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Needle-free delivery of macromolecules through the skin using controllable jet injectors

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E. L. Cuttance, W. A. Mason, J. McDermott, R.A. Laven, B. P. Ruddy, A. J. Taberner, J. W. McKeage & S. A. Turner. (2022) Comparison of Three Anaesthetic Options to Reduce Acute Pain Response in Kid Goats. Journal of Applied Animal Welfare Science 0:0, pages 1-12.
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Articles from other publishers (60)

James W. McKeage, Andrew Z.H. Tan & Andrew J. Taberner. (2024) Large volume subcutaneous delivery using multi-orifice jet injection. International Journal of Pharmaceutics 649, pages 123605.
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Liwei Chang, Arup Mondal, Bhumika Singh, Yisel Martínez‐Noa & Alberto Perez. (2023) Revolutionizing peptide‐based drug discovery: Advances in the post‐AlphaFold era . WIREs Computational Molecular Science.
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Dongping Zeng, Zheng Tang, Wei Wang, Zefeng Wang & Jiamin Li. (2023) Experimental investigation of the optimal driving pressure for a larger-volume controllable jet injection system. Medical Engineering & Physics 119, pages 104033.
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Lei Xi, Zhen Zhao, Qicheng Ruan, Zhengheng Yang, Liang Xu, Jianmin Gao & Yunlong Li. (2023) Numerical Study on the Heating Effect of a Spring-Loaded Actuator—Part Ⅰ: Temperature and Humidity Distribution Characteristics. Actuators 12:6, pages 234.
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Vazula Zulfra Bekkers, Liora Bik, Johanna Catharina van Huijstee, Albert Wolkerstorfer, Errol Prospero Prens & Martijn Bastiaan Adriaan van Doorn. (2023) Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology—a systematic review. Drug Delivery and Translational Research 13:6, pages 1584-1599.
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Zhen Zhao, Lei Xi, Jianmin Gao, Liang Xu & Yunlong Li. (2023) Numerical Study on the Heating Effect of a Spring-Loaded Actuator—Part II: Optimization Design of Heater Parameters. Actuators 12:5, pages 212.
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Carmen Ledesma-Feliciano, Ros Chapman, Jay W. Hooper, Kira Elma, Darin Zehrung, Miles B. Brennan & Erin K. Spiegel. (2023) Improved DNA Vaccine Delivery with Needle-Free Injection Systems. Vaccines 11:2, pages 280.
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Darin Zehrung, Courtney Jarrahian & Manjari Lal. 2023. Plotkin's Vaccines. Plotkin's Vaccines 1397 1431.e18 .
Paul A. Brunton, Mitten McLean, Senthilkumar Vedagiri, James McKeage, Bryan Ruddy, Kate Weatherly, David White, Andrew Taberner & Carolina Loch. (2022) Jet injection needle-free dental anaesthesia: Initial findings. Journal of Dentistry 122, pages 104165.
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Naoto Ono, Tomoya Iibuchi, Hiroaki Todo, Shoko Itakura, Hirotoshi Adachi & Kenji Sugibayashi. (2022) Enhancement of skin permeation of fluorescein isothiocyanate-dextran 4 kDa (FD4) and insulin by thermalporation. European Journal of Pharmaceutical Sciences 170, pages 106096.
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Jelle Schoppink & David Fernandez Rivas. (2022) Jet injectors: Perspectives for small volume delivery with lasers. Advanced Drug Delivery Reviews 182, pages 114109.
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Purva Pingle, Isha Joshi, Rupinder Kaur Sodhi, Jitender Madan, Neelesh Kumar Mehra, Pankaj Kumar Singh, Saurabh Srivastava, Dharmendra Kumar Khatri & Shashi Bala Singh. 2022. Multifunctional Nanocarriers. Multifunctional Nanocarriers 149 173 .
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Sana Kalave, Bappaditya Chatterjee, Parth Shah & Ambikanandan Misra. (2021) Transdermal Delivery of Macromolecules Using Nano Lipid Carriers. Current Pharmaceutical Design 27:42, pages 4330-4340.
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Adrian Williams. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 507 534 .
Mojiz Abbas Trimzi & Young-Bog Ham. (2021) A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery. Pharmaceutics 13:11, pages 1770.
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Zhenping Cao, Sisi Lin & Jinyao Liu. (2021) Bacteria-Based Microdevices for the Oral Delivery of Macromolecules. Pharmaceutics 13:10, pages 1610.
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James Byrne, Hen-Wei Huang, James C. McRae, Sahab Babaee, Amin Soltani, Sarah L. Becker & Giovanni Traverso. (2021) Devices for drug delivery in the gastrointestinal tract: A review of systems physically interacting with the mucosa for enhanced delivery. Advanced Drug Delivery Reviews 177, pages 113926.
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Miguel A. Quetzeri-Santiago, Ian W. Hunter, Devaraj van der Meer & David Fernandez Rivas. (2021) Impact of a microfluidic jet on a pendant droplet. Soft Matter 17:32, pages 7466-7475.
