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Review

Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3

Pages 41-49 | Published online: 01 Feb 2006

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Yildiz Yilmaz, Gareth Williams, Nenad Manevski, Markus Walles, Stephan Krähenbühl & Gian Camenisch. (2019) Functional assessment of rat pulmonary flavin-containing monooxygenase activity. Xenobiotica 49:5, pages 503-512.
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Ursula Gundert-Remy, Ulrike Bernauer, Brunhilde Blömeke, Barbara Döring, Eric Fabian, Carsten Goebel, Stefanie Hessel, Christine Jäckh, Alfonso Lampen, Franz Oesch, Ernst Petzinger, Wolfgang Völkel & Peter H. Roos. (2014) Extrahepatic metabolism at the body's internal–external interfaces. Drug Metabolism Reviews 46:3, pages 291-324.
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Ronald N. Hines, Sevasti B. Koukouritaki, Mark T. Poch & Michael C. Stephens. (2008) Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 40:2, pages 263-301.
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David E. Klick & Ronald N. Hines. (2007) Mechanisms Regulating Human FMO3 Transcription. Drug Metabolism Reviews 39:2-3, pages 419-442.
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Margherita Strolin Benedetti, Rhys Whomsley & Eugène Baltes. (2006) Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 895-921.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Hanna Cheropkina, Gianluca Catucci, Arianna Marucco, Ivana Fenoglio, Gianfranco Gilardi & Sheila J. Sadeghi. (2021) Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate. Biochemical Pharmacology 193, pages 114763.
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Yildiz Yilmaz, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl & Gian Camenisch. (2019) Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS). Drug Metabolism Letters 13:1, pages 53-63.
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A.M. Rowland & G.S. Yost. 2018. Comprehensive Toxicology. Comprehensive Toxicology 194 227 .
Lei Ren, Mujian Teng, Tao Zhang, Xiaoqing Zhang, Bo Sun, Shengying Qin, Lin Zhong, Zhihai Peng & Junwei Fan. (2017) Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients . Pharmacogenomics 18:3, pages 265-275.
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Lai Peng, Stephanie Piekos, Grace L. Guo & Xiao-bo Zhong. (2016) Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver. Acta Pharmaceutica Sinica B 6:5, pages 453-459.
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H. Eng, R. Sharma, A. Wolford, L. Di, R. B. Ruggeri, L. Buckbinder, E. L. Conn, D. K. Dalvie & A. S. Kalgutkar. (2016) Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes. Drug Metabolism and Disposition 44:8, pages 1262-1269.
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C. Y. Li, H. J. Renaud, C. D. Klaassen & J. Y. Cui. (2015) Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors. Drug Metabolism and Disposition 44:7, pages 1038-1049.
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Andrew J. Gow & Henry J. Forman. 2015. Comparative Biology of the Normal Lung. Comparative Biology of the Normal Lung 355 374 .
Swetha Rudraiah, Philip R. Rohrer, Igor Gurevich, Michael J. Goedken, Theodore Rasmussen, Ronald N. Hines & José E. Manautou. (2014) Tolerance to Acetaminophen Hepatotoxicity in the Mouse Model of Autoprotection Is Associated with Induction of Flavin-Containing Monooxygenase-3 (FMO3) in Hepatocytes. Toxicological Sciences 141:1, pages 263-277.
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Marilyn C. Henderson, Lisbeth K. Siddens, Sharon K. Krueger, J. Fred Stevens, Karen Kedzie, Wenkui K. Fang, Todd Heidelbaugh, Phong Nguyen, Ken Chow, Michael Garst, Daniel Gil & David E. Williams. (2014) Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones. Toxicology and Applied Pharmacology 278:2, pages 91-99.
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Meeghan A. O'Connor, Petra Koza-Taylor, Sarah N. Campion, Lauren M. Aleksunes, Xinsheng Gu, Ahmed E. Enayetallah, Michael P. Lawton & Jos? E. Manautou. (2014) Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection). Toxicology and Applied Pharmacology 274:1, pages 156-167.
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Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen & Xiao-bo Zhong. (2013) RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice. Drug Metabolism and Disposition 41:12, pages 2175-2186.
