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Review

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

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Pages 875-894 | Published online: 24 Nov 2006

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Taiji Miyake, Haruka Tsutsui, Manabu Hirabayashi & Tatsuhiko Tachibana. (2023) Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice. Journal of Pharmacology and Experimental Therapeutics 387:2, pages 135-149.
Crossref
Sun A Ock, Seo-Yeon Kim, Won Seok Ju, Young-Im Kim, Ha-Yeon Wi & Poongyeon Lee. (2023) Adipose Tissue-Derived Mesenchymal Stem Cells Extend the Lifespan and Enhance Liver Function in Hepatocyte Organoids. International Journal of Molecular Sciences 24:20, pages 15429.
Crossref
Moyu Dai, Ning Yang, Kai Xu, Jingwen Zhang, Xueke Li, Ying Zhang & Wei Li. (2023) Discovering human cell‐compatible gene therapy virus variants via optimized screening in mouse models. Cell Proliferation.
Crossref
Bang-Yao Chen, Si-Ying Hong, Han-Min Wang, Yi Shi, Peng Wang, Xiao-Juan Wang, Qian-Yang Jiang, Ke-Da Yang, Wei Chen & Xiao-Ling Xu. (2023) The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles. Particle and Fibre Toxicology 20:1.
Crossref
Maike Felipe Santos Barbetta, Icaro Salgado Perovani, Leandro Oka Duarte & Anderson Rodrigo Moraes de Oliveira. (2023) Enantioselective in vitro metabolism of the herbicide diclofop-methyl: Prediction of toxicokinetic parameters and reaction phenotyping. Journal of Pharmaceutical and Biomedical Analysis 235, pages 115639.
Crossref
Nan Zhou, Yujie Zhu, Miaorong Hu, Rongyao Zheng, Mengqi Sun, Yueying Bian, Xijing Chen & Tingting Li. (2023) Evaluation potential effects of Picroside II on cytochrome P450 enzymes in vitro and in vivo. Journal of Ethnopharmacology 314, pages 116582.
Crossref
Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li & Ting Liu. (2023) Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen. Food and Chemical Toxicology 180, pages 114011.
Crossref
Fan He, Fenglian Zeng, Xiaohong Situ, Runmin He, Wei Zheng, Yongzhuang Chen, Dinghong Ou & Yilu Chen. (2023) Detection and identification of imperatorin metabolites in rat, dog, monkey, and human liver microsomes by ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry and Compound Discoverer software. Biomedical Chromatography 37:10.
Crossref
Boyu Fang, Shasha Jin, Wandi Du & Weimin Cai. (2023) Anlotinib and fruquintinib co-administrated with warfarin increases the risk of bleeding: Studied from pharmacokinetic and pharmacodynamic perspectives. European Journal of Pharmaceutical Sciences 188, pages 106507.
Crossref
Jingwei Zhang, Zhixia Qiu, Yongjie Zhang, Guangji Wang & Haiping Hao. (2023) Intracellular spatiotemporal metabolism in connection to target engagement. Advanced Drug Delivery Reviews 200, pages 115024.
Crossref
Philip G. Kasprzyk, Larry Tremaine, Odette A. Fahmi & Jing-Ke Weng. (2023) In Vitro Evaluation of the Potential for Drug Interactions by Salidroside. Nutrients 15:17, pages 3723.
Crossref
Rick Xing Ze Lu, Yimu Zhao & Milica Radisic. (2023) The emerging role of heart‐on‐a‐chip systems in delineating mechanisms of SARS‐CoV ‐2‐induced cardiac dysfunction . Bioengineering & Translational Medicine.
Crossref
Arpon Biswas, Sarvesh Kumar Verma, Shiv Kumar, Tripti Mishra, Mukesh Kumar, Abhijit Deb Choudhury, Sristi Agrawal, Sachin Nashik Sanap, Amol Chhatrapati Bisen, Anjali Mishra, Tadigoppula Narender & Rabi Sankar Bhatta. (2023) Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease. Current Drug Metabolism 24:8, pages 587-598.
