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Expert Opinion on Drug Delivery Volume 5, 2008 - Issue 10
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Novel drug delivery systems for inner ear protection and regeneration after hearing loss

Rachael T Richardson Bionic Ear Institute, 384 Albert Street, East Melbourne, Victoria 3002, Australia +613 9667 7500; +613 9663 1958; [email protected]; University of Melbourne, Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
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Andrew K Wise Bionic Ear Institute, 384 Albert Street, East Melbourne, Victoria 3002, Australia +613 9667 7500; +613 9663 1958; [email protected]; University of Melbourne, Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
,
Jacqueline K Andrew Bionic Ear Institute, 384 Albert Street, East Melbourne, Victoria 3002, Australia +613 9667 7500; +613 9663 1958; [email protected]; University of Melbourne, Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
&
Stephen J O'Leary Bionic Ear Institute, 384 Albert Street, East Melbourne, Victoria 3002, Australia +613 9667 7500; +613 9663 1958; [email protected]; University of Melbourne, Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
Pages 1059-1076 | Published online: 25 Sep 2008

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Meng Bu, Jingling Tang, Yinghui Wei, Yanhui Sun, Xinyu Wang, Linhua Wu & Hongzhuo Liu. (2015) Enhanced bioavailability of nerve growth factor with phytantriol lipid-based crystalline nanoparticles in cochlea. International Journal of Nanomedicine 10, pages 6879-6889.
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Friedrich Ihler, Sabrina Pelz, Melanie Coors, Christoph Matthias & Martin Canis. (2014) Application of a TNF-alpha-inhibitor into the scala tympany after cochlear electrode insertion trauma in guinea pigs: Preliminary audiologic results. International Journal of Audiology 53:11, pages 810-816.
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Philipp Schendzielorz, Agmal Scherzed, Kristen Rak, Johannes Völker, Rudolf Hagen, Robert Mlynski, Katrin Frölich & Andreas Radeloff. (2014) A hydrogel coating for cochlear implant arrays with encapsulated adipose-derived stem cells allows brain-derived neurotrophic factor delivery. Acta Oto-Laryngologica 134:5, pages 497-505.
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Hongzhuo Liu, Shichao Chen, Yanyan Zhou, Xin Che, Zhihong Bao, Sanming Li & Jinghua Xu. (2013) The effect of surface charge of glycerol monooleate-based nanoparticles on the round window membrane permeability and cochlear distribution. Journal of Drug Targeting 21:9, pages 846-854.
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Ali Sameer Mallick, Ali Qureishi, Richard Pearson & Gerrard O'Donoghue. (2013) Neurotrophins and cochlear implants: A solution to sensorineural deafness?. Cochlear Implants International 14:3, pages 158-164.
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Hinrich Staecker & Brian Rodgers. (2013) Developments in delivery of medications for inner ear disease. Expert Opinion on Drug Delivery 10:5, pages 639-650.
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Articles from other publishers (34)

Changling Xu, Jieyu Qi, Xiaojie Hu, Liyan Zhang, Qiuhan Sun, Nianci Li, Xin Chen, Fangfang Guo, Peina Wu, Yi Shi & Renjie Chai. (2023) Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea . Cell Proliferation 56:5.
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Monja Gantumur & Craig Russell. 2023. Practical Pharmaceutics. Practical Pharmaceutics 367 375 .
Jinsong Hao & S. Kevin Li. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 377 392 .
Patricia A. Leake, Stephen J. Rebscher, Chantale Dore‘ & Omar Akil. (2019) AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF. Journal of the Association for Research in Otolaryngology 20:4, pages 341-361.
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Omar AkilBas BlitsLawrence R. LustigPatricia A. Leake. (2019) Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss. Human Gene Therapy 30:1, pages 88-105.
