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Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 2, Issue 1 (2006)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 2, Issue 1 (2006)

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Review

Article

Contribution of CYP2C9 to variability in vitamin K antagonist metabolism

Ann K Daly & Barry P King

Pages: 3-15

Published online: 01 Feb 2006

AbstractforContribution of CYP2C9 to variability in vitamin K antagonist metabolism | Full Text | References | PDF (143.3 KB)

111 Views
11 CrossRef citations
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Article

The role of drug-metabolising enzymes in clinical responses to chemotherapy

Charity D Scripture, William D Figg & Alex Sparreboom

Pages: 17-25

Published online: 01 Feb 2006

AbstractforThe role of drug-metabolising enzymes in clinical responses to chemotherapy | Full Text | References | PDF (102.1 KB)

80 Views
5 CrossRef citations
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Article

Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery

David C Lamb, F Peter Guengerich, Steven L Kelly & Michael R Waterman

Pages: 27-40

Published online: 01 Feb 2006

AbstractforExploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery | Full Text | References | PDF (195.6 KB)

282 Views
34 CrossRef citations
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Article

Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3

Ronald N Hines

Pages: 41-49

Published online: 01 Feb 2006

AbstractforDevelopmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3 | Full Text | References | PDF (122.6 KB)

235 Views
34 CrossRef citations
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Article

Active transport across the human placenta: impact on drug efficacy and toxicity

Denis Evseenko, James W Paxton & Jeffrey A Keelan

Pages: 51-69

Published online: 01 Feb 2006

AbstractforActive transport across the human placenta: impact on drug efficacy and toxicity | Full Text | References | PDF (248.2 KB)

638 Views
67 CrossRef citations
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Article

Mitochondria: new drug targets for oxidative stress-induced diseases

M W Anders, James L Robotham & Shey-Shing Sheu

Pages: 71-79

Published online: 01 Feb 2006

AbstractforMitochondria: new drug targets for oxidative stress-induced diseases | Full Text | References | PDF (121 KB)

192 Views
17 CrossRef citations
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Article

Molecular mechanisms for drug interactions with hERG that cause long QT syndrome

Phillip J Stansfeld, Michael J Sutcliffe & John S Mitcheson

Pages: 81-94

Published online: 01 Feb 2006

AbstractforMolecular mechanisms for drug interactions with hERG that cause long QT syndrome | Full Text | References | PDF (227.6 KB)

333 Views
37 CrossRef citations
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Article

Genomic-based biomarkers of drug-induced nephrotoxicity

John W Davis & Jeffrey A Kramer

Pages: 95-101

Published online: 01 Feb 2006

AbstractforGenomic-based biomarkers of drug-induced nephrotoxicity | Full Text | References | PDF (85.1 KB)

154 Views
24 CrossRef citations
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Article

A perspective on quantitative structure–activity relationships and carbonic anhydrase inhibitors

Brian W Clare & Claudiu T Supuran

Pages: 113-137

Published online: 01 Feb 2006

AbstractforA perspective on quantitative structure–activity relationships and carbonic anhydrase inhibitors | Full Text | References | PDF (572 KB)

125 Views
31 CrossRef citations
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Article

High-throughput pK_a screening and prediction amenable for ADME profiling

Hong Wan & Johan Ulander

Pages: 139-155

Published online: 01 Feb 2006

AbstractforHigh-throughput pK_a screening and prediction amenable for ADME profiling | Full Text | References | PDF (229.8 KB)

401 Views
73 CrossRef citations
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Technology Evaluation

Article

A flexible approach for optimising in silico ADME/Tox characterisation of lead candidates

Yann Bidault

Pages: 157-168

Published online: 01 Feb 2006

AbstractforA flexible approach for optimising in silico ADME/Tox characterisation of lead candidates | Full Text | References | PDF (495.4 KB)

94 Views
7 CrossRef citations
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Editorial

Article

Commentary on variability in vitamin K antagonist metabolism

Dennis A Smith

Pages: 1-2

Published online: 01 Feb 2006

CitationforCommentary on variability in vitamin K antagonist metabolism | Full Text | References | PDF (27.7 KB)

26 Views
1 CrossRef citations
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Review

Article

Two-dimensional gels for toxicological drug discovery applications

Frank A Witzmann & Matthew R Richardson

Pages: 103-111

Published online: 01 Feb 2006

AbstractforTwo-dimensional gels for toxicological drug discovery applications | Full Text | References | PDF (109.3 KB)

77 Views
7 CrossRef citations
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