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Expert Opinion on Drug Metabolism & Toxicology Volume 7, 2011 - Issue 1
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Mechanism of action and toxicities of purgatives used for colonoscopy preparation

Margaret Adamcewicz Temple University School of Medicine, Department of Medicine, Section of Gastroenterology, Philadelphia, 3401 North Broad Street, Philadelphia, PA 19140, USA +1 215 707 4391; +1 215 707 2684; [email protected]
, MD MS,
Dilip Bearelly Temple University School of Medicine, Department of Medicine, Section of Gastroenterology, Philadelphia, 3401 North Broad Street, Philadelphia, PA 19140, USA +1 215 707 4391; +1 215 707 2684; [email protected]
, MD,
Gail Porat Temple University School of Medicine, Department of Medicine, Section of Gastroenterology, Philadelphia, 3401 North Broad Street, Philadelphia, PA 19140, USA +1 215 707 4391; +1 215 707 2684; [email protected]
, MD &
Frank K Friedenberg Temple University School of Medicine, Department of Medicine, Section of Gastroenterology, Philadelphia, 3401 North Broad Street, Philadelphia, PA 19140, USA +1 215 707 4391; +1 215 707 2684; [email protected]
, MD
Pages 89-101 | Published online: 22 Dec 2010

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Pravin Shende, Rohan Khair & Ram S. Gaud. (2019) Nanostructured cochleates: a multi-layered platform for cellular transportation of therapeutics. Drug Development and Industrial Pharmacy 45:6, pages 869-881.
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Ruben Thanacoody, E. Martin Caravati, Bill Troutman, Jonas Höjer, Blaine Benson, Kalle Hoppu, Andrew Erdman, Regis Bedry & Bruno Mégarbane. (2015) Position paper update: Whole bowel irrigation for gastrointestinal decontamination of overdose patients. Clinical Toxicology 53:1, pages 5-12.
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Articles from other publishers (27)