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Philipp Schendzielorz, Maike Vollmer, Kristen Rak, Armin Wiegner, Nashwa Nada, Katrin Radeloff, Rudolf Hagen & Andreas Radeloff. (2017) Adipose-derived stromal cells enhance auditory neuron survival in an animal model of sensory hearing loss. Cytotherapy 19:10, pages 1197-1207.
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Athanasia Warnecke, Adam J. Mellott, Ariane Römer, Thomas Lenarz & Hinrich Staecker. (2017) Advances in translational inner ear stem cell research. Hearing Research 353, pages 76-86.
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Alec Salt, Jared Hartsock, Ruth Gill, Daniel Smyth, Jonathon Kirk & Kristien Verhoeven. (2017) Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs. PLOS ONE 12:8, pages e0183374.
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Benedikt Kramer, Anke Tropitzsch, Marcus Müller & Hubert Löwenheim. (2017) Myelin-induced inhibition in a spiral ganglion organ culture – Approaching a natural environment in vitro. Neuroscience 357, pages 75-83.
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Ilmari Pyykkö, Jing Zou, Annelies Schrott-Fischer, Rudolf Glueckert & Paavo Kinnunen. 2016. Auditory and Vestibular Research. Auditory and Vestibular Research 363 415 .
Sahar Rahmani, Astin M. Ross, Tae-Hong Park, Hakan Durmaz, Acacia F. Dishman, Diane M. Prieskorn, Nathan Jones, Richard A. Altschuler & Joerg Lahann. (2016) Dual Release Carriers for Cochlear Delivery. Advanced Healthcare Materials 5:1, pages 94-100.
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Naila El Kechai, Florence Agnely, Elisabeth Mamelle, Yann Nguyen, Evelyne Ferrary & Amélie Bochot. (2015) Recent advances in local drug delivery to the inner ear. International Journal of Pharmaceutics 494:1, pages 83-101.
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Philipp Schendzielorz, Kristen Rak, Jennifer Nguyen, Katrin Frölich, Agmal Scherzad, Rudolf Hagen & Andreas Radeloff. (2015) Human adipose-derived stem cells enhance the survival and neuritogenesis of auditory neurons. NeuroReport 26:13, pages 797-801.
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Gang Gao, Ya Liu, Chang-Hua Zhou, Ping Jiang & Jian-Jun Sun. (2015) Solid Lipid Nanoparticles Loaded with Edaravone for Inner Ear Protection After Noise Exposure. Chinese Medical Journal 128:2, pages 203-209.
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Silke Helbig, Matthias Helbig, Martin Leinung, Timo Stöver, Uwe Baumann & Tobias Rader. (2015) Hearing Preservation and Improved Speech Perception With a Flexible 28-mm Electrode. Otology & Neurotology 36:1, pages 34-42.
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Suzy Dreijer - van der Glas & Monja Gantumur. 2015. Practical Pharmaceutics. Practical Pharmaceutics 153 161 .
Antonina Wrzeszcz, Melanie Steffens, Sven Balster, Athanasia Warnecke, Barbara Dittrich, Thomas Lenarz & Günter Reuter. (2015) Hydrogel coated and dexamethasone releasing cochlear implants: Quantification of fibrosis in guinea pigs and evaluation of insertion forces in a human cochlea model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 103:1, pages 169-178.
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P. Ceschi, A. Bohl, K. Sternberg, A. Neumeister, V. Senz, K.P. Schmitz, M. Kietzmann, V. Scheper, T. Lenarz, T. Stöver & G. Paasche. (2014) Biodegradable polymeric coatings on cochlear implant surfaces and their influence on spiral ganglion cell survival. Journal of Biomedical Materials Research Part B: Applied Biomaterials 102:6, pages 1255-1267.
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Antonina Wrzeszcz, Barbara Dittrich, Daniel Haamann, Pooyan Aliuos, Doris Klee, Ingo Nolte, Thomas Lenarz & Günter Reuter. (2014) Dexamethasone released from cochlear implant coatings combined with a protein repellent hydrogel layer inhibits fibroblast proliferation. Journal of Biomedical Materials Research Part A 102:2, pages 442-454.
