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Expert Opinion on Drug Metabolism & Toxicology Volume 6, 2010 - Issue 9
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The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism

Elizabeth A Shephard University College London, Institute of Structural and Molecular Biology, Gower Street, London WC1E 6BT, UK +44 20 7679 2321; +44 20 7679 7193; [email protected]; University College London, UCL Genetics Institute, Gower Street, London WC1E 6BT, UK
, BSc Hons MSc PhD (Professor) &
Ian R Phillips Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London E1 4NS, UK +44 20 7882 6338; +44 20 8983 0973; [email protected]
, BSc Hons PhD (Professor)
Pages 1083-1094 | Published online: 14 Jul 2010

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Ian R. Phillips & Elizabeth A. Shephard. (2017) Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 167-181.
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Articles from other publishers (12)

Nuno G. Oliveira, Daniela L. Ramos & Ricardo Jorge Dinis-Oliveira. (2020) Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review. Archives of Toxicology 95:2, pages 375-393.
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Sunil Veeravalli, Ian R. Phillips, Rafael T. Freire, Dorsa Varshavi, Jeremy R. Everett & Elizabeth A. Shephard. (2020) Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. Drug Metabolism and Disposition 48:5, pages 378-385.
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Callum R. Nicoll, Gautier Bailleul, Filippo Fiorentini, María Laura Mascotti, Marco W. Fraaije & Andrea Mattevi. (2019) Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nature Structural & Molecular Biology 27:1, pages 14-24.
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Ian R. Phillips & Elizabeth A. Shephard. (2019) Endogenous Roles of Mammalian Flavin-Containing Monooxygenases. Catalysts 9:12, pages 1001.
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Makiko Shimizu, Hiroshi Suemizu, Sawa Mizuno, Takashi Kusama, Tomonori Miura, Shotaro Uehara & Hiroshi Yamazaki. (2018) Human plasma concentrations of trimethylamine <i>N</i>-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice. The Journal of Toxicological Sciences 43:6, pages 387-393.
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J.R. Cashman. 2018. Comprehensive Toxicology. Comprehensive Toxicology 87 125 .
Lei Ren, Mujian Teng, Tao Zhang, Xiaoqing Zhang, Bo Sun, Shengying Qin, Lin Zhong, Zhihai Peng & Junwei Fan. (2017) Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients . Pharmacogenomics 18:3, pages 265-275.
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Sandra G. Gonzalez Malagon, Anna N. Melidoni, Diana Hernandez, Bilal A. Omar, Lyndsey Houseman, Sunil Veeravalli, Flora Scott, Dorsa Varshavi, Jeremy Everett, Yugo Tsuchiya, John F. Timms, Ian R. Phillips & Elizabeth A. Shephard. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology 96:3, pages 267-277.
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Swetha Rudraiah, Philip R. Rohrer, Igor Gurevich, Michael J. Goedken, Theodore Rasmussen, Ronald N. Hines & José E. Manautou. (2014) Tolerance to Acetaminophen Hepatotoxicity in the Mouse Model of Autoprotection Is Associated with Induction of Flavin-Containing Monooxygenase-3 (FMO3) in Hepatocytes. Toxicological Sciences 141:1, pages 263-277.
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Thy-Hou Lin & Tsung-Lin Tsai. (2014) Constructing a linear QSAR for some metabolizable drugs by human or pig flavin-containing monooxygenases using some molecular features selected by a genetic algorithm trained SVM. Journal of Theoretical Biology 356, pages 85-97.
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Sunil Veeravalli, Bilal A. Omar, Lyndsey Houseman, Matthew Hancock, Sandra G. Gonzalez Malagon, Flora Scott, Azara Janmohamed, Ian R. Phillips & Elizabeth A. Shephard. (2014) The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. Biochemical Pharmacology 90:1, pages 88-95.
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John D. Watson, Stephenie D. Prokopec, Ashley B. Smith, Allan B. Okey, Raimo Pohjanvirta & Paul C. Boutros. (2014) TCDD dysregulation of 13 AHR-target genes in rat liver. Toxicology and Applied Pharmacology 274:3, pages 445-454.
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