOS ONE 15:2, pages e0228849.
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Letícia Mesquita, Joana Galante, Rute Nunes, Bruno Sarmento & José das Neves. (2019) Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems. Pharmaceutics 11:3, pages 145.
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Mélanie Melo, Rute Nunes, Bruno Sarmento & José das Neves. (2018) Rectal administration of nanosystems: from drug delivery to diagnostics. Materials Today Chemistry 10, pages 128-141.
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Yannick L. Traore, Yufei Chen & Emmanuel A. Ho. (2018) Current State of Microbicide Development. Clinical Pharmacology & Therapeutics 104:6, pages 1074-1081.
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Rute Nunes, Francisca Araújo, Luisa Barreiros, Inês Bártolo, Marcela A. Segundo, Nuno Taveira, Bruno Sarmento & José das Neves. (2018) Noncovalent PEG Coating of Nanoparticle Drug Carriers Improves the Local Pharmacokinetics of Rectal Anti-HIV Microbicides. ACS Applied Materials & Interfaces 10:41, pages 34942-34953.
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William C. Goedel, John A. Schneider, H. Rhodes Hambrick, Noah T. Kreski, Jace G. Morganstein, Su Hyun Park, Ofole Mgbako & Dustin T. Duncan. (2017) Are Anal Sex Roles Associated with Preferences for Pre-Exposure Prophylaxis Administration Modalities Among Men Who Have Sex with Men?. Archives of Sexual Behavior 47:7, pages 2123-2133.
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Rute Nunes, Francisca Araújo, Joana Tavares, Bruno Sarmento & José das Neves. (2018) Surface modification with polyethylene glycol enhances colorectal distribution and retention of nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 130, pages 200-206.
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Xuanxuan Zhang, Jinquan Chen, Fei Yu, Chunyan Wang, Ruxia Ren, Qian Wang, Suiyi Tan, Shibo Jiang, Shuwen Liu & Lin Li. (2018) 3-Hydroxyphthalic Anhydride- Modified Rabbit Anti-PAP IgG as a Potential Bifunctional HIV-1 Entry Inhibitor. Frontiers in Microbiology 9.
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Lauren Girard, Kenzie Birse, Johanna B. Holm, Pawel Gajer, Mike S. Humphrys, David Garber, Patricia Guenthner, Laura Noël-Romas, Max Abou, Stuart McCorrister, Garrett Westmacott, Lin Wang, Lisa C. Rohan, Nobuyuki Matoba, Janet McNicholl, Kenneth E. Palmer, Jacques Ravel & Adam D. Burgener. (2018) Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates. Scientific Reports 8:1.
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José A. Bauermeister, R. Giguere, C. S. Leu, C. Dolezal, I. Febo, R. D. Cranston, K. Mayer, I. McGowan & A. Carballo-Diéguez. (2017) Patterns of a Rectal Microbicide Placebo Gel Use in a Preparatory Stage for a Phase I Trial Among Young Men Who Have Sex with Men. AIDS and Behavior 22:2, pages 412-420.
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Sandra Pinto-Cardoso, Nichole R. Klatt & Gustavo Reyes-Terán. (2018) Impact of antiretroviral drugs on the microbiome. Current Opinion in HIV and AIDS 13:1, pages 53-60.
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Tsai-Jung Wu, Hsiao-Yu Chiu, John Yu, Mafalda P. Cautela, Bruno Sarmento, José das Neves, Carme Catala, Nicolas Pazos-Perez, Luca Guerrini, Ramon A. Alvarez-Puebla, Sanja Vranješ-Đurić & Nenad L. Ignjatović. 2018. Nanotechnologies in Preventive and Regenerative Medicine. Nanotechnologies in Preventive and Regenerative Medicine 1 92 .
Shauna Stahlman, Carrie Lyons, Patrick S. Sullivan, Kenneth H. Mayer, Sean Hosein, Chris Beyrer & Stefan D. Baral. (2017) HIV incidence among gay men and other men who have sex with men in 2020: where is the epidemic heading?. Sexual Health 14:1, pages 5.
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Peter A. Newman, Michael P. Cameron, Surachet Roungprakhon, Suchon Tepjan & Riccardo Scarpa. (2015) Acceptability and Preferences for Hypothetical Rectal Microbicides among a Community Sample of Young Men Who Have Sex with Men and Transgender Women in Thailand: A Discrete Choice Experiment. AIDS and Behavior 20:11, pages 2588-2601.
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Andrew W. WoodhamJoseph G. SkeateAdriana M. SannaJulia R. TaylorDiane M. Da SilvaPaula M. CannonW. Martin Kast. (2016) Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment. AIDS Patient Care and STDs 30:7, pages 291-306.
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Ian McGowan, Ross D. Cranston, Kenneth H. Mayer, Irma Febo, Kathryn Duffill, Aaron Siegel, Jarret C. Engstrom, Alexyi Nikiforov, Seo-Young Park, Rhonda M. Brand, Cindy Jacobson, Rebecca Giguere, Curtis Dolezal, Timothy Frasca, Cheng-Shiun Leu, Jill L. Schwartz & Alex Carballo-Diéguez. (2016) Project Gel a Randomized Rectal Microbicide Safety and Acceptability Study in Young Men and Transgender Women. PLOS ONE 11:6, pages e0158310.