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Loeckie L. de Zwart, Johan G. Monbaliu & Pieter P. Annaert. 2013. Pediatric Drug Development. Pediatric Drug Development 222 245 .
Derrek P. Hibar, Jason L. Stein, April B. Ryles, Omid Kohannim, Neda Jahanshad, Sarah E. Medland, Narelle K. Hansell, Katie L. McMahon, Greig I. de Zubicaray, Grant W. Montgomery, Nicholas G. Martin, Margaret J. Wright, Andrew J. Saykin, Clifford R. JackJrJr, Michael W. Weiner, Arthur W. Toga & Paul M. Thompson. (2012) Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects. Brain Imaging and Behavior 7:2, pages 102-115.
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Jane P. F. Bai, Jeffrey S. Barrett, Gibert J. Burckart, Bernd Meibohm, Hari Cheryl Sachs & Lynne Yao. (2013) Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants. The AAPS Journal 15:2, pages 447-454.
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J. Wang, H.Y. Yue, Z.Q. Xia, S.G. Wu, H.J. Zhang, F. Ji, L. Xu & G.H. Qi. (2012) Effect of dietary choline supplementation under different flavin-containing monooxygenase 3 genotypes on trimethylamine metabolism in laying hens. Poultry Science 91:9, pages 2221-2228.
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Julia Yue Cui, Sumedha S. Gunewardena, Byunggil Yoo, Jie Liu, Helen J. Renaud, Hong Lu, Xiao-bo Zhong & Curtis D. Klaassen. (2012) RNA-Seq Reveals Different mRNA Abundance of Transporters and Their Alternative Transcript Isoforms During Liver Development. Toxicological Sciences 127:2, pages 592-608.
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Vita Dolžan. 2012. Pharmacogenetics and Individualized Therapy. Pharmacogenetics and Individualized Therapy 13 80 .
Makiko Shimizu, Travis Denton, Marie Kozono, John R. Cashman, J. Steven Leeder & Hiroshi Yamazaki. (2011) Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood. British Journal of Clinical Pharmacology 71:4, pages 585-591.
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Trine Celius, Andrea Pansoy, Jason Matthews, Allan B. Okey, Marilyn C. Henderson, Sharon K. Krueger & David E. Williams. (2010) Flavin-containing monooxygenase-3: Induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver. Toxicology and Applied Pharmacology 247:1, pages 60-69.
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A.M. Rowland & G.S. Yost. 2010. Comprehensive Toxicology. Comprehensive Toxicology 511 547 .
B. C. Foster. (2009) Therapeutic product disposition in at-risk populations. Radiation Protection Dosimetry 134:3-4, pages 184-190.
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Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, Toshio Kumai, Shinichi Kobayashi, F. Peter Guengerich & Hiroshi Yamazaki. (2009) Inter-individual Variation in Flavin-containing Monooxygenase 3 in Livers from Japanese: Correlation with Hepatic Transcription Factors. Drug Metabolism and Pharmacokinetics 24:3, pages 218-225.
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Trine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta & Allan B. Okey. (2008) Aryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse Liver. Drug Metabolism and Disposition 36:12, pages 2499-2505.
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Marilyn C. Henderson, Lisbeth K. Siddens, Jeffrey T. Morré, Sharon K. Krueger & David E. Williams. (2008) Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicology and Applied Pharmacology 233:3, pages 420-427.
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David E. Klick, Jeff D. Shadley & Ronald N. Hines. (2008) Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein β (C/EBPβ) liver inhibitory and liver activating proteins. Biochemical Pharmacology 76:2, pages 268-278.
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Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Arlene Bridges, Yan Gao, Daniel K. BenjaminJr.Jr. & Dhiren R. Thakker. (2008) Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes. Drug Metabolism and Disposition 36:6, pages 1119-1125.
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Sevasti B. Koukouritaki, Mark T. Poch, Marilyn C. Henderson, Lisbeth K. Siddens, Sharon K. Krueger, Jonathan E. VanDyke, David E. Williams, Nicholas M. Pajewski, Tao Wang & Ronald N. Hines. (2007) Identification and Functional Analysis of Common Human Flavin-Containing Monooxygenase 3 Genetic Variants. Journal of Pharmacology and Experimental Therapeutics 320:1, pages 266-273.
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