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Complexity in the therapeutic delivery of RNAi medicines: an analytical challenge

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Seyma Ceylan, Fatemeh Bahadori & Fahri Akbas. (2020) Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment. Pharmaceutical Development and Technology 25:7, pages 855-864.
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Fanguo Hu, Hanjie Wang, Shuangnan Zhang, Yao Peng, Lin Su, Jin Chang & Gang Liu. (2015) Inhibition of myeloid differentiation factor 88 signaling mediated by histidine-grafted poly(β-amino ester) ester nanovector induces donor-specific liver allograft tolerance. International Journal of Nanomedicine 10, pages 4367-4382.
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Lalitkumar K. Vora, Amol D. Gholap, Keshava Jetha, Raghu Raj Singh Thakur, Hetvi K. Solanki & Vivek P. Chavda. (2023) Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design. Pharmaceutics 15:7, pages 1916.
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Tianqi Wang, Hongqi Zhao, Shaoze Jing, Yang Fan, Gaohong Sheng, Qing Ding, Chaoxu Liu, Hua Wu & Yang Liu. (2023) Magnetofection of miR-21 promoted by electromagnetic field and iron oxide nanoparticles via the p38 MAPK pathway contributes to osteogenesis and angiogenesis for intervertebral fusion. Journal of Nanobiotechnology 21:1.
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Jinghuan Huang, Muyu Yu, Wenjing Yin, Bo Liang, Ang Li, Jingfeng Li, Xiaolin Li, Shichang Zhao & Fang Liu. (2021) Development of a novel RNAi therapy: Engineered miR-31 exosomes promoted the healing of diabetic wounds. Bioactive Materials 6:9, pages 2841-2853.
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Yadong Liu, Penghao Sun, Yuhao Zhao & Bin Liu. (2020) The role of long non‐coding RNAs and downstream signaling pathways in leukemia progression . Hematological Oncology 39:1, pages 27-40.
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Stefano Colombo. 2020. Artificial Intelligence in Healthcare. Artificial Intelligence in Healthcare 85 116 .
Laure Rittié, Takis Athanasopoulos, Miguel Calero-Garcia, Marie L. Davies, David J. Dow, Steven J. Howe, Alastair Morrison, Ida Ricciardelli, Aurore Saudemont, Laurent Jespers & Timothy M. Clay. (2019) The Landscape of Early Clinical Gene Therapies outside of Oncology. Molecular Therapy 27:10, pages 1706-1717.
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Fatemeh Radmanesh, Hamid Sadeghi Abandansari, Sara Pahlavan, Mehdi Alikhani, Mahdi Karimi, Sarah Rajabi, Bahram Kazemi & Hossein Baharvand. (2019) Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine. International Journal of Pharmaceutics 565, pages 391-408.
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Karina Ovejero Paredes, Jesús Ruiz-Cabello, David Izquierdo Alarcón & Marco Filice. 2019. Nucleic Acid Nanotheranostics. Nucleic Acid Nanotheranostics 421 456 .
Kaushik Thanki, Xianghui Zeng, Sarah Justesen, Sarah Tejlmann, Emily Falkenberg, Elize Van Driessche, Hanne Mørck Nielsen, Henrik Franzyk & Camilla Foged. (2017) Engineering of small interfering RNA-loaded lipidoid-poly( DL -lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach. European Journal of Pharmaceutics and Biopharmaceutics 120, pages 22-33.
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Yuqing He, Yanhong Luo, Biyu Liang, Lei Ye, Guangxing Lu & Weiming He. (2017) Potential applications of MEG3 in cancer diagnosis and prognosis. Oncotarget 8:42, pages 73282-73295.
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Martina Tuttolomondo, Cinzia Casella, Pernille Lund Hansen, Ester Polo, Luciana M. Herda, Kenneth A. Dawson, Henrik J. Ditzel & Jan Mollenhauer. (2017) Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery. Molecular Therapy - Nucleic Acids 8, pages 264-276.
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Matthieu Meryet-Figuière, Charlotte Lecerf, Emilie Varin, Jean-Luc Coll, Marie-Hélène Louis, Soizic Dutoit, Florence Giffard, Cécile Blanc-Fournier, Siham Hedir, Nicolas Vigneron, Emilie Brotin, Laurent Pelletier, Véronique Josserand, Christophe Denoyelle & Laurent Poulain. (2017) Atelocollagen-mediated in vivo siRNA transfection in ovarian carcinoma is influenced by tumor site, siRNA target and administration route. Oncology Reports 38:4, pages 1949-1958.
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Matan Goldshtein, Efrat Forti, Emil Ruvinov & Smadar Cohen. (2016) Mechanisms of cellular uptake and endosomal escape of calcium-siRNA nanocomplexes. International Journal of Pharmaceutics 515:1-2, pages 46-56.
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Xiaona Jing, Camilla Foged, Birte Martin-Bertelsen, Anan Yaghmur, Kolja M. Knapp, Martin Malmsten, Henrik Franzyk & Hanne M. Nielsen. (2016) Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System. Molecular Pharmaceutics 13:6, pages 1739-1749.
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Karin E. LundinOlof GissbergC.I. Edvard Smith. (2015) Oligonucleotide Therapies: The Past and the Present. Human Gene Therapy 26:8, pages 475-485.
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Emil Ruvinov, Olga Kryukov, Efrat Forti, Efrat Korin, Matan Goldstein & Smadar Cohen. (2015) Calcium–siRNA nanocomplexes: What reversibility is all about. Journal of Controlled Release 203, pages 150-160.
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Stefano Colombo, Dongmei Cun, Katrien Remaut, Matt Bunker, Jianxin Zhang, Birte Martin-Bertelsen, Anan Yaghmur, Kevin Braeckmans, Hanne M. Nielsen & Camilla Foged. (2015) Mechanistic profiling of the siRNA delivery dynamics of lipid–polymer hybrid nanoparticles. Journal of Controlled Release 201, pages 22-31.
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Xianghui Zeng, Anne Marit de Groot, Alice J. A. M. Sijts, Femke Broere, Erik Oude Blenke, Stefano Colombo, Willem van Eden, Henrik Franzyk, Hanne Mørck Nielsen & Camilla Foged. (2015) Surface coating of siRNA–peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro. Nanoscale 7:46, pages 19687-19698.
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