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Carolina Herrera, Naomi Armanasco, Javier García-Pérez, Paul Ziprin, Natalia Olejniczak, José Alcamí, Jeremy Nuttall & Robin J. Shattock. (2016) Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates. AIDS 30:7, pages 1015-1025.
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J. Bauermeister, R. Giguere, C. Dolezal, C. S. Leu, I. Febo, R. D. Cranston, K. Mayer, I. McGowan & A. Carballo-Diéguez. (2016) To Use a Rectal Microbicide, First Insert the Applicator: Gel and Applicator Satisfaction Among Young Men Who Have Sex With Men. AIDS Education and Prevention 28:1, pages 1-10.
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Carmen H. LogiePeter A. NewmanJames WeaverSurachet RoungkraphonSuchon Tepjan. (2016) HIV-Related Stigma and HIV Prevention Uptake Among Young Men Who Have Sex with Men and Transgender Women in Thailand. AIDS Patient Care and STDs 30:2, pages 92-100.
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Francisco LeyvaEdward J. FuchsRahul BakshiAlex Carballo-DieguezAna VentuneacChen YueBrian CaffoYong DuMichael TorbensonLiye LiGerald MullinLinda LeeLisa RohanPeter A. AntonCraig W. Hendrix. (2015) Simultaneous Evaluation of Safety, Acceptability, Pericoital Kinetics, and Ex Vivo Pharmacodynamics Comparing Four Rectal Microbicide Vehicle Candidates . AIDS Research and Human Retroviruses 31:11, pages 1089-1097.
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Daniel Sepúlveda-Crespo, Rafael Gómez, Francisco Javier De La Mata, José Luis Jiménez & Mª. Ángeles Muñoz-Fernández. (2015) Polyanionic carbosilane dendrimer-conjugated antiviral drugs as efficient microbicides: Recent trends and developments in HIV treatment/therapy. Nanomedicine: Nanotechnology, Biology and Medicine 11:6, pages 1481-1498.
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Douglas S. Krakower & Kenneth H. Mayer. (2015) Pre-Exposure Prophylaxis to Prevent HIV Infection: Current Status, Future Opportunities and Challenges. Drugs 75:3, pages 243-251.
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Verónica Briz, Daniel Sepúlveda-Crespo, Ana Rita Diniz, Pedro Borrego, Berta Rodes, Francisco Javier de la Mata, Rafael Gómez, Nuno Taveira & Mª Ángeles Muñoz-Fernández. (2015) Development of water-soluble polyanionic carbosilane dendrimers as novel and highly potent topical anti-HIV-2 microbicides. Nanoscale 7:35, pages 14669-14683.
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Pamina M. Gorbach, Heather Pines, Marjan Javanbakht, Robert E. Weiss, Robin Jeffries, Ross D. Cranston, Edward J. Fuchs, Marjan Hezerah, Stephen Brown, Alen Voskanian & Peter Anton. (2014) Order of Orifices. JAIDS Journal of Acquired Immune Deficiency Syndromes 67:4, pages 424-429.
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Kathryn E. Muessig & Myron S. Cohen. (2014) Advances in HIV Prevention for Serodiscordant Couples. Current HIV/AIDS Reports 11:4, pages 434-446.
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Rute Nunes, Bruno Sarmento & José das Neves. (2014) Formulation and delivery of anti-HIV rectal microbicides: Advances and challenges. Journal of Controlled Release 194, pages 278-294.
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Jos? A. Fern?ndez Romero, Pedro I. Gil, Viviana R?Melissa Robbiani & Gabriela Paglini. (2014) Microbicidas para la prevenci?n de infecciones de transmisi?n sexual: estado actual y estrategias para la evaluaci?n precl?nica de nuevos candidatos. Revista Argentina de Microbiolog?a 46:3, pages 256-268.
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Ian McGowan. (2014) An Overview of Antiretroviral Pre-Exposure Prophylaxis of HIV Infection. American Journal of Reproductive Immunology 71:6, pages 624-630.
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Mackenzie L. Cottrell & Angela D.M. Kashuba. (2014) Topical microbicides and HIV prevention in the female genital tract. The Journal of Clinical Pharmacology 54:6, pages 603-615.
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Natalia Makarova, Tyana Singletary, M. Melissa Peet, James Mitchell, Angela Holder, Chuong Dinh, Vivek Agrahari, Maria Mendoza, Yi Pan, Walid Heneine, Meredith R. Clark, J. Gerardo Garcia-Lerma, James M. Smith & Gustavo F. Doncel. (2022) Pharmacokinetics and Efficacy of Topical Inserts Containing Tenofovir Alafenamide Fumarate and Elvitegravir Administered Rectally in Macaques. SSRN Electronic Journal.
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