Crossref
Samantha L. Penman, Erin C. Berthold, Abrianna Mihalkovic, Nikki Hammond, Christopher R. McCurdy, Kenneth Blum, Rina D. Eiden, Abhisheak Sharma & Panayotis K. Thanos. (2023) Vaporized Delta-9-tetrahydrocannabinol Inhalation in Female Sprague Dawley Rats: A Pharmacokinetic and Behavioral Assessment. Current Pharmaceutical Design 29:27, pages 2149-2160.
Crossref
Jinhua Li, Namrta Choudhry, Gang Lv, Naganna Nimishetti, Mallu Chenna Reddy, Hong Liu, Thaddeus D. Allen, Jing Zhang & Dun Yang. (2023) In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis. Journal of Pharmaceutical and Biomedical Analysis 232, pages 115415.
Crossref
Diksha Manhas, Shipra Bhatt, Garima Rai, Vinay Kumar, Sahil Bharti, Sumit Dhiman, Shreyans K. Jain, Deepak K. Sharma, Probir Kumar Ojha, Sumit G. Gandhi, Anindya Goswami & Utpal Nandi. (2023) Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy. Chemico-Biological Interactions 380, pages 110524.
Crossref
Kai Tanaka, Shigeto Kawai, Etsuko Fujii, Masumi Yano, Takashi Miyayama, Kiyotaka Nakano, Kimio Terao & Masami Suzuki. (2023) Development of rat duodenal monolayer model with effective barrier function from rat organoids for ADME assay. Scientific Reports 13:1.
Crossref
Shanshan Yang, Chengyu Liu, Mengmeng Jiang, Xiaoqian Liu, Lingling Geng, Yiyuan Zhang, Shuhui Sun, Kang Wang, Jian Yin, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu & Guang-Hui Liu. (2023) A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Protein & Cell.
Crossref
Sébastien Beuché, Marie-Anne Peyronneau, Benoit Jego, Caroline Denis, Paul Bourbon, Capucine Chauvière, Cyrille Santerre, Charles Truillet, Bertrand Kuhnast & Fabien Caillé. (2023) Design, Radiosynthesis, and Evaluation of New Fluorinated Analogs of MeDAS for Myelin PET Imaging. Journal of Medicinal Chemistry 66:12, pages 8030-8042.
Crossref
Kanami Watanabe, Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama & Mayumi Ishizuka. (2023) A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A. Animals 13:12, pages 1939.
Crossref
Joseph M. Cronin & Ai-Ming Yu. (2023) Recombinant Technologies Facilitate Drug Metabolism, Pharmacokinetics, and General Biomedical Research. Drug Metabolism and Disposition 51:6, pages 685-699.
Crossref
Eric Simon, Maciej Motyka, Grietje H. Prins, Mei Li, Werner Rust, Stefan Kauschke, Coralie Viollet, Peter Olinga & Anouk Oldenburger. (2023) Transcriptomic profiling of induced steatosis in human and mouse precision-cut liver slices. Scientific Data 10:1.
Crossref
Mai Takagi, Masumi Yamada, Rie Utoh & Minoru Seki. (2023) A multiscale, vertical-flow perfusion system with integrated porous microchambers for upgrading multicellular spheroid culture. Lab on a Chip 23:9, pages 2257-2267.
Crossref
B Rochat, E Paus, C Maitre & P Baumann. (2023) Citalopram in vitro metabolism in a beagle dog: A role for CYP2D15 in the production of toxic didesmethylcitalopram?. Veterinární medicína 68:4, pages 135-144.
Crossref
Qun Wang, Tiantian Tang, Zengguang Wu, Hong Yang, Yuan Gao, Shiyu Zhang, Xinli Song & Xiaolan Chen. (2023) Study on the liver Drug’s dominant metabolic enzymes for six effective components of the Huang qi Liuyi decoction. Frontiers in Pharmacology 14.
Crossref
David Tess, George C. Chang, Christopher Keefer, Anthony Carlo, Rhys Jones & Li Di. (2023) In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes. The AAPS Journal 25:3.
Crossref
Haijun Yang, Yanjuan Zhang, Rong Zhou, Tianyuan Wu, Peng Zhu, Yujie Liu, Jian Zhou, Yalan Xiong, Yanling Xiong, Honghao Zhou, Wei Zhang, Yan Shu, Xiong Li & Qing Li. (2023) Antibiotics-Induced Depletion of Rat Microbiota Induces Changes in the Expression of Host Drug-Processing Genes and Pharmacokinetic Behaviors of CYPs Probe Drugs. Drug Metabolism and Disposition 51:4, pages 509-520.
