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Review

A perspective on quantitative structure–activity relationships and carbonic anhydrase inhibitors

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Pages 113-137 | Published online: 01 Feb 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Taner Gokcen, Ilhami Gulcin, Turan Ozturk & Ahmet C. Goren. (2016) A class of sulfonamides as carbonic anhydrase I and II inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 180-188.
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Halise Inci Gul, Kaan Kucukoglu, Cem Yamali, Sinan Bilginer, Hafize Yuca, Iknur Ozturk, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2016) Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects. Journal of Enzyme Inhibition and Medicinal Chemistry 31:4, pages 568-573.
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Yasin Çetinkaya, Hülya Göçer, Süleyman Göksu & İlhami Gülçin. (2014) Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 29:2, pages 168-174.
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Shalini Singh, Padmakar V. Khadikar, Andrea Scozzafava & Claudiu T. Supuran. (2009) QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software. Journal of Enzyme Inhibition and Medicinal Chemistry 24:2, pages 337-349.
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Articles from other publishers (26)

Nannan Zheng, Wanyun Jiang, Puyu Zhang, Le Ma, Junzhao Chen & Haiyang Zhang. (2023) Repurposing of World-Approved Drugs for Potential Inhibition against Human Carbonic Anhydrase I: A Computational Study. International Journal of Molecular Sciences 24:16, pages 12619.
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Nurdan Gönül Baltacı, Enver Fehim Koçpınar & Harun Budak. (2021) Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice. Molecular Biology Reports 48:11, pages 7397-7404.
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V. Shyni, D. R. Leenaraj, Reena Ittyachan, Lynnette Joseph & D. Sajan. (2021) Anticancer activity of indapamide adsorbed on gold nanoparticles: DFT , in‐silico, and in‐vitro analysis . Journal of Molecular Recognition 34:10.
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Chandra B. Mishra, Manisha Tiwari & Claudiu T. Supuran. (2020) Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?. Medicinal Research Reviews 40:6, pages 2485-2565.
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Stanislav Kalinin, Alessio Nocentini, Alexander Kovalenko, Vladimir Sharoyko, Alessandro Bonardi, Andrea Angeli, Paola Gratteri, Tatiana B. Tennikova, Claudiu T. Supuran & Mikhail Krasavin. (2019) From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction. European Journal of Medicinal Chemistry 182, pages 111642.
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Lina Jia, Xiao Li, Dengfeng Cheng & Lan Zhang. (2019) Fluorine-18 click radiosynthesis and microPET/CT evaluation of a small peptide-a potential PET probe for carbonic anhydrase IX. Bioorganic & Medicinal Chemistry 27:5, pages 785-789.
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Steven P. Rowe, Yafu Yin & Michael A. Gorin. 2019. Diagnosis and Surgical Management of Renal Tumors. Diagnosis and Surgical Management of Renal Tumors 55 69 .
Vaida Juozapaitienė, Brigita Bartkutė, Vilma Michailovienė, Audrius Zakšauskas, Lina Baranauskienė, Sandra Satkūnė & Daumantas Matulis. (2016) Purification, enzymatic activity and inhibitor discovery for recombinant human carbonic anhydrase XIV. Journal of Biotechnology 240, pages 31-42.
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Xing Yang, Il Minn, Steven P. Rowe, Sangeeta Ray Banerjee, Michael A. Gorin, Mary Brummet, Hye Soo Lee, Soo Min Koo, Polina Sysa-Shah, Ronnie C. Mease, Sridhar Nimmagadda, Mohamad E. Allaf & Martin G. Pomper. (2015) Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor. Oncotarget 6:32, pages 33733-33742.
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Rui Gao, Sha Liao, Chen Zhang, Weilong Zhu, Liyan Wang, Jin Huang, Zhenjiang Zhao, Honglin Li, Xuhong Qian & Yufang Xu. (2013) Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship. European Journal of Medicinal Chemistry 62, pages 597-604.
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Vincenzo Alterio, Anna Di Fiore, Katia D’Ambrosio, Claudiu T. Supuran & Giuseppina De Simone. (2012) Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?. Chemical Reviews 112:8, pages 4421-4468.