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Philipp Schendzielorz, Tobias Schmitz, Claus Moseke, Uwe Gbureck, Katrin FrFlich, Kristen Rak, JRrgen Groll, Rudolf Hagen & Andreas Radeloff. (2014) Plasma-Assisted Hydrophilization of Cochlear Implant Electrode Array Surfaces Enables Adhesion of Neurotrophin-Secreting Cells. ORL 76:5, pages 257-265.
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Hongzhuo Liu, Jinsong Hao & Kevin S. Li. (2013) Current strategies for drug delivery to the inner ear. Acta Pharmaceutica Sinica B 3:2, pages 86-96.
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Patricia A. Leake, Olga Stakhovskaya, Alexander Hetherington, Stephen J. Rebscher & Ben Bonham. (2013) Effects of Brain-Derived Neurotrophic Factor (BDNF) and Electrical Stimulation on Survival and Function of Cochlear Spiral Ganglion Neurons in Deafened, Developing Cats. Journal of the Association for Research in Otolaryngology 14:2, pages 187-211.
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Xiaoping Du, Kejian Chen, Satish Kuriyavar, Richard D. Kopke, Brian P. Grady, David H. Bourne, Wei Li & Kenneth J. Dormer. (2013) Magnetic Targeted Delivery of Dexamethasone Acetate Across the Round Window Membrane in Guinea Pigs. Otology & Neurotology 34:1, pages 41-47.
Crossref
Patricia A. Leake, Olga Stakhovskaya & Stephen J. Rebscher. 2013. Deafness. Deafness 41 81 .
Andrew K Wise & Lisa N Gillespie. (2012) Drug delivery to the inner ear. Journal of Neural Engineering 9:6, pages 065002.
Crossref
Patricia A. Leake, Gary T. Hradek, Alexander M. Hetherington & Olga Stakhovskaya. (2011) Brain‐derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats. Journal of Comparative Neurology 519:8, pages 1526-1545.
Crossref
Lisa N. Pettingill, Andrew K. Wise, Marilyn S. Geaney & Robert K. Shepherd. (2011) Enhanced Auditory Neuron Survival Following Cell-Based BDNF Treatment in the Deaf Guinea Pig. PLoS ONE 6:4, pages e18733.
Crossref
Xinsheng Gao, Youdan Wang, Kejian Chen, Brian P. Grady, Kenneth J. Dormer & Richard D. Kopke. (2010) Magnetic Assisted Transport of PLGA Nanoparticles Through a Human Round Window Membrane Model. Journal of Nanotechnology in Engineering and Medicine 1:3.
Crossref
M. Lie, M. Grover & D.S. Whitlon. (2010) Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience 169:2, pages 855-862.
Crossref
Toribio F. Otero & Joaquín Arias-Pardilla. 2010. Electropolymerization. Electropolymerization 241 272 .
Elena Arisi, Stella Forti, Davide Pagani, Loredana Todini, Sara Torretta, Umberto Ambrosetti & Lorenzo Pignataro. (2010) Cochlear implantation in adolescents with prelinguistic deafness. Otolaryngology–Head and Neck Surgery 142:6, pages 804-808.
Crossref
. (2009) Current World Literature. Current Opinion in Otolaryngology & Head & Neck Surgery 17:5, pages 412-418.
Crossref
Katherine A. Belzner & Brenda M. Ryals. (2009) Cell Replacement Therapy in the Inner Ear: Implications for Cochlear Implantation. Perspectives on Hearing and Hearing Disorders in Childhood 19:2, pages 98-107.
Crossref
Yvonne Bouwman-Boer, Paul Le Brun, Christien Oussoren, Ria Tel & Herman WoerdenbagAnnick Ludwig & Suzy Dreijer. 2009. Recepteerkunde. Recepteerkunde 679 687 .

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