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Volume 6, Issue 9

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 6, Issue 9 (2010)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 6, Issue 9 (2010)

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Editorial

Article

Isolated limb infusion for melanoma: a less morbid alternative to hyperthermic isolated limb perfusion in the US

Alfredo A Santillan (Assistant Professor) MD, MPH & Jonathan S Zager (Assistant Member) MD

Pages: 1033-1037

Published online: 17 Jul 2010

First Page PreviewforIsolated limb infusion for melanoma: a less morbid alternative to hyperthermic isolated limb perfusion in the US | Full Text | References | PDF (209.7 KB)

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Reviews

Article

Isolated limb infusion with melphalan and actinomycin D in melanoma patients: factors predictive of acute regional toxicity

Peter CA Kam (Nuffield Professor of Anaesthetics) MD FANZCA FRCA & John F Thompson (Professor of Melanoma and Surgical Oncology) MD FRACS FACS

Pages: 1039-1045

Published online: 07 Jul 2010

AbstractforIsolated limb infusion with melphalan and actinomycin D in melanoma patients: factors predictive of acute regional toxicity | Full Text | References | PDF (199.1 KB)

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Article

Predicting and preventing acute drug-induced liver injury: what's new in 2010?

Gordon Liss, Sushil Rattan & James H Lewis (Professor of Medicine, Director of Hepatology)

Pages: 1047-1061

Published online: 08 Jul 2010

AbstractforPredicting and preventing acute drug-induced liver injury: what's new in 2010? | Full Text | References | PDF (255.3 KB)

622 Views
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Article

Integration of in silico and in vitro platforms for pharmacokinetic–pharmacodynamic modeling

Jong Hwan Sung PhD, Mandy B Esch & Michael L Shuler

Pages: 1063-1081

Published online: 12 Jun 2010

AbstractforIntegration of in silico and in vitro platforms for pharmacokinetic–pharmacodynamic modeling | Full Text | References | PDF (444.1 KB)

629 Views
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Article

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism

Elizabeth A Shephard (Professor) BSc Hons MSc PhD & Ian R Phillips (Professor) BSc Hons PhD

Pages: 1083-1094

Published online: 14 Jul 2010

AbstractforThe potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism | Full Text | References | PDF (278.2 KB)

270 Views
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Article

Rationalization and prediction of in vivo metabolite exposures: the role of metabolite kinetics, clearance predictions and in vitro parameters

Justin D Lutz PharmD, Yasushi Fujioka PhD & Nina Isoherranen MSc PhD

Pages: 1095-1109

Published online: 17 Jun 2010

AbstractforRationalization and prediction of in vivo metabolite exposures: the role of metabolite kinetics, clearance predictions and in vitro parameters | Full Text | References | PDF (349 KB)

334 Views
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Article

The role of blood–ocular barrier transporters in retinal drug disposition: an overview

Masatoshi Tomi & Ken-ichi Hosoya (Professor)

Pages: 1111-1124

Published online: 03 May 2010

AbstractforThe role of blood–ocular barrier transporters in retinal drug disposition: an overview | Full Text | References | PDF (393.4 KB)

782 Views
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Article

Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs

Junya Nagai & Mikihisa Takano

Pages: 1125-1138

Published online: 10 Jun 2010

AbstractforMolecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs | Full Text | References | PDF (479.4 KB)

395 Views
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Drug Evaluations

Article

Vicriviroc, a new CC-chemokine receptor 5 inhibitor for treatment of HIV: properties, promises and challenges

Johannes Carl Christoph Lenz & Jürgen Kurt Rockstroh

Pages: 1139-1150

Published online: 17 Aug 2010

AbstractforVicriviroc, a new CC-chemokine receptor 5 inhibitor for treatment of HIV: properties, promises and challenges | Full Text | References | PDF (445.4 KB)

134 Views
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Article

Raltegravir: a review of its pharmacokinetics, pharmacology and clinical studies

David M Burger PharmD PhD

Pages: 1151-1160

Published online: 12 Aug 2010

AbstractforRaltegravir: a review of its pharmacokinetics, pharmacology and clinical studies | Full Text | References | PDF (252.7 KB)

689 Views
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Expert Opinion on Drug Metabolism & Toxicology (Vol.6, Iss.9, 2010)

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