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Ruxuan Wang, Qiong Bian, Yihua Xu, Donghang Xu & Jianqing Gao. (2021) Recent advances in mechanical force-assisted transdermal delivery of macromolecular drugs. International Journal of Pharmaceutics 602, pages 120598.
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Andrea Allmendinger. (2021) Opportunities in an Evolving Pharmaceutical Development Landscape: Product Differentiation of Biopharmaceutical Drug Products. Pharmaceutical Research 38:5, pages 739-757.
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Markus Muttenthaler, Glenn F. King, David J. Adams & Paul F. Alewood. (2021) Trends in peptide drug discovery. Nature Reviews Drug Discovery 20:4, pages 309-325.
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James W. Mckeage, Carolina Loch, Johann Zwirner, Niels Hammer, David E. White, Bryan P. Ruddy, Paul A. Brunton & Andrew J. Taberner. (2021) Controllable Jet Injection of Dental Local Anaesthetic. IEEE Journal of Translational Engineering in Health and Medicine 9, pages 1-8.
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Magalí Mercuri & David Fernandez Rivas. (2021) Challenges and opportunities for small volumes delivery into the skin. Biomicrofluidics 15:1.
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Liora Bik, Martijn B. A. Doorn, Edyta Biskup, Vinzent K. Ortner, Merete Haedersdal & Uffe H. Olesen. (2020) Electronic Pneumatic Injection‐Assisted Dermal Drug Delivery Visualized by Ex Vivo Confocal Microscopy. Lasers in Surgery and Medicine 53:1, pages 141-147.
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Éva Kollár, Boglárka Balázs, Tímea Tari & István Siró. (2020) Development challenges of high concentration monoclonal antibody formulations. Drug Discovery Today: Technologies 37, pages 31-40.
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Pankaj Rohilla & Jeremy Marston. (2020) Feasibility of laser induced jets in needle free jet injections. International Journal of Pharmaceutics 589, pages 119714.
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Xiaomin Zhang, Bizhu Luo, Huihui Mo, Lexi Liao, Shuai Wang, Juan Du, Qiuting Liu & Yanhua Liang. (2020) Clinical Evaluation of Sequential Transdermal Delivery of Vitamin B6, Compound Glycyrrhizin, Metronidazole, and Hyaluronic Acid Using Needle-Free Liquid Jet in Facial Seborrheic Dermatitis. Frontiers in Medicine 7.
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Soroosh Haji Hosseinnejad, Thor F. Besier, Andrew J. Taberner & Bryan P. Ruddy. (2020) Coupled electromagnetic and thermal optimisation strategies for direct-drive linear permanent magnet synchronous motors. Coupled electromagnetic and thermal optimisation strategies for direct-drive linear permanent magnet synchronous motors.
Dongping Zeng, Ni Wu, Lei Qian, Hanqing Shi & Yong Kang. (2020) Experimental investigation on penetration performance of larger volume needle-free injection device. Journal of Mechanical Science and Technology 34:9, pages 3897-3909.
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Sophie Bekisz, Lui Holder-Pearson, James Geoffrey Chase & Thomas Desaive. (2020) In silico validation of a new model-based oral-subcutaneous insulin sensitivity testing through Monte Carlo sensitivity analyses. Biomedical Signal Processing and Control 61, pages 102030.
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Katharina Cu, Ruchi Bansal, Samir Mitragotri & David Fernandez Rivas. (2019) Delivery Strategies for Skin: Comparison of Nanoliter Jets, Needles and Topical Solutions. Annals of Biomedical Engineering 48:7, pages 2028-2039.
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Céline Lemoine, Aneesh Thakur, Danina Krajišnik, Romain Guyon, Stephanie Longet, Agnieszka Razim, Sabina Górska, Ivana Pantelić, Tanja Ilić, Ines Nikolić, Ed C. Lavelle, Andrzej Gamian, Snežana Savić & Anita Milicic. (2020) Technological Approaches for Improving Vaccination Compliance and Coverage. Vaccines 8:2, pages 304.
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Dongping Zeng, Ni Wu, Lei Qian, Hanqing Shi & Yong Kang. (2020) A Novel Controllable Pneumatic Needle-Free Injection System for Larger-Volume Drug Delivery. Journal of Pharmaceutical Sciences 109:5, pages 1772-1779.
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Daan J.A. Crommelin, Enrico Mastrobattista, Andrea Hawe, Karin H. Hoogendoorn & Wim Jiskoot. (2020) Shifting Paradigms Revisited: Biotechnology and the Pharmaceutical Sciences. Journal of Pharmaceutical Sciences 109:1, pages 30-43.
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Anastasia Shpichka, Denis Butnaru, Evgeny A. Bezrukov, Roman B. Sukhanov, Anthony Atala, Vitaliy Burdukovskii, Yuanyuan Zhang & Peter Timashev. (2019) Skin tissue regeneration for burn injury. Stem Cell Research & Therapy 10:1.