Salvador Machlab, Esther Francia, Juanjo Mascort, Pilar García-Iglesias, Juan Manuel Mendive, Francesc Riba, Carles Guarner-Argente, Mònica Solanes, Jordi Ortiz & Xavier Calvet. (2023) Riesgos, indicaciones y aspectos técnicos de la colonoscopia en pacientes de edad avanzada o con fragilidad. Documento de posicionamiento de la Societat Catalana de Digestologia, la Societat Catalana de Geriatria i Gerontologia i la Societat Catalana de Medicina de Familia i Comunitaria. Gastroenterología y Hepatología.
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Apichet Sirinawasatien, Pallop Sakulthongthawin, Kanokpoj Chanpiwat & Tanyaporn Chantarojanasiri. (2022) Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial. BMC Gastroenterology 22:1.
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Ja Seol Koo, Jeong-Sik Byeon, Bo-In Lee, Sung-Ae Jung, Tae Il Kim & Yoon Tae Jeen. (2022) Efficacy and Safety of TJP-008 Compared to 2 L PEG with Ascorbate in Colon Cleansing: A Randomized Phase 3 Trial. Gut and Liver 16:2, pages 259-268.
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Milena Di Leo, Andrea Iannone, Monica Arena, Giuseppe Losurdo, Maria Angela Palamara, Giuseppe Iabichino, Pierluigi Consolo, Maria Rendina, Carmelo Luigiano & Alfredo Di Leo. (2021) Novel frontiers of agents for bowel cleansing for colonoscopy. World Journal of Gastroenterology 27:45, pages 7748-7770.
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Yasser Hamada, Ibrahim Emam, Rabab Maher & Hassan El-Garem. (2021) Evaluating lubiprostone for effective bowel preparation before colonoscopy. Egyptian Liver Journal 11:1.
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Menghan Zhang, Wenlu Zou, Changqin Xu, Ruzhen Jia, Keke Liu, Qianqian Xu & Hongwei Xu. (2021) Polyethylene glycol combined with linaclotide is an effective and well-tolerated bowel preparation regimen for colonoscopy: an endoscopist-blinded, randomized, controlled trial. European Journal of Gastroenterology & Hepatology 33:1S, pages e625-e633.
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Zina J. Ricci, Mariya Kobi, Milana Flusberg & Judy Yee. (2021) CT Colonography in Review With Tips and Tricks to Improve Performance. Seminars in Roentgenology 56:2, pages 140-151.
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Chahdah Skaff & Tareq Alayed. (2021) Lethal Complication From Inappropriately Prepared Polyethylene Glycol (Golytely) in a Pediatric Patient. Cureus.
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Xin Yuan, Zhixin Zhang, Jiarong Xie, Yu Zhang, Lu Xu, Weihong Wang & Lei Xu. (2021) Comparison of 1L Adjuvant Auxiliary Preparations with 2L Solely Polyethylene Glycol plus Ascorbic Acid Regime for Bowel Cleaning: A Meta-analysis of Randomized, Controlled Trials. BioMed Research International 2021, pages 1-9.
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Hein Htet & Jonathan Segal. (2020) New Ultra Low Volume Bowel Preparation and Overview of Existing Bowel Preparations. Current Drug Metabolism 21:11, pages 844-849.
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Zina Ricci, Mariya Kobi & Judy Yee. (2020) CT Colonography for Colorectal Cancer Screening. Journal of Radiology Nursing 39:3, pages 185-193.
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Valentine Ongeri Millien & Nabil M. Mansour. (2020) Bowel Preparation for Colonoscopy in 2020: A Look at the Past, Present, and Future. Current Gastroenterology Reports 22:6.
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Parth J. Parekh, Edward C. Oldfield & David A. Johnson. (2019) Bowel preparation for colonoscopy. Current Opinion in Gastroenterology 35:1, pages 51-57.
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Marvin Kajy & Preeti Ramappa. (2018) Atrial Fibrillation After Bowel Preparation for Colonoscopy. American Journal of Therapeutics 25:6, pages e781-e783.
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Martin Windpessl, Christoph Schwarz & Manfred Wallner. (2017) “Bowel prep hyponatremia“ – a state of acute water intoxication facilitated by low dietary solute intake: case report and literature review. BMC Nephrology 18:1.
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Judy A. Corliss. (2017) Effect of Low-Volume Split-Dose Purgative on the Quality of Bowel Prep for Colonoscopy on the Hospitalized Patient. Gastroenterology Nursing 40:6, pages 448-457.
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Samuel B. Ho, Rita Hovsepians & Samir Gupta. (2017) Optimal Bowel Cleansing for Colonoscopy in the Elderly Patient. Drugs & Aging 34:3, pages 163-172.
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Rupa Banerjee, Hrushikesh Chaudhari, Nirish Shah, Arjunan Saravanan, Manu Tandan & D. Nageshwar Reddy. (2016) Addition of Lubiprostone to polyethylene glycol(PEG) enhances the quality & efficacy of colonoscopy preparation: a randomized, double-blind, placebo controlled trial. BMC Gastroenterology 16:1.
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Aiden R. Liu, Amit X. Garg, Kuan Liu, Salimah Z. Shariff, Arsh K. Jain & Matthew A. Weir. (2016) Increased Risk of Adverse Renal Outcome Following Polyethylene Glycol Bowel Preparation Compared to Sodium Picosulfate. The Journal of Clinical Pharmacology 56:8, pages 983-987.
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Zheng Jin, Yi Lu, Yi Zhou & Biao Gong. (2016) Systematic review and meta-analysis: sodium picosulfate/magnesium citrate vs. polyethylene glycol for colonoscopy preparation. European Journal of Clinical Pharmacology 72:5, pages 523-532.
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Peter H. Rubin, Steven Naymagon, Christopher B. Williams & Jerome D. Waye. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 2569 2581 .
Jürgen Pohl, Marc Halphen, Hans Rudolf Kloess & Wolfgang Fischbach. (2015) Impact of the Quality of Bowel Cleansing on the Efficacy of Colonic Cancer Screening: A Prospective, Randomized, Blinded Study. PLOS ONE 10:5, pages e0126067.
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Marta Neira Álvarez, Estefanía Arias Muñana, Rafael Bielza Galindo & Jorge Gómez Cerezo. (2015) Hiperfosfatemia y perforación rectal; complicaciones asociadas al uso de enemas de fosfato. Revista Española de Geriatría y Gerontología 50:2, pages 97-98.
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Douglas K. Rex, Philip O. Katz, Gerald Bertiger, Stephen Vanner, Lawrence C. Hookey, Vivian Alderfer & Raymond E. Joseph. (2013) Split-dose administration of a dual-action, low-volume bowel cleanser for colonoscopy: the SEE CLEAR I study. Gastrointestinal Endoscopy 78:1, pages 132-141.
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Philip O Katz, Douglas K Rex, Michael Epstein, Nav K Grandhi, Stephen Vanner, Lawrence C Hookey, Vivian Alderfer & Raymond E Joseph. (2013) A Dual-Action, Low-Volume Bowel Cleanser Administered the Day Before Colonoscopy: Results From the SEE CLEAR II Study. American Journal of Gastroenterology 108:3, pages 401-409.
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Thomas McKenna, Alice Macgill, Gail Porat & Frank K. Friedenberg. (2012) Colonoscopy Preparation: Polyethylene Glycol with Gatorade Is as Safe and Efficacious as Four Liters of Polyethylene Glycol with Balanced Electrolytes. Digestive Diseases and Sciences 57:12, pages 3098-3105.
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Edith Schir, Sophie Barbouy-des-Courières, François Plottin & Michel Mallaret. (2012) Gastrite érosive sous préparation colique Colokit® (phosphate monosodique et disodique). Therapies 67:5, pages 477-479.
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