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Review

Percutaneous permeation modifiers: enhancement versus retardation

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Pages 517-529 | Published online: 20 May 2008

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Fereshteh Bagheri, Sara Darakhshan, Saharnaz Mazloomi, Behrang Shiri Varnamkhasti & Reza Tahvilian. (2021) Dual loading of Nigella sativa oil-atorvastatin in chitosan–carboxymethyl cellulose nanogel as a transdermal delivery system. Drug Development and Industrial Pharmacy 47:4, pages 569-578.
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Hanumanth Srikanth Cheruvu, Xin Liu, Jeffrey E. Grice & Michael S. Roberts. (2020) Modeling percutaneous absorption for successful drug discovery and development. Expert Opinion on Drug Discovery 15:10, pages 1181-1198.
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Andrej Kováčik, Monika Kopečná & Kateřina Vávrová. (2020) Permeation enhancers in transdermal drug delivery: benefits and limitations. Expert Opinion on Drug Delivery 17:2, pages 145-155.
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Meiyue Shen, Chao Liu, Xiaocao Wan, Nabil Farah & Liang Fang. (2018) Development of a daphnetin transdermal patch using chemical enhancer strategy: insights of the enhancement effect of Transcutol P and the assessment of pharmacodynamics. Drug Development and Industrial Pharmacy 44:10, pages 1642-1649.
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Karrie Marren. (2011) Dimethyl Sulfoxide: An Effective Penetration Enhancer for Topical Administration of NSAIDs. The Physician and Sportsmedicine 39:3, pages 75-82.
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Foziyah Zakir, Bhuvaneshwar Vaidya, Amit K. Goyal, Basant Malik & Suresh P. Vyas. (2010) Development and characterization of oleic acid vesicles for the topical delivery of fluconazole. Drug Delivery 17:4, pages 238-248.
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Bharti Sapra, Subheet Jain & Ashok K. Tiwary. (2009) Transdermal delivery of car vedilol in rats: probing the percutaneous permeation enhancement mechanism of soybean extract–chitosan mixture. Drug Development and Industrial Pharmacy 35:10, pages 1230-1241.
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Articles from other publishers (33)