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Rhys M. J. Williams, James W. McKeage, Bryan P. Ruddy, Poul M. F. Nielsen & Andrew J. Taberner. (2019) Viscous Heating Assists Jet Formation During Needle-Free Jet Injection of Viscous Drugs. IEEE Transactions on Biomedical Engineering 66:12, pages 3472-3479.
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Nick N. L. Do, Andrew J. Taberner & Bryan P. Ruddy. (2019) Application of Linear Permanent Magnet Flux-Switching Motors to Needle-free Jet Injection. Application of Linear Permanent Magnet Flux-Switching Motors to Needle-free Jet Injection.
Nick N.L. Do, Andrew J. Taberner & Bryan P. Ruddy. (2019) Design of a Linear Permanent Magnet Transverse Flux Motor for Needle-free Jet Injection. Design of a Linear Permanent Magnet Transverse Flux Motor for Needle-free Jet Injection.
Nickolas P. Demas & Ian W. Hunter. (2019) An Electronic Force Sensor for Medical Jet Injection. Journal of Medical Devices 13:2.
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Jean-Daniel Lelièvre. (2019) Les vaccins de demain. Revue Francophone des Laboratoires 2019:512, pages 52-63.
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Loreto Oyarte Gálvez, Maria Brió Pérez & David Fernández Rivas. (2019) High speed imaging of solid needle and liquid micro-jet injections. Journal of Applied Physics 125:14.
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Wim Jiskoot, Gideon F. A. Kersten, Enrico Mastrobattista & Bram Slütter. 2019. Pharmaceutical Biotechnology. Pharmaceutical Biotechnology 281 304 .
Nick N. L. Do, Andrew J. Taberner & Bryan P. Ruddy. (2018) Design of a Portable Pulsed Power System for Needle-Free Jet Injection. Design of a Portable Pulsed Power System for Needle-Free Jet Injection.
Dongjoo Kim, Young Hyo Kim & Soonjo Kwon. (2018) Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity. Scientific Reports 8:1.
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Nick N. L. Do, Andrew J. Taberner & Bryan P. Ruddy. (2018) A Linear Permanent Magnet Synchronous Motor for Large Volume Needle-free Jet Injection. IEEE Transactions on Industry Applications, pages 1-1.
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Mark J. Papania, Darin Zehrung & Courtney Jarrahian. 2018. Plotkin's Vaccines. Plotkin's Vaccines 1320 1353.e17 .
Carla Berrospe-RodriguezClaas Willem Visser, Stefan Schlautmann, David Fernandez Rivas & Ruben Ramos-Garcia. (2017) Toward jet injection by continuous-wave laser cavitation. Journal of Biomedical Optics 22:10, pages 1.
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Bryan P. Ruddy, Alex William Dixon, Rhys Michael James Williams & Andrew James Taberner. (2017) Optimization of Portable Electronically Controlled Needle-Free Jet Injection Systems. IEEE/ASME Transactions on Mechatronics 22:5, pages 2013-2021.
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Nick N. L. Do, Andrew J. Taberner & Bryan P. Ruddy. (2017) Design of a linear permanent magnet synchronous motor for needle-free jet injection. Design of a linear permanent magnet synchronous motor for needle-free jet injection.
John Liu, N. Catherine Hogan & Ian Hunter. (2017) Ampoule and nozzle development for needle-free injections. Ampoule and nozzle development for needle-free injections.
James W. Mckeage, Kieran A. Brennan, Geehoon Park, N. Catherine Hogan, Ian W. Hunter, Bryan P. Ruddy, Poul M. F. Nielsen & Andrew J. Taberner. (2017) High-speed X-ray analysis of liquid delivery during jet injection. High-speed X-ray analysis of liquid delivery during jet injection.
Aoyu Zhang, N. Catherine Hogan & Ian W. Hunter. (2017) Needle-free small-volume liquid injection system powered by a rotary actuator. Needle-free small-volume liquid injection system powered by a rotary actuator.
N. Catherine Hogan, Melis N. Anahtar, Andrew J. Taberner & Ian W. Hunter. (2017) Delivery of immunoreactive antigen using a controllable needle-free jet injector. Journal of Controlled Release 258, pages 73-80.
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Hun-Jae Jang, Seonggu Yeo & Jack J. Yoh. (2017) Skin pre-ablation and laser assisted microjet injection for deep tissue penetration. Lasers in Surgery and Medicine 49:4, pages 387-394.
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Xinxin Li, Bryan Ruddy & Andrew Taberner. (2016) Characterization of needle-assisted jet injections. Journal of Controlled Release 243, pages 195-203.
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Jeannette L. Comeau, Jocelyn Chan & Kristine K. Macartney. (2016) New Vaccines on the Horizon. Current Pediatrics Reports 4:3, pages 74-83.
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James W. Mckeage, Bryan P. Ruddy, Poul M. F. Nielsen & Andrew J. Taberner. (2016) A device for controlled jet injection of large volumes of liquid. A device for controlled jet injection of large volumes of liquid.
Jessica R. Walter & Shuai Xu. (2015) Therapeutic transdermal drug innovation from 2000 to 2014: current status and outlook. Drug Discovery Today 20:11, pages 1293-1299.
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