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Expert Opinion on Drug Metabolism & Toxicology Volume 2, 2006 - Issue 1
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Review

Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery

David C Lamb Professor of Biochemistry, Swansea Medical School, University of Wales Swansea, Swansea, SA2 8PP, UK
,
F Peter Guengerich Professor of Biochemistry, Vanderbilt University School of Medicine, Department of Biochemistry, Nashville, TN 37232, USA
,
Steven L Kelly Professor of Microbial Genetics, Swansea Medical School, University of Wales Swansea, Swansea, SA2 8PP, UK
&
Michael R Waterman Professor of Biochemistry, Vanderbilt University School of Medicine, Department of Biochemistry, Nashville, TN 37232, USA. [email protected]
Pages 27-40 | Published online: 01 Feb 2006

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Bin Zhao & Michael R. Waterman. (2007) Novel Properties of P450s in Streptomyces coelicolor. Drug Metabolism Reviews 39:2-3, pages 343-352.
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Articles from other publishers (33)

B. Roja, S. Saranya, L. Thamanna & P. Chellapandi. (2024) Inferring molecular mechanisms of host-microbe-drug interactions in the human gastrointestinal tract. Medicine in Omics 10, pages 100027.
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Susu Lin, Bingbing Ma, Qilin Gao, Jian Yang, Gang Lai, Runhao Lin, Bingxian Yang, Bing‐Nan Han & Lian‐Hua Xu. (2022) The 16α‐Hydroxylation of Progesterone by Cytochrome P450 107X1 from Streptomyces avermitilis . Chemistry & Biodiversity 19:5.
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Yali Kong, Wei Ye, Taomei Liu, Hongxin Liu, Zhaoming Liu & Wei-Min Zhang. (2021) The important role of P450 monooxygenase for the biosynthesis of new benzophenones from Cytospora rhizophorae. Applied Microbiology and Biotechnology 105:24, pages 9219-9230.
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Hemraj Rimal, Pradeep Subedi, Ki -Hwa Kim, Hyun Park, Jun Hyuck Lee & Tae-Jin Oh. (2020) Characterization of CYP125A13, the First Steroid C-27 Monooxygenase from Streptomyces peucetius ATCC27952 . Journal of Microbiology and Biotechnology 30:11, pages 1750-1759.
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Vitchan Kim, Young-Ran Lim, Inho Lee, Jong-ha Lee, Sangjun Han, Tan-Viet Pham, Harim Kim, Rowoon Lee, Lin-Woo Kang & Donghak Kim. (2020) Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus. Archives of Biochemistry and Biophysics 692, pages 108544.
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Bikash Dangi, Chang Woo Lee, Ki‐Hwa Kim, Sun‐Ha Park, Eun‐Ji Yu, Chang‐Sook Jeong, Hyun Park, Jun Hyuck Lee & Tae‐Jin Oh. (2018) Characterization of two steroid hydroxylases from different Streptomyces spp. and their ligand‐bound and ‐unbound crystal structures . The FEBS Journal 286:9, pages 1683-1699.
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Onur Erbilgin, Oliver Rübel, Katherine B. Louie, Matthew Trinh, Markus de Raad, Tony Wildish, Daniel Udwary, Cindi Hoover, Samuel Deutsch, Trent R. Northen & Benjamin P. Bowen. (2019) MAGI: A Method for Metabolite Annotation and Gene Integration. ACS Chemical Biology 14:4, pages 704-714.
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Myung-A Cho, Songhee Han, Young-Ran Lim, Vitchan Kim, Harim Kim & Donghak Kim. (2019) Streptomyces Cytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic Agents . Biomolecules & Therapeutics 27:2, pages 127-133.
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Simone Brixius-Anderko, Frank Hannemann, Michael Ringle, Yogan Khatri & Rita Bernhardt. (2017) An indole-deficient Escherichia coli strain improves screening of cytochromes P450 for biotechnological applications . Biotechnology and Applied Biochemistry 64:3, pages 315-326.
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Songhee Han, Tan-Viet Pham, Joo-Hwan Kim, Young-Ran Lim, Hyoung-Goo Park, Gun-Su Cha, Chul-Ho Yun, Young-Jin Chun, Lin-Woo Kang & Donghak Kim. (2015) Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A. Archives of Biochemistry and Biophysics 575, pages 1-7.
Crossref
Marco Girhard, Patrick J. Bakkes, Osama Mahmoud & Vlada B. Urlacher. 2015. Cytochrome P450. Cytochrome P450 451 520 .
Motoi Ueno, Midori Yamashita, Shigehiro Takase, Motohiro Hino, Michihiko Kobayashi & Akihiko Fujie. (2014) Enhanced oxidative activities of cytochrome P450Rhf from Rhodococcus sp. expressed using the hyper-inducible expression system. Journal of Bioscience and Bioengineering 117:1, pages 19-24.