Crossref
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki & Hiroshi Suemizu. (2023) The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug Metabolism and Disposition 51:4, pages 480-491.
Crossref
Roland Lawson, Petra Čechová, Eliès Zarrouk, James Javellaud, Václav Bazgier, Michal Otyepka, Patrick Trouillas, Nicolas Picard, Pierre Marquet, Franck Saint‐Marcoux & Souleiman El Balkhi. (2022) Metabolic interactions of benzodiazepines with oxycodone ex vivo and toxicity depending on usage patterns in an animal model. British Journal of Pharmacology 180:7, pages 829-842.
Crossref
Susan Wojtalewicz, Sierra Erickson, Jonathon Vizmeg, Jack Shuckra, Keelah Barger, Andrew Cleveland, Jordan Davis, Stefan Niederauer, Michael Beeman, Vanja Panic, Karen Wilcox, Cameron Metcalf, Jayant Agarwal, Caleb Lade & Brett Davis. (2023) Assessment of glyceride-structured oleogels as an injectable extended-release delivery system of bupivacaine. International Journal of Pharmaceutics 637, pages 122887.
Crossref
Aizhen Hu, Qingwang Liu & Jing Ouyang. (2022) Identification and characterization of the metabolites of moscatilin in mouse, rat, dog, monkey and human hepatocytes by LC–Orbitrap–MS/MS combined with diagnostic fragment ions and accurate mass measurements. Biomedical Chromatography 37:4.
Crossref
Artitaya Thiengsusuk, Tullayakorn Plengsuriyakarn & Kesara Na-Bangchang. (2023) Modulatory Effects of Atractylodin and β-Eudesmol on Human Cytochrome P450 Enzymes: Potential Drug-Drug Interactions. Molecules 28:7, pages 3140.
Crossref
Ying Sun, Pengyu Jing, Helina Gan, Xuejiao Wang, Ximing Zhu, Jiangjiang Fan, Haichao Li, Zhipei Zhang, James Chi Jen Lin & Zhongping Gu. (2023) Evaluation of an ex vivo fibrogenesis model using human lung slices prepared from small tissues. European Journal of Medical Research 28:1.
Crossref
Yeshwant Singh, Ravi AkkiReddy, Deepti Sahu, Giridhar Bilagi, Theertha Thykandy, Prajakta Hingole, Deveshkumar Rana, Roopa Naraganti, Sudhir Kumar Tiwari & Pratima Srivastava. (2023) Intersex and interspecies pharmacokinetics of metoprolol after oral and intravenous dose administration in rats and mice. International Journal of Pharmacokinetics 7:1.
Crossref
Lindsay J. Marshall, Jarrod Bailey, Manuela Cassotta, Kathrin Herrmann & Francesca Pistollato. (2023) Poor Translatability of Biomedical Research Using Animals — A Narrative Review. Alternatives to Laboratory Animals 51:2, pages 102-135.
Crossref
L.S. Lautz, A.J. Hendriks, J.L.C.M. Dorne, J. Louisse & N.I. Kramer. (2023) Establishing allometric relationships between microsomal protein and cytochrome P450 content with body weight in vertebrate species. Toxicology 486, pages 153429.
Crossref
Ye Eun Joo, Pil-Soo Jeong, Sanghoon Lee, Se-Been Jeon, Min-Ah Gwon, Min Ju Kim, Hyo-Gu Kang, Bong-Seok Song, Sun-Uk Kim, Seong-Keun Cho & Bo-Woong Sim. (2023) Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway. Journal of Animal Science and Biotechnology 14:1.
Crossref
Albert Avila, Laura Prieto & Andrea Luna-Acosta. (2023) Nine decades of data on environmental chemical pollutant exposure in dogs: a bibliometric analysis. Environmental Science and Pollution Research 30:16, pages 45515-45527.