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Shigeji Matsumoto, Shinki Yoshida, Mizuho Ikeda, Jun Kadoi, Masayuki Takahashi, Takeshi Tanimoto, Junichi Kitagawa, Chikako Saiki, Mamoru Takeda & Yukio Shima. (2011) Effects of Acetazolamide on Transient K+ Currents and Action Potentials in Nodose Ganglion Neurons of Adult Rats. CNS Neuroscience & Therapeutics 17:1, pages 66-79.
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Edita Čapkauskaitė, Lina Baranauskienė, Dmitrij Golovenko, Elena Manakova, Saulius Gražulis, Sigitas Tumkevičius & Daumantas Matulis. (2010) Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII. Bioorganic & Medicinal Chemistry 18:21, pages 7357-7364.
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Jurgis Sūdžius, Lina Baranauskienė, Dmitrij Golovenko, Jurgita Matulienė, Vilma Michailovienė, Jolanta Torresan, Jelena Jachno, Rasa Sukackaitė, Elena Manakova, Saulius Gražulis, Sigitas Tumkevičius & Daumantas Matulis. (2010) 4-[N-(Substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII. Bioorganic & Medicinal Chemistry 18:21, pages 7413-7421.
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E. Matthews & M. G. Hanna. (2010) Muscle channelopathies: does the predicted channel gating pore offer new treatment insights for hypokalaemic periodic paralysis?. The Journal of Physiology 588:11, pages 1879-1886.
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Tatsusada Yoshida, Yohei Munei, Seiji Hitaoka & Hiroshi Chuman. (2010) Correlation Analyses on Binding Affinity of Substituted Benzenesulfonamides with Carbonic Anhydrase Using ab Initio MO Calculations on Their Complex Structures. Journal of Chemical Information and Modeling 50:5, pages 850-860.
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Kalyan K. Sethi, Saurabh M. Verma, Naru Prasanthi, Suvendu K. Sahoo, Rabi N. Parhi & P. Suresh. (2010) 3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors. Bioorganic & Medicinal Chemistry Letters 20:10, pages 3089-3093.
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Mihaela MocanuAncaAnca. (2010) The synthesis and characterization of some new diazoamino derivatives. Chemical Industry and Chemical Engineering Quarterly 16:1, pages 89-95.
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Lalintip Hocharoen & James A. Cowan. (2009) Metallotherapeutics: Novel Strategies in Drug Design. Chemistry - A European Journal 15:35, pages 8670-8676.
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Vincenzo Alterio, Anna Di Fiore, Katia D'Ambrosio, Claudiu T. Supuran & Giuseppina De Simone. 2009. Drug Design of Zinc‐Enzyme Inhibitors. Drug Design of Zinc‐Enzyme Inhibitors 138 66 .
D Tricarico, S Lovaglio, A Mele, G Rotondo, E Mancinelli, G Meola & D C Camerino. (2008) Acetazolamide prevents vacuolar myopathy in skeletal muscle of K + -depleted rats . British Journal of Pharmacology 154:1, pages 183-190.
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Jyoti Singh, Basheerulla Shaik, Shalini Singh, Vijay K. Agrawal, Padmakar V. Khadikar, Omar Deeb & Claudiu T. Supuran. (2008) Comparative QSAR Study on Para-substituted Aromatic Sulphonamides as CAII Inhibitors: Information versus Topological (Distance-Based and Connectivity) Indices. Chemical Biology & Drug Design 71:3, pages 244-259.
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Brendan L. Wilkinson, Alessio Innocenti, Daniela Vullo, Claudiu T. Supuran & Sally-Ann Poulsen. (2008) Inhibition of Carbonic Anhydrases with Glycosyltriazole Benzene Sulfonamides. Journal of Medicinal Chemistry 51:6, pages 1945-1953.
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Vijay M. Krishnamurthy, George K. Kaufman, Adam R. Urbach, Irina Gitlin, Katherine L. Gudiksen, Douglas B. Weibel & George M. Whitesides. (2008) Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding. Chemical Reviews 108:3, pages 946-1051.
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Virginija Dudutienė, Lina Baranauskienė & Daumantas Matulis. (2007) Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase. Bioorganic & Medicinal Chemistry Letters 17:12, pages 3335-3338.
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Aliuska Morales Helguera, J. E. Rodríguez-Borges, Xerardo García-Mera, Franco Fernández & M. Natália D. S. Cordeiro. (2007) Probing the Anticancer Activity of Nucleoside Analogues:  A QSAR Model Approach Using an Internally Consistent Training Set. Journal of Medicinal Chemistry 50:7, pages 1537-1545.
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