Kevin V. Tobin & Nicole K. Brogden. (2023) Thermosensitive biomaterial gels with chemical permeation enhancers for enhanced microneedle delivery of naltrexone for managing opioid and alcohol dependency. Biomaterials Science.
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Roger L. McMullen. 2021. Handbook of Pyrrolidone and Caprolactam Based Materials. Handbook of Pyrrolidone and Caprolactam Based Materials 2273 2314 .
Daniel A. Davis, Patricia P. Martins, Michael S. Zamloot, Shawn A. Kucera, Robert O. WilliamsIIIIII, Hugh D. C. Smyth & Zachary N. Warnken. (2020) Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients. AAPS PharmSciTech 21:5.
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Patricia P. Martins, Hugh D.C. Smyth & Zhengrong Cui. (2019) Strategies to facilitate or block nose-to-brain drug delivery. International Journal of Pharmaceutics 570, pages 118635.
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Keda Zhang, Wanyang Sun, Alfred Fahr, Xiaobin Zeng, Lanlan Ge, Ming Chen, Lingzhi Yang, Shipin Wu, Jia Fei & Boping Zhou. (2019) Skin-permeating components of Lonicera japonica flos : a comprehensive study from observations and model computations . New Journal of Chemistry 43:32, pages 12538-12547.
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Eman Atef & Njoud Altuwaijri. (2017) Using Raman Spectroscopy in Studying the Effect of Propylene Glycol, Oleic Acid, and Their Combination on the Rat Skin. AAPS PharmSciTech 19:1, pages 114-122.
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Hira Choudhury, Bapi Gorain, Manisha Pandey, Lipika Alok Chatterjee, Pinaki Sengupta, Arindam Das, Nagashekhara Molugulu & Prashant Kesharwani. (2017) Recent Update on Nanoemulgel as Topical Drug Delivery System. Journal of Pharmaceutical Sciences 106:7, pages 1736-1751.
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A.K.M.M.H. Bhuiyan & L.J. Waters. (2017) Permeation of pharmaceutical compounds through silicone membrane in the presence of surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects 516, pages 121-128.
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Ashana Puri, Amanpreet Kaur, Kaisar Raza, Shishu Goindi & Om Prakash Katare. (2017) Development and evaluation of topical microemulsion of dibenzoylmethane for treatment of UV induced photoaging. Journal of Drug Delivery Science and Technology 37, pages 1-12.
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Sergio Bernal-Chávez, Lilia Pérez-Carreto, María Nava-Arzaluz & Adriana Ganem-Rondero. (2017) Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators. Molecules 22:1, pages 185.
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Jeffrey E. Grice, Hamid R. Moghimi, Elizabeth Ryan, Qian Zhang, Isha Haridass, Yousuf Mohammed & Michael S. Roberts. 2017. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin 45 75 .
Stéphanie Briançon, Marie-Alexandrine Bolzinger & Yves Chevalier. 2017. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin 229 246 .
Wenting Song, Peng Quan, Shanshan Li, Chao Liu, Siji Lv, Yongshan Zhao & Liang Fang. (2016) Probing the role of chemical enhancers in facilitating drug release from patches: Mechanistic insights based on FT-IR spectroscopy, molecular modeling and thermal analysis. Journal of Controlled Release 227, pages 13-22.
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Luciana B Lopes, Maria Teresa J Garcia & Maria Vitoria LB Bentley. (2015) Chemical penetration enhancers. Therapeutic Delivery 6:9, pages 1053-1061.
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Alexandr Hrabálek & Kateřina Vávrová. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 309 323 .
Ritika Arora, Geeta Aggarwal, S. L. Harikumar & Kirandeep Kaur. (2014) Nanoemulsion Based Hydrogel for Enhanced Transdermal Delivery of Ketoprofen. Advances in Pharmaceutics 2014, pages 1-12.
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M. Boncheva. (2014) The physical chemistry of the stratum corneum lipids. International Journal of Cosmetic Science 36:6, pages 505-515.
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Rattikorn Intarakumhaeng & S. Kevin Li. (2014) Effects of solvent on percutaneous absorption of nonvolatile lipophilic solute. International Journal of Pharmaceutics 476:1-2, pages 266-276.
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Nan Li, Weibu Jia, Yan Zhang, Michelle C. Zhang, Fengping Tan & Jerry Zhang. (2014) Effect of Hydrocarbon Chain Length in 1,2-Alkanediols on Percutaneous Absorption of Metronidazole: Toward Development of a General Vehicle for Controlled Release. AAPS PharmSciTech 15:2, pages 354-363.
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Francesco Cilurzo, Giulio Vistoli, Francesca Selmin, Chiara G. M. Gennari, Umberto M. Musazzi, Silvia Franzé, Matteo Lo Monte & Paola Minghetti. (2014) An Insight into the Skin Penetration Enhancement Mechanism of N -Methylpyrrolidone . Molecular Pharmaceutics 11:3, pages 1014-1021.
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Aurélie Berthet, Nancy B. Hopf, Alexandra Miles, Philipp Spring, Nicole Charrière, Alain Garrigou, Isabelle Baldi & David Vernez. (2013) Human skin in vitro permeation of bentazon and isoproturon formulations with or without protective clothing suit. Archives of Toxicology 88:1, pages 77-88.
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Daniela Karadzovska, James D. Brooks, Nancy A. Monteiro-Riviere & Jim E. Riviere. (2013) Predicting skin permeability from complex vehicles. Advanced Drug Delivery Reviews 65:2, pages 265-277.
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Barbora Janůšová, Barbora Školová, Katarína Tükörová, Lea Wojnarová, Tomáš Šimůnek, Přemysl Mladěnka, Tomáš Filipský, Michal Říha, Jaroslav Roh, Karel Palát, Alexandr Hrabálek & Kateřina Vávrová. (2013) Amino acid derivatives as transdermal permeation enhancers. Journal of Controlled Release 165:2, pages 91-100.
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Steffi Hansen & Claus-Michael Lehr. (2012) Nanoparticles for transcutaneous vaccination. Microbial Biotechnology 5:2, pages 156-167.
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Mila Boncheva. 2012. Treatment of Dry Skin Syndrome. Treatment of Dry Skin Syndrome 125 147 .
Jan Misík, Růžena Pavlíková, Jiří Cabal, Ladislav Novotný & Kamil Kuča. (2011) METHOD OF STATIC DIFFUSION CELLS FOR ASSESSMENT OF PESTICIDES SKIN PERMEATION. Military Medical Science Letters 80:2, pages 46-51.
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Michal Novotný, Jana Klimentová, Barbora Janůšová, Karel Palát, Alexandr Hrabálek & Kateřina Vávrová. (2011) Ammonium carbamates as highly active transdermal permeation enhancers with a dual mechanism of action. Journal of Controlled Release 150:2, pages 164-170.
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E.Y.M. Bonnist, J.-P. Gorce, C. Mackay, R.U. Pendlington & P.D.A. Pudney. (2011) Measuring the Penetration of a Skin Sensitizer and Its Delivery Vehicles Simultaneously with Confocal Raman Spectroscopy. Skin Pharmacology and Physiology 24:5, pages 274-283.
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Diksha Kaushik & Bozena Michniak-Kohn. (2010) Percutaneous Penetration Modifiers and Formulation Effects: Thermal and Spectral Analyses. AAPS PharmSciTech 11:3, pages 1068-1083.
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Michal Novotný, Alexandr Hrabálek, Barbora Janůšová, Jakub Novotný & Kateřina Vávrová. (2010) Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation. Bioorganic & Medicinal Chemistry Letters 20:9, pages 2726-2728.
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Jeffrey E. Grice, Susan Ciotti, Norman Weiner, Peter Lockwood, Sheree E. Cross & Michael S. Roberts. (2010) Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. Journal of Pharmaceutical Sciences 99:2, pages 712-718.
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V. Rai, I. Ghosh, S. Bose, S.M.C. Silva, P. Chandra & B. Michniak-Kohn. (2010) A transdermal review on permeation of drug formulations, modifier compounds and delivery methods. Journal of Drug Delivery Science and Technology 20:2, pages 75-88.
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Karunya K. Kandimalla, R.J. Babu & M. Singh. (2010) Biphasic flux profiles of melatonin: The Yin–Yang of transdermal permeation enhancement mediated by fatty alcohol enhancers**“Yin” and “Yang” describe opposing qualities in a phenomenon, which are in a dynamic equilibrium. Each advance (Yang) is followed by a retreat (Yin), and every fall (Yin) transforms into a rise (Yang). Any mutable phenomenon is a consequence of Yin and Yang.. Journal of Pharmaceutical Sciences 99:1, pages 209-218.
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