Crossref
R. Lock, P. J. H. Webborn, C. W. Vose & R. M. J. Ings. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry 265 297 .
Go Sugahara, Yuji Ishida, Jae Jin Lee, Meng Li, Yasuhito Tanaka, Hyungjin Eoh, Yusuke Higuchi & Takeshi Saito. (2023) Long‐term cell fate and functional maintenance of human hepatocyte through stepwise culture configuration . The FASEB Journal 37:2.
Crossref
Peter S.R. Wright, Katharine A. Briggs, Robert Thomas, Graham F. Smith, Gareth Maglennon, Paulius Mikulskis, Melissa Chapman, Nigel Greene, Benjamin U. Phillips & Andreas Bender. (2023) Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database. Regulatory Toxicology and Pharmacology 138, pages 105308.
Crossref
Zachary R. Sitte, Thomas J. DiProspero & Matthew R. Lockett. (2023) Evaluating the Impact of Physiologically Relevant Oxygen Tensions on Drug Metabolism in 3D Hepatocyte Cultures in Paper Scaffolds. Current Protocols 3:2.
Crossref
Annalaura Brai, Federica Poggialini, Chiara Vagaggini, Claudia Pasqualini, Sauro Simoni, Valeria Francardi & Elena Dreassi. (2023) Tenebrio molitor as a Simple and Cheap Preclinical Pharmacokinetic and Toxicity Model. International Journal of Molecular Sciences 24:3, pages 2296.
Crossref
Caitlin Krause, Kinga Suwada, Eric A. G. Blomme, Kenneth Kowalkowski, Michael J. Liguori, Prathap Kumar Mahalingaiah, Scott Mittelstadt, Richard Peterson, Lauren Rendino, Andy Vo & Terry R. Van Vleet. (2023) Preclinical species gene expression database: Development and meta-analysis. Frontiers in Genetics 13.
Crossref
Ying Li, Changcheng Sun, Yutian Zhang, Xiang Chen, Haoyan Huang, Luyao Han, Han Xing, Di Zhao, Xijing Chen & Yongjie Zhang. (2022) Phase I Metabolism of Pterostilbene, a Dietary Resveratrol Derivative: Metabolite Identification, Species Differences, Isozyme Contribution, and Further Bioactivation. Journal of Agricultural and Food Chemistry 71:1, pages 331-346.
Crossref
Masao Togao, Takashi Kurakawa, Shinnosuke Tajima, Gaku Wagai, Yuki Ohta-Takada, Jun Otsuka, Akinobu Kurita & Koji Kawakami. (2023) Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study. The Journal of Toxicological Sciences 48:6, pages 333-343.
Crossref
Azusa Kawashima, Naoto Uramaru, Toshiyasu Mikuma, Makoto Osabe & Toshiyuki Higuchi. (2023) Differential expression of Cytochrome P450 1A2 in simple fatty liver and steatohepatitis. Fundamental Toxicological Sciences 10:6, pages 265-277.
Crossref
永敏 刘. (2023) Research Progress of CYP450 Substrates, Inhibitors, Inducers and Species Specificity. Pharmacy Information 12:02, pages 70-80.
Crossref
Peng-Xin Ge, Ting Tai, Li-Ping Jiang, Jin-Zi Ji, Qiong-Yu Mi, Ting Zhu, Yi-Fei Li & Hong-Guang Xie. (2023) Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway. Journal of Thrombosis and Haemostasis 21:1, pages 117-132.
Crossref
Robin Maximilian Awad & Karine Breckpot. 2023.
Tasaduq Manzoor, Irfan Ahad Dar, Aarif Ali, Tawseef Manzoor, Sheikh Bilal Ahmad, Sameena Ismail, John Mohd Muneeb, Syed Ovais, Azher Arafah & Syed Mudasir Ahmad. 2023. Pharmacogenomics. Pharmacogenomics 33 55 .
Hao Liu, Siyuan Guo & Shuyi Xi. (2022) A high‐resolution accurate mass approach to identification of graveoline metabolites using ultra‐high‐performance liquid chromatography combined with a photo diode array detector and quadrupole/time‐of‐flight tandem mass spectrometry. Biomedical Chromatography 37:1.
Crossref
M. V. Miroshnikov, K. T. Sultanova, M. N. Makarova & V. G. Makarov. (2022) A comparative review of the activity of enzymes of the cytochrome P450 system in humans and laboratory animals. Prognostic value of preclinical models in vivo. Translational Medicine 9:5, pages 44-77.