Crossref
Clemens von Bühler, Priska Le-Huu & Vlada B. Urlacher. (2013) Cluster Screening: An Effective Approach for Probing the Substrate Space of Uncharacterized Cytochrome P450s. ChemBioChem 14:16, pages 2189-2198.
Crossref
Shinya Yamada, Taka-Aki Miyagawa, Ren Yamada, Hatsumi Shiratori-Takano, Noboru Sayo, Takao Saito, Hideaki Takano, Teruhiko Beppu & Kenji Ueda. (2013) Amide-transforming activity of Streptomyces: possible application to the formation of hydroxy amides and aminoalcohols. Applied Microbiology and Biotechnology 97:14, pages 6223-6230.
Crossref
Young-Ran Lim, Myoung-Ki Hong, Jin-Kwang Kim, Thanh Thi Ngoc Doan, Dong-Hyun Kim, Chul-Ho Yun, Young-Jin Chun, Lin-Woo Kang & Donghak Kim. (2012) Crystal structure of cytochrome P450 CYP105N1 from Streptomyces coelicolor, an oxidase in the coelibactin siderophore biosynthetic pathway. Archives of Biochemistry and Biophysics 528:2, pages 111-117.
Crossref
Bin Zhao, Suzy C. Moody, Robert C. Hider, Li Lei, Steven L. Kelly, Michael R. Waterman & David C. Lamb. (2012) Structural Analysis of Cytochrome P450 105N1 Involved in the Biosynthesis of the Zincophore, Coelibactin. International Journal of Molecular Sciences 13:7, pages 8500-8513.
Crossref
Zhan Zhou, Jianying Gu, Yong-Quan Li & Yufeng Wang. (2012) Genome plasticity and systems evolution in Streptomyces. BMC Bioinformatics 13:S10.
Crossref
Marco Girhard, Katja Koschorreck & Vlada B. Urlacher. (2012) Biokatalyse ? Schl?ssel zur selektiven Oxidation. BIOspektrum 18:2, pages 212-215.
Crossref
Vlada B. Urlacher & Marco Girhard. (2012) Cytochrome P450 monooxygenases: an update on perspectives for synthetic application. Trends in Biotechnology 30:1, pages 26-36.
Crossref
F. Peter Guengerich & Qian Cheng. (2011) Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology. Pharmacological Reviews 63:3, pages 684-699.
Crossref
Stephen Wang. 2011. Oral Bioavailability. Oral Bioavailability 401 412 .
Bishnu Prasad Pandey, Nahum Lee, Kwon-Young Choi, Eunok Jung, Da-hye Jeong & Byung-Gee Kim. (2011) Screening of bacterial cytochrome P450s responsible for regiospecific hydroxylation of (iso)flavonoids. Enzyme and Microbial Technology 48:4-5, pages 386-392.
Crossref
Murielle Lombard, Isabelle Salard, Marie-Agnès Sari, Daniel Mansuy & Didier Buisson. (2011) A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis. Archives of Biochemistry and Biophysics 508:1, pages 54-63.
Crossref
Amane El Ouarradi, Murielle Lombard & Didier Buisson. (2010) Biooxidation of methyl group: Part 2. Evidences for the involvement of cytochromes P450 in microbial multistep oxidation of terfenadine. Journal of Molecular Catalysis B: Enzymatic 67:3-4, pages 172-178.
Crossref
Qian ChengDavid C. LambSteven L. KellyLi LeiF. Peter Guengerich. (2010) Cyclization of a Cellular Dipentaenone by Streptomyces coelicolor Cytochrome P450 154A1 without Oxidation/Reduction . Journal of the American Chemical Society 132:43, pages 15173-15175.
Crossref
Marco Girhard & Vlada B. Urlacher. 2010. Modern Oxidation Methods. Modern Oxidation Methods 421 450 .
Faith O Robert, Jagroop Pandhal & Phillip C Wright. (2010) Exploiting cyanobacterial P450 pathways. Current Opinion in Microbiology 13:3, pages 301-306.
Crossref
Toshiki Furuya & Kuniki Kino. (2010) Genome mining approach for the discovery of novel cytochrome P450 biocatalysts. Applied Microbiology and Biotechnology 86:4, pages 991-1002.
Crossref
Carlos Olano, Carmen Méndez & José A. Salas. (2010) Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Natural Product Reports 27:4, pages 571.
Crossref
Kamila Z. RosÅoniec, Maarten H. Wilbrink, Jenna K. Capyk, William W. Mohn, Martin Ostendorf, Robert van der Geize, Lubbert Dijkhuizen & Lindsay D. Eltis. (2009) Cytochrome P450â125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1 . Molecular Microbiology 74:5, pages 1031-1043.
Crossref
Donghak Kim & Paul R. Ortiz de Montellano. (2009) Tricistronic overexpression of cytochrome P450 cam , putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. Biotechnology Letters 31:9, pages 1427-1431.
Crossref
Emre M. Isin & F. Peter Guengerich. (2007) Complex reactions catalyzed by cytochrome P450 enzymes. Biochimica et Biophysica Acta (BBA) - General Subjects 1770:3, pages 314-329.
Crossref
Y.-J. Chun, T. ShimadaM.R. WatermanF.P. Guengerich. (2006) Understanding electron transport systems of Streptomyces cytochrome P450 . Biochemical Society Transactions 34:6, pages 1183-1185.
Crossref

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