Crossref
Selina Hemmer, Lea Wagmann, Benedikt Pulver, Folker Westphal & Markus R. Meyer. (2022) In Vitro and In Vivo Toxicometabolomics of the Synthetic Cathinone PCYP Studied by Means of LC-HRMS/MS. Metabolites 12:12, pages 1209.
Crossref
Ran Xu, Elijah G. Kiarie, Alexandros Yiannikouris, Lvhui Sun & Niel A. Karrow. (2022) Nutritional impact of mycotoxins in food animal production and strategies for mitigation. Journal of Animal Science and Biotechnology 13:1.
Crossref
Haonan Li, Xiaodan Wang, Yalong Wang, Mengxian Zhang, Fan Hong, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji & Ye-Guang Chen. (2022) Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium. Cell Regeneration 11:1.
Crossref
Maria das Graças Coelho de Souza, Iasmim Bento Leal, Fatima Zely Garcia de Almeida Cyrino & Eliete Bouskela. (2022) Effects of different routes of administration and doses of Sulodexide on leukocyte-endothelium interaction and tissue perfusion on an animal model of low flow and high pressure in veins. Phlebology: The Journal of Venous Disease 37:10, pages 721-731.
Crossref
Zhenxu Yang, Xiaochen Liu, Elise M. Cribbin, Alice M. Kim, Jiao Jiao Li & Ken-Tye Yong. (2022) Liver-on-a-chip: Considerations, advances, and beyond. Biomicrofluidics 16:6.
Crossref
Wenxiang Hu & Mitchell A. Lazar. (2022) Modelling metabolic diseases and drug response using stem cells and organoids. Nature Reviews Endocrinology 18:12, pages 744-759.
Crossref
Natalícia de Jesus Antunes, Gemma Coombes, Kelly Francisco da Cunha, Fernanda de Lima Moreira, Alan C. Pilon, Norberto Peporine Lopes, José Luiz da Costa, Karin Kipper, Lewis Couchman, Atholl Johnston & Gilberto De Nucci. (2022) In vitro metabolism of the new antifungal dapaconazole using liver microsomes. Drug Metabolism and Pharmacokinetics 47, pages 100475.
Crossref
So Shinya, Yusuke Kawai, Mitsuki Kondo, Shouta M.M. Nakayama, Mayumi Ishizuka & Yoshinori Ikenaka. (2022) Characteristics of cytochrome P450-dependent metabolism against acetamiprid in the musk shrew (Suncus murinus). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, pages 109537.
Crossref
Hong Huang, Er-Bing Zhang, Ou-Yang Yi, Han Wu, Guiming Deng, Yu-Ming Huang, Wen-Liang Liu, Jian-Ye Yan & Xiong Cai. (2022) Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats. Archives of Toxicology 96:12, pages 3245-3255.
Crossref
Jinping Zhou, Rui Zhang, Pengpeng Guo, Peixia Li, Xixi Huang, Ye Wei, Chunxiao Yang, Jiali Zhou, Tingyu Yang, Yani Liu & Shaojun Shi. (2022) Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats. Frontiers in Microbiology 13.
Crossref
Nadda Muhamad, Tullayakorn Plengsuriyakarn & Kesara Na-Bangchang. (2022) Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLOS ONE 17:11, pages e0277614.
Crossref
Przemysław J. Danek & Władysława A. Daniel. (2022) The Atypical Antipsychotic Lurasidone Affects Brain but Not Liver Cytochrome P450 2D (CYP2D) Activity. A Comparison with Other Novel Neuroleptics and Significance for Drug Treatment of Schizophrenia. Cells 11:21, pages 3513.
Crossref
Neerja Trivedi, Helen E. Erickson, Veenu Bala, Yashpal S. Chhonker & Daryl J. Murry. (2022) A Concise Review of Liquid Chromatography-Mass Spectrometry-Based Quantification Methods for Short Chain Fatty Acids as Endogenous Biomarkers. International Journal of Molecular Sciences 23:21, pages 13486.
Crossref
Tim Sinioja, Johanna Bodin, Daniel Duberg, Hubert Dirven, Hanne Friis Berntsen, Karin Zimmer, Unni C. Nygaard, Matej Orešič & Tuulia Hyötyläinen. (2022) Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice. Metabolomics 18:11.
Crossref
Pradeep Subedi, Hackwon Do, Jun Hyuck Lee & Tae-Jin Oh. (2022) Crystal Structure and Biochemical Analysis of a Cytochrome P450 CYP101D5 from Sphingomonas echinoides. International Journal of Molecular Sciences 23:21, pages 13317.
Crossref
Derek Simonsen, Jacob Heffelfinger, David M. Cwiertny & Hans-Joachim Lehmler. (2022) The dichloroacetamide safener benoxacor is enantioselectively metabolized by monkey liver microsomes and cytosol. Environmental Toxicology and Pharmacology 96, pages 104008.
Crossref
Rui Liu, Kate Marshall, Rui Ma, Kim Lien Thi Pham, Gauri Shetye, Zhihao Liu, Sanghyun Cho, Hyunyoung Jeong, Scott G. Franzblau, Garrett C. Moraski & Marvin J. Miller. (2022) Syntheses and studies of deuterated Imdiazo[1,2-a]pyridine-3-carboxamides with potent anti-tuberculosis activity and improved metabolic properties. Bioorganic Chemistry 128, pages 106074.
Crossref
Ai Goto, Kengo Sakamoto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Yasunari Kanda & Atsushi Sugiyama. (2022) Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile. Toxicological Sciences 190:1, pages 99-109.
Crossref
Colin N. Haile, Miah D. Baker, Sergio A. Sanchez, Carlos A. Lopez Arteaga, Anantha L. Duddupudi, Gregory D. Cuny, Elizabeth B. Norton, Thomas R. Kosten & Therese A. Kosten. (2022) An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats. Pharmaceutics 14:11, pages 2290.
Crossref
Jonathan M. Warawa, Xiaoxian Duan, Charles D. Anderson, Julie B. Sotsky, Daniel E. Cramer, Tia L. Pfeffer, Haixun Guo, Scott Adcock, Alexander J. Lepak, David R. Andes, Stacey A. Slone, Arnold J. Stromberg, Jon D. Gabbard, William E. Severson & Matthew B. Lawrenz. (2022) Validated Preclinical Mouse Model for Therapeutic Testing against Multidrug-Resistant Pseudomonas aeruginosa Strains. Microbiology Spectrum 10:5.
Crossref
Qun Wang, Yonglin Wang, Wen Liu, Dingyan Lu, Yang Jin, Nian Tang, Ya Shi, Zipeng Gong, Weiyi Tian & Ting Liu. (2022) Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-10.
Crossref
Mo'tasem M. Alsmadi, Laith N. AL Eitan, Nasir M. Idkaidek & Karem H. Alzoubi. (2022) The Development of a PBPK Model for Atomoxetine Using Levels in Plasma, Saliva and Brain Extracellular Fluid in Patients with Normal and Deteriorated Kidney Function. CNS & Neurological Disorders - Drug Targets 21:8, pages 704-716.
Crossref
Jinli Wu, Chao Yu, Xianggang Zeng, Yini Xu & Chengyi Sun. (2022) Protection of propofol on liver ischemia reperfusion injury by regulating Cyp2b10/ Cyp3a25 pathway. Tissue and Cell 78, pages 101891.
Crossref
Ewa Bromek, Przemysław Jan Danek, Jacek Wójcikowski, Agnieszka Basińska-Ziobroń, Renata Pukło, Joanna Solich, Marta Dziedzicka-Wasylewska & Władysława Anna Daniel. (2022) The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice. Pharmacological Reports 74:5, pages 1107-1114.
Crossref
Samar H. Gerges & Ayman O.S. El-Kadi. (2022) Sexual Dimorphism in the Expression of Cytochrome P450 Enzymes in Rat Heart, Liver, Kidney, Lung, Brain, and Small Intestine . Drug Metabolism and Disposition, pages DMD-AR-2022-000915.
Crossref
Martina Panzarea, Andrea Terron, Tamara Coja & Olavi Pelkonen. (2022) Editorial: Relevance of dog studies for the derivation of health‐based guidance values for plant protection products approval. EFSA Journal 20:9.
Crossref
Yan Weng, Kari R. Fonseca, Yi-an Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Andrew J. Bessire, Mathew A. Cerny, David A. Tess, A. David Rodrigues, Amit S. Kalgutkar, John Litchfield, Li Di & Manthena V. S. Varma. (2022) Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition 50:9, pages 1312-1321.
Crossref
Rieko Tanaka‐Yachi, Kazuko Aizawa, Kie shimizu, Hidenori Akutsu & Kazuaki Nakamura. (2022) Low‐density cell culture enhances hepatic function through tight junction formation in HepG2 cells. Biology of the Cell 114:9, pages 225-236.
Crossref
Su Gwon Lee, Kwan Hyung Cho, Thi-Thao-Linh Nguyen, Dang-Khoa Vo, Yoon-Jee Chae & Han-Joo Maeng. (2022) Inhibitory effect of 20(S)-protopanaxadiol on cytochrome P450: Potential of its pharmacokinetic interactions in vivo. Biomedicine & Pharmacotherapy 153, pages 113514.
Crossref
Elizabeth A. Terhune, Anna M. Monley, Melissa T. Cuevas, Cambria I. Wethey, Ryan S. Gray & Nancy Hadley-Miller. (2022) Genetic animal modeling for idiopathic scoliosis research: history and considerations. Spine Deformity 10:5, pages 1003-1016.
Crossref
Anna Zerdoug, Marc Le Vée, Shotaro Uehara, Béatrice Lopez, Christophe Chesné, Hiroshi Suemizu & Olivier Fardel. (2022) Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives. European Journal of Drug Metabolism and Pharmacokinetics 47:5, pages 621-637.
Crossref
Faiza Jabbar, Young-Su Kim & Sang Ho Lee. (2022) Biological Influence of Pulmonary Disease Conditions Induced by Particulate Matter on Microfluidic Lung Chips. BioChip Journal 16:3, pages 305-316.
Crossref
Mohammad Majd Hammour, Amnah Othman, Romina Aspera-Werz, Bianca Braun, Michaela Weis-Klemm, Silvia Wagner, Silvio Nadalin, Tina Histing, Marc Ruoß & Andreas K. Nüssler. (2022) Optimisation of the HepaRG cell line model for drug toxicity studies using two different cultivation conditions: advantages and limitations. Archives of Toxicology 96:9, pages 2511-2521.
Crossref
Bangzhen Hong, Shizhong Hong, Xuerui Hu, Fan He, Xiaoxiao Shan, Lei Wang & Weidong Chen. (2022) Evaluation of Zuo-Gui Yin Decoction Effects on Six CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS. BioMed Research International 2022, pages 1-13.
Crossref
Samantha V. Crosby, Izzeldin Y. Ahmed, Laura R. Osborn, Zeyuan Wang, Mary A. Schleiff, William E. Fantegrossi, Swati Nagar, Paul L. Prather, Gunnar Boysen & Grover P. Miller. (2022) Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes. Metabolites 12:8, pages 773.
Crossref
Fulin Jiang, Chang Zhang, Zihan Lu, Jingyu Liu, Peiqing Liu, Min Huang & Guoping Zhong. (2022) Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method. Frontiers in Pharmacology 13.
Crossref
Sandy Lemm, Susanne Köhler, Robert Wodtke, Friedrich Jung, Jan-Heiner Küpper, Jens Pietzsch & Markus Laube. (2022) Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines. Cells 11:15, pages 2447.
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Isaac Zamora-Bello, Daniel Hernandez-Baltazar, Juan Francisco Rodríguez-Landa & Eduardo Rivadeneyra-Domínguez. (2022) Optimizing rat and human blood cells sampling for in silico morphometric analysis. Acta Histochemica 124:6, pages 151917.
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Fei-Ke Zhao, Ren-Bin Shi, Yu-Bin Sun, Shuang-Yun Yang, Liang-Zhu Chen & Bing-Hu Fang. (2022) A Comprehensive Study to Identify Major Metabolites of an Amoxicillin–Sulbactam Hybrid Molecule in Rats and Its Metabolic Pathway Using UPLC-Q-TOF-MS/MS. Metabolites 12:7, pages 662.
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